Cefaclor hydrate (BioDeep_00000015242)

   


代谢物信息卡片


Cefaclor Monohydrate

化学式: C15H16ClN3O5S (385.0499156)
中文名称: 一水合头孢克洛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl.O
InChI: /m1./s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

2 个代谢物同义名

Cefaclor Monohydrate; Cefaclor hydrate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • A Alper Öztürk, İrem Namlı, Abdurrahman Aygül. Cefaclor Monohydrate-Loaded Colon-Targeted Nanoparticles for Use in COVID-19 Dependent Coinfections and Intestinal Symptoms: Formulation, Characterization, Release Kinetics, and Antimicrobial Activity. Assay and drug development technologies. 2021 04; 19(3):156-175. doi: 10.1089/adt.2020.1014. [PMID: 33728979]
  • Young Hee Nam, So Hee Lee, Hyo In Rhyou, Young Soo Lee, Seung Hee Park, Young Hee Lee, Yoo Seob Shin, Hae Sim Park, Young Min Ye. Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy. Yonsei medical journal. 2018 Oct; 59(8):968-974. doi: 10.3349/ymj.2018.59.8.968. [PMID: 30187704]
  • M Ali Fadel, Reem H El-Gebaly, Shaimaa A Mohamed, Ashraf M M Abdelbacki. Biophysical control of the growth of Agrobacterium tumefaciens using extremely low frequency electromagnetic waves at resonance frequency. Biochemical and biophysical research communications. 2017 12; 494(1-2):365-371. doi: 10.1016/j.bbrc.2017.10.008. [PMID: 28988110]
  • Shazia Naz, Muhammad Harris Shoaib, Lubna Bashir, Rabia Ismail Yousuf, Fakhsheena Anjum, Fahad Siddiqui, Saima Yaseen. HPLC method development and validation for the determination of Cefaclor in human plasma. Pakistan journal of pharmaceutical sciences. 2017 Sep; 30(5):1645-1649. doi: NULL. [PMID: 29084685]
  • Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid. Use of platelet-rich plasma for regeneration in non-vital immature permanent teeth: Clinical and cone-beam computed tomography evaluation. The Journal of international medical research. 2017 Apr; 45(2):583-593. doi: 10.1177/0300060517692935. [PMID: 28415948]
  • Zdenko Tomić, Ana Tomas, Saša Vukmirović, Momir Mikov, Olga Horvat, Nataša Tomić, Ana Sabo. Do We Bury Antibacterials When Launching? Cefaclor Example. Journal of pharmaceutical sciences. 2016 Mar; 105(3):1295-300. doi: 10.1016/j.xphs.2015.12.003. [PMID: 26886327]
  • Giorgio Piccinelli, Valeria Biscaro, Franco Gargiulo, Arnaldo Caruso, Maria Antonia De Francesco. Characterization and antibiotic susceptibility of Streptococcus agalactiae isolates causing urinary tract infections. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2015 Aug; 34(?):1-6. doi: 10.1016/j.meegid.2015.07.001. [PMID: 26144658]
  • Hye-Soo Yoo, Seung-Hyun Kim, Hyouk-Soo Kwon, Tae-Bum Kim, Young-Hee Nam, Young-Min Ye, Hae-Sim Park. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei medical journal. 2014 Nov; 55(6):1473-83. doi: 10.3349/ymj.2014.55.6.1473. [PMID: 25323882]
  • Chenrong Huang, Wei Wang, Liyan Miao. Determination of cefaclor by UPLC-MS-MS for a Chinese pharmacokinetic study. Journal of chromatographic science. 2014 Aug; 52(7):636-40. doi: 10.1093/chromsci/bmt092. [PMID: 23839802]
  • T Bezgin, A D Yilmaz, B N Celik, H Sönmez. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. International endodontic journal. 2014 Jan; 47(1):41-9. doi: 10.1111/iej.12144. [PMID: 23772873]
  • Zhen Zhang, Yun Xiang, Baoxiang Wang, Hongbo Chen, Xiaofang Cai, Xiaomei Wang, Lin Mei, Yi Zheng. Intestinal mucosal permeability of children with cefaclor-associated serum sickness-like reactions. European journal of pediatrics. 2013 Apr; 172(4):537-43. doi: 10.1007/s00431-012-1926-y. [PMID: 23296953]
  • Bazigha K Abdul Rasool, Sahar A Fahmy. Development of coated beads for oral controlled delivery of cefaclor: In vitro evaluation. Acta pharmaceutica (Zagreb, Croatia). 2013 Mar; 63(1):31-44. doi: 10.2478/acph-2013-0003. [PMID: 23482311]
  • J Chen, B Jiang, H Lou, L Yu, Z Ruan. Bioequivalence studies of 2 oral cefaclor capsule formulations in chinese healthy subjects. Arzneimittel-Forschung. 2012 Mar; 62(3):134-7. doi: 10.1055/s-0031-1298012. [PMID: 22286978]
  • Zhuming Wang, Zhenghua Song, Donghua Chen. Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method. Talanta. 2010 Dec; 83(2):312-9. doi: 10.1016/j.talanta.2010.09.029. [PMID: 21111139]
  • Jun-Mei Li, Cen Li, Ye Jiang, Shu-Meng Ren. Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltrate device for the determination of cefaclor concentrations in human plasma. Journal of chromatography. A. 2010 Oct; 1217(44):6824-8. doi: 10.1016/j.chroma.2010.08.059. [PMID: 20863507]
  • . Cefaclor: serum sickness. Prescrire international. 2010 Apr; 19(106):75. doi: . [PMID: 20568494]
  • Jing Ma, Max Bellon, Judith M Wishart, Richard L Young, Karen L Jones, Michael Horowitz, Christopher K Rayner. Effects of cefaclor on gastric emptying and cholecystokinin release in healthy humans. Regulatory peptides. 2010 Jan; 159(1-3):156-9. doi: 10.1016/j.regpep.2009.11.009. [PMID: 19914303]
  • Kenneth Chibuzor Ofokansi, Ogbonna Okorie, Michael Umale Adikwu. Biodegradable microspheres based on gelatin-porcine mucin admixtures: in vitro and in vivo delivery studies. Biological & pharmaceutical bulletin. 2009 Oct; 32(10):1754-9. doi: 10.1248/bpb.32.1754. [PMID: 19801839]
  • Qian Gong, Zhe-yi Hu, Zhi-zhuang Huang, Li-qing Wang, Wen-fang Liu, Xin Guo, Wei Cao, Ting Wang, Ze-neng Cheng. Pharmacokinetic interaction between cefaclor and bromhexine in healthy Chinese volunteers. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2007 Oct; 32(5):855-61. doi: NULL. [PMID: 18007084]
  • K Stamatiou, A Alevizos, G Petrakos, I Lentzas, M Papathanasiou, A Mariolis, P Panagopoulos, F Sofras. Study on the efficacy of cefaclor for the treatment of asymptomatic bacteriuria and lower urinary tract infections in pregnant women with a history of hypersensitivity to penicillin. Clinical and experimental obstetrics & gynecology. 2007; 34(2):85-7. doi: . [PMID: 17629158]
  • Meng Li, Gail D Anderson, Brian R Phillips, Wei Kong, Danny D Shen, Joanne Wang. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug metabolism and disposition: the biological fate of chemicals. 2006 Apr; 34(4):547-55. doi: 10.1124/dmd.105.006791. [PMID: 16434549]
  • Yukoh Aihara, Shuichi Ito, Michiko Aihara, Yoshinori Kobayashi, Shumpei Yokota. Different patterns of cytokines, ECP and immunoglobulin profiles at two adverse drug reactions in a patient. Pediatrics international : official journal of the Japan Pediatric Society. 2005 Dec; 47(6):616-21. doi: 10.1111/j.1442-200x.2005.02143.x. [PMID: 16354212]
  • Sang-Hoon Kim, Jeong-Hee Choi, Hae-Sim Park. Heterogeneity of the IgE response to allergenic determinants of cefaclor in serum samples from patients with cefaclor-induced anaphylaxis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2005 Jun; 94(6):700-4. doi: 10.1016/s1081-1206(10)61331-2. [PMID: 15984605]
  • Yong-hong Xiao, Lei Gao, Yun Li, Yuan Lü, Jian Liu, Yan Liu. [Comparison of pharmacokinetics/pharmacodynamics of cefdinir, cefpodoxime proxetil and cefaclor against common bacteria of community acquired infections]. Zhonghua yi xue za zhi. 2004 Nov; 84(22):1867-71. doi: . [PMID: 15631795]
  • B A H Khan, T Ahmed, S Karim, T Monif, N Saha, P L Sharma. Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet. European journal of drug metabolism and pharmacokinetics. 2004 Apr; 29(2):125-32. doi: 10.1007/bf03190587. [PMID: 15230341]
  • B A King, G C Geelhoed. Adverse skin and joint reactions associated with oral antibiotics in children: the role of cefaclor in serum sickness-like reactions. Journal of paediatrics and child health. 2003 Dec; 39(9):677-81. doi: 10.1046/j.1440-1754.2003.00267.x. [PMID: 14629499]
  • S Karim, T Ahmed, T Monif, N Saha, P L Sharma. The effect of four different types of food on the bioavailability of cefaclor. European journal of drug metabolism and pharmacokinetics. 2003 Jul; 28(3):185-90. doi: 10.1007/bf03190484. [PMID: 14527091]
  • Kazunari Kaneko, Yoshiyuki Ohtomo, Toshiaki Shimizu, Yuichiro Yamashiro, Atsuyuki Yamataka, Takeshi Miyano. Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatric nephrology (Berlin, Germany). 2003 May; 18(5):468-70. doi: 10.1007/s00467-003-1111-7. [PMID: 12736811]
  • F Mattioli, P Tognoni, C Corbu, A Martelli. Low plasma cefaclor levels in cystectomized bladder cancer patients with various types of urinary diversion. European journal of clinical pharmacology. 2003 Feb; 58(10):715-6. doi: 10.1007/s00228-002-0536-4. [PMID: 12610750]
  • Xiaoyan Chen, Dafang Zhong, Bin Huang, Jian Cui. Determination of cefaclor in human plasma by a sensitive and specific liquid chromatographic-tandem mass spectrometric method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 784(1):17-24. doi: 10.1016/s1570-0232(02)00656-6. [PMID: 12504178]
  • Masaaki Kai, Hiromi Kinoshita, Kazuko Ohta, Shuuji Hara, Myung Koo Lee, Jianzhong Lu. Sensitive determination of a beta-lactam antibiotic, cefaclor by liquid chromatography with chemiluminescence detection. Journal of pharmaceutical and biomedical analysis. 2003 Jan; 30(6):1765-71. doi: 10.1016/s0731-7085(02)00519-8. [PMID: 12485718]
  • Makoto Ichimiya, Yoshiaki Hamamoto, Masahiko Muto. A case of baboon syndrome associated with group a streptococcal infection. The Journal of dermatology. 2003 Jan; 30(1):69-71. doi: NULL. [PMID: 12598713]
  • T D Leach, S A Sadek, J C Mason. An unusual abdominal mass in a renal transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society. 2002 Dec; 4(4):218-22. doi: 10.1034/j.1399-3062.2002.t01-1-01009.x. [PMID: 12535266]
  • M U Sanklecha. Cefaclor induced serum sickness like reaction. Indian journal of pediatrics. 2002 Oct; 69(10):921. doi: 10.1007/bf02723724. [PMID: 12450309]
  • Joseph Yerushalmi, Alex Zvulunov, Sima Halevy. Serum sickness-like reactions. Cutis. 2002 May; 69(5):395-7. doi: NULL. [PMID: 12041822]
  • la Peña Amparo de, Martin Brunner, Hans-Georg Eichler, Edelgard Rehak, Jens Gross, Ursula Thyroff-Friesinger, Markus Müller, Hartmut Derendorf. Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans. Journal of clinical pharmacology. 2002 Apr; 42(4):403-11. doi: 10.1177/00912700222011454. [PMID: 11936565]
  • A De La Peña, T Dalla Costa, J D Talton, E Rehak, J Gross, U Thyroff-Friesinger, A I Webb, M Müller, H Derendorf. Penetration of cefaclor into the interstitial space fluid of skeletal muscle and lung tissue in rats. Pharmaceutical research. 2001 Sep; 18(9):1310-4. doi: 10.1023/a:1013042128791. [PMID: 11683245]
  • D Isaacs. Serum sickness-like reaction to cefaclor. Journal of paediatrics and child health. 2001 Jun; 37(3):298-9. doi: 10.1046/j.1440-1754.2001.00632.x. [PMID: 11468048]
  • M Tutunji, O Jarrar, M Musameh, S M Alam, Quamruzaman, R Dham. Bioequivalence evaluation of two brands of cefaclor 500 mg capsules: quantification of cefaclor using solid phase extraction technique. Journal of clinical pharmacy and therapeutics. 2001 Apr; 26(2):149-53. doi: 10.1046/j.1365-2710.2001.00337.x. [PMID: 11350539]
  • S Gupta, B B Prasad. Determination of cefaclor by selective sample enrichment/clean-up on silica gel bonded polyelectrolyte in ion-exchange column chromatography. Journal of pharmaceutical and biomedical analysis. 2000 Aug; 23(2-3):307-13. doi: 10.1016/s0731-7085(00)00304-6. [PMID: 10933523]
  • A P Leigh, M A Nemeth, C H Keyserling, L H Hotary, K J Tack. Cefdinir versus cefaclor in the treatment of uncomplicated urinary tract infection. Clinical therapeutics. 2000 Jul; 22(7):818-25. doi: 10.1016/s0149-2918(00)80054-5. [PMID: 10945508]
  • D M Johnson, D J Biedenbach, M L Beach, M A Pfaller, R N Jones. Antimicrobial activity and in vitro susceptibility test development for cefditoren against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus species. Diagnostic microbiology and infectious disease. 2000 Jun; 37(2):99-105. doi: 10.1016/s0732-8893(00)00136-x. [PMID: 10863104]
  • M Cazzola, F Di Perna, B Boveri, F Di Marco, F Diamare, S Centanni. Interrelationship between the pharmacokinetics and pharmacodynamics of cefaclor advanced formulation in patients with acute exacerbation of chronic bronchitis. Journal of chemotherapy (Florence, Italy). 2000 Jun; 12(3):216-22. doi: 10.1179/joc.2000.12.3.216. [PMID: 10877516]
  • T Mazzei, A Novelli, S Esposito, P Periti. New insight into the clinical pharmacokinetics of cefaclor: tissue penetration. Journal of chemotherapy (Florence, Italy). 2000 Feb; 12(1):53-62. doi: 10.1179/joc.2000.12.1.53. [PMID: 10768516]
  • M Hefnawy, Y El-Shabrawy, F Belal. Spectrofluorometric determination of alpha-aminocephalosporins in biological fluids and pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis. 1999 Dec; 21(4):703-7. doi: 10.1016/s0731-7085(99)00208-3. [PMID: 10701934]
  • L N Rodrigues, M V Zanoni, A G Fogg. Indirect polarographic and cathodic stripping voltammetric determination of cefaclor as an alkaline degradation product. Journal of pharmaceutical and biomedical analysis. 1999 Nov; 21(3):497-505. doi: 10.1016/s0731-7085(99)00174-0. [PMID: 10701416]
  • R Phillips. New warning about cefaclor and serum sickness in children. Australian family physician. 1999 Jun; 28(6):539. doi: NULL. [PMID: 10399381]
  • C S Parshuram, R J Phillips, M C Nash. Serum sickness in a paediatric emergency department: the role of cefaclor. Journal of paediatrics and child health. 1999 Apr; 35(2):223-4. doi: NULL. [PMID: 10365368]
  • M Grouhi, D Hummel, C M Roifman. Anaphylactic reaction to oral cefaclor in a child. Pediatrics. 1999 Apr; 103(4):e50. doi: 10.1542/peds.103.4.e50. [PMID: 10103342]
  • G I Joubert, K Hadad, D Matsui, J Gloor, M J Rieder. Selection of treatment of cefaclor-associated urticarial, serum sickness-like reactions and erythema multiforme by emergency pediatricians: lack of a uniform standard of care. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique. 1999; 6(4):197-201. doi: NULL. [PMID: 10601753]
  • I W Boyd. Cefaclor-associated serum sickness. The Medical journal of Australia. 1998 Oct; 169(8):443-4. doi: 10.5694/j.1326-5377.1998.tb126844.x. [PMID: 9830397]
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  • K Sato, K Kobayashi, C M Moore, Y Mizuno, Y Katsumata. Semi-quantitative analysis of cefaclor in human serum by capillary high performance liquid chromatography/fast atom bombardment mass spectrometry. Forensic science international. 1993 Apr; 59(1):71-7. doi: 10.1016/0379-0738(93)90313-y. [PMID: 8505030]
  • B H Stricker, J G Tijssen. Serum sickness-like reactions to cefaclor. Journal of clinical epidemiology. 1992 Oct; 45(10):1177-84. doi: 10.1016/0895-4356(92)90158-j. [PMID: 1474414]
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  • F M Parra, J M Igea, J A Martín, M D Alonso, A Lezaun, T Sainz. Serum sickness-like syndrome associated with cefaclor therapy. Allergy. 1992 Aug; 47(4 Pt 2):439-40. doi: 10.1111/j.1398-9995.1992.tb02086.x. [PMID: 1456417]
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