Imidapril hydrochloride (BioDeep_00000015230)
代谢物信息卡片
Imidapril (hydrochloride)
化学式: C20H28ClN3O6 (441.16665380000006)
中文名称: 咪达普利盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C2=O)C)C(=O)O.Cl
InChI: /m0./s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31691
- KEGG: C77009
- KEGGdrug: D01549
- PubChem: 5485193
- ChEMBL: CHEMBL3183293
- CAS: 89396-94-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kyoko Nitta, Sen Shi, Takako Nagai, Megumi Kanasaki, Munehiro Kitada, Swayam Prakash Srivastava, Masakazu Haneda, Keizo Kanasaki, Daisuke Koya. Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen.
BioMed research international.
2016; 2016(?):9172157. doi:
10.1155/2016/9172157. [PMID: 27088094] - Takashi Yokota, Hirofumi Tomita, Yasuhiro Mori, Takeshi Kudo, Hitoshi Hiraga, Naoyuki Suto, Takumi Higuma, Naoki Abe, Hiroyuki Hanada, Tomohiro Osanai, Ken Okumura. Imidapril and enalapril similarly inhibit plasma matrix metalloproteinase activities and attenuate left ventricular remodeling in patients with acute myocardial infarction.
Journal of cardiovascular pharmacology.
2014 Jun; 63(6):528-32. doi:
10.1097/fjc.0000000000000077. [PMID: 24709636] - Jochen Springer, Anika Tschirner, Arash Haghikia, Stephan von Haehling, Hind Lal, Aleksandra Grzesiak, Elena Kaschina, Sandra Palus, Mareike Pötsch, Karoline von Websky, Berthold Hocher, Celine Latouche, Frederic Jaisser, Lars Morawietz, Andrew J S Coats, John Beadle, Josep M Argiles, Thomas Thum, Gabor Földes, Wolfram Doehner, Denise Hilfiker-Kleiner, Thomas Force, Stefan D Anker. Prevention of liver cancer cachexia-induced cardiac wasting and heart failure.
European heart journal.
2014 Apr; 35(14):932-41. doi:
10.1093/eurheartj/eht302. [PMID: 23990596] - Hikaru Yoneda, Kiichiro Ueta, Masaaki Nagasaki, Kenji Arakawa. Involvement of heparan sulfate in the renoprotective effects of imidapril, an angiotensin-converting enzyme inhibitor, in diabetic db/db mice.
Journal of receptor and signal transduction research.
2014 Feb; 34(1):21-5. doi:
10.3109/10799893.2013.845788. [PMID: 24094140] - Roberto Fogari, Amedeo Mugellini, Annalisa Zoppi, Roberta Gualtierotti, Pierangelo Lazzari, Giuseppe Derosa, Angela D'Angelo. Effect of imidapril versus ramipril on urinary albumin excretion in hypertensive patients with type 2 diabetes and microalbuminuria.
Expert opinion on pharmacotherapy.
2013 Dec; 14(18):2463-73. doi:
10.1517/14656566.2013.848195. [PMID: 24195786] - Hong Li, Yu-sheng Wang. An angiotensin-converting enzyme inhibitor modulates stromal-derived factor-1 through CD26/dipeptidyl peptidase IV to inhibit laser-induced choroidal neovascularization.
Molecular vision.
2013; 19(?):1107-21. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Feb; 35(2):234-8. doi:
10.1038/hr.2011.165. [PMID: 21993212] - Kouichi Utsumi, Fumihiko Yasuda, Yoko Watanabe, Seiichiro Higo, Akio Hirama, Emiko Fujita, Kae Ueda, Akiko Mii, Tomohiro Kaneko, Masahiro Mishina, Yasuhiko Iino, Yasuo Katayama. Effects of olmesartan and imidapril on the plasma adiponectin, P-selectin, and MDA-LDL levels of diabetic nephropathy patients.
Clinica chimica acta; international journal of clinical chemistry.
2012 Jan; 413(1-2):348-9. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Dec; 34(12):1321-6. doi:
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Medicine.
2011 Jul; 90(4):279-283. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Apr; 34(4):509-15. doi:
10.1038/hr.2010.260. [PMID: 21179101] - Fen Wei, Xiu-Jie Jia, Su-Qin Yu, Ye Gu, Li Wang, Xiao-Mei Guo, Min Wang, Feng Zhu, Xiang Cheng, Yu-Miao Wei, Zi-Hua Zhou, Micheal Fu, Yu-Hua Liao. Candesartan versus imidapril in hypertension: a randomised study to assess effects of anti-AT1 receptor autoantibodies.
Heart (British Cardiac Society).
2011 Mar; 97(6):479-84. doi:
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Circulation journal : official journal of the Japanese Circulation Society.
2010 Nov; 74(11):2346-52. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2010 Nov; 33(11):1150-4. doi:
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Brain research.
2010 Sep; 1352(?):176-86. doi:
10.1016/j.brainres.2010.07.006. [PMID: 20627092] - Tetsuya Matsumoto, Hiroyuki Takashima, Ichiro Nakae, Tetsunobu Yamane, Hideki Hayashi, Minoru Horie. Angiotensin-converting enzyme inhibition augments coronary release of tissue plasminogen activator in women but not in men.
Hypertension (Dallas, Tex. : 1979).
2010 Sep; 56(3):364-8. doi:
10.1161/hypertensionaha.110.154278. [PMID: 20606106] - Yosuke Takeda, Toshio Nishikimi, Kazumi Akimoto, Hiroaki Matsuoka, Toshihiko Ishimitsu. Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction.
Hypertension research : official journal of the Japanese Society of Hypertension.
2010 Sep; 33(9):965-73. doi:
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Clinical immunology (Orlando, Fla.).
2010 Aug; 136(2):188-96. doi:
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Vnitrni lekarstvi.
2010 Mar; 56(3):210-6. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2009 Dec; 63(10):754-61. doi:
10.1016/j.biopha.2009.02.006. [PMID: 19304450] - Naohito Ide, Seiichi Gotou, Masami Mori. [Hospital pharmacists prevented advance of lithium intoxication through pharmaceutical interventions].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2009 Aug; 129(8):1007-11. doi:
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International journal of molecular medicine.
2007 Apr; 19(4):571-9. doi:
10.3892/ijmm.19.4.571. [PMID: 17334632] - Tomas Dolezal. Imidapril in heart failure.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2006 Sep; 7(3):146-54. doi:
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Journal of the American Society of Nephrology : JASN.
2006 Jul; 17(7):1950-61. doi:
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Journal of pharmacological sciences.
2006 Jun; 101(2):159-65. doi:
10.1254/jphs.fp0060031. [PMID: 16766855] - Susumu Ogawa, Kazuhisa Takeuchi, Takefumi Mori, Kazuhiro Nako, Sadayoshi Ito. Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor.
Clinical and experimental pharmacology & physiology.
2006 May; 33(5-6):477-9. doi:
10.1111/j.1440-1681.2006.04390.x. [PMID: 16700881] - Nobuko Matsumoto, Toshihiko Ishimitsu, Atsushi Okamura, Hitoshi Seta, Masaki Takahashi, Hiroaki Matsuoka. Effects of imidapril on left ventricular mass in chronic hemodialysis patients.
Hypertension research : official journal of the Japanese Society of Hypertension.
2006 Apr; 29(4):253-60. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2005 Nov; 17(11):670-2. doi:
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International heart journal.
2005 Jul; 46(4):701-10. doi:
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Archives of pharmacal research.
2005 Apr; 28(4):463-8. doi:
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American journal of hypertension.
2005 Jan; 18(1):13-7. doi:
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Journal of hypertension.
2004 Jul; 22(7):1389-95. doi:
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World journal of gastroenterology.
2004 May; 10(10):1471-5. doi:
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2004 Jan; 36(1):34-8. doi:
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Neurology.
2003 Dec; 61(11):1625-6. doi:
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Hypertension (Dallas, Tex. : 1979).
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Hypertension research : official journal of the Japanese Society of Hypertension.
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European journal of clinical pharmacology.
2001 Jul; 57(4):275-84. doi:
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The Journal of international medical research.
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Fundamental & clinical pharmacology.
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Journal of the American College of Cardiology.
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Hypertension (Dallas, Tex. : 1979).
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American journal of hypertension.
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British journal of clinical pharmacology.
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