Chlorhexidine Gluconate (BioDeep_00000015268)

   


代谢物信息卡片


Chlorhexidine digluconate

化学式: C34H54Cl2N10O14 (896.3197844)
中文名称: 氯己定 二葡糖酸盐 溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.C(C(C(C(C(C(=O)O)O)O)O)O)O.C(C(C(C(C(C(=O)O)O)O)O)O)O
InChI: 2*2-,3-,4+,5-/m.11/s1

描述信息

COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D007004 - Hypoglycemic Agents > D001645 - Biguanides
D000890 - Anti-Infective Agents
D003879 - Dermatologic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

2 个代谢物同义名

Chlorhexidine digluconate; Chlorhexidine Gluconate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Romério Alves Silva, Benise Ferreira da Silva, Mainara Saraiva Pereira, Paulo Adenes Teixeira Coelho, Renata Albuquerque Costa, Andrey Carvalho Chaves, Isaac Goes Neto Silva, Victor Alves Carneiro. Combinatorial effects between aromatic plant compounds and chlorhexidine digluconate against canine otitis-related Staphylococcus spp. Research in veterinary science. 2024 Apr; 170(?):105182. doi: 10.1016/j.rvsc.2024.105182. [PMID: 38377791]
  • Niloofar Jamshidinia, Fatemeh Saadatpour, Ehsan Arefian, Fatemeh Mohammadipanah. Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid. Archives of virology. 2023 Nov; 168(12):302. doi: 10.1007/s00705-023-05932-1. [PMID: 38036721]
  • Fara Azwin Adam, Nurulhuda Mohd, Haslina Rani, Mohd Yusmiaidil Putera Mohd Yusof, Badiah Baharin. A systematic review and meta-analysis on the comparative effectiveness of Salvadora persica - extract mouthwash with chlorhexidine gluconate in periodontal health. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115863. doi: 10.1016/j.jep.2022.115863. [PMID: 36283639]
  • Nanthicha Thajai, Pornchai Rachtanapun, Sarinthip Thanakkasaranee, Thanongsak Chaiyaso, Yuthana Phimolsiripol, Noppol Leksawasdi, Sarana Rose Sommano, Korawan Sringarm, Tanpong Chaiwarit, Warintorn Ruksiriwanich, Pensak Jantrawut, Araya Kodsangma, Sukunya Ross, Patnarin Worajittiphon, Winita Punyodom, Kittisak Jantanasakulwong. Antimicrobial thermoplastic starch reactive blend with chlorhexidine gluconate and epoxy resin. Carbohydrate polymers. 2023 Feb; 301(Pt B):120328. doi: 10.1016/j.carbpol.2022.120328. [PMID: 36446505]
  • Shahla Kakoei, Nahid Karbasi, Mahboobeh Raeiszadeh, Haleh Tajadini, Amir H Nekouei. The efficacy of henna (Lawsonia inermis L.) mouthwash versus chlorhexidine gluconate 0.2\% mouthwash as adjuvant therapy of oral lichen planus: A randomized double-blind clinical trial. Journal of ethnopharmacology. 2022 May; 290(?):115037. doi: 10.1016/j.jep.2022.115037. [PMID: 35134489]
  • Rowan Watson, Morwenna Oldfield, Jack A Bryant, Lily Riordan, Harriet J Hill, Julie A Watts, Morgan R Alexander, Michael J Cox, Zania Stamataki, David J Scurr, Felicity de Cogan. Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens. Scientific reports. 2022 03; 12(1):2803. doi: 10.1038/s41598-022-06579-9. [PMID: 35264599]
  • Hiro Inoue, Kenta Torigoe, Miki Torigoe, Kumiko Muta, Yoko Obata, Takehiro Suzuki, Chitose Suzuki, Takaaki Abe, Takehiko Koji, Hiroshi Mukae, Tomoya Nishino. Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice. Medical molecular morphology. 2022 Mar; 55(1):27-40. doi: 10.1007/s00795-021-00305-6. [PMID: 34622315]
  • Tae-Hyun Lee, Jae-Eun Hyun, Yeong-Hun Kang, Seung-Joon Baek, Cheol-Yong Hwang. In vitro antifungal activity of cold atmospheric microwave plasma and synergistic activity against Malassezia pachydermatis when combined with chlorhexidine gluconate. Veterinary medicine and science. 2022 03; 8(2):524-529. doi: 10.1002/vms3.719. [PMID: 35089639]
  • Akash Sharma, Srikant Kulkarni, Anu Thukral, M Jeeva Sankar, Ramesh Agarwal, A K Deorari, Sarita Mohapatra, Thirumurthy Velpandian, Minu Bajpai. Aqueous chlorhexidine 1\% versus 2\% for neonatal skin antisepsis: a randomised non-inferiority trial. Archives of disease in childhood. Fetal and neonatal edition. 2021 Nov; 106(6):643-648. doi: 10.1136/archdischild-2020-321174. [PMID: 34108192]
  • Vunjia Tiong, Pouya Hassandarvish, Sazaly Abu Bakar, Nurul Azmawati Mohamed, Wan Shahida Wan Sulaiman, Nizam Baharom, Farishah Nur Abdul Samad, Ilina Isahak. The effectiveness of various gargle formulations and salt water against SARS-CoV-2. Scientific reports. 2021 10; 11(1):20502. doi: 10.1038/s41598-021-99866-w. [PMID: 34654867]
  • Y Hanna Huang, Jong T Huang. Use of chlorhexidine to eradicate oropharyngeal SARS-CoV-2 in COVID-19 patients. Journal of medical virology. 2021 Jul; 93(7):4370-4373. doi: 10.1002/jmv.26954. [PMID: 33755218]
  • Ryohei Hirose, Risa Bandou, Hiroshi Ikegaya, Naoto Watanabe, Takuma Yoshida, Tomo Daidoji, Yuji Naito, Yoshito Itoh, Takaaki Nakaya. Disinfectant effectiveness against SARS-CoV-2 and influenza viruses present on human skin: model-based evaluation. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2021 Jul; 27(7):1042.e1-1042.e4. doi: 10.1016/j.cmi.2021.04.009. [PMID: 33901670]
  • Chaminda J Seneviratne, Preethi Balan, Kwan Ki Karrie Ko, Nadeeka S Udawatte, Deborah Lai, Dorothy Hui Lin Ng, Indumathi Venkatachalam, Kheng Sit Lim, Moi Lin Ling, Lynette Oon, Bee Tin Goh, Xiang Ying Jean Sim. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection. 2021 Apr; 49(2):305-311. doi: 10.1007/s15010-020-01563-9. [PMID: 33315181]
  • Ryota Nomura, Hiroaki Inaba, Saaya Matayoshi, Sho Yoshida, Yuki Matsumi, Michiyo Matsumoto-Nakano, Kazuhiko Nakano. Inhibitory effect of a mouth rinse formulated with chlorhexidine gluconate, ethanol, and green tea extract against major oral bacterial species. Journal of oral science. 2020 Mar; 62(2):206-211. doi: 10.2334/josnusd.18-0483. [PMID: 32161231]
  • Min Seok Yoo, Hyung-Joo Jin, Si Young Lee. Synergistic Antibacterial Efficacies of Chlorhexidine Digluconate or Protamine Sulfate Combined with Laminaria japonica or Rosmarinus officinalis Extracts against Streptococcus mutans. Biocontrol science. 2020; 25(1):41-44. doi: 10.4265/bio.25.41. [PMID: 32173666]
  • Surapon Nochaiwong, Chidchanok Ruengorn, Kajohnsak Noppakun, Setthapon Panyathong, Phongsak Dandecha, Manish M Sood, Chalermpong Saenjum, Ratanaporn Awiphan, Sasithorn Sirilun, Pajaree Mongkhon, Wilaiwan Chongruksut, Kednapa Thavorn. Comparative Effectiveness of Local Application of Chlorhexidine Gluconate, Mupirocin Ointment, and Normal Saline for the Prevention of Peritoneal Dialysis-related Infections (COSMO-PD Trial): a multicenter randomized, double-blind, controlled protocol. Trials. 2019 Dec; 20(1):754. doi: 10.1186/s13063-019-3953-8. [PMID: 31856900]
  • Tian Xu, Tao Lin, Jingyuan Xie, Hong Ren, Nan Chen, Weiming Wang. Comparison of anti-peritoneal fibrotic effects between an mTORC1-specific blocker and a PI3K/mTOR dual-blocker. Renal failure. 2019 Nov; 41(1):267-277. doi: 10.1080/0886022x.2019.1596818. [PMID: 30982374]
  • Jacqueline Cosmo Andrade, Ana Raquel Pereira da Silva, Maria Audilene Freitas, Bárbara de Azevedo Ramos, Thiago Sampaio Freitas, Franz de Assis G Dos Santos, Melyna C Leite-Andrade, Michellângelo Nunes, Saulo Relison Tintino, Márcia Vanusa da Silva, Maria Tereza Dos Santos Correia, Reginaldo Gonçalves de Lima-Neto, Rejane P Neves, Henrique Douglas Melo Coutinho. Control of bacterial and fungal biofilms by natural products of Ziziphus joazeiro Mart. (Rhamnaceae). Comparative immunology, microbiology and infectious diseases. 2019 Aug; 65(?):226-233. doi: 10.1016/j.cimid.2019.06.006. [PMID: 31300118]
  • Kathryn Dormstetter, Linda K M Olson, Assumpta Bennaars-Eiden, Stéphanie F Bernatchez. Evaluation of activity and potential for development of antimicrobial resistance to a new tinted 2\% chlorhexidine gluconate/70\% isopropyl alcohol film-forming sterile preoperative skin preparation. Journal of global antimicrobial resistance. 2019 06; 17(?):160-167. doi: 10.1016/j.jgar.2018.12.008. [PMID: 30583012]
  • Merve Harman, Nimet Ovayolu, Ozlem Ovayolu. The effect of three different solutions on preventing oral mucositis in cancer patients undergoing stem cell transplantation: a non-randomized controlled trial: A Turkish study - NON-RANDOMISED TRIAL. JPMA. The Journal of the Pakistan Medical Association. 2019 Jun; 69(6):811-816. doi: ". [PMID: 31189287]
  • Cláudio Rodrigues Rezende Costa, Bruna Rabelo Amorim, Sandra Márcia Mazutti da Silva, Ana Carolina Acevedo, Pérola de Oliveira Magalhães, Eliete Neves Silva Guerra. In vitro evaluation of Eugenia dysenterica in primary culture of human gingival fibroblast cells. Brazilian oral research. 2019 Apr; 33(?):e035. doi: 10.1590/1807-3107bor-2019.vol33.0035. [PMID: 31038569]
  • Annamaria Cucina, Samira Filali, Arnaud Risler, Camille Febvay, Damien Salmon, Christine Pivot, Michel Pelandakis, Fabrice Pirot. Dual 0.02\% chlorhexidine digluconate - 0.1\% disodium EDTA loaded thermosensitive ocular gel for Acanthamoeba keratitis treatment. International journal of pharmaceutics. 2019 Feb; 556(?):330-337. doi: 10.1016/j.ijpharm.2018.12.016. [PMID: 30553004]
  • Xin Xu, Zhen M Ou, Christine D Wu. Growth Media Affect Assessment of Antimicrobial Activity of Plant-Derived Polyphenols. BioMed research international. 2018; 2018(?):8308640. doi: 10.1155/2018/8308640. [PMID: 29854796]
  • Juliana Barchelli Pinheiro, Marina Peris Vomero, Cássio do Nascimento, Evandro Watanabe, Helena de Freitas Oliveira Paranhos, Neide Pena Coto, Reinaldo Brito Dias, Viviane Cássia de Oliveira, Cláudia Helena Silva-Lovato. Genomic identification of microbial species adhering to maxillofacial prostheses and susceptibility to different hygiene protocols. Biofouling. 2018 01; 34(1):15-25. doi: 10.1080/08927014.2017.1403591. [PMID: 29258349]
  • Meshari Alabdullatif, Imen Boujezza, Mohamed Mekni, Mariam Taha, Dilini Kumaran, Qi-Long Yi, Ahmed Landoulsi, Sandra Ramirez-Arcos. Enhancing blood donor skin disinfection using natural oils. Transfusion. 2017 12; 57(12):2920-2927. doi: 10.1111/trf.14298. [PMID: 28905380]
  • Maria Alcionéia Carvalho de Oliveira, Aline Chiodi Borges, Fernanda Lourenção Brighenti, Marcos José Salvador, Aline Vidal Lacerda Gontijo, Cristiane Yumi Koga-Ito. Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity. Brazilian oral research. 2017 Nov; 31(?):e89. doi: 10.1590/1807-3107bor-2017.vol31.0089. [PMID: 29116300]
  • Noha Samir Kabil, Amira Saad Badran, Mariem Osama Wassel. Effect of the addition of chlorhexidine and miswak extract on the clinical performance and antibacterial properties of conventional glass ionomer: an in vivo study. International journal of paediatric dentistry. 2017 Sep; 27(5):380-387. doi: 10.1111/ipd.12273. [PMID: 27766712]
  • Ahmad Salimi, Bahare Alami, Jalal Pourahmad. Analysis of cytotoxic effects of chlorhexidine gluconate as antiseptic agent on human blood lymphocytes. Journal of biochemical and molecular toxicology. 2017 Aug; 31(8):. doi: 10.1002/jbt.21918. [PMID: 28510277]
  • Md Jalaluddin, U B Rajasekaran, Sam Paul, R S Dhanya, C B Sudeep, V J Adarsh. Comparative Evaluation of Neem Mouthwash on Plaque and Gingivitis: A Double-blind Crossover Study. The journal of contemporary dental practice. 2017 Jul; 18(7):567-571. doi: 10.5005/jp-journals-10024-2085. [PMID: 28713109]
  • Amy M Holmes, David J Scurr, Jon R Heylings, Ka-Wai Wan, Gary P Moss. Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017 Jun; 104(?):90-101. doi: 10.1016/j.ejps.2017.03.034. [PMID: 28363491]
  • Muammer Bilici, Ibrahim Ilker Oz, Sevil Uygun Ilikhan, Ali Borazan. Effects of Erythropoiesis-stimulating Agents on Intestinal Flora in Peritoneal Fibrosis. Iranian journal of kidney diseases. 2017 May; 11(3):223-228. doi: NULL. [PMID: 28575883]
  • H Below, O Assadian, R Baguhl, U Hildebrandt, B Jäger, K Meissner, D J Leaper, A Kramer. Measurements of chlorhexidine, p-chloroaniline, and p-chloronitrobenzene in saliva after mouth wash before and after operation with 0.2\% chlorhexidine digluconate in maxillofacial surgery: a randomised controlled trial. The British journal of oral & maxillofacial surgery. 2017 Feb; 55(2):150-155. doi: 10.1016/j.bjoms.2016.10.007. [PMID: 27789177]
  • Tripti Thapa Gupta, Surya B Karki, Jyl S Matson, Daniel J Gehling, Halim Ayan. Sterilization of Biofilm on a Titanium Surface Using a Combination of Nonthermal Plasma and Chlorhexidine Digluconate. BioMed research international. 2017; 2017(?):6085741. doi: 10.1155/2017/6085741. [PMID: 29057263]
  • R Sushma, Tanuja Tanaji Sathe, Anand Farias, Pronob Kumar Sanyal, Shashi Kiran. 'Nature cures:' An alternative herbal formulation as a denture cleanser. Annals of African medicine. 2017 Jan; 16(1):6-12. doi: 10.4103/aam.aam_43_16. [PMID: 28300045]
  • Oliver Laugisch, Christoph A Ramseier, Giovanni E Salvi, Tobias T Hägi, Walter Bürgin, Sigrun Eick, Anton Sculean. Effects of two different post-surgical protocols including either 0.05 \% chlorhexidine herbal extract or 0.1 \% chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement. Clinical oral investigations. 2016 Nov; 20(8):2175-2183. doi: 10.1007/s00784-016-1713-7. [PMID: 26795622]
  • Isha Jain, Pankaj Jain. Comparative evaluation of antimicrobial efficacy of three different formulations of mouth rinses with multi-herbal mouth rinse. Journal of the Indian Society of Pedodontics and Preventive Dentistry. 2016 Oct; 34(4):315-23. doi: 10.4103/0970-4388.191409. [PMID: 27681394]
  • Mohammed S Bin-Shuwaish. Effects and Effectiveness of Cavity Disinfectants in Operative Dentistry: A Literature Review. The journal of contemporary dental practice. 2016 Oct; 17(10):867-879. doi: 10.5005/jp-journals-10024-1946. [PMID: 27794161]
  • Margaret McCann, Fidelma Fitzpatrick, George Mellotte, Michael Clarke. Is 2\% chlorhexidine gluconate in 70\% isopropyl alcohol more effective at preventing central venous catheter-related infections than routinely used chlorhexidine gluconate solutions: A pilot multicenter randomized trial (ISRCTN2657745)?. American journal of infection control. 2016 08; 44(8):948-9. doi: 10.1016/j.ajic.2016.02.019. [PMID: 27079247]
  • A Malakhov, J Wen, B-X Zhang, H Wang, H Geng, X-D Chen, Y Sun, C-K Yeh. Rechargeable anticandidal denture material with sustained release in saliva. Oral diseases. 2016 Jul; 22(5):391-8. doi: 10.1111/odi.12456. [PMID: 26855200]
  • Carlos Eduardo Bezerra Gomes, Dhiogo Gonçalves Cavalcante, José Eduardo Girão Filho, Flávio Nogueira da Costa, Sérgio Luís da Silva Pereira. Clinical effect of a mouthwash containing Anacardium occidentale Linn. on plaque and gingivitis control: A randomized controlled trial. Indian journal of dental research : official publication of Indian Society for Dental Research. 2016 Jul; 27(4):364-369. doi: 10.4103/0970-9290.191883. [PMID: 27723631]
  • Hui Chen, Qi Shi, Ying Qing, Yi-Chen Yao, Ying-Guang Cao. Cytotoxicity of modified nonequilibrium plasma with chlorhexidine digluconate on primary cultured human gingival fibroblasts. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2016 Feb; 36(1):137-141. doi: 10.1007/s11596-016-1556-0. [PMID: 26838755]
  • Banu Uygun-Can, Tanju Kadir, Birsay Gumru. Effect of oral antiseptic agents on phospholipase and proteinase enzymes of Candida albicans. Archives of oral biology. 2016 Feb; 62(?):20-7. doi: 10.1016/j.archoralbio.2015.11.006. [PMID: 26615573]
  • Eduardo B Moffa, Fernanda E Izumida, Janaina H Jorge, Maria C M Mussi, Walter L Siqueira, Eunice T Giampaolo. Effectiveness of chemical disinfection on biofilms of relined dentures: A randomized clinical trial. American journal of dentistry. 2016 Feb; 29(1):15-9. doi: ". [PMID: 27093771]
  • Kiyoshi Tomiyama, Yoshiharu Mukai, Masahiro Saito, Kiyoko Watanabe, Hidefumi Kumada, Tomotaro Nihei, Nobushiro Hamada, Toshio Teranaka. Antibacterial Action of a Condensed Tannin Extracted from Astringent Persimmon as a Component of Food Addictive Pancil PS-M on Oral Polymicrobial Biofilms. BioMed research international. 2016; 2016(?):5730748. doi: 10.1155/2016/5730748. [PMID: 26981533]
  • Maria Denise Rodrigues De Moraes, Jéssica Rodrigues Mendes Carneiro, Vanara Florêncio Passos, Sérgio Lima Santiago. Effect of green tea as a protective measure against dental erosion in coronary dentine. Brazilian oral research. 2016; 30(?):. doi: 10.1590/1807-3107bor-2016.vol30.0013. [PMID: 26676195]
  • Rutger Matthes, Lukasz Jablonowski, Ina Koban, Antje Quade, Nils-Olaf Hübner, Rabea Schlueter, Klaus-Dieter Weltmann, Thomas von Woedtke, Axel Kramer, Thomas Kocher. In vitro treatment of Candida albicans biofilms on denture base material with volume dielectric barrier discharge plasma (VDBD) compared with common chemical antiseptics. Clinical oral investigations. 2015 Dec; 19(9):2319-26. doi: 10.1007/s00784-015-1463-y. [PMID: 25898894]
  • Yuka Ueda, Kenji Tsuchida, Daigo Okada, Yasuto Muromiya, Takehiro Suenaga, Narushi Yokota, Kana Kawahara, Kojiro Nagai, Hiro-omi Kanayama, Jun Minakuchi. Evaluation of sterilization using the MEH200® (cotton pack) in vascular access puncture. The journal of vascular access. 2015 Nov; 16 Suppl 10(?):S70-3. doi: 10.5301/jva.5000414. [PMID: 26349880]
  • J P Randall, W K Seow, L J Walsh. Antibacterial activity of fluoride compounds and herbal toothpastes on Streptococcus mutans: an in vitro study. Australian dental journal. 2015 Sep; 60(3):368-74. doi: 10.1111/adj.12247. [PMID: 25348354]
  • Devanand Gupta, Ankita Jain. Effect of Cinnamon Extract and Chlorhexidine Gluconate (0.2\%) on the Clinical Level of Dental Plaque and Gingival Health: A 4-Week, Triple-Blind Randomized Controlled Trial. Journal of the International Academy of Periodontology. 2015 Jul; 17(3):91-8. doi: ". [PMID: 26373226]
  • Qi Shi, Ke Song, Xincai Zhou, Zilan Xiong, Tianfeng Du, Xinpei Lu, Yingguang Cao. Effects of non-equilibrium plasma in the treatment of ligature-induced peri-implantitis. Journal of clinical periodontology. 2015 May; 42(5):478-87. doi: 10.1111/jcpe.12403. [PMID: 25867215]
  • S Salvatico, C Feuillolay, Y Mas, F Verrière, C Roques. Bactericidal activity of 3 cutaneous/mucosal antiseptic solutions in the presence of interfering substances: Improvement of the NF EN 13727 European Standard?. Medecine et maladies infectieuses. 2015 Mar; 45(3):89-94. doi: 10.1016/j.medmal.2015.01.006. [PMID: 25779009]
  • Kaori Sadakane, Takamichi Ichinose. Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice. International journal of medical sciences. 2015; 12(2):116-25. doi: 10.7150/ijms.10322. [PMID: 25589887]
  • Kamal Dua, Ravi Sheshala, Haider A Al-Waeli, Gauarv Gupta, Dinesh K Chellappan. Antimicrobial Efficacy of Extemporaneously Prepared Herbal Mouthwashes. Recent patents on drug delivery & formulation. 2015; 9(3):257-61. doi: 10.2174/1872211309666150608095106. [PMID: 26051152]
  • Sug-Joon Ahn, Soon-Nang Park, Young Ju Lee, Eun-Jung Cho, Yun Kyong Lim, Xue Min Li, Mi-Hwa Choi, Young-Woo Seo, Joong-Ki Kook. In vitro antimicrobial activities of 1-methoxyficifolinol, licorisoflavan A, and 6,8-diprenylgenistein against Streptococcus mutans. Caries research. 2015; 49(1):78-89. doi: 10.1159/000362676. [PMID: 25531232]
  • P Zheng, M Zaruba, T Attin, A Wiegand. Effect of different matrix metalloproteinase inhibitors on microtensile bond strength of an etch-and-rinse and a self-etching adhesive to dentin. Operative dentistry. 2015 Jan; 40(1):80-6. doi: 10.2341/13-162-l. [PMID: 24815915]
  • Mineaki Kitamura, Tomoya Nishino, Yoko Obata, Satoru Oka, Shinichi Abe, Kumiko Muta, Yoshiyuki Ozono, Takehiko Koji, Shigeru Kohno. The kampo medicine Daikenchuto inhibits peritoneal fibrosis in mice. Biological & pharmaceutical bulletin. 2015; 38(2):193-200. doi: 10.1248/bpb.b14-00469. [PMID: 25747978]
  • Y Nakatsuka, T Nagasawa, Y Yumoto, F Nakazawa, Y Furuichi. Inhibitory effects of sword bean extract on alveolar bone resorption induced in rats by Porphyromonas gingivalis infection. Journal of periodontal research. 2014 Dec; 49(6):801-9. doi: 10.1111/jre.12166. [PMID: 24494651]
  • Gunjan Gupta, Dipika Mitra, K P Ashok, Arun Gupta, Sweta Soni, Sameer Ahmed, Ashtha Arya. Efficacy of preprocedural mouth rinsing in reducing aerosol contamination produced by ultrasonic scaler: a pilot study. Journal of periodontology. 2014 Apr; 85(4):562-8. doi: 10.1902/jop.2013.120616. [PMID: 23855840]
  • A Furiga, C Roques, C Badet. Preventive effects of an original combination of grape seed polyphenols with amine fluoride on dental biofilm formation and oxidative damage by oral bacteria. Journal of applied microbiology. 2014 Apr; 116(4):761-71. doi: 10.1111/jam.12395. [PMID: 24251548]
  • R Matthes, N-O Hübner, C Bender, I Koban, S Horn, S Bekeschus, K-D Weltmann, T Kocher, A Kramer, O Assadian. Efficacy of different carrier gases for barrier discharge plasma generation compared to chlorhexidine on the survival of Pseudomonas aeruginosa embedded in biofilm in vitro. Skin pharmacology and physiology. 2014; 27(3):148-57. doi: 10.1159/000353861. [PMID: 24434726]
  • Nicolas Tabary, Feng Chai, Nicolas Blanchemain, Christel Neut, Lucile Pauchet, Sabrina Bertini, Elisabeth Delcourt-Debruyne, Hartmut Frederic Hildebrand, Bernard Martel. A chlorhexidine-loaded biodegradable cellulosic device for periodontal pockets treatment. Acta biomaterialia. 2014 Jan; 10(1):318-29. doi: 10.1016/j.actbio.2013.09.032. [PMID: 24090988]
  • Chung-Jen Lee, Yi-Maun Subeq, Ru-Ping Lee, Hung-Hsiang Liou, Bang-Gee Hsu. Calcitriol decreases TGF-β1 and angiotensin II production and protects against chlorhexide digluconate-induced liver peritoneal fibrosis in rats. Cytokine. 2014 Jan; 65(1):105-18. doi: 10.1016/j.cyto.2013.10.003. [PMID: 24210651]
  • Istemi Han Celik, Serife Suna Oguz, Ugur Dilmen. Chlorhexidine-associated transient hyperchloremia in an infant. Pediatric dermatology. 2014 Jan; 31(1):110-1. doi: 10.1111/j.1525-1470.2012.01763.x. [PMID: 22639793]
  • Mark Nicholls. Clinical experiences of using Biopatch: a chlorhexidine gluconate-impregnated sponge dressing. Case study 1: renal setting. British journal of nursing (Mark Allen Publishing). 2014; 23(14 Suppl):S20-1. doi: NULL. [PMID: 25373253]
  • Tianfeng Du, Qi Shi, Ya Shen, Yingguang Cao, Jingzhi Ma, Xinpei Lu, Zilan Xiong, Markus Haapasalo. Effect of modified nonequilibrium plasma with chlorhexidine digluconate against endodontic biofilms in vitro. Journal of endodontics. 2013 Nov; 39(11):1438-43. doi: 10.1016/j.joen.2013.06.027. [PMID: 24139270]
  • Hiroshi Kinashi, Yasuhiko Ito, Masashi Mizuno, Yasuhiro Suzuki, Takeshi Terabayashi, Fumiko Nagura, Ryohei Hattori, Yoshihisa Matsukawa, Tomohiro Mizuno, Yukihiro Noda, Hayato Nishimura, Ryosuke Nishio, Shoichi Maruyama, Enyu Imai, Seiichi Matsuo, Yoshifumi Takei. TGF-β1 promotes lymphangiogenesis during peritoneal fibrosis. Journal of the American Society of Nephrology : JASN. 2013 Oct; 24(10):1627-42. doi: 10.1681/asn.2012030226. [PMID: 23990681]
  • M A Mazher, A Kallen, J R Edwards, R M Donlan. An in vitro evaluation of disinfection protocols used for needleless connectors of central venous catheters. Letters in applied microbiology. 2013 Oct; 57(4):282-7. doi: 10.1111/lam.12108. [PMID: 23710651]
  • A K Chapman, S W Aucott, M M Gilmore, S Advani, W Clarke, A M Milstone. Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates. Journal of perinatology : official journal of the California Perinatal Association. 2013 Oct; 33(10):768-71. doi: 10.1038/jp.2013.61. [PMID: 23702618]
  • Shamila K Shetty, Karanth Sharath, Santhosh Shenoy, Chandini Sreekumar, Rashmi N Shetty, Thomas Biju. Compare the effcacy of two commercially available mouthrinses in reducing viable bacterial count in dental aerosol produced during ultrasonic scaling when used as a preprocedural rinse. The journal of contemporary dental practice. 2013 Sep; 14(5):848-51. doi: 10.5005/jp-journals-10024-1414. [PMID: 24685786]
  • Toshinori Ueno, Ayumu Nakashima, Shigehiro Doi, Takeshi Kawamoto, Kiyomasa Honda, Yukio Yokoyama, Toshiki Doi, Yukihito Higashi, Noriaki Yorioka, Yukio Kato, Nobuoki Kohno, Takao Masaki. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling. Kidney international. 2013 Aug; 84(2):297-307. doi: 10.1038/ki.2013.81. [PMID: 23486522]
  • Hadi Darvishi Khezri, Mohammad Ali Haidari Gorji, Ali Morad, Heidari Gorji. Comparison of the antibacterial effects of matrica & Persica™ and chlorhexidine gluconate mouthwashes in mechanically ventilated ICU patients: a double blind randomized clinical trial. Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia. 2013 Aug; 30(4):361-73. doi: 10.4067/s0716-10182013000400003. [PMID: 24248104]
  • Eesha Jain, Ramesh K Pandey, Richa Khanna. Liquorice root extracts as potent cariostatic agents in pediatric practice. Journal of the Indian Society of Pedodontics and Preventive Dentistry. 2013 Jul; 31(3):146-52. doi: 10.4103/0970-4388.117964. [PMID: 24021323]
  • Marco Montevecchi, Antonio Dorigo, Monica Cricca, Luigi Checchi. Comparison of the antibacterial activity of an ozonated oil with chlorhexidine digluconate and povidone-iodine. A disk diffusion test. The new microbiologica. 2013 Jul; 36(3):289-302. doi: ". [PMID: 23912871]
  • Karen Smith, Douglas P Robertson, David F Lappin, Gordon Ramage. Commercial mouthwashes are ineffective against oral MRSA biofilms. Oral surgery, oral medicine, oral pathology and oral radiology. 2013 May; 115(5):624-9. doi: 10.1016/j.oooo.2012.12.014. [PMID: 23510687]
  • Christian Hannig, Jasmin Kirsch, Ali Al-Ahmad, Anna Kensche, Matthias Hannig, Klaus Kümmerer. Do edible oils reduce bacterial colonization of enamel in situ?. Clinical oral investigations. 2013 Mar; 17(2):649-58. doi: 10.1007/s00784-012-0734-0. [PMID: 22552590]
  • O A González, C Escamilla, R J Danaher, J Dai, J L Ebersole, R J Mumper, C S Miller. Antibacterial effects of blackberry extract target periodontopathogens. Journal of periodontal research. 2013 Feb; 48(1):80-6. doi: 10.1111/j.1600-0765.2012.01506.x. [PMID: 22812456]
  • Rutger Matthes, Claudia Bender, Rabea Schlüter, Ina Koban, René Bussiahn, Stephan Reuter, Jürgen Lademann, Klaus-Dieter Weltmann, Axel Kramer. Antimicrobial efficacy of two surface barrier discharges with air plasma against in vitro biofilms. PloS one. 2013; 8(7):e70462. doi: 10.1371/journal.pone.0070462. [PMID: 23894661]
  • Arzu Velioglu, Halil Tugtepe, Ebru Asicioglu, Neslihan Yilmaz, Deniz Filinte, Hakki Arikan, Mehmet Koc, Serhan Tuglular, Handan Kaya, Cetin Ozener. Role of tyrosine kinase inhibition with imatinib in an encapsulating peritoneal sclerosis rat model. Renal failure. 2013; 35(4):531-7. doi: 10.3109/0886022x.2013.773915. [PMID: 23473055]
  • Aswini Y Balappanavar, Varun Sardana, Malkeet Singh. Comparison of the effectiveness of 0.5\% tea, 2\% neem and 0.2\% chlorhexidine mouthwashes on oral health: a randomized control trial. Indian journal of dental research : official publication of Indian Society for Dental Research. 2013 Jan; 24(1):26-34. doi: 10.4103/0970-9290.114933. [PMID: 23852229]
  • Behzad Houshmand, Faranak Mahjour, Omid Dianat. Antibacterial effect of different concentrations of garlic (Allium sativum) extract on dental plaque bacteria. Indian journal of dental research : official publication of Indian Society for Dental Research. 2013 Jan; 24(1):71-5. doi: 10.4103/0970-9290.114957. [PMID: 23852236]
  • Olga Labovitiadi, Andrew J Lamb, Kerr H Matthews. Lyophilised wafers as vehicles for the topical release of chlorhexidine digluconate--release kinetics and efficacy against Pseudomonas aeruginosa. International journal of pharmaceutics. 2012 Dec; 439(1-2):157-64. doi: 10.1016/j.ijpharm.2012.10.017. [PMID: 23085374]
  • Emma Hendry, Barbara Conway, Tony Worthington. Antimicrobial efficacy of a novel eucalyptus oil, chlorhexidine digluconate and isopropyl alcohol biocide formulation. International journal of molecular sciences. 2012 Oct; 13(11):14016-25. doi: 10.3390/ijms131114016. [PMID: 23203047]
  • Nihal R Devker, Jyoti Mohitey, Akshay Vibhute, Vivek Singh Chouhan, Prithviraj Chavan, Sachin Malagi, Rosemary Joseph. A study to evaluate and compare the efficacy of preprocedural mouthrinsing and high volume evacuator attachment alone and in combination in reducing the amount of viable aerosols produced during ultrasonic scaling procedure. The journal of contemporary dental practice. 2012 Sep; 13(5):681-9. doi: 10.5005/jp-journals-10024-1209. [PMID: 23250175]
  • Vincenzo Summa, Steven W Ludmerer, John A McCauley, Christine Fandozzi, Christine Burlein, Giuliano Claudio, Paul J Coleman, Jillian M Dimuzio, Marco Ferrara, Marcello Di Filippo, Adam T Gates, Donald J Graham, Steven Harper, Daria J Hazuda, Qian Huang, Carolyn McHale, Edith Monteagudo, Vincenzo Pucci, Michael Rowley, Michael T Rudd, Aileen Soriano, Mark W Stahlhut, Joseph P Vacca, David B Olsen, Nigel J Liverton, Steven S Carroll. MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrobial agents and chemotherapy. 2012 Aug; 56(8):4161-7. doi: 10.1128/aac.00324-12. [PMID: 22615282]
  • Viviane Carlin, Mariza A Matsumoto, Patricia P Saraiva, André Artioli, Celina T F Oshima, Daniel Araki Ribeiro. Cytogenetic damage induced by mouthrinses formulations in vivo and in vitro. Clinical oral investigations. 2012 Jun; 16(3):813-20. doi: 10.1007/s00784-011-0559-2. [PMID: 21547372]
  • Tianfeng Du, Jingzhi Ma, Ping Yang, Zilan Xiong, Xinpei Lu, Yingguang Cao. Evaluation of antibacterial effects by atmospheric pressure nonequilibrium plasmas against Enterococcus faecalis biofilms in vitro. Journal of endodontics. 2012 Apr; 38(4):545-9. doi: 10.1016/j.joen.2011.10.021. [PMID: 22414847]
  • Hideki Yokoi, Masato Kasahara, Kiyoshi Mori, Yoshihisa Ogawa, Takashige Kuwabara, Hirotaka Imamaki, Tomoko Kawanishi, Kenichi Koga, Akira Ishii, Yukiko Kato, Keita P Mori, Naohiro Toda, Shoko Ohno, Hisako Muramatsu, Takashi Muramatsu, Akira Sugawara, Masashi Mukoyama, Kazuwa Nakao. Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis. Kidney international. 2012 Jan; 81(2):160-9. doi: 10.1038/ki.2011.305. [PMID: 21881556]
  • Letícia Resende Davi, Daniela Nair Borges Felipucci, Raphael Freitas de Souza, Osvaldo Luiz Bezzon, Cláudia Helena Lovato-Silva, Valéria Oliveira Pagnano, Helena de Freitas Oliveira Paranhos. Effect of denture cleansers on metal ion release and surface roughness of denture base materials. Brazilian dental journal. 2012; 23(4):387-93. doi: 10.1590/s0103-64402012000400013. [PMID: 23207854]
  • A G Baradari, H D Khezri, S Arabi. Comparison of antibacterial effects of oral rinses chlorhexidine and herbal mouth wash in patients admitted to intensive care unit. Bratislavske lekarske listy. 2012; 113(9):556-60. doi: 10.4149/bll_2012_125. [PMID: 22979913]
  • Sérgio Luís da Silva Pereira, José Weslley Gonçalves de Oliveira, Keyles Karla Sá Vieira Angelo, Angela Maria Alves da Costa, Flávio Costa. Clinical effect of a mouth rinse containing Ocimum gratissimum on plaque and gingivitis control. The journal of contemporary dental practice. 2011 Sep; 12(5):350-5. doi: 10.5005/jp-journals-10024-1058. [PMID: 22269195]
  • P F Waghmare, A U Chaudhari, V M Karhadkar, A S Jamkhande. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study. The journal of contemporary dental practice. 2011 Jul; 12(4):221-4. doi: 10.5005/jp-journals-10024-1038. [PMID: 22186854]
  • Yi-Maun Subeq, Chen-Yen Ke, Nien-Tsung Lin, Chung-Jen Lee, Yi-Han Chiu, Bang-Gee Hsu. Valsartan decreases TGF-β1 production and protects against chlorhexidine digluconate-induced liver peritoneal fibrosis in rats. Cytokine. 2011 Feb; 53(2):223-30. doi: 10.1016/j.cyto.2010.11.004. [PMID: 21129996]
  • Anniek Vlijm, Denise E Sampimon, Marijke de Graaff, Dirk G Struijk, Raymond T Krediet. Experimental peritoneal sclerosis models should not be based on chlorhexidine gluconate anymore. Nephron. Experimental nephrology. 2011; 117(1):e1-8. doi: 10.1159/000319651. [PMID: 20689329]
  • Christof Duss, Niklaus P Lang, Jan Cosyn, G Rutger Persson. A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05\% chlorhexidine/herbal extract and a 0.1\% chlorhexidine mouthrinse adjunct to periodontal surgery. Journal of clinical periodontology. 2010 Nov; 37(11):988-97. doi: 10.1111/j.1600-051x.2010.01609.x. [PMID: 20738456]
  • Christopher J Weight, Michael C Lee, Jeffrey S Palmer. Avagard hand antisepsis vs. traditional scrub in 3600 pediatric urologic procedures. Urology. 2010 Jul; 76(1):15-7. doi: 10.1016/j.urology.2010.01.017. [PMID: 20363495]
  • Nitin C Mohire, Adhikrao V Yadav. Chitosan-based polyherbal toothpaste: as novel oral hygiene product. Indian journal of dental research : official publication of Indian Society for Dental Research. 2010 Jul; 21(3):380-4. doi: 10.4103/0970-9290.70808. [PMID: 20930349]
  • Chun-Yen Ke, Chia-Chi Lee, Chung-Jen Lee, Yi-Maun Subeq, Ru-Ping Lee, Bang-Gee Hsu. Aliskiren ameliorates chlorhexidine digluconate-induced peritoneal fibrosis in rats. European journal of clinical investigation. 2010 Apr; 40(4):301-9. doi: 10.1111/j.1365-2362.2010.02264.x. [PMID: 20486991]
  • E R Hendry, T Worthington, B R Conway, P A Lambert. Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm cultures. The Journal of antimicrobial chemotherapy. 2009 Dec; 64(6):1219-25. doi: 10.1093/jac/dkp362. [PMID: 19837714]
  • Yanti, Yaya Rukayadi, Kwan-Hyoung Lee, Jae-Kwan Hwang. Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro. Journal of oral science. 2009 Mar; 51(1):87-95. doi: 10.2334/josnusd.51.87. [PMID: 19325204]