tolmetin sodium (BioDeep_00000015164)

   


代谢物信息卡片


tolmetin sodium

化学式: C15H14NNaO3 (279.08713339999997)
中文名称: 托美丁钠
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-].[Na+]
InChI: /q

描述信息

D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

tolmetin sodium



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Patrick Camilleri, Akshay Buch, Brandi Soldo, Andrew J Hutt. The influence of physicochemical properties on the reactivity and stability of acyl glucuronides †. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Sep; 48(9):958-972. doi: 10.1080/00498254.2017.1384967. [PMID: 28967291]
  • Shohei Yamashita, Shingo Oda, Hideko Endo, Koichi Tsuneyama, Tsuyoshi Yokoi. Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice. Chemico-biological interactions. 2018 Jan; 279(?):102-110. doi: 10.1016/j.cbi.2017.11.011. [PMID: 29154782]
  • Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume, Tsuyoshi Yokoi. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice. Drug metabolism and disposition: the biological fate of chemicals. 2016 07; 44(7):888-96. doi: 10.1124/dmd.116.069575. [PMID: 27112166]
  • Silvia Neamtu, Nicoleta Tosa, Mircea Bogdan. Spectroscopic investigation of tolmetin interaction with human serum albumin. Journal of pharmaceutical and biomedical analysis. 2013 Nov; 85(?):277-82. doi: 10.1016/j.jpba.2013.07.032. [PMID: 23973633]
  • Aida Kulo, Sarah Hendrickx, Jan de Hoon, Nedzad Mulabegovic, Kristel van Calsteren, Rene Verbesselt, Karel Allegaert. The impact of pregnancy on urinary ketorolac metabolites after single intravenous bolus. European journal of drug metabolism and pharmacokinetics. 2013 Mar; 38(1):1-4. doi: 10.1007/s13318-012-0108-7. [PMID: 23179562]
  • Zhihui Rong, Yanjiao Xu, Chengliang Zhang, Daochun Xiang, Xiping Li, Dong Liu. Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability. Life sciences. 2013 Feb; 92(3):245-51. doi: 10.1016/j.lfs.2012.12.010. [PMID: 23333829]
  • Cláudia Nunes, Gerald Brezesinski, Daniela Lopes, José L F C Lima, Salette Reis, Marlene Lúcio. Lipid-drug interaction: biophysical effects of tolmetin on membrane mimetic systems of different dimensionality. The journal of physical chemistry. B. 2011 Nov; 115(43):12615-23. doi: 10.1021/jp206013z. [PMID: 21936545]
  • Philip Gardiner, Stuart W Paine. The impact of hepatic uptake on the pharmacokinetics of organic anions. Drug metabolism and disposition: the biological fate of chemicals. 2011 Oct; 39(10):1930-8. doi: 10.1124/dmd.111.039842. [PMID: 21778353]
  • Kishore Kumar Hotha, D Vijaya Bharathi, S Sirish Kumar, Y Narsimha Reddy, Pankaj Chatki, L K Ravindranath, K N Jaya Veera, Ramesh Mullangi. Validation and clinical application of an LC-ESI-MS/MS method for simultaneous determination of tolmetin and MED5, the metabolites of amtolmetin guacil in human plasma. Biomedical chromatography : BMC. 2010 Oct; 24(10):1100-7. doi: 10.1002/bmc.1411. [PMID: 20853464]
  • Marta Cruz-Vera, Rafael Lucena, Soledad Cárdenas, Miguel Valcárcel. Ionic liquid-based dynamic liquid-phase microextraction: application to the determination of anti-inflammatory drugs in urine samples. Journal of chromatography. A. 2008 Aug; 1202(1):1-7. doi: 10.1016/j.chroma.2008.06.035. [PMID: 18632109]
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  • Gregory S Walker, James Atherton, Jonathan Bauman, Christopher Kohl, Wing Lam, Michael Reily, Zhen Lou, Abdul Mutlib. Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy. Chemical research in toxicology. 2007 Jun; 20(6):876-86. doi: 10.1021/tx600297u. [PMID: 17536843]
  • M Kirkova, A Alexandova, M Kesiova, S Todorov. In vivo effects of amtolmetin guacyl on lipid peroxidation and antioxidant defence systems. Comparison with non-selective and COX-2 selective NSAIDs. Autonomic & autacoid pharmacology. 2007 Apr; 27(2):99-104. doi: 10.1111/j.1474-8673.2007.00395.x. [PMID: 17391279]
  • Amichand Dairam, Adrienne C Müller, Santy Daya. Non-steroidal anti-inflammatory agents, tolmetin and sulindac attenuate quinolinic acid (QA)-induced oxidative stress in primary hippocampal neurons and reduce QA-induced spatial reference memory deficits in male Wistar rats. Life sciences. 2007 Mar; 80(15):1431-8. doi: 10.1016/j.lfs.2007.01.006. [PMID: 17266991]
  • Zhesheng Chen, Tom G Holt, James V Pivnichny, Kwan Leung. A simple in vitro model to study the stability of acylglucuronides. Journal of pharmacological and toxicological methods. 2007 Jan; 55(1):91-5. doi: 10.1016/j.vascn.2006.03.008. [PMID: 16713308]
  • Amichand Dairam, Prakash Chetty, Santy Daya. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons. Metabolic brain disease. 2006 Sep; 21(2-3):221-33. doi: 10.1007/s11011-006-9014-5. [PMID: 16850258]
  • Jørgen Olsen, Chunze Li, Inga Bjørnsdottir, Ulrik Sidenius, Steen Honoré Hansen, Leslie Z Benet. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chemical research in toxicology. 2005 Nov; 18(11):1729-36. doi: 10.1021/tx0501785. [PMID: 16300382]
  • Guoyun Bai, Yanfang Cui, Yunhuang Yang, Chaohui Ye, Maili Liu. A competitive low-affinity binding model for determining the mutual and specific sites of two ligands on protein. Journal of pharmaceutical and biomedical analysis. 2005 Jul; 38(4):588-93. doi: 10.1016/j.jpba.2004.12.037. [PMID: 15967285]
  • Jessica H Kennedy, Nancy Korn, Ronald J Thurston. Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility. Reproductive biology and endocrinology : RB&E. 2003 Oct; 1(?):74. doi: 10.1186/1477-7827-1-74. [PMID: 14613550]
  • J Olsen, I Bjørnsdottir, S Honorè Hansen. Identification of coenzyme A-related tolmetin metabolites in rats: relationship with reactive drug metabolites. Xenobiotica; the fate of foreign compounds in biological systems. 2003 May; 33(5):561-70. doi: 10.1080/0049825031000085942. [PMID: 12746110]
  • P Van Eenoo, F T Delbeke, K Roels, K Baert. Detection and disposition of tolmetin in the horse. Journal of pharmaceutical and biomedical analysis. 2003 Mar; 31(4):723-30. doi: 10.1016/s0731-7085(02)00687-8. [PMID: 12644199]
  • José Pérez-Urizar, Francisco J Flores-Murrieta, Gilberto Castañeda-Hernández. Effect of experimental hypoalbuminemia on the plasma protein binding of tolmetin. Life sciences. 2002 Jul; 71(9):1015-22. doi: 10.1016/s0024-3205(02)01788-5. [PMID: 12088761]
  • Klaus Klarskov, Stephen Naylor. India ink staining after sodium dodecyl sulfate polyacrylamide gel electrophoresis and in conjunction with Western blots for peptide mapping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM. 2002; 16(1):35-42. doi: 10.1002/rcm.522. [PMID: 11754245]
  • C Mardones, A Ríos, M Valcárcel. Determination of nonsteroidal anti-inflammatory drugs in biological fluids by automatic on-line integration of solid-phase extraction and capillary electrophoresis. Electrophoresis. 2001 Feb; 22(3):484-90. doi: 10.1002/1522-2683(200102)22:3<484::aid-elps484>3.0.co;2-x. [PMID: 11258759]
  • M Wang, R G Dickinson. Bile duct ligation promotes covalent drug-protein adduct formation in plasma but not in liver of rats given zomepirac. Life sciences. 2000 Dec; 68(5):525-37. doi: 10.1016/s0024-3205(00)00958-9. [PMID: 11197750]
  • S Sortino, J C Scaiano, G De Guidi, S Monti. Effect of beta-cyclodextrin complexation on the photochemical and photosensitizing properties of tolmetin: a steady-state and time-resolved study. Photochemistry and photobiology. 1999 Oct; 70(4):549-56. doi: ". [PMID: 10546551]
  • J A Nicolás Torralba, M Rigabert Montiel, V Bañón Pérez, P Valdelvira Nadal, M Pérez Albacete. [Intramuscular ketorolac compared to subcutaneous tramadol in the initial emergency treatment of renal colic]. Archivos espanoles de urologia. 1999 Jun; 52(5):435-7. doi: NULL. [PMID: 10427881]
  • M Bosch-Marcè, J Clària, E Titos, J L Masferrer, R Altuna, J L Poo, W Jiménez, V Arroyo, F Rivera, J Rodés. Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites. Gastroenterology. 1999 May; 116(5):1167-75. doi: 10.1016/s0016-5085(99)70020-x. [PMID: 10220509]
  • G S Browne, C Nelson, T Nguyen, B A Ellis, R O Day, K M Williams. Stereoselective and substrate-dependent inhibition of hepatic mitochondria beta-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac. Biochemical pharmacology. 1999 Apr; 57(7):837-44. doi: 10.1016/s0006-2952(98)00342-6. [PMID: 10075090]
  • R E Kauffman, M W Lieh-Lai, H G Uy, M K Aravind. Enantiomer-selective pharmacokinetics and metabolism of ketorolac in children. Clinical pharmacology and therapeutics. 1999 Apr; 65(4):382-8. doi: 10.1016/s0009-9236(99)70131-1. [PMID: 10223774]
  • K Perttunen, E Nilsson, E Kalso. I.v. diclofenac and ketorolac for pain after thoracoscopic surgery. British journal of anaesthesia. 1999 Feb; 82(2):221-7. doi: 10.1093/bja/82.2.221. [PMID: 10364998]
  • F Jamali, R Lovlin, B W Corrigan, N M Davies, G Aberg. Stereospecific pharmacokinetics and toxicodynamics of ketorolac after oral administration of the racemate and optically pure enantiomers to the rat. Chirality. 1999; 11(3):201-5. doi: 10.1002/(sici)1520-636x(1999)11:3<201::aid-chir5>3.0.co;2-z. [PMID: 10079499]
  • D Gravenstein, A Suri, H C Derendorf, A J Koska. Influence of plasma expansion on plasma protein binding of ketorolac. Journal of clinical anesthesia. 1998 Sep; 10(6):464-8. doi: 10.1016/s0952-8180(98)00064-6. [PMID: 9793809]
  • A Licker, L Höhn, A Schweizer. Ketorolac does not increase the risk of renal dysfunction after lung surgery. British journal of anaesthesia. 1998 Sep; 81(3):484-5. doi: 10.1093/bja/81.3.484-a. [PMID: 9861150]
  • E Cohen, R Hafner, Z Rotenberg, M Fadilla, M Garty. Comparison of ketorolac and diclofenac in the treatment of renal colic. European journal of clinical pharmacology. 1998 Aug; 54(6):455-8. doi: 10.1007/s002280050492. [PMID: 9776434]
  • K Pasloske, J Burger, P Conlon. Plasma prostaglandin E2 concentrations after single dose administration of ketorolac tromethamine (Toradol) in dogs. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 1998 Jul; 62(3):237-40. doi: NULL. [PMID: 9684056]
  • T H Eichhold, T G Filloon, K R Wehmeyer. Comparison of p-fluoroketorolac and [18O3]ketorolac for use as internal standards for the determination of ketorolac by gas chromatography/mass spectrometry (GC/MS). Journal of pharmaceutical and biomedical analysis. 1998 Jun; 17(2):227-31. doi: 10.1016/s0731-7085(97)00181-7. [PMID: 9638574]
  • M Jaquenod, C Rönnhedh, M J Cousins, R P Eckstein, V Jordan, L E Mather, I Power. Factors influencing ketorolac-associated perioperative renal dysfunction. Anesthesia and analgesia. 1998 May; 86(5):1090-7. doi: 10.1097/00000539-199805000-00036. [PMID: 9585304]
  • P S Myles, I Power. Does ketorolac cause postoperative renal failure: how do we assess the evidence?. British journal of anaesthesia. 1998 Apr; 80(4):420-1. doi: 10.1093/bja/80.4.420. [PMID: 9640143]
  • Y Qiu, A L Burlingame, L Z Benet. Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals. 1998 Mar; 26(3):246-56. doi: . [PMID: 9492388]
  • T Mizuma, L Z Benet, E T Lin. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides. Preparative biochemistry & biotechnology. 1998 Feb; 28(1):37-47. doi: 10.1080/10826069808010125. [PMID: 9516641]
  • J A Cold, T L ZumBrunnen, M A Simpson, B G Augustin, E Awad, M W Jann. Increased lithium serum and red blood cell concentrations during ketorolac coadministration. Journal of clinical psychopharmacology. 1998 Feb; 18(1):33-7. doi: 10.1097/00004714-199802000-00006. [PMID: 9472840]
  • L Genç, M Demirel, E Güler, N Hegazy. Microencapsulation of ketorolac tromethamine by means of a coacervation-phase separation technique induced by the addition of non-solvent. Journal of microencapsulation. 1998 Jan; 15(1):45-53. doi: 10.3109/02652049809006834. [PMID: 9463806]
  • G K Buller, M A Perazella. Acute renal failure and ketorolac. Annals of internal medicine. 1997 Sep; 127(6):493-4. doi: 10.7326/0003-4819-127-6-199709150-00022. [PMID: 9313014]
  • G Castiglione, M E Hauf, E Panascia, C Scuderi, G Crimi. [Does the preoperative administration of ketorolac improve postoperative analgesia]. Minerva anestesiologica. 1997 Jul; 63(7-8):237-43. doi: NULL. [PMID: 9489309]
  • H C Mofenson, T R Caraccio. Safety of intravenous ketorolac therapy. The Journal of pediatrics. 1997 May; 130(5):846. doi: 10.1016/s0022-3476(97)80042-x. [PMID: 9152303]
  • J B Forrest, E L Heitlinger, S Revell. Ketorolac for postoperative pain management in children. Drug safety. 1997 May; 16(5):309-29. doi: 10.2165/00002018-199716050-00003. [PMID: 9187531]
  • G González-Martin, L Maggio, J González-Sotomayor, S Zuniga. Pharmacokinetics of ketorolac in children after abdominal surgery. International journal of clinical pharmacology and therapeutics. 1997 Apr; 35(4):160-3. doi: NULL. [PMID: 9112137]
  • D J Reinhart, M E Goldberg, J V Roth, R Dua, I Nevo, K W Klein, M Torjman, D Vekeman. Transdermal fentanyl system plus im ketorolac for the treatment of postoperative pain. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1997 Apr; 44(4):377-84. doi: 10.1007/bf03014457. [PMID: 9104519]
  • T Otti, M Weindel, B Bastani. Ketorolac induced acute reversible hearing loss in a patient maintained on CAPD. Clinical nephrology. 1997 Mar; 47(3):208-9. doi: NULL. [PMID: 9105776]
  • D M Benson. Analgesia in renal colic. Annals of emergency medicine. 1997 Feb; 29(2):297; author reply 297-9. doi: NULL. [PMID: 9018202]
  • A J Smally. Analgesia in renal colic. Annals of emergency medicine. 1997 Feb; 29(2):296; author reply 297-9. doi: NULL. [PMID: 9018200]
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  • H C Mofenson, T R Caraccio. Analgesia in renal colic. Annals of emergency medicine. 1997 Feb; 29(2):296-7; author reply 297. doi: NULL. [PMID: 9018201]
  • O Borgå, B Borgå. Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study. Journal of pharmacokinetics and biopharmaceutics. 1997 Feb; 25(1):63-77. doi: 10.1023/a:1025719827072. [PMID: 9353694]
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  • J J O'Hanlon, H Beers, B K Huss, K R Milligan. A comparison of the effect of intramuscular diclofenac, ketorolac or piroxicam on post-operative pain following laparoscopy. European journal of anaesthesiology. 1996 Jul; 13(4):404-7. doi: 10.1046/j.1365-2346.1996.d01-365.x. [PMID: 8842665]
  • A Dasgupta, A Volk. Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions. Therapeutic drug monitoring. 1996 Jun; 18(3):284-7. doi: 10.1097/00007691-199606000-00011. [PMID: 8738769]
  • E Mroszczak, D Combs, M Chaplin, I Tsina, T Tarnowski, C Rocha, Y Tam, A Boyd, J Young, L Depass. Chiral kinetics and dynamics of ketorolac. Journal of clinical pharmacology. 1996 Jun; 36(6):521-39. doi: 10.1002/j.1552-4604.1996.tb05042.x. [PMID: 8809637]
  • B K Thwaites, D B Nigus, G W Bouska, P D Mongan, E F Ayala, G A Merrill. Intravenous ketorolac tromethamine worsens platelet function during knee arthroscopy under spinal anesthesia. Anesthesia and analgesia. 1996 Jun; 82(6):1176-81. doi: 10.1097/00000539-199606000-00013. [PMID: 8638787]
  • M D Witting. Renal papillary necrosis following emergency department treatment of migraine. The Journal of emergency medicine. 1996 May; 14(3):373-6. doi: 10.1016/0736-4679(96)00036-4. [PMID: 8782036]
  • G C Murrell, T Leake, P J Hughes. A comparison of the efficacy of ketorolac and indomethacin for postoperative analgesia following laparoscopic surgery in day patients. Anaesthesia and intensive care. 1996 Apr; 24(2):237-40. doi: 10.1177/0310057x9602400216. [PMID: 9133199]
  • M J Bailey, R G Dickinson. Chemical and immunochemical comparison of protein adduct formation of four carboxylate drugs in rat liver and plasma. Chemical research in toxicology. 1996 Apr; 9(3):659-66. doi: 10.1021/tx960017o. [PMID: 8728513]
  • S Revell. Ketorolac-induced renal failure. Wisconsin medical journal. 1996 Mar; 95(3):147. doi: NULL. [PMID: 8775277]
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