Danofloxacin Mesylate (BioDeep_00000015290)
natural product
代谢物信息卡片
化学式: C20H24FN3O6S (453.1369776)
中文名称: 甲磺酸达氟沙星
谱图信息:
最多检出来源 Escherichia coli(natural_products) 66.67%
分子结构信息
SMILES: C12(N(C3CC3)C=C(C(C=1C=C(C(=C2)N4[C@]5(C[C@@](C4)(N(C5)C)[H])[H])F)=O)C(O)=O).S(C)(O)(=O)=O
InChI: /m0./s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:181474
- KEGG: C71643
- PubChem: 71334
- ChEMBL: CHEMBL2106153
- CAS: 119478-55-6
- MoNA: CCMSLIB00000078563
- MoNA: CCMSLIB00000078562
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Saranya Poapolathep, Narumol Klangkaew, Tara Wongwaipairoj, Narongsak Chaiyabutr, Mario Giorgi, Amnart Poapolathep. Pharmacokinetics of danofloxacin in freshwater crocodiles (Crocodylus siamensis) after intramuscular injection.
Journal of veterinary pharmacology and therapeutics.
2022 Jul; 45(4):352-357. doi:
10.1111/jvp.13072
. [PMID: 35582881] - Wipasitnee Wanmad, Thanaphan Chomcheun, Oranee Jongkolpath, Narumol Klangkaew, Napasorn Phaochoosak, Rattapong Sukkheewan, Weerapong Laovechprasit, Kraisiri Khidkhan, Mario Giorgi, Amnart Poapolathep, Saranya Poapolathep. Pharmacokinetic characteristics of danofloxacin in green sea (Chelonia mydas) and hawksbill sea (Eretmochelys imbricata) turtles.
Journal of veterinary pharmacology and therapeutics.
2022 Jul; 45(4):402-408. doi:
10.1111/jvp.13054
. [PMID: 35332549] - Ashenafi Feyisa Beyi, Jonathan P Mochel, Géraldine Magnin, Tyler Hawbecker, Clare Slagel, Grant Dewell, Renee Dewell, Orhan Sahin, Johann F Coetzee, Qijing Zhang, Paul J Plummer. Comparisons of plasma and fecal pharmacokinetics of danofloxacin and enrofloxacin in healthy and Mannheimia haemolytica infected calves.
Scientific reports.
2022 03; 12(1):5107. doi:
10.1038/s41598-022-08945-z
. [PMID: 35332195] - Han Wang, Fang Yang, Zhe-Wen Song, Hao-Tian Shao, Mei Zhang, Yan-Bo Ma, Fan Yang. Influence of Escherichia coli endotoxemia on danofloxacin pharmacokinetics in broilers following single oral administration.
Journal of veterinary pharmacology and therapeutics.
2022 Mar; 45(2):220-225. doi:
10.1111/jvp.13035
. [PMID: 34882308] - Han Wang, Fang Yang, Zhe-Wen Song, Hao-Tian Shao, Dong-Ying Bai, Yan-Bo Ma, Tao Kong, Fan Yang. The influence of immune stress induced by Escherichia coli lipopolysaccharide on the pharmacokinetics of danofloxacin in broilers.
Poultry science.
2022 Mar; 101(3):101629. doi:
10.1016/j.psj.2021.101629
. [PMID: 34986447] - Irene Sartini, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Amnart Poapolathep, Mario Giorgi. Danofloxacin pharmacokinetics and tissue residues in Bilgorajska geese.
Research in veterinary science.
2021 May; 136(?):11-17. doi:
10.1016/j.rvsc.2021.01.017
. [PMID: 33556838] - Alba M Garcia-Lino, Dafne Garcia-Mateos, Indira Alvarez-Fernandez, Esther Blanco-Paniagua, Juan M Medina, Gracia Merino, Ana I Alvarez. Role of eprinomectin as inhibitor of the ruminant ABCG2 transporter: Effects on plasma distribution of danofloxacin and meloxicam in sheep.
Research in veterinary science.
2021 May; 136(?):478-483. doi:
10.1016/j.rvsc.2021.03.026
. [PMID: 33838457] - Yuqi Yang, Ping Cheng, Tianshi Xiao, Jargalsaikhan Ulziikhutag, Hongxiao Yu, Jiarui Li, Ruimeng Liu, Ishfaq Muhammad, Xiuying Zhang. Pharmacokinetics and pharmacodynamics integration of danofloxacin against Eschrichia coli in piglet ileum ultrafiltration probe model.
Scientific reports.
2021 01; 11(1):681. doi:
10.1038/s41598-020-80272-7
. [PMID: 33436914] - Christine A Parker-Graham, Wesley C Siniard, Barbara A Byrne, Heather K Knych, Esteban Soto. Pharmacokinetics of danofloxacin following intramuscular administration of a single dose in koi (Cyprinus carpio).
American journal of veterinary research.
2020 Sep; 81(9):708-713. doi:
10.2460/ajvr.81.9.708
. [PMID: 33112164] - María Ramos-Payán, Juan Antonio Ocaña-González, Rut Fernández-Torres, Miguel Ángel Bello-López. A Method for the Determination of Veterinary Drugs from Different Therapeutic Classes in Animal Urine.
Journal of chromatographic science.
2020 Jan; 58(2):127-135. doi:
10.1093/chromsci/bmz084
. [PMID: 32154562] - Todd L Schmitt, Hendrik H Nollens, Claire A Simeone, Mark G Papich. Population Pharmacokinetics of Danofloxacin After Single Intramuscular Dose Administration in California Brown Pelicans (Pelecanus occidentalis californicus).
Journal of avian medicine and surgery.
2019 Dec; 33(4):361-368. doi:
10.1647/2018-366
. [PMID: 31833304] - Mohamed Aboubakr, Ahmed Soliman. Pharmacokinetics of danofloxacin in African catfish (Clarias gariepinus) after intravenous and intramuscular administrations.
Acta veterinaria Hungarica.
2019 12; 67(4):602-609. doi:
10.1556/004.2019.059
. [PMID: 31842594] - Orhan Corum, Feray Altan, Ramazan Yildiz, Merve Ider, Mahmut Ok, Kamil Uney. Pharmacokinetics of enrofloxacin and danofloxacin in premature calves.
Journal of veterinary pharmacology and therapeutics.
2019 Nov; 42(6):624-631. doi:
10.1111/jvp.12787
. [PMID: 31190327] - Orhan Corum, Duygu Durna Corum, Feray Altan, Ayse Er, Gul Cetin, Kamil Uney. Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans).
The Journal of veterinary medical science.
2019 May; 81(5):753-757. doi:
10.1292/jvms.18-0609
. [PMID: 30853667] - Orhan Corum, Duygu Durna Corum, Orkun Atik, Hatice Eser Faki, Feray Altan, Kamil Uney. Pharmacokinetics and bioavailability of danofloxacin in chukar partridge (Alectoris chukar) following intravenous, intramuscular, subcutaneous, and oral administrations.
Journal of veterinary pharmacology and therapeutics.
2019 Mar; 42(2):207-213. doi:
10.1111/jvp.12737
. [PMID: 30474236] - Yuqi Yang, Yixin Zhang, Jiarui Li, Ping Cheng, Tianshi Xiao, Ishfaq Muhammad, Hongxiao Yu, Ruimeng Liu, Xiuying Zhang. Susceptibility breakpoint for Danofloxacin against swine Escherichia coli.
BMC veterinary research.
2019 Feb; 15(1):51. doi:
10.1186/s12917-019-1783-2
. [PMID: 30717803] - Danielle A Mzyk, Claire M Bublitz, Marilyn N Martinez, Jennifer L Davis, Ronald E Baynes, Geof W Smith. Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves.
PloS one.
2019; 14(6):e0218864. doi:
10.1371/journal.pone.0218864
. [PMID: 31233558] - Xia Xiao, Weixuan Lan, Ying Wang, Lijie Jiang, Yongjia Jiang, Zhiqiang Wang. Comparative pharmacokinetics of danofloxacin in healthy and Pasteurella multocida infected ducks.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):912-918. doi:
10.1111/jvp.12712
. [PMID: 30182430] - Orhan Corum, Duygu Durna Corum, Ayse Er, Ertugrul Terzi, Kamil Uney. Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2018 Dec; 35(12):2340-2347. doi:
10.1080/19440049.2018.1530458
. [PMID: 30352010] - Jon Andoni Otero, Dafne García-Mateos, Indira Alvarez-Fernández, Rocío García-Villalba, Juan Carlos Espín, Ana Isabel Álvarez, Gracia Merino. Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep.
BMC veterinary research.
2018 Jan; 14(1):14. doi:
10.1186/s12917-018-1341-3
. [PMID: 29334949] - J M Serrano-Rodríguez, C Cárceles-García, C M Cárceles-Rodríguez, M L Gabarda, J M Serrano-Caballero, E Fernández-Varón. Susceptibility and PK/PD relationships of Staphylococcus aureus strains from ovine and caprine with clinical mastitis against five veterinary fluoroquinolones.
The Veterinary record.
2017 Apr; 180(15):376. doi:
10.1136/vr.103964
. [PMID: 28213532] - D A Mzyk, R E Baynes, K M Messenger, M Martinez, G W Smith. Pharmacokinetics and distribution in interstitial and pulmonary epithelial lining fluid of danofloxacin in ruminant and preruminant calves.
Journal of veterinary pharmacology and therapeutics.
2017 Apr; 40(2):179-191. doi:
10.1111/jvp.12346
. [PMID: 27476495] - Min Yao, Weihua Gao, Hengxun Tao, Jun Yang, Tinghua Huang. The regulation effects of danofloxacin on pig immune stress induced by LPS.
Research in veterinary science.
2017 Feb; 110(?):65-71. doi:
10.1016/j.rvsc.2016.11.005
. [PMID: 28159239] - Nan Zhang, Xiaomei Ye, Yuzhi Wu, Zilong Huang, Xiaoyan Gu, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding. Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin.
PloS one.
2017; 12(1):e0169134. doi:
10.1371/journal.pone.0169134
. [PMID: 28052123] - Vincenzo Ferrone, Maura Carlucci, Paola Palumbo, Giuseppe Carlucci. Development and validation of a MEPS-UHPLC-PDA method for determination of ulifloxacin in human plasma and urine of patients with peripheral arterial disease.
Journal of pharmaceutical and biomedical analysis.
2016 Sep; 128(?):313-321. doi:
10.1016/j.jpba.2016.06.001
. [PMID: 27318081] - Marina Rusch, Annika Kauschat, Astrid Spielmeyer, Andreas Römpp, Heike Hausmann, Holger Zorn, Gerd Hamscher. Biotransformation of the Antibiotic Danofloxacin by Xylaria longipes Leads to an Efficient Reduction of Its Antibacterial Activity.
Journal of agricultural and food chemistry.
2015 Aug; 63(31):6897-904. doi:
10.1021/acs.jafc.5b02343
. [PMID: 26189577] - Yang-Chi Fan, Shi-Yuan Sheu, Hong-Thih Lai, Ming-Huang Chang, Pei-Heng Chen, Yi-Chih Lei, Tzong-Fu Kuo, Chia-Yih Wang. Residue Depletion Study of Danofloxacin in Cultured Tilapia (Oreochromis mossambicus).
Journal of AOAC International.
2015 May; 98(3):575-579. doi:
10.5740/jaoacint.13-327
. [PMID: 26025372] - F Yang, N Sun, Y M Liu, Z L Zeng. Estimating danofloxacin withdrawal time in broiler chickens based on physiologically based pharmacokinetics modeling.
Journal of veterinary pharmacology and therapeutics.
2015 Apr; 38(2):174-82. doi:
10.1111/jvp.12162
. [PMID: 25236844] - B S Lopez, S Giguère, L J Berghaus, M A Mullins, J L Davis. Pharmacokinetics of danofloxacin and N-desmethyldanofloxacin in adult horses and their concentration in synovial fluid.
Journal of veterinary pharmacology and therapeutics.
2015 Apr; 38(2):123-9. doi:
10.1111/jvp.12152
. [PMID: 25224604] - J A Otero, B Barrera, A de la Fuente, J G Prieto, M Marqués, A I Álvarez, G Merino. Short communication: The gain-of-function Y581S polymorphism of the ABCG2 transporter increases secretion into milk of danofloxacin at the therapeutic dose for mastitis treatment.
Journal of dairy science.
2015 Jan; 98(1):312-7. doi:
10.3168/jds.2014-8288
. [PMID: 25465626] - Lisa A H Rottbøll, Christian Friis. Microdialysis as a tool for drug quantification in the bronchioles of anaesthetized pigs.
Basic & clinical pharmacology & toxicology.
2014 Mar; 114(3):226-32. doi:
10.1111/bcpt.12147
. [PMID: 24112297] - D J Dimitrova, A M Haritova, T D Dinev, R G Moutafchieva, L D Lashev. Comparative pharmacokinetics of danofloxacin in common pheasants, guinea fowls and Japanese quails after intravenous and oral administration.
British poultry science.
2014 Feb; 55(1):120-5. doi:
10.1080/00071668.2013.871502
. [PMID: 24392829] - Seok-Jin Kang, Sang-Hee Jeong, Eun-Joo Kim, Young-Il Park, Sung-Won Park, Hyo-Sook Shin, Seong-Wan Son, Hwan-Goo Kang. Toxic effects of methylmercury, arsanilic acid and danofloxacin on the differentiation of mouse embryonic stem cells into neural cells.
Journal of veterinary science.
2014; 15(1):61-71. doi:
10.4142/jvs.2014.15.1.61
. [PMID: 24136205] - Chun-Hong Yu, Zhao-Ying Liu, Lei-Sheng Sun, Yu-Juan Li, Da-Sheng Zhang, Ren-Tao Pan, Zhi-Liang Sun. Effect of Danofloxacin on Reactive Oxygen Species Production, Lipid Peroxidation and Antioxidant Enzyme Activities in Kidney Tubular Epithelial Cell Line, LLC-PK1.
Basic & clinical pharmacology & toxicology.
2013 Dec; 113(6):377-84. doi:
10.1111/bcpt.12110
. [PMID: 23855763] - Borja Barrera, Lucía González-Lobato, Jon A Otero, Rebeca Real, Julio G Prieto, Ana I Álvarez, Gracia Merino. Effects of triclabendazole on secretion of danofloxacin and moxidectin into the milk of sheep: role of triclabendazole metabolites as inhibitors of the ruminant ABCG2 transporter.
Veterinary journal (London, England : 1997).
2013 Nov; 198(2):429-36. doi:
10.1016/j.tvjl.2013.07.033
. [PMID: 23981352] - Miriam Perez, Jon A Otero, Borja Barrera, Julio G Prieto, Gracia Merino, Ana I Alvarez. Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: effect on plasma and milk levels of danofloxacin in sheep.
Veterinary journal (London, England : 1997).
2013 May; 196(2):203-8. doi:
10.1016/j.tvjl.2012.09.012
. [PMID: 23083838] - Jon A Otero, Rebeca Real, Álvaro de la Fuente, Julio G Prieto, Margarita Marqués, Ana I Álvarez, Gracia Merino. The bovine ATP-binding cassette transporter ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the fluoroquinolone danofloxacin.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Mar; 41(3):546-9. doi:
10.1124/dmd.112.049056
. [PMID: 23230133] - Mariana Ballent, Adrián Lifschitz, Guillermo Virkel, Juan Sallovitz, Laura Maté, Carlos Lanusse. In vivo and ex vivo assessment of the interaction between ivermectin and danofloxacin in sheep.
Veterinary journal (London, England : 1997).
2012 Jun; 192(3):422-7. doi:
10.1016/j.tvjl.2011.09.006
. [PMID: 22079145] - John D Mitchell, Quintin A McKellar, Declan J McKeever. Pharmacodynamics of antimicrobials against Mycoplasma mycoides mycoides small colony, the causative agent of contagious bovine pleuropneumonia.
PloS one.
2012; 7(8):e44158. doi:
10.1371/journal.pone.0044158
. [PMID: 22952911] - Amir M Ramezani, Jamshid L Manzoori, Mohammad Amjadi, Abolghasem Jouyban. Spectrofluorimetric determination of human serum albumin using terbium-danofloxacin probe.
TheScientificWorldJournal.
2012; 2012(?):940541. doi:
10.1100/2012/940541
. [PMID: 22645474] - R Real, E Egido, M Pérez, L González-Lobato, B Barrera, J G Prieto, A I Alvarez, G Merino. Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin.
Journal of veterinary pharmacology and therapeutics.
2011 Aug; 34(4):313-21. doi:
10.1111/j.1365-2885.2010.01241.x
. [PMID: 20950350] - Z Zeng, G Deng, X Shen, M Rizwan-Ul-Haq, D Zeng, H Ding. Plasma and tissue pharmacokinetics of danofloxacin in healthy and in experimentally infected chickens with Pasteurella multocida.
Journal of veterinary pharmacology and therapeutics.
2011 Feb; 34(1):101-4. doi:
10.1111/j.1365-2885.2010.01223.x
. [PMID: 21219355] - Ravinder Sappal, Rakesh Kumar Chaudhary, Harpal Singh Sandhu, Pritam Kaur Sidhu. Pharmacokinetics, urinary excretion and plasma protein binding of danofloxacin following intravenous administration in buffalo calves (Bubalus bubalis).
Veterinary research communications.
2009 Oct; 33(7):659-67. doi:
10.1007/s11259-009-9215-6
. [PMID: 19296232] - A Goudah, S M Mouneir. Disposition kinetics and tissue residues of danofloxacin in Muscovy ducks.
British poultry science.
2009 Sep; 50(5):613-9. doi:
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Talanta.
2009 Apr; 78(2):348-57. doi:
10.1016/j.talanta.2008.11.021
. [PMID: 19203594] - N Mestorino, M L Marchetti, E Turic, J Pesoa, J Errecalde. Concentrations of danofloxacin 18\% solution in plasma, milk and tissues after subcutaneous injection in dairy cows.
Analytica chimica acta.
2009 Apr; 637(1-2):33-9. doi:
10.1016/j.aca.2008.09.055
. [PMID: 19286009] - Valeria A Lozano, Romà Tauler, Gabriela A Ibañez, Alejandro C Olivieri. Standard addition analysis of fluoroquinolones in human serum in the presence of the interferent salicylate using lanthanide-sensitized excitation-time decay luminescence data and multivariate curve resolution.
Talanta.
2009 Mar; 77(5):1715-23. doi:
10.1016/j.talanta.2008.10.020
. [PMID: 19159788] - Pedro Marín, Alejandro Bayón, Emilio Fernández-Varón, Elisa Escudero, Cristina Clavel, Ramon Almela, Carlos M Cárceles. Pharmacokinetics of danofloxacin after single dose intravenous, intramuscular and subcutaneous administration to loggerhead turtles Caretta caretta.
Diseases of aquatic organisms.
2008 Dec; 82(3):231-6. doi:
10.3354/dao01987
. [PMID: 19244975] - Marilyn J Schneider. A rapid fluorescence assay for danofloxacin in beef muscle: effect of muscle type on limit of quantitation.
Journal of food protection.
2008 Aug; 71(8):1720-3. doi:
10.4315/0362-028x-71.8.1720
. [PMID: 18724771] - A M Haritova, J Schrickx, L D Lashev, J Fink-Gremmels. Expression of MDR1, MRP2 and BCRP mRNA in tissues of turkeys.
Journal of veterinary pharmacology and therapeutics.
2008 Aug; 31(4):378-85. doi:
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Journal of veterinary pharmacology and therapeutics.
2007 Dec; 30(6):572-7. doi:
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Journal of veterinary pharmacology and therapeutics.
2007 Feb; 30(1):18-24. doi:
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Equine veterinary journal.
2006 Jul; 38(4):342-6. doi:
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Journal of AOAC International.
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Se pu = Chinese journal of chromatography.
2005 May; 23(3):285-8. doi:
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. [PMID: 16124577] - Terry N TerHune, Terry L Skogerboe, Valerie K Shostrom, Daniel J Weigel. Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica.
American journal of veterinary research.
2005 Feb; 66(2):342-9. doi:
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Research in veterinary science.
2003 Jun; 74(3):247-59. doi:
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Research in veterinary science.
2003 Jun; 74(3):271-7. doi:
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Research in veterinary science.
2003 Jun; 74(3):261-70. doi:
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. [PMID: 12726745] - F Shojaee Aliabadi, Badrelin H Ali, M F Landoni, P Lees. Pharmacokinetics and PK-PD modelling of danofloxacin in camel serum and tissue cage fluids.
Veterinary journal (London, England : 1997).
2003 Mar; 165(2):104-18. doi:
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Antimicrobial agents and chemotherapy.
2003 Feb; 47(2):626-35. doi:
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. [PMID: 12543670] - Patxi Sarasola, Peter Lees, Fariborz Shojaee AliAbadi, Quintin A McKellar, William Donachie, Kate A Marr, Simon J Sunderland, Tim G Rowan. Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica.
Antimicrobial agents and chemotherapy.
2002 Sep; 46(9):3013-9. doi:
10.1128/aac.46.9.3013-3019.2002
. [PMID: 12183261] - Margarita Hernández, Francesc Borrull, Marta Calull. Using nonaqueous capillary electrophoresis to analyze several quinolones in pig kidney samples.
Electrophoresis.
2002 Feb; 23(3):506-11. doi:
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American journal of veterinary research.
2001 Dec; 62(12):1979-89. doi:
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. [PMID: 11763192] - A Y el-Gendi, H A el-Banna, M Abo Norag, M Gaber. Disposition kinetics of danofloxacin and ciprofloxacin in broiler chickens.
DTW. Deutsche tierarztliche Wochenschrift.
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