Corlan (BioDeep_00000015196)
代谢物信息卡片
Hydrocortisone Sodium Succinate
化学式: C25H33NaO8 (484.20730180000004)
中文名称: 氢化可的松琥珀酸钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
InChI: /q
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000893 - Anti-Inflammatory Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:5782
- KEGG: C08178
- KEGGdrug: D00978
- PubChem: 23694214
- Metlin: METLIN66842
- ChEMBL: CHEMBL1200495
- CAS: 125-04-2
- PubChem: 10378
- NIKKAJI: J5.365A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Vurmaz, E Atay. Antioxidant effects of piperine on steroid-induced hepatotoxicity.
European review for medical and pharmacological sciences.
2021 Sep; 25(17):5500-5506. doi:
10.26355/eurrev_202109_26659. [PMID: 34533800] - Le Zhou, Qing-Jun He, Li-Wei Lu, Feng Zhao, Yan Zhang, Xiao-Xiao Huang, Bin Lin, Shao-Jiang Song. Tripterfordins A-O, Dihydro-β-agarofuran Sesquiterpenoids from the Leaves of Tripterygium wilfordii.
Journal of natural products.
2019 10; 82(10):2696-2706. doi:
10.1021/acs.jnatprod.9b00089. [PMID: 31556299] - Ayhan Vurmaz, Reşat Duman, Mehmet Cem Sabaner, Tolga Ertekin, Abdülkadir Bilir. Antioxidant effects of piperine in in-vivo chick embryo cataract model induced by steroids.
Cutaneous and ocular toxicology.
2019 Jun; 38(2):182-189. doi:
10.1080/15569527.2019.1570521. [PMID: 30678496] - F K Zeugswetter, F Neffe, I Schwendenwein, A Tichy, E Möstl. Configuration of antibodies for assay of urinary cortisol in dogs influences analytic specificity.
Domestic animal endocrinology.
2013 Aug; 45(2):98-104. doi:
10.1016/j.domaniend.2013.06.003. [PMID: 23849086] - Kelsey A Hart, Levent Dirikolu, Duncan C Ferguson, Natalie A Norton, Michelle H Barton. Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals.
American journal of veterinary research.
2012 Jan; 73(1):68-75. doi:
10.2460/ajvr.73.1.68. [PMID: 22204290] - Jian-Hua Shi, Wen-Hua Du, Xiao-Yan Liu, Yan-Ping Fan, Xiao-Lei Hu, Hai-Yan Zhou, Huan-Bai Xu, Xiao-Mei Zhang, Ping Xiang, Feng-Ling Chen. Glucocorticoids decrease serum adiponectin level and WAT adiponectin mRNA expression in rats.
Steroids.
2010 Dec; 75(12):853-8. doi:
10.1016/j.steroids.2010.05.001. [PMID: 20471407] - Fang Deng, Ling Lu, Qin Zhang, Bo Hu, Shi-jie Wang, Na Huang. Henoch-Schönlein purpura in childhood: treatment and prognosis. Analysis of 425 cases over a 5-year period.
Clinical rheumatology.
2010 Apr; 29(4):369-74. doi:
10.1007/s10067-009-1329-2. [PMID: 20033243] - Jian-hua Lin, Zhong-lin Cui, Jie Zhou. [Glucocorticoid treatment for early postoperative cholangiole cholestasis hyperbilirubinemia after liver transplantation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Feb; 30(2):377-8. doi:
NULL. [PMID: 20159728] - Mark P Yeager, Athos J Rassias, Patricia A Pioli, Michael L Beach, Kathleen Wardwell, Jane E Collins, Hong-Kee Lee, Paul M Guyre. Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin.
Critical care medicine.
2009 Oct; 37(10):2727-32. doi:
10.1097/ccm.0b013e3181a592b3. [PMID: 19885996] - Wendy Saltzman, David H Abbott. Effects of elevated circulating cortisol concentrations on maternal behavior in common marmoset monkeys (Callithrix jacchus).
Psychoneuroendocrinology.
2009 Sep; 34(8):1222-34. doi:
10.1016/j.psyneuen.2009.03.012. [PMID: 19362777] - Sebastián Tornero Patricio, José Antonio Bermúdez de la Vega, Daniel Nehme Alvarez, Francisco Javier Gentil González, María Dolores Lluch Fernández, José González Hachero. [Primary adrenal insufficiency as the form of onset of adrenoleukodystrophy in a 4-year-old boy].
Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.
2009 Jan; 56(1):40-2. doi:
10.1016/s1575-0922(09)70192-5. [PMID: 19627707] - Lars Hållström, Elisabeth Berghäll, Claes Frostell, Alf Sollevi, Anne L Soop. Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia.
Critical care medicine.
2008 Nov; 36(11):3043-7. doi:
10.1097/ccm.0b013e318186f5b2. [PMID: 18824917] - Makoto Ando, In-Sam Park, Naoki Wada, Yukihiro Takahashi. Steroid supplementation: a legitimate pharmacotherapy after neonatal open heart surgery.
The Annals of thoracic surgery.
2005 Nov; 80(5):1672-8; discusison 1678. doi:
10.1016/j.athoracsur.2005.04.035. [PMID: 16242437] - Lawrence A Trissel, Christopher A Saenz. Physical compatibility of antithymocyte globulin (rabbit) with heparin sodium and hydrocortisone sodium succinate.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2003 Aug; 60(16):1650-2. doi:
10.1093/ajhp/60.16.1650. [PMID: 12966908] - Tulsidas G Shrivastav, Anupam Basu, Kiran P Kariya. Substitution of carbonate buffer by water for IgG immobilization in enzyme linked immunosorbent assay.
Journal of immunoassay & immunochemistry.
2003; 24(2):191-203. doi:
10.1081/ias-120020084. [PMID: 12778971] - Tulsidas G Shrivastav. Preparation of horseradish peroxidase hydrazide and its use in immunoassay.
Journal of immunoassay & immunochemistry.
2003; 24(3):301-9. doi:
10.1081/ias-120022939. [PMID: 12953974] - Tulsidas G Shrivastav, Anupam Basu, Kiran P Kariya. One step enzyme linked immunosorbent assay for direct estimation of serum testosterone.
Journal of immunoassay & immunochemistry.
2003; 24(2):205-17. doi:
10.1081/ias-120020085. [PMID: 12778972] - Luminiţa Pleşca-Manea, Alina Elena Pârvu, M Pârvu, M Taămaş, R Buia, M Puia. Effects of Melilotus officinalis on acute inflammation.
Phytotherapy research : PTR.
2002 Jun; 16(4):316-9. doi:
10.1002/ptr.875. [PMID: 12112285] - T Nishimura, T Nakano. Nuclear localization of bovine immunoglobulin G (bIgG) in the liver of rats injected with hydrocortisone-bIgG conjugate intravenously.
Okajimas folia anatomica Japonica.
2001 Oct; 78(4):107-14. doi:
10.2535/ofaj1936.78.4_107. [PMID: 11774745] - R F Gagnon, M L Halperin. Possible mechanisms to explain the absence of hyperkalaemia in Addison's disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2001 Jun; 16(6):1280-4. doi:
10.1093/ndt/16.6.1280. [PMID: 11390735] - H A Lincoff, I Kreissig, N Lincoff, R Silverman, J Nisselbaum. Elevated concentration of intraocular cortisol obtained by sequential parabulbar injection in rabbit model.
Klinische Monatsblatter fur Augenheilkunde.
2001 Jun; 218(6):445-50. doi:
10.1055/s-2001-16260. [PMID: 11488012] - H Watanabe, H Kosano, H Nishigori. Steroid-induced short term diabetes in chick embryo: reversible effects of insulin on metabolic changes and cataract formation.
Investigative ophthalmology & visual science.
2000 Jun; 41(7):1846-52. doi:
. [PMID: 10845608] - D B Church, W A Lamb, D R Emslie. Plasma cortisol concentrations in normal dogs given hydrocortisone sodium succinate.
Australian veterinary journal.
1999 May; 77(5):316-7. doi:
10.1111/j.1751-0813.1999.tb10271.x. [PMID: 10376103] - J S Samra, M L Clark, S M Humphreys, I A MacDonald, P A Bannister, K N Frayn. Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism.
1998 Feb; 83(2):626-31. doi:
10.1210/jcem.83.2.4547. [PMID: 9467584] - J A Posener, J J Schildkraut, G H Williams, A F Schatzberg. Cortisol feedback effects on plasma corticotropin levels in healthy subjects.
Psychoneuroendocrinology.
1997 Apr; 22(3):169-76. doi:
10.1016/s0306-4530(96)00046-7. [PMID: 9203227] - I Murakami, H Kosano, I Ogihara-Umeda, H Nishigori, S Uga, S Ishikawa. Comparison of lens biochemistry and structure between BSO-treated and glucocorticoid-treated developing chick embryos.
Experimental eye research.
1996 Dec; 63(6):673-81. doi:
10.1006/exer.1996.0161. [PMID: 9068374] - B A Mohamed. Examining of changes in continuous GMK cell cultures treated with hydrocortisonum hemisuccinatum, propranolol and diazepam.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
1996; 51(?):81-8. doi:
. [PMID: 9467252] - A Giustina, E Bresciani, G Bugari, A R Bussi, R Deghenghi, B Imbimbo, G Giustina. Hexarelin, a novel GHRP-6 analog, counteracts the inhibitory effect of hydrocortisone on growth hormone secretion in acromegaly.
Endocrine research.
1995 Aug; 21(3):569-82. doi:
10.1080/07435809509030474. [PMID: 7588427] - B A Mohamed. [Examination of changes in continuous culture of GMK cells under the influence of Hydrocortisone hemisuccinate, propranolol and diazepam].
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
1995; 50(?):173-8. doi:
. [PMID: 9304385] - H Nishigori, J W Lee, M Iwatsuru. Glucocorticoid-induced cataract of the developing chick embryo-prevention by propylene glycol.
Ophthalmic research.
1995; 27(6):350-5. doi:
10.1159/000267747. [PMID: 8927308] - W A Lamb, D B Church, D R Emslie. Effect of chronic hypocortisolaemia on plasma cortisol concentrations during intravenous infusions of hydrocortisone sodium succinate in dogs.
Research in veterinary science.
1994 Nov; 57(3):349-52. doi:
10.1016/0034-5288(94)90129-5. [PMID: 7871256] - M C Wright, A J Paine, P Skett, R Auld. Induction of rat hepatic glucocorticoid-inducible cytochrome P450 3A by metyrapone.
The Journal of steroid biochemistry and molecular biology.
1994 Feb; 48(2-3):271-6. doi:
10.1016/0960-0760(94)90155-4. [PMID: 7908222] - N M Nguyen, J E Lehr, C I Shelley, J C Andersen, K J Pienta. The effect of maltose tetrapalmitate (MTP) on prostate cancer growth in vivo and in vitro.
Anticancer research.
1993 Nov; 13(6A):2053-8. doi:
". [PMID: 7507653] - A Giustina, A R Bussi, M Licini, G Pizzocolo, M Schettino, W B Wehrenberg. Acute effects of hydrocortisone on circulating growth hormone levels in patients with acromegaly.
Hormone research.
1992; 37(6):212-6. doi:
10.1159/000182314. [PMID: 1363409] - J W Lee, M Iwatsuru, H Nishigori. Preventive effect of isocitrate on glucocorticoid-induced cataract formation of developing chick embryo.
Current eye research.
1991 Jul; 10(7):629-35. doi:
10.3109/02713689109013854. [PMID: 1914499] - M Mazzorana, G Baffet, B Kneip, B Launois, C Guguen-Guillouzo. Expression of coagulation factor V gene by normal adult human hepatocytes in primary culture.
British journal of haematology.
1991 Jun; 78(2):229-35. doi:
10.1111/j.1365-2141.1991.tb04421.x. [PMID: 2064962] - K Aoyagi, M Narita, M Mori, M Tatibana. Regulation of acetylglutamate in the liver: effect of glucocorticoid and renal failure.
Contributions to nephrology.
1991; 92(?):182-90. doi:
10.1159/000420096. [PMID: 1756641] - Z D Zhao. [Experimental treatment of smoke inhalation injury with anti-lipid peroxidation agents].
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns.
1990 Dec; 6(4):294-8, 319. doi:
. [PMID: 2282597] - D J Wu, J Mifune, K Taga, S Hifumi, Y Takahashi, S Yamashida, S Nishioka, T Murakami, T Tanaka. Anginal attack following a sodium bicarbonate and hydrocortisone injection.
Japanese heart journal.
1990 Jan; 31(1):109-13. doi:
10.1536/ihj.31.109. [PMID: 2159572] - P Kongtawelert, P M Brooks, P Ghosh. Pentosan polysulfate (Cartrophen) prevents the hydrocortisone induced loss of hyaluronic acid and proteoglycans from cartilage of rabbit joints as well as normalizes the keratan sulfate levels in their serum.
The Journal of rheumatology.
1989 Nov; 16(11):1454-9. doi:
NULL. [PMID: 2481039] - T Otamiri. Oxygen radicals, lipid peroxidation, and neutrophil infiltration after small-intestinal ischemia and reperfusion.
Surgery.
1989 May; 105(5):593-7. doi:
. [PMID: 2539652] - H Raff, R J Flemma, J W Findling. Fast cortisol-induced inhibition of the adrenocorticotropin response to surgery in humans.
The Journal of clinical endocrinology and metabolism.
1988 Dec; 67(6):1146-8. doi:
10.1210/jcem-67-6-1146. [PMID: 2848053] - D D Morris, P J Strzemienski, G Gaulin, P Spencer. The effects of corticosteroid administration on the migration, phagocytosis and bactericidal capacity of equine neutrophils.
The Cornell veterinarian.
1988 Jul; 78(3):243-52. doi:
NULL. [PMID: 3402220] - S Durant, D Duval, F Homo-Delarche. Effect of cortisol on the plasma and lymphoid tissue distributions of tritiated glucocorticoids in C57BL/6 mice.
The Journal of endocrinology.
1988 Jun; 117(3):373-8. doi:
10.1677/joe.0.1170373. [PMID: 3392494] - M G Bergeron, Y Bergeron, D Beauchamp. Influence of hydrocortisone succinate on intrarenal accumulation of gentamicin in endotoxemic rats.
Antimicrobial agents and chemotherapy.
1987 Nov; 31(11):1816-21. doi:
10.1128/aac.31.11.1816. [PMID: 3435128] - R W Steele, C R Steele, N S Pilkington, R K Charlton. Functional capacity of marginated and bone marrow reserve granulocytes.
Infection and immunity.
1987 Oct; 55(10):2359-63. doi:
10.1128/iai.55.10.2359-2363.1987. [PMID: 3653982] - A Obinata, M Kawada, H Endo. Induction of epidermal mucous metaplasia by culture of recombinants of undifferentiated epidermis and retinol-treated dermis in a chemically defined medium.
Developmental biology.
1987 Sep; 123(1):59-62. doi:
10.1016/0012-1606(87)90427-1. [PMID: 3622935] - E Iwasaki. Hydrocortisone succinate and hydrocortisone simultaneously determined in plasma by reversed-phase liquid chromatography, and their pharmacokinetics in asthmatic children.
Clinical chemistry.
1987 Aug; 33(8):1412-5. doi:
. [PMID: 3608158] - Y Sakata, S Komatsubara, M Watanabe, H Mineyama, N Abe. [Antiemetic efficacy of high-dose hydrocortisone in patients receiving cisplatin therapy].
Hinyokika kiyo. Acta urologica Japonica.
1986 Dec; 32(12):1799-812. doi:
NULL. [PMID: 3825825] - C E Lawrence, J M Wright, C G Knight. Cortisol succinate is slowly hydrolysed in organ cultures of porcine articular tissues and is not equivalent to cortisol.
Cell biochemistry and function.
1986 Oct; 4(4):277-81. doi:
10.1002/cbf.290040408. [PMID: 3791569] - B J Gordon, K S Latimer, C M Murray, J N Moore. Evaluation of leukapheresis and thrombocytapheresis in the horse.
American journal of veterinary research.
1986 May; 47(5):997-1001. doi:
NULL. [PMID: 3717747] - J M Redding, A deLuze, J Leloup-Hatey, J Leloup. Suppression of plasma thyroid hormone concentrations by cortisol in the European eel Anguilla anguilla.
Comparative biochemistry and physiology. A, Comparative physiology.
1986; 83(3):409-13. doi:
10.1016/0300-9629(86)90124-6. [PMID: 2870843] - S el Rouby, F Praz, L Halbwachs-Mecarelli, M Papiernik. Thymic reticulum in mice. IV. The rosette formation between phagocytic cells of the thymic reticulum and cortical type thymocytes is mediated by complement receptor type three.
Journal of immunology (Baltimore, Md. : 1950).
1985 Jun; 134(6):3625-31. doi:
NULL. [PMID: 3886787] - Z Hemady, S Gellis, M Chambers, R E Rocklin. Effect of dexamethasone on de novo IgE synthesis by human blood lymphocytes.
The Journal of allergy and clinical immunology.
1985 Feb; 75(2):304-12. doi:
10.1016/0091-6749(85)90062-4. [PMID: 3918092] - P Casassus, C Audrouin, D Fischer, P Karsenti, A Paraf, P Lortholary. [Granulopoiesis in the alcoholic and cirrhotic patient. Exploration of neutropenia in cirrhosis using bone marrow cultures and a hydrocortisone test].
Annales de medecine interne.
1985; 136(3):213-5. doi:
NULL. [PMID: 4026108] - J R Moore, B S Turner, J T LaMont. Hydrocortisone inhibits mucin secretion from guinea pig gallbladder.
The American journal of physiology.
1984 Oct; 247(4 Pt 1):G427-31. doi:
10.1152/ajpgi.1984.247.4.g427. [PMID: 6496680] - B F Heslop, L J McNeilage, S Sengupta. Allogeneic lymphocyte cytotoxicity in rats: the effects of various pharmacological agents.
Immunology.
1984 Sep; 53(1):43-53. doi:
NULL. [PMID: 6088391] - L Stárka, J Obenberger, R Hampl. Effect of glucocorticoids on the composition of the aqueous humour of the rabbit eye.
Ophthalmic research.
1984; 16(4):190-3. doi:
10.1159/000265315. [PMID: 6472798] - D C Cumming, M E Quigley, S S Yen. Acute suppression of circulating testosterone levels by cortisol in men.
The Journal of clinical endocrinology and metabolism.
1983 Sep; 57(3):671-3. doi:
10.1210/jcem-57-3-671. [PMID: 6348068] - H R Rubin, R U Sorensen, P A Chase, J D Klinger. Suppression of in vitro lymphocyte DNA synthesis by killed Pseudomonas aeruginosa.
Infection and immunity.
1983 Feb; 39(2):630-7. doi:
10.1128/iai.39.2.630-637.1983. [PMID: 6219951] - K R van der Ploeg, B G Wolthers, G T Nagel, M Volmer, N M Drayer. The diagnosis of 21-hydroxylase deficiency in a prematurely born infant on the basis of the urinary steroid excretion pattern.
Clinica chimica acta; international journal of clinical chemistry.
1982 Apr; 120(3):341-53. doi:
10.1016/0009-8981(82)90375-8. [PMID: 6978779] - R Tammi, R Santti. Ultrastructural study of hydrocortisone action in cultured human epidermis.
The British journal of dermatology.
1982 Jan; 106(1):65-75. doi:
10.1111/j.1365-2133.1982.tb00903.x. [PMID: 7059506] - M Schöneshöfer, B Schefzig, A Fenner, B Weber, H J Dulce. Evaluation of a sensitive radioimmunoassay of plasma corticotropin using commercial reagents.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1981 Feb; 19(2):75-9. doi:
10.1515/cclm.1981.19.2.75. [PMID: 6260890] - R Nakamura, K Tsutaho, H Hashimoto, S Sakuma. Influence of 6 alpha-methylprednisolone 21-sodium succinate on the pituitary, adrenal glands, and the gastrointestinal tract in rats. (Comparative toxicity study with hydrocortisone 21-sodium succinate).
The Journal of toxicological sciences.
1980 Nov; 5(4):303-9. doi:
10.2131/jts.5.303. [PMID: 7012379] - B L Fariss, S Hane, J Shinsako, P H Forsham. Comparison of absorption of cortisone acetate and hydrocortisone hemisuccinate.
The Journal of clinical endocrinology and metabolism.
1978 Nov; 47(5):1137-40. doi:
10.1210/jcem-47-5-1137. [PMID: 233690] - E DOWDLE, S J SAUNDERS. The acute effect of hydrocortisone sodium succinate on the proteinurea of the nephrotic syndrome.
South African journal of laboratory and clinical medicine. Suid-Afrikaanse tydskrif vir laboratorium- en kliniekwerk.
1957 Mar; 3(1):39-47. doi:
NULL. [PMID: 13432948]