Alprenolol hydrochloride (BioDeep_00000015292)
代谢物信息卡片
Alprenolol hydrochloride
化学式: C15H24ClNO2 (285.14954739999996)
中文名称: 阿普洛尔 盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=CC=C1CC=C)O.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31191
- KEGG: C72492
- KEGGdrug: D01182
- PubChem: 66368
- ChEMBL: CHEMBL1256179
- MeSH: Alprenolol
- CAS: 13707-88-5
- CAS: 15132-12-4
- medchemexpress: HY-B1517A
分类词条
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文献列表
- Mohammed M Nooh, Salvatore Mancarella, Suleiman W Bahouth. Novel Paradigms Governing β1-Adrenergic Receptor Trafficking in Primary Adult Rat Cardiac Myocytes.
Molecular pharmacology.
2018 08; 94(2):862-875. doi:
10.1124/mol.118.112045. [PMID: 29848777] - Virgínia M F Gonçalves, Patrícia Rodrigues, Cláudia Ribeiro, Maria E Tiritan. Quantification of alprenolol and propranolol in human plasma using a two-dimensional liquid chromatography (2D-LC).
Journal of pharmaceutical and biomedical analysis.
2017 Jul; 141(?):1-8. doi:
10.1016/j.jpba.2017.03.064. [PMID: 28412606] - Jonathan A Rose, Nicholas Wanner, Hoi I Cheong, Kimberly Queisser, Patrick Barrett, Margaret Park, Corrine Hite, Sathyamangla V Naga Prasad, Serpil Erzurum, Kewal Asosingh. Flow Cytometric Quantification of Peripheral Blood Cell β-Adrenergic Receptor Density and Urinary Endothelial Cell-Derived Microparticles in Pulmonary Arterial Hypertension.
PloS one.
2016; 11(6):e0156940. doi:
10.1371/journal.pone.0156940. [PMID: 27270458] - Iqbal Mahmood, Xinli Liu, Saburo Neya, Tyuji Hoshino. Influence of lipid composition on the structural stability of g-protein coupled receptor.
Chemical & pharmaceutical bulletin.
2013; 61(4):426-37. doi:
10.1248/cpb.c12-01059. [PMID: 23546002] - Naoya Kishikawa, Mizuho Ohkuma, Mitsuhiro Wada, Kaname Ohyama, Rie Ikeda, Kenichiro Nakashima, Naotaka Kuroda. Labeling of alprenolol with fluorescent aryl iodide as a reagent based on Mizoroki-Heck coupling reaction.
Journal of chromatography. A.
2011 May; 1218(20):3002-6. doi:
10.1016/j.chroma.2011.03.030. [PMID: 21489541] - Maki Mizogami, Ko Takakura, Hironori Tsuchiya. The interactivities with lipid membranes differentially characterize selective and nonselective beta1-blockers.
European journal of anaesthesiology.
2010 Sep; 27(9):829-34. doi:
10.1097/eja.0b013e32833bf5e4. [PMID: 20601889] - Harri Härmä, Anita Rozwandowicz-Jansen, Eija Martikkala, Heini Frang, Ilkka Hemmilä, Niko Sahlberg, Vidal Fey, Merja Perälä, Pekka Hänninen. A new simple cell-based homogeneous time-resolved fluorescence QRET technique for receptor-ligand interaction screening.
Journal of biomolecular screening.
2009 Sep; 14(8):936-43. doi:
10.1177/1087057109341657. [PMID: 19684287] - Hiroyuki Kobayashi, Koji Ogawa, Rong Yao, Olivier Lichtarge, Michel Bouvier. Functional rescue of beta-adrenoceptor dimerization and trafficking by pharmacological chaperones.
Traffic (Copenhagen, Denmark).
2009 Aug; 10(8):1019-33. doi:
10.1111/j.1600-0854.2009.00932.x. [PMID: 19515093] - Xiaogang Hu, Jialiang Pan, Yuling Hu, Gongke Li. Preparation and evaluation of propranolol molecularly imprinted solid-phase microextraction fiber for trace analysis of beta-blockers in urine and plasma samples.
Journal of chromatography. A.
2009 Jan; 1216(2):190-7. doi:
10.1016/j.chroma.2008.11.064. [PMID: 19084232] - Hongliang Jiang, Xiangyu Jiang, Qin C Ji. Enantioselective determination of alprenolol in human plasma by liquid chromatography with tandem mass spectrometry using cellobiohydrolase chiral stationary phases.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 872(1-2):121-7. doi:
10.1016/j.jchromb.2008.07.022. [PMID: 18691951] - Giovanni D'Orazio, Salvatore Fanali. Enantiomeric separation by using nano-liquid chromatography with on-column focusing.
Journal of separation science.
2008 Aug; 31(14):2567-71. doi:
10.1002/jssc.200800114. [PMID: 18623279] - N Venkat Appa Rao, Carlo Macchi, Cinzia Tortorella, M Firoz Ahmad, Gastone G Nussdorfer. Neuropeptide Y and glucocorticoid secretion from guinea pig adrenal gland: an in vivo and in vitro study.
International journal of molecular medicine.
2007 Sep; 20(3):345-9. doi:
. [PMID: 17671739] - Dipali Raha, Cinzia Tortorella, Giuliano Neri, Anita Prasad, Bushra Raza, Ranu Raskar, Rakhi Dubey, Nisarga S Sen, Carlo Macchi, Ludwick K Malendowicz, M Firoz Ahmad, Gastone G Nussdorfer. Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines.
International journal of molecular medicine.
2006 Apr; 17(4):633-6. doi:
10.3892/ijmm.17.4.633. [PMID: 16525720] - Maria A Martinez-Gomez, Rosa M Villanueva-Camañas, Salvador Sagrado, Maria J Medina-Hernández. Multivariate optimization approach for chiral resolution of drugs using human serum albumin in affinity electrokinetic chromatography-partial filling technique.
Electrophoresis.
2005 Nov; 26(21):4116-26. doi:
10.1002/elps.200500304. [PMID: 16252317] - J Carron, C Morel, J W Blum, H M Hammon. Effects of dexamethasone and colostrum feeding on mRNA levels and binding capacities of beta-adrenergic receptors in the liver of neonatal calves.
Domestic animal endocrinology.
2005 Apr; 28(3):257-71. doi:
10.1016/j.domaniend.2004.10.001. [PMID: 15760667] - Savitha Devanathan, Zhiping Yao, Zdzislaw Salamon, Brian Kobilka, Gordon Tollin. Plasmon-waveguide resonance studies of ligand binding to the human beta 2-adrenergic receptor.
Biochemistry.
2004 Mar; 43(11):3280-8. doi:
10.1021/bi035825a. [PMID: 15023079] - Haruyo Sanbe, Jun Haginaka. Restricted access media-molecularly imprinted polymer for propranolol and its application to direct injection analysis of beta-blockers in biological fluids.
The Analyst.
2003 Jun; 128(6):593-7. doi:
10.1039/b301257n. [PMID: 12866873] - Hitoshi Imamura, Takafumi Komori, Ahmed Ismail, Ayaka Suenaga, Masaki Otagiri. Stereoselective protein binding of alprenolol in the renal diseased state.
Chirality.
2002 Jul; 14(7):599-603. doi:
10.1002/chir.10097. [PMID: 12112335] - A Can, K Sayar, E Friedman, C Ambrosio, E Erdemli, H Gurdal. The effects of agonist stimulation and beta(2)-adrenergic receptor level on cellular distribution of gs(alpha) protein.
Cellular signalling.
2000 May; 12(5):303-9. doi:
10.1016/s0898-6568(00)00071-1. [PMID: 10822171] - G Albertin, L K Malendowicz, C Tortorella, G Mazzocchi, G G Nussdorfer. Evidence for a paracrine role of adrenomedullin in the physiological resetting of aldosterone secretion by rat adrenal zona glomerulosa.
Peptides.
2000 Mar; 21(3):413-7. doi:
10.1016/s0196-9781(00)00162-5. [PMID: 10793225] - J Haginaka, H Matsunaga. Separation of enantiomers on HPLC chiral stationary phases based on human plasma alpha1-acid glycoprotein: effect of sugar moiety on chiral recognition ability.
Enantiomer.
2000; 5(1):37-45. doi:
NULL. [PMID: 10763868] - T Seifert, O Zschörnig, J Arnhold, K Arnold. Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro.
Chemistry and physics of lipids.
1997 Jan; 85(1):13-21. doi:
10.1016/s0009-3084(96)02637-0. [PMID: 9032944] - B Baranowska, E Wasilewska-Dziubińska, M Radzikowska, A Płlonowski, K Roguski, E Krawczyk, M Kawalec. Effects of PACAP and VIP on adrenal progesterone release.
Annals of the New York Academy of Sciences.
1996 Dec; 805(?):628-33. doi:
10.1111/j.1749-6632.1996.tb17532.x. [PMID: 8993452] - K Wieland, H M Zuurmond, C Krasel, A P Ijzerman, M J Lohse. Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.
Proceedings of the National Academy of Sciences of the United States of America.
1996 Aug; 93(17):9276-81. doi:
10.1073/pnas.93.17.9276. [PMID: 8799191] - H Okuda, C Morimoto, T Tsujita. Beta-Adrenergic receptors in rat fat cells and their relationship with lipolysis.
Journal of biochemistry.
1996 May; 119(5):852-6. doi:
10.1093/oxfordjournals.jbchem.a021321. [PMID: 8797083] - K M Höld, D de Boer, K L Bos, R D van Ooijen, J Zuidema, R A Maes. Enantioselective quantitation of (R)- and (S)-alprenolol by gas chromatography-mass spectrometry in human saliva an plasma.
Journal of chromatographic science.
1996 Jan; 34(1):13-9. doi:
10.1093/chromsci/34.1.13. [PMID: 8586675] - K Nonogaki, A H Moser, X M Pan, I Staprans, C Grunfeld, K R Feingold. Lipoteichoic acid stimulates lipolysis and hepatic triglyceride secretion in rats in vivo.
Journal of lipid research.
1995 Sep; 36(9):1987-95. doi:
NULL. [PMID: 8558086] - J V Gobburu, W H Shelver. Quantitative structure-pharmacokinetic relationships (QSPR) of beta blockers derived using neural networks.
Journal of pharmaceutical sciences.
1995 Jul; 84(7):862-5. doi:
10.1002/jps.2600840715. [PMID: 7562438] - L Hovgaard, H Brøndsted, A Buur, H Bundgaard. Drug delivery studies in Caco-2 monolayers. Synthesis, hydrolysis, and transport of O-cyclopropane carboxylic acid ester prodrugs of various beta-blocking agents.
Pharmaceutical research.
1995 Mar; 12(3):387-92. doi:
10.1023/a:1016204602471. [PMID: 7617526] - F Belachgar, F Discala-Blondeau, D Tondelier, M Baudouin-Legros, T Anagnostopoulos. Actions of isoproterenol in frog proximal tubules.
Cellular signalling.
1995 Feb; 7(2):131-8. doi:
10.1016/0898-6568(94)00078-p. [PMID: 7794685] - M Johansson, P Sjöberg, A M Hesselgren, T Salmonson. Enantioselective assay of beta-receptor antagonists present in microdialysis and plasma samples of rats.
Chirality.
1995; 7(4):290-6. doi:
10.1002/chir.530070417. [PMID: 7640173] - M Rosenbaum, C C Malbon, J Hirsch, R L Leibel. Lack of beta 3-adrenergic effect on lipolysis in human subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism.
1993 Aug; 77(2):352-5. doi:
10.1210/jcem.77.2.8393882. [PMID: 8393882] - M von Zastrow, B K Kobilka. Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.
The Journal of biological chemistry.
1992 Feb; 267(5):3530-8. doi:
NULL. [PMID: 1371121] - D F Cousineau, C A Goresky, C P Rose, A J Schwab. Cardiac microcirculatory effects of beta-adrenergic blockade during sympathetic stimulation.
Circulation research.
1991 Apr; 68(4):997-1006. doi:
10.1161/01.res.68.4.997. [PMID: 1849061] - T Friedrich, G Burckhardt. Inhibition of the rat renal Na+/H+ exchanger by beta-adrenergic antagonists.
Biochemical and biophysical research communications.
1991 Feb; 175(1):311-7. doi:
10.1016/s0006-291x(05)81236-7. [PMID: 1671814] - J Segal, S H Ingbar. Evidence that an increase in cytoplasmic calcium is the initiating event in certain plasma membrane-mediated responses to 3,5,3'-triiodothyronine in rat thymocytes.
Endocrinology.
1989 Apr; 124(4):1949-55. doi:
10.1210/endo-124-4-1949. [PMID: 2538316] - K P Devi, K V Rao, S K Baveja, T Leemann, P Dayer. Determination of alprenolol and metoprolol in plasma by column liquid chromatography.
Journal of chromatography.
1988 Dec; 434(1):265-70. doi:
10.1016/0378-4347(88)80086-0. [PMID: 3243824] - J Segal. Biphasic stimulation of cellular calcium concentration by 3,5,3'-triiodothyronine in rat thymocytes.
Biochemistry.
1988 Apr; 27(7):2586-90. doi:
10.1021/bi00407a047. [PMID: 3382641] - J R Jasper, H J Motulsky, P A Insel. Characterization of a bromoacetylated derivative of pindolol as a high affinity, irreversible beta adrenergic antagonist in cultured cells.
The Journal of pharmacology and experimental therapeutics.
1988 Mar; 244(3):820-4. doi:
NULL. [PMID: 2908047] - S Q Alam, Y F Ren, B S Alam. [3H]forskolin- and [3H]dihydroalprenolol-binding sites and adenylate cyclase activity in heart of rats fed diets containing different oils.
Lipids.
1988 Mar; 23(3):207-13. doi:
10.1007/bf02535459. [PMID: 3374274] - L U Gerdes, H J Jürgensen, P H Groot, O Faergeman. The long-term effect of alprenolol on plasma apolipoproteins A-I and B.
Acta medica Scandinavica.
1988; 223(5):419-22. doi:
10.1111/j.0954-6820.1988.tb15892.x. [PMID: 3132028] - P H Fishman, J P Finberg. Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells.
Journal of neurochemistry.
1987 Jul; 49(1):282-9. doi:
10.1111/j.1471-4159.1987.tb03427.x. [PMID: 3035098] - P Seideman, K O Borg, K Haglund, C Von Bahr. Decreased plasma concentrations and clinical effects of alprenolol during combined treatment with pentobarbitone in hypertension.
British journal of clinical pharmacology.
1987 Mar; 23(3):267-71. doi:
10.1111/j.1365-2125.1987.tb03044.x. [PMID: 3567041] - O Gyllenhaal. Derivatization of 2-amino alcohols with phosgene in aqueous media: limitations of the reaction selectivity as found in the presence of O-glucuronides of alprenolol in urine.
Journal of chromatography.
1987 Jan; 413(?):270-6. doi:
10.1016/0378-4347(87)80238-4. [PMID: 3558679] - K Brismar, L Mogensen, L Wetterberg. Depressed melatonin secretion in patients with nightmares due to beta-adrenoceptor blocking drugs.
Acta medica Scandinavica.
1987; 221(2):155-8. doi:
10.1111/j.0954-6820.1987.tb01260.x. [PMID: 2884812] - Y Kawai, S M Graham, H Yoshioka, I J Arinze. Beta-adrenergic receptors in guinea-pig liver plasma membranes and thermal lability of [3H]dihydroalprenolol binding sites.
Biochemical pharmacology.
1986 Dec; 35(24):4387-93. doi:
10.1016/0006-2952(86)90753-7. [PMID: 3024648] - G S Duchateau, W M Albers, H H van Rooij. Rapid and simple determination of alprenolol in serum.
Journal of chromatography.
1986 Nov; 383(1):212-7. doi:
10.1016/s0378-4347(00)83463-5. [PMID: 2880857] - M Wood. Plasma drug binding: implications for anesthesiologists.
Anesthesia and analgesia.
1986 Jul; 65(7):786-804. doi:
NULL. [PMID: 3087239] - B J Shields, J J Lima, P F Binkley, C V Leier, J J MacKichan. Determination of pindolol in human plasma and urine by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography.
1986 May; 378(1):163-71. doi:
10.1016/s0378-4347(00)80709-4. [PMID: 3733969] - G Sager, D Sandnes, I Aakesson, S Jacobsen. Effect of serum, alpha-1 acid glycoprotein, lipoproteins and albumin on human mononuclear leucocyte beta-adrenoceptors.
Acta pharmacologica et toxicologica.
1986 Mar; 58(3):193-203. doi:
10.1111/j.1600-0773.1986.tb00094.x. [PMID: 3012942] - O E Brodde, X L Wang, N O'Hara, A Daul, W Schiess. Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S70-3. doi:
10.1097/00005344-198608006-00016. [PMID: 2439825] - S G Olovson, N Havu, C G Regårdh, A Sandberg. Oesophageal ulcerations and plasma levels of different alprenolol salts: potential implications for the clinic.
Acta pharmacologica et toxicologica.
1986 Jan; 58(1):55-60. doi:
10.1111/j.1600-0773.1986.tb00070.x. [PMID: 3953295] - O Gyllenhaal. Direct derivatization of alprenolol and its 4-hydroxy metabolite in urine with phosgene and methanol prior to analysis by capillary column gas chromatography.
Journal of chromatography.
1985 Dec; 349(2):447-56. doi:
10.1016/s0021-9673(01)83804-8. [PMID: 4086647] - I S Chekman, L I Budarin, N E Nurishchenko, L V Ivanov, P V Pogrebnoĭ. [Interaction of beta-adrenergic agents with the plasma membranes of the myocardium].
Biulleten' eksperimental'noi biologii i meditsiny.
1985 Aug; 100(8):208-10. doi:
NULL. [PMID: 2862931] - G Sager, D Sandnes, A Bessesen, S Jacobsen. Adrenergic ligand binding in human serum.
Biochemical pharmacology.
1985 Aug; 34(15):2812-5. doi:
10.1016/0006-2952(85)90584-2. [PMID: 4015719] - J Segal, C Buckley, S H Ingbar. Stimulation of adenylate cyclase activity in rat thymocytes in vitro by 3,5,3'-triiodothyronine.
Endocrinology.
1985 May; 116(5):2036-43. doi:
10.1210/endo-116-5-2036. [PMID: 2985369] - H Tsuchihashi, T Nagatomo. Influence of polymeric effectors on binding of 3H-dihydroalprenolol to beta-adrenergic receptor of rat brain.
Japanese journal of pharmacology.
1985 May; 38(1):17-23. doi:
10.1254/jjp.38.17. [PMID: 2991640] - J G Guillet, S V Kaveri, O Durieu, C Delavier, J Hoebeke, A D Strosberg. beta-Adrenergic agonist activity of a monoclonal anti-idiotypic antibody.
Proceedings of the National Academy of Sciences of the United States of America.
1985 Mar; 82(6):1781-4. doi:
10.1073/pnas.82.6.1781. [PMID: 2858851] - O E Brodde, A Daul, N Stuka, N O'Hara, U Borchard. Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the 'intrinsic sympathomimetic activity'.
Naunyn-Schmiedeberg's archives of pharmacology.
1985 Feb; 328(4):417-22. doi:
10.1007/bf00692910. [PMID: 2859531] - A D Strosberg, S Chamat, J G Guillet, B Lavaud, L Emorine, J Hoebeke. Idiotypy of catecholamine-binding proteins.
Annales de l'Institut Pasteur. Immunologie.
1985 Jan; 136C(1):157-68. doi:
10.1016/s0769-2625(85)80047-7. [PMID: 2986515] - J B Lecaillon, N Febvre, C Souppart. Influence of solute polarity in column-switching chromatography for the assay of drugs in plasma and urine.
Journal of chromatography.
1984 Dec; 317(?):493-506. doi:
10.1016/s0021-9673(01)91689-9. [PMID: 6530451] - F Pedersen, S L Rasmussen, K Kølendorf, E Christiansen. The effect of alprenolol on serum myoglobin levels in acute myocardial infarction.
Scandinavian journal of clinical and laboratory investigation.
1984 Nov; 44(7):649-54. doi:
10.3109/00365518409083625. [PMID: 6531653] - S A Bai, T Walle. Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites.
Drug metabolism and disposition: the biological fate of chemicals.
1984 Nov; 12(6):749-54. doi:
NULL. [PMID: 6150825] - K E Meier, A E Ruoho. Uptake of L-[propyl-2,3-3H]dihydroalprenolol by intact HeLa cells.
Biochimica et biophysica acta.
1984 Jul; 804(3):331-40. doi:
10.1016/0167-4889(84)90136-8. [PMID: 6146352] - D Cousineau, C A Goresky, G G Bach, C P Rose. Effect of beta-adrenergic blockade on in vivo norepinephrine release in canine heart.
The American journal of physiology.
1984 Feb; 246(2 Pt 2):H283-92. doi:
10.1152/ajpheart.1984.246.2.h283. [PMID: 6141743] - H Perrild, F Pedersen, S L Rasmussen, H J Jürgensen, L Skovsted. Long-term alprenolol treatment affects serum T4, T3 and rT3 in euthyroid patients with ischaemic heart disease.
Acta endocrinologica.
1984 Feb; 105(2):190-3. doi:
10.1530/acta.0.1050190. [PMID: 6364669] - F Pedersen, H Perrild, S L Rasmussen, L Skovsted. 'Low T3-syndrome' in acute myocardial infarction--relationship to beta-adrenergic blockade and clinical course.
European journal of clinical pharmacology.
1984; 26(6):669-73. doi:
10.1007/bf00541923. [PMID: 6149125] - A Bruinink, W Lichtensteiger. Effects of pH and ascorbic acid on 3H-spiperone and 3H-dihydroalprenolol binding in rat forebrain homogenates.
Journal of receptor research.
1984; 4(1-6):127-39. doi:
10.3109/10799898409042544. [PMID: 6527352] - M Lehmann, P Schmid, E Bergdolt, H Porzig, J Keul. [Determination of beta-receptors on intact polymorphonuclear leukocytes in autologous plasma].
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1983 Dec; 21(12):805-11. doi:
NULL. [PMID: 6319533] - G D Johnston, A S Nies, J Gal. Determination of metoprolol in human blood plasma using high-performance liquid chromatography.
Journal of chromatography.
1983 Nov; 278(1):204-8. doi:
10.1016/s0378-4347(00)84776-3. [PMID: 6662882] - R E Heikkila. Ascorbate-induced lipid peroxidation and the binding of [3H]dihydroalprenolol.
European journal of pharmacology.
1983 Sep; 93(1-2):79-85. doi:
10.1016/0014-2999(83)90032-8. [PMID: 6628548] - G Matsumoto. [Characteristics of lipolytic activities in the genetically obese Zucker fatty rats--experimental study on (-)-[3H]dihydroalprenolol binding in the intact fat cells].
Nihon Naibunpi Gakkai zasshi.
1983 Aug; 59(8):1145-59. doi:
10.1507/endocrine1927.59.8_1145. [PMID: 6141076] - M Imai, R Nakamura, E Kusano. [Specific binding of [3H]-dihydroalprenolol and [3H]-prazosin to kidney tubules].
Nihon Jinzo Gakkai shi.
1983 Jul; 25(7):881-4. doi:
NULL. [PMID: 6663872] - P O Couraud, B Z Lü, A D Strosberg. Cyclical antiidiotypic response to anti-hormone antibodies due to neutralization by autologous anti-antiidiotype antibodies that bind hormone.
The Journal of experimental medicine.
1983 May; 157(5):1369-78. doi:
10.1084/jem.157.5.1369. [PMID: 6602199] - M Wilkinson, R Bhanot, D A Wilkinson, G Eskes, W H Moger. Photoperiodic modification of opiate but not beta-adrenergic or benzodiazepine binding sites in hamster brain.
Biology of reproduction.
1983 May; 28(4):878-82. doi:
10.1095/biolreprod28.4.878. [PMID: 6134560] - H Perrild, J M Hansen, L Skovsted, L K Christensen. Different effects of propranolol, alprenolol, sotalol, atenolol and metoprolol on serum T3 and serum rT3 in hyperthyroidism.
Clinical endocrinology.
1983 Feb; 18(2):139-42. doi:
10.1111/j.1365-2265.1983.tb03196.x. [PMID: 6133659] - A Borsodi, A Bogdany, G Toth, G Grigorian, N Halasz. Purification and characterization of beta-adrenoreceptor rich heart plasma membrane.
Biochemistry international.
1983 Feb; 6(2):157-62. doi:
NULL. [PMID: 6089806] - L Herngren, M Ehrnebo, L O Boréus. Drug binding to plasma proteins during human pregnancy and in the perinatal period. Studies on cloxacillin and alprenolol.
Developmental pharmacology and therapeutics.
1983; 6(2):110-24. doi:
10.1159/000457284. [PMID: 6861596] - J Segal, S H Ingbar. Specific binding sites for the triiodothyronine in the plasma membrane of rat thymocytes. Correlation with biochemical responses.
The Journal of clinical investigation.
1982 Nov; 70(5):919-26. doi:
10.1172/jci110703. [PMID: 6290538] - E M Dax, J S Partilla, R I Gregerman. The (--)[3H]dihydroalprenolol binding to rat adipocyte membranes: an explanation of curvilinear Scatchard plots and implications for quantitation of beta-adrenergic sites.
Journal of lipid research.
1982 Sep; 23(7):1001-8. doi:
10.1016/s0022-2275(20)38072-x. [PMID: 6292316] - R J Lefkowitz, M G Caron, T Michel, J M Stadel. Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase.
Federation proceedings.
1982 Aug; 41(10):2664-70. doi:
NULL. [PMID: 6125416] - N Marén, G Alvan, B M Calissendorff, K Haglund, P Seideman. Additive intraocular pressure reducing effect of topical timolol during systemic beta-blockade.
Acta ophthalmologica.
1982 Feb; 60(1):16-23. doi:
10.1111/j.1755-3768.1982.tb05777.x. [PMID: 6127860] - R Winek, R Bhalla. Temperature dependence of [3H]dihydroalprenolol binding in rat myocardium.
European journal of pharmacology.
1982 Jan; 77(2-3):89-94. doi:
10.1016/0014-2999(82)90001-2. [PMID: 6277664] - J Hermansson, C von Bahr. Determination of (R)-AND (S)-alprenolol-and (R)- and (S)-metoprolol as their diastereomeric derivatives in human plasma by reversed-phase liquid chromatography.
Journal of chromatography.
1982 Jan; 227(1):113-27. doi:
10.1016/s0378-4347(00)80361-8. [PMID: 7056805] - H J Jürgensen, H Meinertz, O Faergeman. Plasma lipids and lipoproteins in long-term beta-adrenergic blockade.
Acta medica Scandinavica.
1982; 211(6):449-52. doi:
10.1111/j.0954-6820.1982.tb01980.x. [PMID: 6126072] - K L Audus, D L Johnson, M A Gordon. Use of fluorescent probes to monitor propranolol effects on the murine splenic lymphocyte.
Journal of immunopharmacology.
1982 198; 4(4):329-53. doi:
10.3109/08923978209019452. [PMID: 7184964] - O Bonacker, H Glossmann. Mammalian beta-adrenoceptors: concomitant biospecific elution with protein kinase activity from Sepharose-alprenolol.
European journal of pharmacology.
1981 Nov; 75(4):197-204. doi:
10.1016/0014-2999(81)90545-8. [PMID: 6274666] - J Segal, S H Ingbar. Studies of the mechanism by which 3,5,3'- triiodothyronine stimulates 2-deoxyglucose uptake in rat thymocytes in vitro. Role of calcium and adenosine 3':5'-monophosphate.
The Journal of clinical investigation.
1981 Jul; 68(1):103-10. doi:
10.1172/jci110224. [PMID: 6265495] - J H Jürgensen, J Frederiksen, D A Hansen, O Pedersen-Bjergaard. Limitation of myocardial infarct size in patients less than 66 years treated with alprenolol.
British heart journal.
1981 May; 45(5):583-8. doi:
10.1136/hrt.45.5.583. [PMID: 7016150] - U K Walle, M J Wilson, T Walle. Propranolol, alprenolol and oxprenolol metabolism in the dog. Identification of N-methylated metabolites.
Biomedical mass spectrometry.
1981 Feb; 8(2):78-84. doi:
10.1002/bms.1200080206. [PMID: 7272467] - A Vedin, C Wilhelmsson. Beta blockers after myocardial infarction--aspects on study design based on current knowledge.
Acta medica Scandinavica. Supplementum.
1981; 651(?):227-33. doi:
10.1111/j.0954-6820.1981.tb03661.x. [PMID: 6119877] - C Schmitt, V J Lotti, J C Le Douarec. Penetration of five beta-adrenergic antagonists into the rabbit eye after ocular instillation.
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology.
1981; 217(3):167-74. doi:
10.1007/bf00411147. [PMID: 6118072] - M A Weber, J I Drayer. Renal effects of beta-adrenoceptor blockade.
Kidney international.
1980 Nov; 18(5):686-99. doi:
10.1038/ki.1980.186. [PMID: 6109787] - T Ochiai, K Watanabe, H Nishijima, R Hayashi, H Sato, T Takagi, K Mikami, T Nishikawa, Y Tamura, A Kumagai. Results of treatment of hypertension after renal transplantation: effects of converting enzyme inhibitor, angiotensin II analog, beta-blockade, and dopamine beta-hydroxylase inhibitor.
Transplantation proceedings.
1980 Sep; 12(3):520-5. doi:
NULL. [PMID: 6261430] - E A Woodcock, C I Johnston. Negative cooperativity of rat kidney beta-adrenergic receptors.
Biochimica et biophysica acta.
1980 Aug; 631(2):317-26. doi:
10.1016/0304-4165(80)90305-0. [PMID: 6250638] - D B Jack, S Dean, M J Kendall, S Laugher. Detection of some antihypertensive drugs and their metabolites in urine by thin-layer chromatography: II. A further five beta blockers and dihydralazine.
Journal of chromatography.
1980 Aug; 196(1):189-92. doi:
10.1016/s0021-9673(00)80377-5. [PMID: 6105163] - E A Woodcock, C I Johnston. Alpha-Adrenergic receptors modulate beta-receptor affinity in rat kidney membranes.
Nature.
1980 Jul; 286(5769):159-60. doi:
10.1038/286159a0. [PMID: 6250041] - G M Boriskina, Iu V Postnov. [Characteristics of 3H-dihydroalprenolol binding to beta-receptors in the fat cells of rats and spontaneous genetic hypertension and in hypertensive disease].
Kardiologiia.
1980 Jul; 20(7):84-8. doi:
NULL. [PMID: 6249954] - C F Poole, L Johansson, J Vessman. Formation of electron-capturing derivatives of alprenolol by transboronation: application to the determination of alprenolol in plasma.
Journal of chromatography.
1980 Jun; 194(3):365-77. doi:
10.1016/s0021-9673(00)81427-2. [PMID: 7391216]