Phenelzine sulfate (BioDeep_00000015146)

   


代谢物信息卡片


Phenelzine (sulfate)

化学式: C8H14N2O4S (234.0674244)
中文名称: 苯肼,硫酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CCNN.OS(=O)(=O)O
InChI: (H2,1,2,3,4)

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor

同义名列表

2 个代谢物同义名

Phenelzine (sulfate); Phenelzine sulfate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rachel L Hill, Indrapal N Singh, Juan A Wang, Jacqueline R Kulbe, Edward D Hall. Protective effects of phenelzine administration on synaptic and non-synaptic cortical mitochondrial function and lipid peroxidation-mediated oxidative damage following TBI in young adult male rats. Experimental neurology. 2020 08; 330(?):113322. doi: 10.1016/j.expneurol.2020.113322. [PMID: 32325157]
  • Josep Mercader, Agustín G Sabater, Sophie Le Gonidec, Pauline Decaunes, Alice Chaplin, Saioa Gómez-Zorita, Fermín I Milagro, Christian Carpéné. Oral Phenelzine Treatment Mitigates Metabolic Disturbances in Mice Fed a High-Fat Diet. The Journal of pharmacology and experimental therapeutics. 2019 11; 371(2):555-566. doi: 10.1124/jpet.119.259895. [PMID: 31270215]
  • Alexander Dmitriev, Dmitry Filimonov, Alexey Lagunin, Dmitry Karasev, Pavel Pogodin, Anastasiya Rudik, Vladimir Poroikov. Prediction of Severity of Drug-Drug Interactions Caused by Enzyme Inhibition and Activation. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213955. [PMID: 31683720]
  • Glen Baker, Dmitriy Matveychuk, Erin M MacKenzie, Andrew Holt, Yanlin Wang, Satyabrata Kar. Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine. Chemico-biological interactions. 2019 May; 304(?):139-147. doi: 10.1016/j.cbi.2019.03.003. [PMID: 30857888]
  • Rachel L Hill, Indrapal N Singh, Juan A Wang, Edward D Hall. Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury. Journal of neurotrauma. 2019 04; 36(8):1231-1251. doi: 10.1089/neu.2018.5946. [PMID: 30358485]
  • Ayman G Mustafa, Othman Al-Shboul, Mahmoud A Alfaqih, Mohammad A Al-Qudah, Ahmed N Al-Dwairi. Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins. Archives of physiology and biochemistry. 2018 Dec; 124(5):418-423. doi: 10.1080/13813455.2017.1415939. [PMID: 29256275]
  • Christian Carpéné, Saioa Gómez-Zorita, Alice Chaplin, Josep Mercader. Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice. International journal of molecular sciences. 2018 Sep; 19(10):. doi: 10.3390/ijms19102904. [PMID: 30257452]
  • Christian Carpéné, Josep Mercader, Sophie Le Gonidec, Stéphane Schaak, Jeanne Mialet-Perez, Alexia Zakaroff-Girard, Jean Galitzky. Body fat reduction without cardiovascular changes in mice after oral treatment with the MAO inhibitor phenelzine. British journal of pharmacology. 2018 06; 175(12):2428-2440. doi: 10.1111/bph.14211. [PMID: 29582416]
  • Jacqueline R Kulbe, Indrapal N Singh, Juan A Wang, John E Cebak, Edward D Hall. Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats. Journal of neurotrauma. 2018 06; 35(11):1280-1293. doi: 10.1089/neu.2017.5353. [PMID: 29336204]
  • John E Cebak, Indrapal N Singh, Rachel L Hill, Juan A Wang, Edward D Hall. Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection. Journal of neurotrauma. 2017 04; 34(7):1302-1317. doi: 10.1089/neu.2016.4624. [PMID: 27750484]
  • M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 2016 Aug; 233(15-16):2955-71. doi: 10.1007/s00213-016-4342-6. [PMID: 27259485]
  • Zhe Chen, Jonghyuck Park, Breanne Butler, Glen Acosta, Sasha Vega-Alvarez, Lingxing Zheng, Jonathan Tang, Robyn McCain, Wenpeng Zhang, Zheng Ouyang, Peng Cao, Riyi Shi. Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury. Journal of neurochemistry. 2016 07; 138(2):328-38. doi: 10.1111/jnc.13639. [PMID: 27060873]
  • Liam E Potter, John W Paylor, Jee Su Suh, Gustavo Tenorio, Jayalakshmi Caliaperumal, Fred Colbourne, Glen Baker, Ian Winship, Bradley J Kerr. Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis. Journal of neuroinflammation. 2016 06; 13(1):142. doi: 10.1186/s12974-016-0609-4. [PMID: 27282914]
  • Raja Reddy Kallem, Bhupathi Jillela, Arun Reddy Ravula, Ramakrishna Samala, Adinarayana Andy, Mullangi Ramesh, Jvln Seshagiri Rao. Highly sensitive LC-MS/MS-ESI method for determination of phenelzine in human plasma and its application to a human pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jun; 1022(?):126-132. doi: 10.1016/j.jchromb.2016.04.006. [PMID: 27085800]
  • C Carpéné, S Gomez-Zorita, R Gupta, S Grès, C Rancoule, T Cadoudal, J Mercader, A Gomez, C Bertrand, Z Iffiu-Soltész. Combination of low dose of the anti-adipogenic agents resveratrol and phenelzine in drinking water is not sufficient to prevent obesity in very-high-fat diet-fed mice. European journal of nutrition. 2014 Dec; 53(8):1625-35. doi: 10.1007/s00394-014-0668-1. [PMID: 24531732]
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  • Christian Carpéné, Sandra Grès, Simon Rascalou. The amine oxidase inhibitor phenelzine limits lipogenesis in adipocytes without inhibiting insulin action on glucose uptake. Journal of neural transmission (Vienna, Austria : 1996). 2013 Jun; 120(6):997-1003. doi: 10.1007/s00702-012-0951-3. [PMID: 23242743]
  • Indrapal N Singh, Lesley K Gilmer, Darren M Miller, John E Cebak, Juan A Wang, Edward D Hall. Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013 Apr; 33(4):593-9. doi: 10.1038/jcbfm.2012.211. [PMID: 23321786]
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  • Françoise Chiche, Morwenna Le Guillou, Gérard Chétrite, Françoise Lasnier, Isabelle Dugail, Christian Carpéné, Marthe Moldes, Bruno Fève. Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes. Molecular pharmacology. 2009 May; 75(5):1052-61. doi: 10.1124/mol.108.052563. [PMID: 19201819]
  • Zaorui Zhao, Han-Ting Zhang, Elianna Bootzin, Mark J Millan, James M O'Donnell. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 May; 34(6):1467-81. doi: 10.1038/npp.2008.183. [PMID: 18923402]
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  • Tom K Birkenhäger, Walter W van den Broek, Paul G Mulder, Jan A Bruijn, Peter Moleman. Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients. The Journal of clinical psychiatry. 2004 Nov; 65(11):1505-10. doi: 10.4088/jcp.v65n1110. [PMID: 15554763]
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  • L J Urichuk, K Allison, A Holt, A J Greenshaw, G B Baker. Comparison of neurochemical effects of the monoamine oxidase inhibitors phenelzine, moclobemide and brofaromine in the rat after short- and long-term administration. Journal of affective disorders. 2000 May; 58(2):135-44. doi: 10.1016/s0165-0327(99)00105-6. [PMID: 10781703]
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