Diphemanil Methylsulfate (BioDeep_00000015170)

   


代谢物信息卡片


Diphenmanil (methylsulfate)

化学式: C21H27NO4S (389.1660702000001)
中文名称: 甲基硫酸地芬尼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]
InChI: /p-1

描述信息

C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat. IC50 value: Target: mAChR Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body.

同义名列表

3 个代谢物同义名

Diphenmanil (methylsulfate); Diphemanil Methylsulfate; Diphemanil mesylate



数据库引用编号

8 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • B Do, S Goulay-Dufaÿ, M D Le Hoang, N Adoui, H Graffard, F Guyon, D Pradeau. Sensitive quantification of diphemanil methyl sulphate in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jan; 845(1):104-8. doi: 10.1016/j.jchromb.2006.07.057. [PMID: 16962397]
  • P Urios, A M Grigorova-Borsos, G Mozère, S Nakib, F Dauchy, J Peyroux, M Sternberg. Cyclic guanosylmonophosphate urinary excretion in parasympathicomimetic or parasympatholytic syndromes induced by reserpine or diphemanil-methylsulfate. Life sciences. 1999; 64(2):113-23. doi: 10.1016/s0024-3205(98)00541-4. [PMID: 10069489]
  • A Pariente-Khayat, A M Vidal, G Cheron, F Vauzelle-Kervroedan, P D'Athis, E Rey, J B Gouyon, C Wood, G Olive, G Pons. Pharmacokinetics of diphemanil methylsulphate in neonates and in premature infants. European journal of clinical pharmacology. 1996; 50(5):429-30. doi: 10.1007/s002280050136. [PMID: 8839669]
  • G Chéron, A M Vidal, E Rey, G Pons, P d'Athis, G Olive. [Pharmacokinetics of diphemanil methylsulfate in infants]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 1994 Jan; 1(1):33-7. doi: NULL. [PMID: 8087216]
  • A M Vidal, E Rey, G Pons, J Y Pello, P d'Athis, G Olive. Pharmacokinetics of diphemanil methylsulphate in healthy subjects. European journal of clinical pharmacology. 1992; 42(6):689-91. doi: 10.1007/bf00265939. [PMID: 1623915]