Besifloxacin HCl (BioDeep_00000015167)
代谢物信息卡片
化学式: C19H22Cl2FN3O3 (429.1022174)
中文名称: 盐酸贝西沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCN(CC(C1)N)C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F.Cl
InChI: /m1./s1
描述信息
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGG: C75052
- KEGGdrug: D08872
- PubChem: 10224595
- ChEMBL: CHEMBL1201761
- CAS: 1398566-43-2
- CAS: 405165-61-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Heybet Kerem Polat, Nihat Kurt, Eren Aytekin, Yagmur Akdağ Çaylı, Sibel Bozdağ Pehlivan, Sema Çalış. Design of Besifloxacin HCl-Loaded Nanostructured Lipid Carriers: In Vitro and Ex Vivo Evaluation.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2022 Jul; 38(6):412-423. doi:
10.1089/jop.2022.0008
. [PMID: 35675672] - Xiao-Fei Gu, Bai-Yang Mao, Min Xia, Yang Yang, Jia-Li Zhang, Da-Song Yang, Wei-Xin Wu, Ying-Xiang Du, Bin Di, Meng-Xiang Su. Rapid, sensitive and selective HPLC-MS/MS method for the quantification of topically applied besifloxacin in rabbit plasma and ocular tissues: Application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):37-46. doi:
10.1016/j.jpba.2015.08.023
. [PMID: 26340560] - Xianyong Yu, Bingfei Jiang, Zhixi Liao, Yue Jiao, Pinggui Yi. Study on the interaction between Besifloxacin and bovine serum albumin by spectroscopic techniques.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015; 149(?):116-21. doi:
10.1016/j.saa.2015.04.023
. [PMID: 25950636] - Shellise Glogowski, Keith W Ward, Matthew S Lawrence, Robin J Goody, Joel W Proksch. The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2012 Jun; 28(3):290-8. doi:
10.1089/jop.2011.0164
. [PMID: 22235843] - Bikash Roy, Utpal Nandi, Anjan Das, Tapan Kumar Pal. Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats.
Environmental toxicology and pharmacology.
2011 Jul; 32(1):82-101. doi:
10.1016/j.etap.2011.03.015
. [PMID: 21787734] - Joel W Proksch, Keith W Ward. Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2010 Oct; 26(5):449-58. doi:
10.1089/jop.2010.0054
. [PMID: 20874668] - Joel W Proksch, Camille P Granvil, Raphaële Siou-Mermet, Timothy L Comstock, Michael R Paterno, Keith W Ward. Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2009 Aug; 25(4):335-44. doi:
10.1089/jop.2008.0116
. [PMID: 19492955] - Keith W Ward, Jean-François Lepage, Jean-Yves Driot. Nonclinical pharmacodynamics, pharmacokinetics, and safety of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2007 Jun; 23(3):243-56. doi:
10.1089/jop.2006.0137
. [PMID: 17593008]