Ciclesonide (BioDeep_00000015136)
代谢物信息卡片
2-[(1S,2S,4R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-8-yl]-2-oxoethyl 2-methylpropanoate
化学式: C32H44O7 (540.3086874)
中文名称: 环索奈德
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6
InChI: InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
COVID info from Guide to PHARMACOLOGY, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D018926 - Anti-Allergic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:31397
- KEGG: C72110
- KEGGdrug: D01703
- PubChem: 6918155
- PubChem: 444033
- Metlin: METLIN85511
- DrugBank: DB01410
- ChEMBL: CHEMBL2040682
- CAS: 126544-47-6
- CAS: 141845-82-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexandre Duvignaud, Edouard Lhomme, Racha Onaisi, Rémi Sitta, Ambre Gelley, Julie Chastang, Lionel Piroth, Christine Binquet, Julie Dupouy, Alain Makinson, Benjamin Lefèvre, Jean-Marc Naccache, Caroline Roussillon, Roland Landman, Cédrick Wallet, Sophie Karcher, Valérie Journot, Duc Nguyen, Thierry Pistone, Stéphane Bouchet, Marie-Edith Lafon, Mathieu Molimard, Rodolphe Thiébaut, Xavier de Lamballerie, Jean-Philippe Joseph, Laura Richert, Olivier Saint-Lary, Sarah Djabarouti, Linda Wittkop, Xavier Anglaret, Denis Malvy. Inhaled ciclesonide for outpatient treatment of COVID-19 in adults at risk of adverse outcomes: a randomised controlled trial (COVERAGE).
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2022 Jul; 28(7):1010-1016. doi:
10.1016/j.cmi.2022.02.031. [PMID: 35304280] - Genichiro Tsuji, Shogo Nakajima, Koichi Watashi, Shiho Torii, Rigel Suzuki, Takasuke Fukuhara, Nobumichi Ohoka, Takao Inoue, Yosuke Demizu. Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication.
Journal of pharmacological sciences.
2022 Jul; 149(3):81-84. doi:
10.1016/j.jphs.2022.04.001. [PMID: 35641031] - Chao-Hsien Chen, Cheng-Yi Wang, Chih-Cheng Lai. Inhaled Ciclesonide for Patients With Asthma or Chronic Obstructive Pulmonary Disease and COVID-19.
JAMA internal medicine.
2022 05; 182(5):571-572. doi:
10.1001/jamainternmed.2022.0207. [PMID: 35311912] - Brian M Clemency, David J Koster, Michael S Blaiss. Inhaled Ciclesonide for Patients With Asthma or Chronic Obstructive Pulmonary Disease and COVID-19-Reply.
JAMA internal medicine.
2022 05; 182(5):572. doi:
10.1001/jamainternmed.2022.0210. [PMID: 35311914] - Stéphane Trevisiol, Yves Moulard, Zied Kaabia, Vivian Delcourt, Benoit Loup, Patrice Garcia, Sophie Boyer, Karine Dauriac, Guillaume Groseille, Sébastien Rouger, Ruediger Narbe, Marie-Agnès Popot, Ludovic Bailly-Chouriberry. LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes.
Drug testing and analysis.
2022 Feb; 14(2):252-261. doi:
10.1002/dta.3174. [PMID: 34634175] - Brian M Clemency, Renoj Varughese, Yaneicy Gonzalez-Rojas, Caryn G Morse, Wanda Phipatanakul, David J Koster, Michael S Blaiss. Efficacy of Inhaled Ciclesonide for Outpatient Treatment of Adolescents and Adults With Symptomatic COVID-19: A Randomized Clinical Trial.
JAMA internal medicine.
2022 01; 182(1):42-49. doi:
10.1001/jamainternmed.2021.6759. [PMID: 34807241] - Hanan M El-Laithy, Amal Youssef, Shereen S El-Husseney, Nesrine S El Sayed, Ahmed Maher. Enhanced alveo pulmonary deposition of nebulized ciclesonide for attenuating airways inflammations: a strategy to overcome metered dose inhaler drawbacks.
Drug delivery.
2021 Dec; 28(1):826-843. doi:
10.1080/10717544.2021.1905747. [PMID: 33928836] - Hiroyuki Fujii, Taisuke Tsuji, Mio Sugitani, Yosuke Matsumoto, Tatsuya Yuba, Shunya Tanaka, Yoshifumi Suga, Aosa Matsuyama, Shiho Goda, Ayaka Omura, Shinsuke Shiotsu, Chieko Takumi, Seiko Ono, Noriya Hiraoka. Prolonged persistence of SARS-CoV-2 infection during A+AVD therapy for classical Hodgkin's lymphoma: A case report.
Current problems in cancer.
2021 12; 45(6):100739. doi:
10.1016/j.currproblcancer.2021.100739. [PMID: 33810911] - Nicole Ezer, Sara Belga, Nick Daneman, Adrienne Chan, Benjamin M Smith, Shay-Anne Daniels, Kristen Moran, Charlotte Besson, Louisa Y Smyth, Susan J Bartlett, Andrea Benedetti, James G Martin, Todd C Lee, Emily G McDonald. Inhaled and intranasal ciclesonide for the treatment of covid-19 in adult outpatients: CONTAIN phase II randomised controlled trial.
BMJ (Clinical research ed.).
2021 11; 375(?):e068060. doi:
10.1136/bmj-2021-068060. [PMID: 34728476] - Abdullahi Tsanni. African scientists race to test COVID drugs - but face major hurdles.
Nature.
2021 11; 599(7883):25-27. doi:
10.1038/d41586-021-02995-5. [PMID: 34732862] - Juliann D Jaumotte, Alexis L Franks, Erin M Bargerstock, Edwina Philip Kisanga, Heather L Menden, Alexis Ghersi, Mahmoud Omar, Liping Wang, Anthony Rudine, Kelly L Short, Neerupama Silswal, Timothy J Cole, Venkatesh Sampath, A Paula Monaghan-Nichols, Donald B DeFranco. Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Neurobiology of disease.
2021 08; 156(?):105422. doi:
10.1016/j.nbd.2021.105422. [PMID: 34126164] - Genichiro Tsuji, Kenzo Yonemitsu, Takahito Ito, Yuta Yanase, Masashi Uema, Nobumichi Ohoka, Takao Inoue, Hiroshi Asakura, Yosuke Demizu. Development of ciclesonide analogues that block SARS-CoV-2 RNA replication.
Bioorganic & medicinal chemistry letters.
2021 07; 43(?):128052. doi:
10.1016/j.bmcl.2021.128052. [PMID: 33887440] - Akiko Yuno, Yoshiyuki Kenmotsu, Yuka Takahashi, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, Yu Yamashita, Junichi Nakamura, Sho Nakakubo, Keisuke Kamada, Masaru Suzuki, Hirokazu Sugino, Naoko Inoshita, Satoshi Konno, Hideaki Miyoshi, Tatsuya Atsumi, Yutaka Sawamura, Akira Shimatsu. Successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia.
Endocrine journal.
2021 Apr; 68(4):477-484. doi:
10.1507/endocrj.ej20-0613. [PMID: 33361650] - Eiichi Yamamoto, Yuhji Taquahashi, Makiko Kuwagata, Hirokatsu Saito, Kohei Matsushita, Takeshi Toyoda, Futoshi Sato, Satoshi Kitajima, Kumiko Ogawa, Ken-Ichi Izutsu, Yoshiro Saito, Yoko Hirabayashi, Yasuo Iimura, Masamitsu Honma, Haruhiro Okuda, Yukihiro Goda. Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging.
International journal of pharmaceutics.
2021 Feb; 595(?):120241. doi:
10.1016/j.ijpharm.2021.120241. [PMID: 33484917] - Nobuaki Mori, Mitsuya Katayama, Shigenari Nukaga. Triple therapy with hydroxychloroquine, azithromycin, and ciclesonide for COVID-19 pneumonia.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2021 Feb; 54(1):109-112. doi:
10.1016/j.jmii.2020.09.003. [PMID: 33054978] - Kunal Deokar, Mehul Agarwal, Naveen Dutt, Nishant Chauhan, Ram Niwas, Benhur Joel Shadrach, Gopal Chawla. A review of Ciclesonide in COVID-19. Still a long way to go.
Advances in respiratory medicine.
2021; 89(1):79-81. doi:
10.5603/arm.a2020.0173. [PMID: 33471354] - Shutoku Matsuyama, Miyuki Kawase, Naganori Nao, Kazuya Shirato, Makoto Ujike, Wataru Kamitani, Masayuki Shimojima, Shuetsu Fukushi. The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells.
Journal of virology.
2020 12; 95(1):. doi:
10.1128/jvi.01648-20. [PMID: 33055254] - Yukitaka Yamasaki, Seido Ooka, Tomoya Tsuchida, Yuta Nakamura, Yuta Hagiwara, Yoshiyuki Naitou, Yuki Ishibashi, Hiroki Ikeda, Tsutomu Sakurada, Hiroshi Handa, Hiroki Nishine, Mumon Takita, Daiki Morikawa, Hideki Yoshida, Shuichi Fujii, Kenichiro Morisawa, Hiromu Takemura, Shigeki Fujitani, Hiroyuki Kunishima. The peripheral lymphocyte count as a predictor of severe COVID-19 and the effect of treatment with ciclesonide.
Virus research.
2020 12; 290(?):198089. doi:
10.1016/j.virusres.2020.198089. [PMID: 32629085] - Hiroyuki Yoshida, Yasuhiro Abe, Akiko Usui, Ken-Ichi Izutsu. [Evaluation of Valved Holding Chambers Simulating Repurposing Use of Ciclesonide Metered-dose Inhaler by Patients with Pneumonia].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2020 Dec; 140(12):1495-1500. doi:
10.1248/yakushi.20-00169. [PMID: 32981902] - Hiroyuki Fujii, Taisuke Tsuji, Tatsuya Yuba, Shunya Tanaka, Yoshifumi Suga, Aosa Matsuyama, Ayaka Omura, Shinsuke Shiotsu, Chieko Takumi, Seiko Ono, Masahito Horiguchi, Noriya Hiraoka. High levels of anti-SSA/Ro antibodies in COVID-19 patients with severe respiratory failure: a case-based review : High levels of anti-SSA/Ro antibodies in COVID-19.
Clinical rheumatology.
2020 Nov; 39(11):3171-3175. doi:
10.1007/s10067-020-05359-y. [PMID: 32844364] - Hideyuki Takano. Pulmonary surfactant itself must be a strong defender against SARS-CoV-2.
Medical hypotheses.
2020 Nov; 144(?):110020. doi:
10.1016/j.mehy.2020.110020. [PMID: 32590326] - Hiroaki Baba, Hajime Kanamori, Kengo Oshima, Issei Seike, Ikumi Niitsuma-Sugaya, Kentaro Takei, Yukio Sato, Koichi Tokuda, Tetsuji Aoyagi. Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 Oct; 26(10):1100-1103. doi:
10.1016/j.jiac.2020.06.022. [PMID: 32631736] - Yoshinori Kadono, Yusaku Nakamura, Yoshihiko Ogawa, Shota Yamamoto, Ryuichiro Kajikawa, Yoshikazu Nakajima, Masayasu Matsumoto, Haruhiko Kishima. A case of COVID-19 infection presenting with a seizure following severe brain edema.
Seizure.
2020 08; 80(?):53-55. doi:
10.1016/j.seizure.2020.06.015. [PMID: 32540636] - Hirokazu Kimura, Hiromu Kurusu, Mitsuru Sada, Daisuke Kurai, Koichi Murakami, Wataru Kamitani, Haruyoshi Tomita, Kazuhiko Katayama, Akihide Ryo. Molecular pharmacology of ciclesonide against SARS-CoV-2.
The Journal of allergy and clinical immunology.
2020 08; 146(2):330-331. doi:
10.1016/j.jaci.2020.05.029. [PMID: 32593491] - Yuki Kondo, Shinichi Miyazaki, Ryo Yamashita, Takuya Ikeda. Coinfection with SARS-CoV-2 and influenza A virus.
BMJ case reports.
2020 Jul; 13(7):. doi:
10.1136/bcr-2020-236812. [PMID: 32611659] - Sangeun Jeon, Meehyun Ko, Jihye Lee, Inhee Choi, Soo Young Byun, Soonju Park, David Shum, Seungtaek Kim. Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00819-20. [PMID: 32366720] - Keisuke Iwabuchi, Koichiro Yoshie, Yuichi Kurakami, Kota Takahashi, Yoshio Kato, Tsuneo Morishima. Therapeutic potential of ciclesonide inahalation for COVID-19 pneumonia: Report of three cases.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 Jun; 26(6):625-632. doi:
10.1016/j.jiac.2020.04.007. [PMID: 32362440] - Kento Nakajima, Fumihiro Ogawa, Kazuya Sakai, Munehito Uchiyama, Yutaro Oyama, Hideaki Kato, Ichiro Takeuchi. A Case of Coronavirus Disease 2019 Treated With Ciclesonide.
Mayo Clinic proceedings.
2020 06; 95(6):1296-1297. doi:
10.1016/j.mayocp.2020.04.007. [PMID: 32402512] - Yu-Luan Chen, Weimin Wang, Armand Gatien Ngounou Wetie, Lei Shi, John Eddy, Zhong-Ping John Lin, Soujanya Sunkaraneni. An Ultrasensitive LC-APPI-MS/MS Method for Simultaneous Determination of Ciclesonide and Active Metabolite Desisobutyryl-Ciclesonide in Human Serum and Its Application to a Clinical Study.
The journal of applied laboratory medicine.
2020 01; 5(1):41-53. doi:
10.1373/jalm.2019.029397. [PMID: 31662413] - J-P Lavoie, M Bullone, N Rodrigues, P Germim, B Albrecht, M von Salis-Soglio. Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with experimentally induced mild to severe airway obstruction.
Equine veterinary journal.
2019 Nov; 51(6):779-786. doi:
10.1111/evj.13093. [PMID: 30854685] - Qi Yang, Fei Wang, Bin Li, Wenbin Wu, Dengpiao Xie, Li He, Nan Xiang, Yan Dong. The efficacy and safety of ciclesonide for the treatment of perennial allergic rhinitis: a systematic review and meta-analysis.
Brazilian journal of otorhinolaryngology.
2019 May; 85(3):371-378. doi:
10.1016/j.bjorl.2018.10.008. [PMID: 30522830] - Tao-Tao Fu, Yun Zhao, Fei-Fei Yang, Han Wen, Chun-Yu Liu, Yong-Hong Liao. Ciclesonide and budesonide suspensions for nebulization delivery: An in vivo inhalation biopharmaceutics investigation.
International journal of pharmaceutics.
2018 Oct; 549(1-2):21-30. doi:
10.1016/j.ijpharm.2018.07.048. [PMID: 30048776] - Jatinder Kaur Mukker, Ravi Shankar Prasad Singh, Hartmut Derendorf. Ciclesonide: A Pro-Soft Drug Approach for Mitigation of Side Effects of Inhaled Corticosteroids.
Journal of pharmaceutical sciences.
2016 09; 105(9):2509-2514. doi:
10.1016/j.xphs.2016.05.004. [PMID: 27339407] - Boška Hrvačić, Kristina Šitum, Koraljka Đurić, Berislav Bošnjak, Željko Ferenčić, Karmen Brajša, Stribor Marković, Ines Glojnarić. Relative potencies of three glucocorticoids to induce hypoplasia of the physis and concomitant biochemical alterations in the rat.
Drug and chemical toxicology.
2015; 38(3):272-7. doi:
10.3109/01480545.2014.947502. [PMID: 25109225] - Sharon Kramer, Bart L Rottier, Rob J P M Scholten, Nicole Boluyt. Ciclesonide versus other inhaled corticosteroids for chronic asthma in children.
The Cochrane database of systematic reviews.
2013 Feb; ?(2):CD010352. doi:
10.1002/14651858.cd010352. [PMID: 23450613] - Takahide Teramoto, Eiko Matsui, Toshiyuki Fukao, Kazuaki Sakai, Hiroshi Yonezawa, Zenichiro Kato, Hidenori Ohnishi, Hideo Kaneko, Naomi Kondo, Junichi Azuma, Sankei Nishima. Repeated-dose pharmacokinetics of inhaled ciclesonide (CIC-HFA) in Japanese children with bronchial asthma: a phase I study.
Allergology international : official journal of the Japanese Society of Allergology.
2012 Dec; 61(4):619-24. doi:
10.2332/allergolint.11-oa-0378. [PMID: 23000724] - Deepti Chopra, Bharti Bhandari, Neeta Wardhan. Ciclesonide--a novel corticosteroid for the management of asthma.
Current clinical pharmacology.
2012 May; 7(2):73-7. doi:
10.2174/157488412800228901. [PMID: 22283615] - Michela Silvestri, Fabio Morandi, Vito Pistoia, Ignazia Prigione, Giovanni A Rossi. Ciclesonide modulates in vitro allergen-driven activation of blood mononuclear cells and allergen-specific T-cell blasts.
Immunology letters.
2012 Jan; 141(2):190-6. doi:
10.1016/j.imlet.2011.10.003. [PMID: 22015638] - Paul H Ratner, Charles Andrews, Bruce Martin, William Howland, Shailesh Y Desai, Holly Huang, Joseph Hinkle, Fred Bode. A study of the efficacy and safety of ciclesonide hydrofluoroalkane nasal aerosol in patients with seasonal allergic rhinitis from mountain cedar pollen.
Allergy and asthma proceedings.
2012 Jan; 33(1):27-35. doi:
10.2500/aap.2012.33.3490. [PMID: 22370531] - Ashley Woodcock, Eugene R Bleecker, William W Busse, Jan Lötvall, Neil G Snowise, Lucy Frith, Loretta Jacques, Brett Haumann, Eric D Bateman. Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma.
Respiratory research.
2011 Dec; 12(?):160. doi:
10.1186/1465-9921-12-160. [PMID: 22188590] - Rituparna Maiti, Jyothirmai Jaida, Jalelur Rahman, Rajasri Gaddam, Anuradha Palani. Olopatadine hydrochloride and rupatadine fumarate in seasonal allergic rhinitis: A comparative study of efficacy and safety.
Journal of pharmacology & pharmacotherapeutics.
2011 Oct; 2(4):270-6. doi:
10.4103/0976-500x.85958. [PMID: 22025856] - Paul Ratner, Mark A Wingertzahn, Rolf Herzog, Holly Huang, Shailesh Y Desai, Gary Maier, Ruediger Nave. An investigation of the pharmacokinetics, pharmacodynamics, safety, and tolerability of ciclesonide hydrofluoroalkane nasal aerosol in healthy subjects and subjects with perennial allergic rhinitis.
Pulmonary pharmacology & therapeutics.
2011 Aug; 24(4):426-33. doi:
10.1016/j.pupt.2011.04.002. [PMID: 21501692] - Meng-xiang Su, Min Song, Ying Zhuang, Yong-qing Wang, Tai-Jun Hang. Simultaneous determination of ciclesonide and its active metabolite desisobutyryl-ciclesonide in human plasma by LC-APCI-MS/MS: application to pharmacokinetic study in healthy Chinese volunteers.
Journal of pharmaceutical and biomedical analysis.
2011 Apr; 55(1):230-5. doi:
10.1016/j.jpba.2011.01.009. [PMID: 21296519] - Jorge F Maspero, Hendrik Nolte, Iván Chérrez-Ojeda. Long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2010 Dec; 47(10):1106-15. doi:
10.3109/02770903.2010.514634. [PMID: 20874458] - Brian J O'Connor, Stephen Kilfeather, David Cheung, Henri Kafé, Mark D Blagden, Noël Schlösser, Jon G Ayres, Hans-Jochen Weber, Renate Engelstätter. Efficacy and safety of ciclesonide in patients with severe asthma: a 12-week, double-blind, randomized, parallel-group study with long-term (1-year) follow-up.
Expert opinion on pharmacotherapy.
2010 Dec; 11(17):2791-803. doi:
10.1517/14656566.2010.526603. [PMID: 20958119] - R Nave, H Watz, H Hoffmann, H Boss, H Magnussen. Deposition and metabolism of inhaled ciclesonide in the human lung.
The European respiratory journal.
2010 Nov; 36(5):1113-9. doi:
10.1183/09031936.00172309. [PMID: 20351025] - Søren Pedersen, Paul Potter, Svetoslav Dachev, Miroslava Bosheva, Jadwiga Kaczmarek, Ewa Springer, Jochen Dunkel, Renate Engelstätter. Efficacy and safety of three ciclesonide doses vs placebo in children with asthma: the RAINBOW study.
Respiratory medicine.
2010 Nov; 104(11):1618-28. doi:
10.1016/j.rmed.2010.06.012. [PMID: 20619624] - Jian Xu, Rüdiger Nave, Gezim Lahu, Eric Derom, Hartmut Derendorf. Population pharmacokinetics and pharmacodynamics of inhaled ciclesonide and fluticasone propionate in patients with persistent asthma.
Journal of clinical pharmacology.
2010 Oct; 50(10):1118-27. doi:
10.1177/0091270009354994. [PMID: 20150524] - Xiaofan Zhang, Julia Li Zhong, Wei Liu, Zuhua Gao, Xia Xue, Pan Yue, Limei Wang, Cuirong Zhao, Wenfang Xu, Xianjun Qu. N(3)-o-toluyl-fluorouracil inhibits human hepatocellular carcinoma cell growth via sustained release of 5-FU.
Cancer chemotherapy and pharmacology.
2010 May; 66(1):11-9. doi:
10.1007/s00280-009-1128-0. [PMID: 19756602] - Po-Chang Chiang, Yiding Hu, Jason D Blom, David C Thompson. Evaluating the suitability of using rat models for preclinical efficacy and side effects with inhaled corticosteroids nanosuspension formulations.
Nanoscale research letters.
2010 Apr; 5(6):1010-9. doi:
10.1007/s11671-010-9597-y. [PMID: 20672144] - Lone Agertoft, Søren Pedersen. Lower-leg growth rates in children with asthma during treatment with ciclesonide and fluticasone propionate.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2010 Feb; 21(1 Pt 2):e199-205. doi:
10.1111/j.1399-3038.2009.00879.x. [PMID: 19320851] - Ruediger Nave, Rolf Herzog, Aziz Laurent, Mark A Wingertzahn. Pharmacokinetics of ciclesonide and desisobutyryl ciclesonide after administration via aqueous nasal spray or hydrofluoroalkane nasal aerosol compared with orally inhaled ciclesonide: an open-label, single-dose, three-period crossover study in healthy volunteers.
Clinical therapeutics.
2009 Dec; 31(12):2988-99. doi:
10.1016/j.clinthera.2009.12.002. [PMID: 20110036] - Renate Engelstätter, M Szlávik, Claudia Gerber, Ekkehard Beck. Once-daily ciclesonide via metered-dose inhaler: Similar efficacy and safety with or without a spacer.
Respiratory medicine.
2009 Nov; 103(11):1643-50. doi:
10.1016/j.rmed.2009.06.004. [PMID: 19596188] - M van den Berge, S H Arshad, P W Ind, H Magnussen, E Hamelmann, F Kanniess, D S Postma. Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering.
Respiratory medicine.
2009 Aug; 103(8):1216-23. doi:
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