Vadadustat (BioDeep_00000015212)
代谢物信息卡片
Vadadustat
化学式: C14H11ClN2O4 (306.0407316)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
InChI: InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
B - Blood and blood forming organs > B03 - Antianemic preparations
C78275 - Agent Affecting Blood or Body Fluid
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor[1]. Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo[1][2].
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- KEGG: C71001
- KEGGdrug: D11078
- PubChem: 23634441
- DrugBank: DB12255
- ChEMBL: CHEMBL3646221
- CAS: 1000025-07-9
- medchemexpress: HY-101277
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiong Huang, Zhenyi Liao, Xiaoyan Liu, Yun Xia, Jing Wang. Efficacy and safety of vadadustat compared to darbepoetin alfa on anemia in patients with chronic kidney disease: a meta-analysis.
International urology and nephrology.
2023 Feb; 55(2):325-334. doi:
10.1007/s11255-022-03316-z. [PMID: 35960479] - Susan K Paulson, Jimena Martinez, Rishikesh Sawant, Steven K Burke, Ajit Chavan. Effect of Phosphate Binders and a Dietary Iron Supplement on the Pharmacokinetics of a Single Dose of Vadadustat in Healthy Adults.
Clinical pharmacology in drug development.
2022 04; 11(4):475-485. doi:
10.1002/cpdd.1033. [PMID: 35172045] - Masaomi Nangaku, Kazuoki Kondo, Souichirou Takabe, Kiichiro Ueta, Tsubasa Tandai, Yutaka Kawaguchi, Yasuhiro Komatsu. A phase 3, open-label, single-arm study of vadadustat for anemia in chronic kidney disease for Japanese patients on hemodialysis not receiving erythropoiesis-stimulating agents.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2022 Feb; 26(1):45-54. doi:
10.1111/1744-9987.13699. [PMID: 34115437] - Kai-Uwe Eckardt, Rajiv Agarwal, Youssef Mk Farag, Alan G Jardine, Zeeshan Khawaja, Mark J Koury, Wenli Luo, Kunihiro Matsushita, Peter A McCullough, Patrick Parfrey, Geoffrey Ross, Mark J Sarnak, Dennis Vargo, Wolfgang C Winkelmayer, Glenn M Chertow. Global Phase 3 programme of vadadustat for treatment of anaemia of chronic kidney disease: rationale, study design and baseline characteristics of dialysis-dependent patients in the INNO2VATE trials.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 11; 36(11):2039-2048. doi:
10.1093/ndt/gfaa204. [PMID: 33188693] - H Franklin Bunn. Vadadustat for Anemia in Patients with Dialysis-Dependent or Non-Dialysis-Dependent Chronic Kidney Disease.
The New England journal of medicine.
2021 10; 385(16):e56. doi:
10.1056/nejmc2110095. [PMID: 34644481] - Glenn M Chertow, Kai-Uwe Eckardt. Vadadustat for Anemia in Patients with Dialysis-Dependent or Non-Dialysis-Dependent Chronic Kidney Disease. Reply.
The New England journal of medicine.
2021 10; 385(16):e56. doi:
10.1056/nejmc2110095. [PMID: 34644482] - Masaomi Nangaku, Kazuoki Kondo, Souichirou Takabe, Kiichiro Ueta, Genki Kaneko, Makiko Otsuka, Yutaka Kawaguchi, Yasuhiro Komatsu. Vadadustat for anemia in chronic kidney disease patients on peritoneal dialysis: A phase 3 open-label study in Japan.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2021 Oct; 25(5):642-653. doi:
10.1111/1744-9987.13611. [PMID: 33283981] - Ajit Chavan, Leontia Burke, Rishikesh Sawant, Pamela Navarro-Gonzales, Dennis Vargo, Susan K Paulson. Effect of Moderate Hepatic Impairment on the Pharmacokinetics of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor.
Clinical pharmacology in drug development.
2021 08; 10(8):950-958. doi:
10.1002/cpdd.927. [PMID: 33661566] - Yoshimasa Kokado, Kouji Kawai, Takehiro Nanjo, Shuji Kinoshita, Kazuoki Kondo. In Vitro and Clinical Pharmacokinetic Studies of the Effects of Iron-containing Agents on Vadadustat, an Oral Hypoxia-inducible Factor-Prolyl Hydroxylase Inhibitor.
Clinical therapeutics.
2021 08; 43(8):1408-1418.e5. doi:
10.1016/j.clinthera.2021.06.013. [PMID: 34511184] - Mark R Hanudel, Shirley Wong, Grace Jung, Bo Qiao, Victoria Gabayan, Anna Zuk, Tomas Ganz. Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone.
Kidney international.
2021 07; 100(1):79-89. doi:
10.1016/j.kint.2021.03.019. [PMID: 33811979] - Yasumasa Ikeda. Novel roles of HIF-PHIs in chronic kidney disease: the link between iron metabolism, kidney function, and FGF23.
Kidney international.
2021 07; 100(1):14-16. doi:
10.1016/j.kint.2021.04.030. [PMID: 34154707] - Glenn M Chertow, Pablo E Pergola, Rajiv Agarwal, Geoffrey A Block, Youssef M K Farag, Alan G Jardine, Mark J Koury, Wenli Luo, Zeeshan Khawaja, Eldrin F Lewis, Kunihiro Matsushita, Peter A McCullough, Patrick S Parfrey, Janet Wittes, Kimberly A Walters, Carol Tseng, Tim Lin, Mark J Sarnak, Dennis L Vargo, Wolfgang C Winkelmayer, Kai-Uwe Eckardt. Cardiovascular safety and efficacy of vadadustat for the treatment of anemia in non-dialysis-dependent CKD: Design and baseline characteristics.
American heart journal.
2021 05; 235(?):1-11. doi:
10.1016/j.ahj.2020.10.068. [PMID: 33129989] - Glenn M Chertow, Pablo E Pergola, Youssef M K Farag, Rajiv Agarwal, Susan Arnold, Gabriel Bako, Geoffrey A Block, Steven Burke, Fausto P Castillo, Alan G Jardine, Zeeshan Khawaja, Mark J Koury, Eldrin F Lewis, Tim Lin, Wenli Luo, Bradley J Maroni, Kunihiro Matsushita, Peter A McCullough, Patrick S Parfrey, Prabir Roy-Chaudhury, Mark J Sarnak, Amit Sharma, Bruce Spinowitz, Carol Tseng, James Tumlin, Dennis L Vargo, Kimberly A Walters, Wolfgang C Winkelmayer, Janet Wittes, Kai-Uwe Eckardt. Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD.
The New England journal of medicine.
2021 04; 384(17):1589-1600. doi:
10.1056/nejmoa2035938. [PMID: 33913637] - Kai-Uwe Eckardt, Rajiv Agarwal, Ahmad Aswad, Ahmed Awad, Geoffrey A Block, Marcelo R Bacci, Youssef M K Farag, Steven Fishbane, Harold Hubert, Alan Jardine, Zeeshan Khawaja, Mark J Koury, Bradley J Maroni, Kunihiro Matsushita, Peter A McCullough, Eldrin F Lewis, Wenli Luo, Patrick S Parfrey, Pablo Pergola, Mark J Sarnak, Bruce Spinowitz, James Tumlin, Dennis L Vargo, Kimberly A Walters, Wolfgang C Winkelmayer, Janet Wittes, Rafal Zwiech, Glenn M Chertow. Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.
The New England journal of medicine.
2021 04; 384(17):1601-1612. doi:
10.1056/nejmoa2025956. [PMID: 33913638] - Adeera Levin. Therapy for Anemia in Chronic Kidney Disease - New Interventions and New Questions.
The New England journal of medicine.
2021 04; 384(17):1657-1658. doi:
10.1056/nejme2103937. [PMID: 33913643] - Monica Mazzarino, Ilaria Perretti, Carlotta Stacchini, Fabio Comunità, Xavier de la Torre, Francesco Botrè. UPLC-MS-Based Procedures to Detect Prolyl-Hydroxylase Inhibitors of HIF in Urine.
Journal of analytical toxicology.
2021 Feb; 45(2):184-194. doi:
10.1093/jat/bkaa055. [PMID: 32435795] - Victoria H Ko, Lumeng J Yu, Duy T Dao, Xiaoran Li, Jordan D Secor, Lorenzo Anez-Bustillos, Bennet S Cho, Amy Pan, Paul D Mitchell, Hiroko Kishikawa, Mark Puder. Roxadustat (FG-4592) accelerates pulmonary growth, development, and function in a compensatory lung growth model.
Angiogenesis.
2020 11; 23(4):637-649. doi:
10.1007/s10456-020-09735-9. [PMID: 32666268] - Anthony Markham. Vadadustat: First Approval.
Drugs.
2020 Sep; 80(13):1365-1371. doi:
10.1007/s40265-020-01383-z. [PMID: 32852744] - Neil S Sanghani, Volker H Haase. Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.
Advances in chronic kidney disease.
2019 07; 26(4):253-266. doi:
10.1053/j.ackd.2019.04.004. [PMID: 31477256] - Volker H Haase, Glenn M Chertow, Geoffrey A Block, Pablo E Pergola, Emil M deGoma, Zeeshan Khawaja, Amit Sharma, Bradley J Maroni, Peter A McCullough. Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 01; 34(1):90-99. doi:
10.1093/ndt/gfy055. [PMID: 29672740] - Amit A Joharapurkar, Vrajesh B Pandya, Vishal J Patel, Ranjit C Desai, Mukul R Jain. Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases.
Journal of medicinal chemistry.
2018 08; 61(16):6964-6982. doi:
10.1021/acs.jmedchem.7b01686. [PMID: 29712435] - Francesco Locatelli, Steven Fishbane, Geoffrey A Block, Iain C Macdougall. Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients.
American journal of nephrology.
2017; 45(3):187-199. doi:
10.1159/000455166. [PMID: 28118622] - Edouard R Martin, Mark T Smith, Bradley J Maroni, Qing C Zuraw, Emil M deGoma. Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease.
American journal of nephrology.
2017; 45(5):380-388. doi:
10.1159/000464476. [PMID: 28343225] - Pablo E Pergola, Bruce S Spinowitz, Charlotte S Hartman, Bradley J Maroni, Volker H Haase. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease.
Kidney international.
2016 11; 90(5):1115-1122. doi:
10.1016/j.kint.2016.07.019. [PMID: 27650732]