Triptorelin (BioDeep_00000015155)
代谢物信息卡片
[D-Trp6]-LH-RH
化学式: C64H82N18O13 (1310.6308)
中文名称: 曲普瑞林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
InChI: InChI=1S/C64H82N18O13/c1-34(2)23-46(56(88)75-45(13-7-21-69-64(66)67)63(95)82-22-8-14-52(82)62(94)72-31-53(65)85)76-58(90)48(25-36-28-70-42-11-5-3-9-40(36)42)78-57(89)47(24-35-15-17-39(84)18-16-35)77-61(93)51(32-83)81-59(91)49(26-37-29-71-43-12-6-4-10-41(37)43)79-60(92)50(27-38-30-68-33-73-38)80-55(87)44-19-20-54(86)74-44/h3-6,9-12,15-18,28-30,33-34,44-52,70-71,83-84H,7-8,13-14,19-27,31-32H2,1-2H3,(H2,65,85)(H,68,73)(H,72,94)(H,74,86)(H,75,88)(H,76,90)(H,77,93)(H,78,89)(H,79,92)(H,80,87)(H,81,91)(H4,66,67,69)/t44-,45-,46-,47-,48+,49-,50-,51-,52-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AE - Gonadotropin releasing hormone analogues
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1910 - Gonadotropin-releasing Hormone Analog
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D012102 - Reproductive Control Agents > D008186 - Luteolytic Agents
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:63633
- KEGG: C75704
- KEGGdrug: D06247
- PubChem: 25074470
- DrugBank: DB06825
- ChEMBL: CHEMBL1201334
- MeSH: Triptorelin Pamoate
- CAS: 57773-63-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xiao-Lin Jiang, He Tai, Jin-Song Kuang, Jing-Yi Zhang, Shi-Chao Cui, Yu-Xuan Lu, Shu-Bo Qi, Shi-Yu Zhang, Shun-Min Li, Jian-Ping Chen, Xian-Sheng Meng. Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Aging.
2022 10; 14(20):8321-8345. doi:
10.18632/aging.204320. [PMID: 36309912] - Kianna M Spencer, Giorgia Podico, Ameer A Megahed, Kristi L Jones, João H J Bittar, Igor F Canisso. Ovulatory response to GnRH agonist during early and late fall in mares.
Theriogenology.
2022 Jun; 185(?):140-148. doi:
10.1016/j.theriogenology.2022.03.003. [PMID: 35405532] - Anna Rückl, Donald L Thompson, Jean-Michel Hatt. Effect of the Prolactin Inhibitor Cabergoline and the Gonadotropin Releasing-Hormone Agonist Deslorelin in the Suppression of Plasma Prolactin Concentrations and Egg Laying in Quail (Coturnix japonica).
Journal of avian medicine and surgery.
2022 May; 36(1):39-52. doi:
10.1647/20-00075. [PMID: 35526163] - Orsolya Balogh, Bence Somoskői, Eszter Kollár, Mariusz P Kowalewski, Aykut Gram, Iris M Reichler, Ruth Klein, Noritoshi Kawate, László Mester, Beate Walter, Linda Müller. Anti-Müllerian hormone, testosterone, and insulin-like peptide 3 as biomarkers of Sertoli and Leydig cell function during deslorelin-induced testicular downregulation in the dog.
Theriogenology.
2021 Nov; 175(?):100-110. doi:
10.1016/j.theriogenology.2021.08.017. [PMID: 34534687] - Shumin Zhan, Ke Huang, Wei Wu, Danni Zhang, Ana Liu, Robert M Dorazio, Jianrong Shi, Rahim Ullah, Li Zhang, Jinling Wang, Guanping Dong, Yan Ni, Junfen Fu. The Use of Morning Urinary Gonadotropins and Sex Hormones in the Management of Early Puberty in Chinese Girls.
The Journal of clinical endocrinology and metabolism.
2021 10; 106(11):e4520-e4530. doi:
10.1210/clinem/dgab448. [PMID: 34160619] - Lindsey Yoojin Chung, Eungu Kang, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee. Efficacy of Triptorelin 3-Month Depot Compared to 1-Month Depot for the Treatment of Korean Girls with Central Precocious Puberty in Single Tertiary Center.
Journal of Korean medical science.
2021 Aug; 36(34):e219. doi:
10.3346/jkms.2021.36.e219. [PMID: 34463062] - Bella Martazanova, Nona Mishieva, Valentina Vtorushina, Irina Vedikhina, Lev Levkov, Irina Korneeva, Anastasia Kirillova, Lubov Krechetova, Aydar Abubakirov, Gennady T Sukhikh. Angiogenic cytokine and interleukin 8 levels in early luteal phase after triggering ovulation with gonadotropin-releasing hormone agonist in high-responder patients.
American journal of reproductive immunology (New York, N.Y. : 1989).
2021 06; 85(6):e13381. doi:
10.1111/aji.13381. [PMID: 33247970] - Xiu Luo, Li Pei, Fujie Li, Chunli Li, Guoning Huang, Hong Ye. Fixed versus flexible antagonist protocol in women with predicted high ovarian response except PCOS: a randomized controlled trial.
BMC pregnancy and childbirth.
2021 May; 21(1):348. doi:
10.1186/s12884-021-03833-2. [PMID: 33934703] - Zhenni Mu, Yuanhong Sa, Zhengao Sun, Yang Yi. Ovulation induction with high progesterone levels may be more suitable for elderly patients with low ovarian response.
Journal of gynecology obstetrics and human reproduction.
2021 Feb; 50(2):101661. doi:
10.1016/j.jogoh.2019.101661. [PMID: 31809957] - M Kaps, C T C Okada, C Gautier, J Aurich, D Scarlet, J Kuhl, C Aurich. Transient suppression of ovulatory ovarian function in pony mares after treatment with slow-release deslorelin implants.
Domestic animal endocrinology.
2021 01; 74(?):106505. doi:
10.1016/j.domaniend.2020.106505. [PMID: 32846375] - Qing Liu, Daiyong Cui, Guanglei Cong, Jinliang Ma, Jie Yu, Chuanliang Ji, Shenming Zeng. Timed Artificial Insemination by Combining Estrous Behavior Observation With Deslorelin Treatment in Jennies.
Journal of equine veterinary science.
2020 12; 95(?):103279. doi:
10.1016/j.jevs.2020.103279. [PMID: 33276933] - Sebastian E E Schagen, Femke M Wouters, Peggy T Cohen-Kettenis, Louis J Gooren, Sabine E Hannema. Bone Development in Transgender Adolescents Treated With GnRH Analogues and Subsequent Gender-Affirming Hormones.
The Journal of clinical endocrinology and metabolism.
2020 12; 105(12):. doi:
10.1210/clinem/dgaa604. [PMID: 32909025] - Claudia Massarotti, Valentina La Pica, Fausta Sozzi, Paola Scaruffi, Valentino Remorgida, Paola Anserini. Influence of age on response to controlled ovarian stimulation in women with low levels of serum anti-Müllerian hormone.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2020 Dec; 36(12):1074-1078. doi:
10.1080/09513590.2020.1737668. [PMID: 32148116] - Ahmad Pourahadi, Saeed Nojavan, Saied Saeed Hosseiny Davarani. Gel-electromembrane extraction of peptides: Determination of five hypothalamic agents in human plasma samples.
Talanta.
2020 Sep; 217(?):121025. doi:
10.1016/j.talanta.2020.121025. [PMID: 32498910] - Eleonora Bonacina, Gabriela Negri, Silvana Mattiello, Gianfranco Gabai, Debora Groppetti. Deslorelin subcutaneous implants in Oryx dammah males for reproductive control.
Theriogenology.
2020 Jun; 149(?):72-78. doi:
10.1016/j.theriogenology.2020.03.018. [PMID: 32247215] - Wenwen Wang, Xiangyi Ma, Wei Zhang, Zhiying Li, Yan Wang, Zhiying Yu, Chunlian Zhang, Li Hong, Ruoyu Luo, Hui Xing, Wuliang Wang, Qingfen Yue, Jia Wei, Minli Zhang, Shixuan Wang. Relapse after conservative surgery combined with triptorelin acetate versus conservative surgery only in women with focal adenomyosis: study protocol for a multicenter, prospective, randomized controlled trial.
Trials.
2020 Apr; 21(1):364. doi:
10.1186/s13063-020-04294-2. [PMID: 32345377] - Özge Yüce, Aysun Bideci, Nurullah Çelik, Orhun Çamurdan, Peyami Cinaz. Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment.
Archives of endocrinology and metabolism.
2020 Apr; 64(2):121-127. doi:
10.20945/2359-3997000000212. [PMID: 32236310] - Yuehong Tao, Caiyun Si, Haiyan Li, Jing Han, Huidan Hou, Mei Yang. Effect of gonadotropin-releasing hormone analog on ovarian reserve in children with central precocious puberty.
Annals of palliative medicine.
2020 Jan; 9(1):53-62. doi:
10.21037/apm.2020.01.04. [PMID: 32005063] - B Popovic-Todorovic, S Santos-Ribeiro, P Drakopoulos, M De Vos, A Racca, S Mackens, Y Thorrez, G Verheyen, H Tournaye, L Quintero, C Blockeel. Predicting suboptimal oocyte yield following GnRH agonist trigger by measuring serum LH at the start of ovarian stimulation.
Human reproduction (Oxford, England).
2019 10; 34(10):2027-2035. doi:
10.1093/humrep/dez132. [PMID: 31560740] - Zhi Zhang, Runzhi Li, Shihao Liu, Lei Yin, Tongtong Xu, John Paul Fawcett, Jingkai Gu. Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma.
Journal of separation science.
2019 Sep; 42(18):3033-3040. doi:
10.1002/jssc.201900359. [PMID: 31257725] - Myungsun Shim, Woo Jin Bang, Cheol Young Oh, Yong Seong Lee, Jin Seon Cho. Effectiveness of three different luteinizing hormone-releasing hormone agonists in the chemical castration of patients with prostate cancer: Goserelin versus triptorelin versus leuprolide.
Investigative and clinical urology.
2019 07; 60(4):244-250. doi:
10.4111/icu.2019.60.4.244. [PMID: 31294133] - Stefano Romagnoli, Anna Baldan, Silvia Ferro, Camilla Righetti, Ludovico Scenna, Gianfranco Gabai, Tamara Badon, Christelle Fontaine, Antonio Mollo, Calogero Stelletta, Chiara Milani. Length of efficacy and effect of implant location in adult tom cats treated with a 9.4 mg deslorelin subcutaneous implant.
Journal of feline medicine and surgery.
2019 06; 21(6):507-519. doi:
10.1177/1098612x18788157. [PMID: 30056772] - Saied Saeed Hosseiny Davarani, Ahmad Pourahadi, Peivand Ghasemzadeh. Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC-UV.
Electrophoresis.
2019 04; 40(7):1074-1081. doi:
10.1002/elps.201800481. [PMID: 30653693] - Peter B Østergren, Caroline Kistorp, Mikkel Fode, Finn N Bennedbaek, Jens Faber, Jens Sønksen. Metabolic consequences of gonadotropin-releasing hormone agonists vs orchiectomy: a randomized clinical study.
BJU international.
2019 04; 123(4):602-611. doi:
10.1111/bju.14609. [PMID: 30388320] - Tianming Ren, Zhi Zhang, John Paul Fawcett, Dong Sun, Jingkai Gu. Micro-solid phase extraction and LC-MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 Mar; 166(?):13-19. doi:
10.1016/j.jpba.2018.12.039. [PMID: 30599277] - Jingjing Jiang, Shanshan Gao, Jin Xu. Efficacy and Safety of gonadotropin-releasing hormone (GnRH) Agonists Triptorelin Acetate and Cetrorelix Acetate in Assisted Reproduction.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Nov; 24(?):7996-8000. doi:
10.12659/msm.911345. [PMID: 30405094] - Sabine Schäfer-Somi, Duygu Kaya, Mahmut Sözmen, Semra Kaya, Selim Aslan. Pre-pubertal treatment with a GnRH agonist in bitches-Effect on the uterus and hormone receptor expression.
Reproduction in domestic animals = Zuchthygiene.
2018 Nov; 53 Suppl 3(?):103-109. doi:
10.1111/rda.13337. [PMID: 30474335] - Yaping Ma, Shuang Nie, Ze Ben, Zhuangjian Xu, Huan Zhou, Jinling Zhao, Feng Ren, Qing Wang, Shuyan Xie, Tingting Zhang. The Dynamic Trends of Urinary LH and FSH Assayed by ICMA During Triptorelin Stimulation Tests in Girls - a Pilot Study.
Clinical laboratory.
2018 Oct; 64(10):1701-1708. doi:
10.7754/clin.lab.2018.180514. [PMID: 30336539] - Junjun Miao, Qianhua Yan, Lijuan Wang, Xin Wang. Three cases of transient hyperthyroidism after triptorelin treatment - case report and literature review.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Sep; 34(9):734-735. doi:
10.1080/09513590.2018.1445710. [PMID: 29484896] - Romina Nuñez Favre, María Florencia García, María Carla García Mitacek, Ramiro Rearte, Christelle Fontaine, Rodolfo Luzbel de la Sota, María Alejandra Stornelli. Reestablishment of sperm quality after long-term deslorelin suppression in tomcats.
Animal reproduction science.
2018 Aug; 195(?):302-308. doi:
10.1016/j.anireprosci.2018.06.008. [PMID: 29934121] - Camille Gautier, Kathrin Schmidt, Jörg Aurich, Christine Aurich. Effects of implants containing the GnRH agonist deslorelin on testosterone release and semen characteristics in Shetland stallions.
Animal reproduction science.
2018 Aug; 195(?):230-241. doi:
10.1016/j.anireprosci.2018.05.027. [PMID: 29859702] - Jiang-Feng Mao, Xi Wang, Jun-Jie Zheng, Zhao-Xiang Liu, Hong-Li Xu, Bing-Kun Huang, Min Nie, Xue-Yan Wu. Predictive factors for pituitary response to pulsatile GnRH therapy in patients with congenital hypogonadotropic hypogonadism.
Asian journal of andrology.
2018 Jul; 20(4):319-323. doi:
10.4103/aja.aja_83_17. [PMID: 29516878] - Qi Yao, Yuanjiao Liang, Yong Shao, Wenwen Bian, Haiyan Fu, Juanjuan Xu, Liucai Sui, Bing Yao, Meiling Li. Advanced glycation end product concentrations in follicular fluid of women undergoing IVF/ICSI with a GnRH agonist protocol.
Reproductive biomedicine online.
2018 Jan; 36(1):20-25. doi:
10.1016/j.rbmo.2017.09.003. [PMID: 29174168] - Ellen Werber Leschek, Armando C Flor, Joy C Bryant, Janet V Jones, Kevin M Barnes, Gordon B Cutler. Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty.
The Journal of pediatrics.
2017 11; 190(?):229-235. doi:
10.1016/j.jpeds.2017.07.047. [PMID: 29144249] - Pegah Varamini, Amirreza Rafiee, Ashwini Kumar Giddam, Friederike M Mansfeld, Frederik Steyn, Istvan Toth. Development of New Gonadotropin-Releasing Hormone-Modified Dendrimer Platforms with Direct Antiproliferative and Gonadotropin Releasing Activity.
Journal of medicinal chemistry.
2017 10; 60(20):8309-8320. doi:
10.1021/acs.jmedchem.6b01771. [PMID: 28958147] - Prajakta Tambe, Pramod Kumar, Yogesh A Karpe, Kishore M Paknikar, Virendra Gajbhiye. Triptorelin Tethered Multifunctional PAMAM-Histidine-PEG Nanoconstructs Enable Specific Targeting and Efficient Gene Silencing in LHRH Overexpressing Cancer Cells.
ACS applied materials & interfaces.
2017 Oct; 9(41):35562-35573. doi:
10.1021/acsami.7b11024. [PMID: 28949503] - Y L Boakari, J C Ferreira, H S Canesin, D L Thompson, F S Lima, J C F Pantoja, C Meira. Influence of two ovulation-inducing agents on the pituitary response and follicle blood flow in mares.
Theriogenology.
2017 Sep; 100(?):95-99. doi:
10.1016/j.theriogenology.2017.05.032. [PMID: 28708540] - Ned J Place, Adrienne E Crosier, Pierre Comizzoli, Jennifer B Nagashima, Holly Haefele, Anne Schmidt-Küntzel, Laurie L Marker. Age-associated and deslorelin-induced declines in serum anti-Müllerian hormone concentrations in female cheetahs, Acinonyx jubatus.
General and comparative endocrinology.
2017 09; 250(?):54-57. doi:
10.1016/j.ygcen.2017.06.003. [PMID: 28602789] - Romain Potier, Emma Monge, Tatiana Loucachevsky, Robert Hermes, Frank Göritz, Daphné Rochel, Emmanuel Risi. Effects of deslorelin acetate on plasma testosterone concentrations in captive yellow-bellied sliders (Trachemys scripta sp.).
Acta veterinaria Hungarica.
2017 09; 65(3):440-445. doi:
10.1556/004.2017.041. [PMID: 28956487] - Marjorie J MacGregor, Cheryl S Asa, Donal C Skinner. Variable duration of reproductive suppression in male coyotes (Canis latrans) treated with a high dose of the gonadotrophin-releasing hormone agonist deslorelin.
Reproduction, fertility, and development.
2017 Jul; 29(7):1271-1279. doi:
10.1071/rd15253. [PMID: 27161891] - Peter B Østergren, Caroline Kistorp, Mikkel Fode, James Henderson, Finn N Bennedbæk, Jens Faber, Jens Sønksen. Luteinizing Hormone-Releasing Hormone Agonists are Superior to Subcapsular Orchiectomy in Lowering Testosterone Levels of Men with Prostate Cancer: Results from a Randomized Clinical Trial.
The Journal of urology.
2017 06; 197(6):1441-1447. doi:
10.1016/j.juro.2016.12.003. [PMID: 27939836] - S Goericke-Pesch. Long-term effects of GnRH agonists on fertility and behaviour.
Reproduction in domestic animals = Zuchthygiene.
2017 Apr; 52 Suppl 2(?):336-347. doi:
10.1111/rda.12898. [PMID: 28025851] - Jürgen Breul, Eija Lundström, Daniela Purcea, Werner P Venetz, Patrick Cabri, Pascale Dutailly, Evan R Goldfischer. Efficacy of Testosterone Suppression with Sustained-Release Triptorelin in Advanced Prostate Cancer.
Advances in therapy.
2017 02; 34(2):513-523. doi:
10.1007/s12325-016-0466-7. [PMID: 28028737] - Nilgün Gültiken, Selim Aslan, Serhan Serhat Ay, Mustafa Yavuz Gülbahar, Julianna Thuróczy, Ece Koldaş, Duygu Kaya, Murat Fındık, Sabine Schäfer-Somi. Effect of deslorelin on testicular function, serum dihydrotestosterone and oestradiol concentrations during and after suppression of sexual activity in tom cats.
Journal of feline medicine and surgery.
2017 02; 19(2):123-131. doi:
10.1177/1098612x15615381. [PMID: 26574498] - Stefano Romagnoli, Anna Baldan, Camilla Righetti, Chiara Milani, Antonio Mollo, Calogero Stelletta. Semen quality and interval to sterility in tom cats treated with a 9.4 mg deslorelin implant.
Journal of feline medicine and surgery.
2017 02; 19(2):194-199. doi:
10.1177/1098612x15623985. [PMID: 26763267] - Yavuz Emre Şükür, Batuhan Özmen, Elif Didem Özdemir, Mehmet Murat Seval, Erkan Kalafat, Murat Sönmezer, Bülent Berker, Ruşen Aytaç, Cem Somer Atabekoğlu. Final oocyte maturation with two different GnRH agonists in antagonist co-treated cycles at risk of ovarian hyperstimulation syndrome.
Reproductive biomedicine online.
2017 Jan; 34(1):5-10. doi:
10.1016/j.rbmo.2016.10.004. [PMID: 27771155] - G Mayrhofer, D Wegner, T Voß. [Urolithiasis in the Long-Term GnRH Agonist Treatment of Patients with Paraphilia: 3 Case Studies].
Aktuelle Urologie.
2016 12; 47(6):487-490. doi:
10.1055/s-0042-112999. [PMID: 27701680] - Masoumeh Zoghi, Amir R Jalilian, Ali Niazi, Fariba Johari-Daha, Behrouz Alirezapour, Saeed Ramezanpour. Development of a (68)Ga-peptide tracer for PET GnRH1-imaging.
Annals of nuclear medicine.
2016 Jul; 30(6):400-8. doi:
10.1007/s12149-016-1074-y. [PMID: 27083468] - Lanlan Fang, Yiping Yu, Ruizhe Zhang, Jingyan He, Ying-Pu Sun. Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF/ICSI-ET.
Scientific reports.
2016 06; 6(?):28036. doi:
10.1038/srep28036. [PMID: 27329327] - Salvatore Gizzo, Marco Noventa, Michela Quaranta, Amerigo Vitagliano, Federica Esposito, Alessandra Andrisani, Roberta Venturella, Carlo Alviggi, Mario Plebani, Michele Gangemi, Giovanni Battista Nardelli, Donato D'Antona. The Potential Role of GnRH Agonists and Antagonists in Inducing Thyroid Physiopathological Changes During IVF.
Reproductive sciences (Thousand Oaks, Calif.).
2016 Apr; 23(4):515-23. doi:
10.1177/1933719115608000. [PMID: 26445999] - Eberhard Varenhorst, Rami Klaff, Anders Berglund, Per Olov Hedlund, Gabriel Sandblom. Predictors of early androgen deprivation treatment failure in prostate cancer with bone metastases.
Cancer medicine.
2016 Mar; 5(3):407-14. doi:
10.1002/cam4.594. [PMID: 26765317] - Analía Verónica Freire, Mirta Graciela Gryngarten, María Gabriela Ballerini, Andrea Josefina Arcari, María Eugenia Escobar, Ignacio Bergadá, María Gabriela Ropelato. Assessment of Estradiol Response after Depot Triptorelin Administration in Girls with Central Precocious Puberty.
Hormone research in paediatrics.
2016; 85(1):58-64. doi:
10.1159/000442523. [PMID: 26675317] - M L Schulman, R M Kirberger, A S W Tordiffe, L L Marker, A Schmidt-Küntzel, M J Hartman. Ultrasonographic and laparoscopic evaluation of the reproductive tract in older captive female cheetahs (Acinonyx jubatus).
Theriogenology.
2015 Dec; 84(9):1611-9. doi:
10.1016/j.theriogenology.2015.08.011. [PMID: 26381758] - Olivia A Petritz, David Sanchez-Migallon Guzman, Michelle G Hawkins, Philip H Kass, Alan J Conley, Joanne Paul-Murphy. COMPARISON OF TWO 4.7-MILLIGRAM TO ONE 9.4-MILLIGRAM DESLORELIN ACETATE IMPLANTS ON EGG PRODUCTION AND PLASMA PROGESTERONE CONCENTRATIONS IN JAPANESE QUAIL (COTURNIX COTURNIX JAPONICA).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2015 Dec; 46(4):789-97. doi:
10.1638/2014-0210.1. [PMID: 26667535] - Karagh Murphy, David A Wilson, Mark Burton, Shayla Slaugh, Jeffery L Dunning, Jonathan F Prather. Effectiveness of the GnRH agonist Deslorelin as a tool to decrease levels of circulating testosterone in zebra finches.
General and comparative endocrinology.
2015 Oct; 222(?):150-7. doi:
10.1016/j.ygcen.2015.09.014. [PMID: 26391838] - Ya-Qin Wang, Jin Luo, Wang-Min Xu, Qin-Zhen Xie, Wen-Jie Yan, Geng-Xiang Wu, Jin Yang. Can steroidal ovarian suppression during the luteal phase after oocyte retrieval reduce the risk of severe OHSS?.
Journal of ovarian research.
2015 Sep; 8(?):63. doi:
10.1186/s13048-015-0190-y. [PMID: 26400057] - Christine M Molter, Deidre K Fontenot, Scott P Terrell. Use of Deslorelin Acetate Implants to Mitigate Aggression in Two Adult Male Domestic Turkeys (Meleagris gallopavo) and Correlating Plasma Testosterone Concentrations.
Journal of avian medicine and surgery.
2015 Sep; 29(3):224-30. doi:
10.1647/2014-041. [PMID: 26378669] - Mariya Balyura, Evgeny Gelfgat, Monika Ehrhart-Bornstein, Barbara Ludwig, Zohar Gendler, Uriel Barkai, Baruch Zimerman, Avi Rotem, Norman L Block, Andrew V Schally, Stefan R Bornstein. Transplantation of bovine adrenocortical cells encapsulated in alginate.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Feb; 112(8):2527-32. doi:
10.1073/pnas.1500242112. [PMID: 25675525] - Zheng Li, Hong Yuan Zhang, Ying Jun Zhu, Yuan Jing Hu, Peng Peng Qu. A randomized study comparing the side effects and hormonal status of triptorelin and leuprorelin following conservative laparoscopic surgery for ovarian endometriosis in Chinese women.
European journal of obstetrics, gynecology, and reproductive biology.
2014 Dec; 183(?):164-8. doi:
10.1016/j.ejogrb.2014.10.022. [PMID: 25461372] - Luis Martínez-Piñeiro, Jack A Schalken, Patrick Cabri, Pascal Maisonobe, Alexandre de la Taille. Evaluation of urinary prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG score changes when starting androgen-deprivation therapy with triptorelin 6-month formulation in patients with locally advanced and metastatic prostate cancer.
BJU international.
2014 Oct; 114(4):608-16. doi:
10.1111/bju.12542. [PMID: 24806330] - Hao Wang, Yantong Sun, Wei Guo, Chunxue Fang, J Paul Fawcett, Wei Li, Yin Gao, Yan Yang, Jingkai Gu. Determination of a deuterohemin-peptide conjugate in rat plasma by liquid chromatography-tandem mass spectrometry and application to a preclinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2014 Sep; 98(?):401-6. doi:
10.1016/j.jpba.2014.06.026. [PMID: 25005890] - Jianzhi Ren, Aiguo Sha, Dongmei Han, Ping Li, Jie Geng, Chaihui Ma. Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?.
Fertility and sterility.
2014 Jul; 102(1):75-81. doi:
10.1016/j.fertnstert.2014.03.030. [PMID: 24746740] - C Wynne Collins, Steven L Monfort, Mandi M Vick, Barbara A Wolfe, Rachael B Weiss, Carol L Keefer, Nucharin Songsasen. Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski's horse (Equus ferus przewalskii).
Animal reproduction science.
2014 Jul; 148(1-2):42-52. doi:
10.1016/j.anireprosci.2014.03.018. [PMID: 24856195] - Jixia Wang, Song Kong, Jingyu Yan, Gaowa Jin, Zhimou Guo, Aijin Shen, Junyan Xu, Xiuli Zhang, Lijuan Zou, Xinmiao Liang. Hydrophilic interaction liquid chromatography-solid phase extraction directly combined with protein precipitation for the determination of triptorelin in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jun; 960(?):214-21. doi:
10.1016/j.jchromb.2014.04.036. [PMID: 24820974] - Melinda Lee Cowan, Graeme Bruce Martin, Deborah Jane Monks, Stephen Douglas Johnston, Robert James Tyson Doneley, Margaret Anne Blackberry. Inhibition of the reproductive system by deslorelin in male and female pigeons (Columba livia).
Journal of avian medicine and surgery.
2014 Jun; 28(2):102-8. doi:
10.1647/2013-027. [PMID: 25115038] - Jiangbin Han, Shu Zhang, Wanhui Liu, Guangyi Leng, Kaoxiang Sun, Youxin Li, Xin Di. An analytical strategy to characterize the pharmacokinetics and pharmacodynamics of triptorelin in rats based on simultaneous LC-MS/MS analysis of triptorelin and endogenous testosterone in rat plasma.
Analytical and bioanalytical chemistry.
2014 Apr; 406(9-10):2457-65. doi:
10.1007/s00216-014-7616-z. [PMID: 24510211] - Nikolay N Dygalo, Tatjana V Shemenkova, Tatjana S Kalinina, Galina T Shishkina. A critical point of male gonad development: neuroendocrine correlates of accelerated testicular growth in rats during early life.
PloS one.
2014; 9(4):e93007. doi:
10.1371/journal.pone.0093007. [PMID: 24695464] - M Karimi-Zarchi, M Forat-Yazdi, M R Vafaeenasab, M Nakhaie-Moghadam, A Miratashi-Yazdi, S Teimoori, A Dehghani-Tafti. Evaluation of the effect of GnRH agonist on menstrual reverse in breast cancer cases treated with cyclophosphamide.
European journal of gynaecological oncology.
2014; 35(1):59-61. doi:
NULL. [PMID: 24654464] - Onder Celik, Ebru Celik, Ercan Yilmaz, Nilüfer Celik, Ilgın Turkcuoglu, Mustafa Ulas, Banu Kumbak, Erdal Aktan, Ibrahim Ozerol. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin-releasing hormone agonist and antagonists, on follicular fluid stem cell factor and serum urocortin 1 levels on the day of oocyte retrieval.
Archives of gynecology and obstetrics.
2013 Dec; 288(6):1417-22. doi:
10.1007/s00404-013-2804-1. [PMID: 23801011] - Roberto Matorras, Maider Andrés, Rosario Mendoza, Begoña Prieto, Jose Ignacio Pijoan, Antonia Expósito. Prevention of ovarian hyperstimulation syndrome in GnRH agonist IVF cycles in moderate risk patients: randomized study comparing hydroxyethyl starch versus cabergoline and hydroxyethyl starch.
European journal of obstetrics, gynecology, and reproductive biology.
2013 Oct; 170(2):439-43. doi:
10.1016/j.ejogrb.2013.07.010. [PMID: 23932181] - A Polisca, R Orlandi, A Troisi, G Brecchia, M Zerani, C Boiti, R Zelli. Clinical efficacy of the GnRH agonist (deslorelin) in dogs affected by benign prostatic hyperplasia and evaluation of prostatic blood flow by Doppler ultrasound.
Reproduction in domestic animals = Zuchthygiene.
2013 Aug; 48(4):673-80. doi:
10.1111/rda.12143. [PMID: 23320475] - S Larson, T Belting, K Rifenbury, G Fisher, S M Boutelle. Preliminary findings of fecal gonadal hormone concentrations in six captive sea otters (Enhydra lutris) after deslorelin implantation.
Zoo biology.
2013 May; 32(3):307-15. doi:
10.1002/zoo.21032. [PMID: 22753108] - Lutz R Asmus, Jean-Christophe Tille, Béatrice Kaufmann, Louise Melander, Torsten Weiss, Kerstin Vessman, Wolfgang Koechling, Grégoire Schwach, Robert Gurny, Michael Möller. In vivo biocompatibility, sustained-release and stability of triptorelin formulations based on a liquid, degradable polymer.
Journal of controlled release : official journal of the Controlled Release Society.
2013 Feb; 165(3):199-206. doi:
10.1016/j.jconrel.2012.11.014. [PMID: 23220105] - Olivia A Petritz, David Sanchez-Migallon Guzman, Joanne Paul-Murphy, Kellie Fecteau, Aslı Mete, Philip H Kass, Michelle G Hawkins. Evaluation of the efficacy and safety of single administration of 4.7-mg deslorelin acetate implants on egg production and plasma sex hormones in Japanese quail (Coturnix coturnix japonica).
American journal of veterinary research.
2013 Feb; 74(2):316-23. doi:
10.2460/ajvr.74.2.316. [PMID: 23363360] - Colette Meyer, Andrew H Sims, Kevin Morgan, Beth Harrison, Morwenna Muir, Jianing Bai, Dana Faratian, Robert P Millar, Simon P Langdon. Transcript and protein profiling identifies signaling, growth arrest, apoptosis, and NF-κB survival signatures following GNRH receptor activation.
Endocrine-related cancer.
2013 Feb; 20(1):123-36. doi:
10.1530/erc-12-0192. [PMID: 23202794] - Xia Liu, Hong-xia Zhang, Li-ping Wang, Wei-ping Fu. [Application of half-dose depot long-acting triptorelin in postoperative adjuvant therapy for endometriosis].
Zhonghua yi xue za zhi.
2013 Jan; 93(3):208-11. doi:
NULL. [PMID: 23570596] - Guillaume Ploussard, Pierre Mongiat-Artus. Triptorelin in the management of prostate cancer.
Future oncology (London, England).
2013 Jan; 9(1):93-102. doi:
10.2217/fon.12.158. [PMID: 23252566] - Zohreh Karamizadeh, Mahmoodreza Tabebordbar, Forough Saki, Hamdollah Karamifar, Gholamhossein Amirhakimi. The side effects of gonadotropin releasing hormone analog (diphereline) in treatment of idiopathic central precocious puberty.
Acta medica Iranica.
2013; 51(1):41-6. doi:
NULL. [PMID: 23456583] - A Heidenreich, D Porres, R Epplen, T van Erps, D Pfister. [Change of the LHRH analogue in progressive castration-refractory prostate cancer].
Der Urologe. Ausg. A.
2012 Sep; 51(9):1282-7. doi:
10.1007/s00120-012-2948-9. [PMID: 22733398] - C L Ackermann, R Volpato, F C Destro, E Trevisol, N Ruas Sousa, C R F Guaitolini, A A P Derussi, T S Rascado, M D Lopes. Ovarian activity reversibility after the use of deslorelin acetate as a short-term contraceptive in domestic queens.
Theriogenology.
2012 Sep; 78(4):817-22. doi:
10.1016/j.theriogenology.2012.03.030. [PMID: 22578612] - Elba Romero, Nieves Vélez de Mendizabal, Josep-María Cendrós, Concepción Peraire, Emma Bascompta, Rosendo Obach, Iñaki F Trocóniz. Pharmacokinetic/pharmacodynamic model of the testosterone effects of triptorelin administered in sustained release formulations in patients with prostate cancer.
The Journal of pharmacology and experimental therapeutics.
2012 Sep; 342(3):788-98. doi:
10.1124/jpet.112.195560. [PMID: 22691297] - Jiangbin Han, Jiye Sun, Chunjie Sha, Jinfeng Zhang, Yunyun Gai, Youxin Li, Wanhui Liu. Quantitation of slow release triptorelin in beagle dog plasma by liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2012 Jul; 66(?):334-8. doi:
10.1016/j.jpba.2012.02.021. [PMID: 22444328] - Chien-Chang Kao, Yen-Hwa Chang, Tony Wu, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha. Open, multi-center, phase IV study to assess the efficacy and tolerability of triptorelin in Taiwanese patients with advanced prostate cancer.
Journal of the Chinese Medical Association : JCMA.
2012 Jun; 75(6):255-61. doi:
10.1016/j.jcma.2012.04.010. [PMID: 22721619] - A W Smith, C S Asa, B S Edwards, W J Murdoch, D C Skinner. Predominant suppression of follicle-stimulating hormone β-immunoreactivity after long-term treatment of intact and castrate adult male rats with the gonadotrophin-releasing hormone agonist deslorelin.
Journal of neuroendocrinology.
2012 May; 24(5):737-47. doi:
10.1111/j.1365-2826.2011.02271.x. [PMID: 22172059] - C Salvador, J Planas, C Raventós, J Ropero, J Placer, M A López, J Morote. [Impact of androgen deprivation on the lipid profile and atherogenic risk in prostate cancer patients].
Actas urologicas espanolas.
2012 Apr; 36(4):205-9. doi:
10.1016/j.acuro.2011.09.006. [PMID: 22178349] - T S F Toydemir, M R Kılıçarslan, V Olgaç. Effects of the GnRH analogue deslorelin implants on reproduction in female domestic cats.
Theriogenology.
2012 Feb; 77(3):662-74. doi:
10.1016/j.theriogenology.2011.07.046. [PMID: 22015158] - Peer Briken, Wolfgang Berner. Double-blind, controlled, clinical trial planned in germany to investigate the efficacy of psychotherapy combined with triptorelin in adult male patients with severe pedophilic disorders: presentation of the study protocol.
The Israel journal of psychiatry and related sciences.
2012; 49(4):306-13. doi:
NULL. [PMID: 23585468] - Marlena Juszczak, Magdalena Roszczyk. Oxytocin and vasopressin secretion from the rat hypothalamo-neurohypophysial system is stimulated by triptorelin.
Endokrynologia Polska.
2012; 63(3):176-81. doi:
NULL. [PMID: 22744622] - Ying Qi, Pin Li, Yongyu Zhang, Lulu Cui, Zi Guo, Guoxiang Xie, Mingming Su, Xin Li, Xiaojiao Zheng, Yunping Qiu, Yumin Liu, Aihua Zhao, Weiping Jia, Wei Jia. Urinary metabolite markers of precocious puberty.
Molecular & cellular proteomics : MCP.
2012 Jan; 11(1):M111.011072. doi:
10.1074/mcp.m111.011072. [PMID: 22027199] - Chen Yan-hua, Lian Fang, Na Shi. [Clinical effects of shen-nourishing and menstruation-regulating method combined with triptorelin acetate injection on patient with luteinized unruptured follicle syndrome].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 Dec; 31(12):1604-6. doi:
". [PMID: 22384543] - Sh Abashzadeh, R Dinarvand, M Sharifzadeh, G Hassanzadeh, M Amini, F Atyabi. Formulation and evaluation of an in situ gel forming system for controlled delivery of triptorelin acetate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2011 Nov; 44(4):514-21. doi:
10.1016/j.ejps.2011.09.011. [PMID: 21946260] - Con Mallidis, Agnieszka Czerwiec, Sandra Filippi, Jason O'Neill, Mario Maggi, Neil McClure. Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism.
Reproduction (Cambridge, England).
2011 Jul; 142(1):63-71. doi:
10.1530/rep-10-0472. [PMID: 21464116] - Miki Bloch, Inbar Aharonov, Irit Ben Avi, Shaul Schreiber, Ami Amit, Abraham Weizman, Foad Azem. Gonadal steroids and affective symptoms during in vitro fertilization: implication for reproductive mood disorders.
Psychoneuroendocrinology.
2011 Jul; 36(6):790-6. doi:
10.1016/j.psyneuen.2010.10.018. [PMID: 21106297] - María Cerrillo, Alberto Pacheco, Sara Rodríguez, Raúl Gómez, Francisco Delgado, Antonio Pellicer, Juan A Garcia-Velasco. Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome.
Fertility and sterility.
2011 Jun; 95(8):2517-9. doi:
10.1016/j.fertnstert.2010.12.054. [PMID: 21269615] - B Walter, C Otzdorff, N Brugger, J Braun. Estrus induction in Beagle bitches with the GnRH-agonist implant containing 4.7 mg Deslorelin.
Theriogenology.
2011 Apr; 75(6):1125-9. doi:
10.1016/j.theriogenology.2010.11.022. [PMID: 21220159] - Sandra Goericke-Pesch, Plamen Georgiev, Anton Antonov, Maxime Albouy, Axel Wehrend. Clinical efficacy of a GnRH-agonist implant containing 4.7 mg deslorelin, Suprelorin, regarding suppression of reproductive function in tomcats. Sandra.Pesch@vetmed.uni-giessen.de.
Theriogenology.
2011 Mar; 75(5):803-10. doi:
10.1016/j.theriogenology.2010.10.020. [PMID: 21196037] - S P Arlt, S Spankowsky, W Heuwieser. Follicular cysts and prolonged oestrus in a female dog after administration of a deslorelin implant.
New Zealand veterinary journal.
2011 Mar; 59(2):87-91. doi:
10.1080/00480169.2011.552858. [PMID: 21409735] - Amit Assa, Mordechai Weiss, Dorit Aharoni, Anat Mor, Mariana Rachmiel, Tzvi Bistritzer. Evaluation of bone density in girls with precocious and early puberty during treatment with GnRH agonist.
Journal of pediatric endocrinology & metabolism : JPEM.
2011; 24(7-8):505-10. doi:
10.1515/jpem.2011.170. [PMID: 21932589] - V Rouach, S Katzburg, Y Koch, N Stern, D Somjen. Bone loss in ovariectomized rats: dominant role for estrogen but apparently not for FSH.
Journal of cellular biochemistry.
2011 Jan; 112(1):128-37. doi:
10.1002/jcb.22908. [PMID: 21053364]
