Fenoldopam mesylate (BioDeep_00000015294)
代谢物信息卡片
Fenoldopam (mesylate)
化学式: C17H20ClNO6S (401.07)
中文名称: 6-氯-2,3,4,5-四氢-1-(4-羟苯基)-1H-3-苯并氮杂卓-7,8-二醇甲磺酸盐
谱图信息:
最多检出来源 Homo sapiens(not specific) 50%
分子结构信息
SMILES: CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
InChI: 1H3,(H,2,3,4)
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:5003
- KEGG: C76117
- KEGGdrug: D00613
- PubChem: 49659
- ChEMBL: CHEMBL1026
- MeSH: Fenoldopam
- CAS: 67227-57-0
- medchemexpress: HY-B0735A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Bibhas Amatya, Sufei Yang, Peiying Yu, Pedro A S Vaz de Castro, Ines Armando, Chunyu Zeng, Robin A Felder, Laureano D Asico, Pedro A Jose, Hewang Lee. Peroxiredoxin-4 and dopamine D5 receptor interact to reduce oxidative stress and inflammation in the kidney.
Antioxidants & redox signaling.
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10.1089/ars.2022.0034. [PMID: 36401517] - Xiao Teng, Sijia Chen, Yingying Nie, Peng Xiao, Xiao Yu, Zhenhua Shao, Sanduo Zheng. Ligand recognition and biased agonism of the D1 dopamine receptor.
Nature communications.
2022 06; 13(1):3186. doi:
10.1038/s41467-022-30929-w. [PMID: 35676276] - Cindy Zeng, Tianyang Xia, Shuo Zheng, Lijia Liang, Yue Chen. Synergistic Effect of Uroguanylin and D1 Dopamine Receptors on Sodium Excretion in Hypertension.
Journal of the American Heart Association.
2022 03; 11(6):e022827. doi:
10.1161/jaha.121.022827. [PMID: 35229618] - Gianluigi Ardissino, Antenore Giussani, Valentina Capone, Sara Testa, Cristiano Gandini, Giovanni Montini. Fenoldopam and renal hemodynamics in shiga toxin-related hemolytic uremic syndrome.
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NMR in biomedicine.
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Transplantation proceedings.
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Minerva anestesiologica.
2010 Apr; 76(4):249-59. doi:
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Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2010 Mar; 75 Suppl 1(?):S15-20. doi:
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Journal of cardiothoracic and vascular anesthesia.
2010 Feb; 24(1):58-62. doi:
10.1053/j.jvca.2009.04.012. [PMID: 19553140] - Massimo Meco, Silvia Cirri. The effect of various fenoldopam doses on renal perfusion in patients undergoing cardiac surgery.
The Annals of thoracic surgery.
2010 Feb; 89(2):497-503. doi:
10.1016/j.athoracsur.2009.09.071. [PMID: 20103330] - Marco Ranucci. Invited commentary.
The Annals of thoracic surgery.
2010 Feb; 89(2):503-4. doi:
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Current opinion in critical care.
2009 Dec; 15(6):514-9. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Dec; 297(6):R1660-9. doi:
10.1152/ajpregu.00147.2009. [PMID: 19726707] - Alan B Weder, Lillian Gleiberman, Amit Sachdeva. Urinary dopamine excretion and renal responses to fenoldopam infusion in blacks and whites.
Journal of clinical hypertension (Greenwich, Conn.).
2009 Dec; 11(12):707-12. doi:
10.1111/j.1751-7176.2009.00197.x. [PMID: 20021527] - Sarah E Yoder, Bradley A Yoder. An evaluation of off-label fenoldopam use in the neonatal intensive care unit.
American journal of perinatology.
2009 Nov; 26(10):745-50. doi:
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Hypertension (Dallas, Tex. : 1979).
2009 Nov; 54(5):1070-6. doi:
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Hypertension (Dallas, Tex. : 1979).
2009 Jun; 53(6):1054-61. doi:
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Hypertension (Dallas, Tex. : 1979).
2009 Mar; 53(3):564-70. doi:
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Journal of cardiothoracic and vascular anesthesia.
2009 Feb; 23(1):128; author reply 128-9. doi:
10.1053/j.jvca.2008.01.012. [PMID: 18834777] - Zaccaria Ricci, Giulia V Stazi, Luca Di Chiara, Stefano Morelli, Vincenzo Vitale, Chiara Giorni, Claudio Ronco, Sergio Picardo. Fenoldopam in newborn patients undergoing cardiopulmonary bypass: controlled clinical trial.
Interactive cardiovascular and thoracic surgery.
2008 Dec; 7(6):1049-53. doi:
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BMJ clinical evidence.
2008 Sep; 2008(?):. doi:
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Journal of veterinary internal medicine.
2008 Sep; 22(5):1210-5. doi:
10.1111/j.1939-1676.2008.0146.x. [PMID: 18638020] - Brady S Moffett, Antonio R Mott, David P Nelson, Stuart L Goldstein, John Lynn Jefferies. Renal effects of fenoldopam in critically ill pediatric patients: A retrospective review.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2008 Jul; 9(4):403-6. doi:
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The International journal of artificial organs.
2008 Jun; 31(6):561. doi:
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Critical care medicine.
2008 May; 36(5):1427-35. doi:
10.1097/ccm.0b013e31816f48ba. [PMID: 18434903] - Dean R Jones, H Thomas Lee. Perioperative renal protection.
Best practice & research. Clinical anaesthesiology.
2008 Mar; 22(1):193-208. doi:
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Pediatric nephrology (Berlin, Germany).
2008 Mar; 23(3):495-8. doi:
10.1007/s00467-007-0659-z. [PMID: 18000686] - Weixing Han, Hewang Li, Van Anthony M Villar, Annabelle M Pascua, Mustafa I Dajani, Xiaoyang Wang, Aruna Natarajan, Mark T Quinn, Robin A Felder, Pedro A Jose, Peiying Yu. Lipid rafts keep NADPH oxidase in the inactive state in human renal proximal tubule cells.
Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):481-7. doi:
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Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):360-6. doi:
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Journal of cardiothoracic and vascular anesthesia.
2008 Feb; 22(1):27-33. doi:
10.1053/j.jvca.2007.07.015. [PMID: 18249327] - Agostino Roasio, Rosetta Lobreglio, Agostino Santin, Giovanni Landoni, Claudio Verdecchia. Fenoldopam reduces the incidence of renal replacement therapy after cardiac surgery.
Journal of cardiothoracic and vascular anesthesia.
2008 Feb; 22(1):23-6. doi:
10.1053/j.jvca.2007.07.012. [PMID: 18249326] - Tereza Pucelikova, George Dangas, Roxana Mehran. Contrast-induced nephropathy.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2008 Jan; 71(1):62-72. doi:
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Journal of cardiothoracic and vascular anesthesia.
2007 Dec; 21(6):847-50. doi:
10.1053/j.jvca.2007.02.022. [PMID: 18068064] - G Nicoletta, M Cascelli, L Marchesini, S Tesoro. A probable case of nitroprusside intoxication.
Minerva anestesiologica.
2007 Sep; 73(9):471-3. doi:
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Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.
2007 Aug; 14(4):520-7. doi:
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Transplantation proceedings.
2007 Jul; 39(6):1794-6. doi:
10.1016/j.transproceed.2007.05.065. [PMID: 17692615] - F Pugliese, F Ruberto, K Bruno, S Martelli, S Perrella, A Cappannoli, A D'Alio, T Messina, D Summonti, C Pietropaoli, M Rossi, G Novelli, P B Berloco, P Pietropaoli. Fenoldopam and gastric tonometry during orthotopic liver transplantation.
Transplantation proceedings.
2007 Jul; 39(6):1886-8. doi:
10.1016/j.transproceed.2007.05.063. [PMID: 17692643] - Roxana Mehran. Contrast-induced nephropathy remains a serious complication of PCI.
Journal of interventional cardiology.
2007 Jun; 20(3):236-40. doi:
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American journal of physiology. Renal physiology.
2007 May; 292(5):F1435-42. doi:
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