Oxyclozanide (BioDeep_00000015283)
代谢物信息卡片
Oxyclozanide
化学式: C13H6Cl5NO3 (398.879)
中文名称: 五氯柳胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1NC(=O)C2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl)Cl
InChI: InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- KEGG: C74174
- KEGGdrug: D08320
- PubChem: 16779
- ChEMBL: CHEMBL2105450
- MeSH: Oxyclozanide
- CAS: 1353867-74-9
- CAS: 2277-92-1
- PMhub: MS000003422
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yue Ma, Ying-Hui He, Peng Deng, Shao-Yong Zhang, Yan-Yan Ding, Zhi-Jun Zhang, Bao-Qi Zhang, Jun-Xia An, Yi-Rong Wang, Ying-Qian Liu. Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses.
Chemistry & biodiversity.
2023 Nov; 20(11):e202300998. doi:
10.1002/cbdv.202300998. [PMID: 37755070] - Jili Zhang, Yubin Bai, Bing Li, Xuzheng Zhou, Hongfei Si, Jiyu Zhang. Determination and pharmacokinetics study of oxyclozanide suspension in cattle by LC-MS/MS.
BMC veterinary research.
2019 Jun; 15(1):210. doi:
10.1186/s12917-019-1963-0. [PMID: 31234851] - Haroon Mohammad, Ahmed AbdelKhalek, Nader S Abutaleb, Mohamed N Seleem. Repurposing niclosamide for intestinal decolonization of vancomycin-resistant enterococci.
International journal of antimicrobial agents.
2018 Jun; 51(6):897-904. doi:
10.1016/j.ijantimicag.2018.02.003. [PMID: 29432868] - Rodrigo Sanabria, Laura Moreno, Luis Alvarez, Carlos Lanusse, Jorge Romero. Efficacy of oxyclozanide against adult Paramphistomum leydeni in naturally infected sheep.
Veterinary parasitology.
2014 Dec; 206(3-4):277-81. doi:
10.1016/j.vetpar.2014.09.022. [PMID: 25458118] - Cengiz Gokbulut, Hande Sultan Yalinkilinc, Dilek Aksit, Vincenzo Veneziano. Comparative pharmacokinetics of levamisole-oxyclozanide combination in sheep and goats following per os administration.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Oct; 78(4):316-20. doi:
NULL. [PMID: 25356001] - M K Khan, M S Sajid, M N Khan, Z Iqbal, M Arshad, A Hussain. Point prevalence of bovine fascioliasis and the influence of chemotherapy on the milk yield in a lactating bovine population from the district of Toba Tek Singh, Pakistan.
Journal of helminthology.
2011 Sep; 85(3):334-8. doi:
10.1017/s0022149x10000659. [PMID: 21062526] - Laura Ceballos, Laura Moreno, Luis Alvarez, Laura Shaw, Ian Fairweather, Carlos Lanusse. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.
BMC veterinary research.
2010 Feb; 6(?):8. doi:
10.1186/1746-6148-6-8. [PMID: 20128898] - M Caldow, M Sharman, M Kelly, J Day, S Hird, J A Tarbin. Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2009 Nov; 1216(46):8200-5. doi:
10.1016/j.chroma.2009.04.008. [PMID: 19426989] - Alparslan Yildirim, Vehbi Güneş, Anil Iça, Savaş Sariözkan, Onder Düzlü, Abdullah Inci, Hasan Albasan. [The investigation of short term efficiency of oxfendazole + oxyclozanide paste and tablet formulations against gastrointestinal nematodes in sheep].
Turkiye parazitolojii dergisi.
2008; 32(2):134-8. doi:
NULL. [PMID: 18645944] - Kenji Fujinuma, Kazue Takeba, Kunihiro Kamata. [Concentration in plasma and excretion in milk of lactating cows after oral administration of tribromsalan, oxyclozanide and bromofenofos].
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan.
2006 Dec; 47(6):249-53. doi:
10.3358/shokueishi.47.249. [PMID: 17228788] - P Díaz, C Lomba, J Pedreira, M Arias, R Sánchez-Andrade, J L Suárez, P Díez-Baños, P Morrondo, A Paz-Silva. Analysis of the IgG antibody response against Paramphistomidae trematoda in naturally infected cattle. Application to serological surveys.
Veterinary parasitology.
2006 Sep; 140(3-4):281-8. doi:
10.1016/j.vetpar.2006.04.007. [PMID: 16672179] - S A Spence, G C Fraser, S Chang. Responses in milk production to control of gastrointestinal nematode and paramphistome parasites in dairy cattle.
Australian veterinary journal.
1996 Dec; 74(6):456-9. doi:
10.1111/j.1751-0813.1996.tb07569.x. [PMID: 9006864] - O Hindsbo, P A Anderson, P Lind. Worm kinetics and serum IgE in hooded lister rats infected with the acanthocephalan Moniliformis moniliformis and the nematode Nippostrongylus brasiliensis.
International journal for parasitology.
1996 Nov; 26(11):1287-94. doi:
10.1016/s0020-7519(96)00129-4. [PMID: 9024874] - D Levieux, A Levieux, C Mage, J P Garel. Immunological detection of chemotherapeutic success in bovine fasciolosis using the specific antigen f2.
Veterinary parasitology.
1992 Dec; 45(1-2):81-8. doi:
10.1016/0304-4017(92)90029-9. [PMID: 1485423] - S A Spence, G C Fraser, E B Dettmann, D F Battese. Production responses to internal parasite control in dairy cattle.
Australian veterinary journal.
1992 Sep; 69(9):217-20. doi:
10.1111/j.1751-0813.1992.tb09928.x. [PMID: 1449457] - I Bremner, W R Humphries, P C Morrice, W W Carlyle. Control of selenium and cobalt deficiency in lambs by supplementation of oral anthelmintics.
The Veterinary record.
1988 Aug; 123(9):217-8. doi:
10.1136/vr.123.9.217. [PMID: 3176281] - J Mabus, J E Huffman, B Fried. Humoral and cellular response to infection with Echinostoma revolutum in the golden hamster, Mesocricetus auratus.
Journal of helminthology.
1988 Jun; 62(2):127-32. doi:
10.1017/s0022149x00011366. [PMID: 3397514] - P F Rolfe, J C Boray. Chemotherapy of paramphistomosis in cattle.
Australian veterinary journal.
1987 Nov; 64(11):328-32. doi:
10.1111/j.1751-0813.1987.tb06060.x. [PMID: 3447575] - N A Mohammed-Ali, J A Bogan. The pharmacodynamics of the flukicidal salicylanilides, rafoxanide, closantel and oxyclosanide.
Journal of veterinary pharmacology and therapeutics.
1987 Jun; 10(2):127-33. doi:
10.1111/j.1365-2885.1987.tb00089.x. [PMID: 3612940] - R Maffei Facino, M Carini, C Genchi. Decrease in hepatic microsomal UDP-glucuronosyl-transferase activity in rats and cattle with fascioliasis: impaired in vitro glucuronidation of oxyclozanide.
Toxicology letters.
1985 Jul; 26(1):65-71. doi:
10.1016/0378-4274(85)90186-9. [PMID: 3927525] - J M Owen. Liver fluke infection in horses and ponies.
Equine veterinary journal.
1977 Jan; 9(1):29-31. doi:
10.1111/j.2042-3306.1977.tb03969.x. [PMID: 837900] - J Vyhnálek, J Kocman, J Skaloud. [Effectiveness of Nilzan and Dovenix in the treatment of fascioliasis in cattle and sheep].
Veterinarni medicina.
1976 Jul; 21(7):427-33. doi:
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