Pranlukast (BioDeep_00000015133)
natural product
代谢物信息卡片
Pranlukast
化学式: C27H23N5O4 (481.17499580000003)
中文名称: 普鲁司特
谱图信息:
最多检出来源 Escherichia coli(natural_products) 50%
分子结构信息
SMILES: C12=C(C=C(C=C1)NC(C3=CC=C(C=C3)OCCCCC4=CC=CC=C4)=O)OC(=CC2=O)C5=NN=NN5
InChI: InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DC - Leukotriene receptor antagonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94810
- KEGG: C71133
- KEGGdrug: D08408
- PubChem: 4887
- DrugBank: DB01411
- ChEMBL: CHEMBL21333
- CAS: 103177-37-3
- MoNA: CCMSLIB00000078304
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuanying Fang, Lamees Hegazy, Brian N Finck, Bahaa Elgendy. Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor.
Journal of medicinal chemistry.
2021 12; 64(24):17545-17571. doi:
10.1021/acs.jmedchem.1c01017. [PMID: 34889100] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Priyanka Lohar, Manish Kumar Sharma, Amit Kumar Sahu, Rajeswari Rathod, Pinaki Sengupta. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats.
Biomedical chromatography : BMC.
2019 Dec; 33(12):e4672. doi:
10.1002/bmc.4672. [PMID: 31386207] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Eric E Figueroa, Meghan Kramer, Kevin Strange, Jerod S Denton. CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
American journal of physiology. Cell physiology.
2019 10; 317(4):C857-C866. doi:
10.1152/ajpcell.00281.2019. [PMID: 31390227] - Hiromasa Uchiyama, Kazunori Kadota, Akihito Nakanishi, Mahamadou Tandia, Yuichi Tozuka. A simple blending with α-glycosylated naringin produces enhanced solubility and absorption of pranlukast hemihydrate.
International journal of pharmaceutics.
2019 Aug; 567(?):118490. doi:
10.1016/j.ijpharm.2019.118490. [PMID: 31271814] - Valérie Capra, Chiara Carnini, Maria Rosa Accomazzo, Antonio Di Gennaro, Marco Fiumicelli, Emanuele Borroni, Ivan Brivio, Carola Buccellati, Paolo Mangano, Silvia Carnevali, Gianenrico Rovati, Angelo Sala. Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.
Prostaglandins & other lipid mediators.
2015 Jul; 120(?):115-25. doi:
10.1016/j.prostaglandins.2015.03.007. [PMID: 25839425] - Q J Shi, H Wang, Z X Liu, S H Fang, X M Song, Y B Lu, W P Zhang, X Y Sa, H Z Ying, E Q Wei. HAMI 3379, a CysLT2R antagonist, dose- and time-dependently attenuates brain injury and inhibits microglial inflammation after focal cerebral ischemia in rats.
Neuroscience.
2015 Apr; 291(?):53-69. doi:
10.1016/j.neuroscience.2015.02.002. [PMID: 25681271] - Yanli Hao, Lan Wang, Jun Li, Nan Liu, Jinfeng Feng, Mojiao Zhao, Xiaoning Zhang. Enhancement of Solubility, Transport Across Madin-Darby Canine Kidney Monolayers and Oral Absorption of Pranlukast Through Preparation of a Pranlukast-Phospholipid Complex.
Journal of biomedical nanotechnology.
2015 Mar; 11(3):469-77. doi:
10.1166/jbn.2015.1914. [PMID: 26307829] - Eun-Sol Ha, In-hwan Baek, Jin-Wook Yoo, Yunjin Jung, Min-Soo Kim. Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization.
Drug design, development and therapy.
2015; 9(?):3257-66. doi:
10.2147/dddt.s87738. [PMID: 26150699] - Hikaru Sugihara, Yuji Matsui, Hirofumi Takeuchi, Ian Wilding, Alyson Connor, Kazuya Abe, Akio Nishiura. Development of a gastric retentive system as a sustained-release formulation of pranlukast hydrate and its subsequent in vivo verification in human studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Mar; 53(?):62-8. doi:
10.1016/j.ejps.2013.11.018. [PMID: 24316098] - Nutthapoom Pathomthongtaweechai, Sunhapas Soodvilai, Varanuj Chatsudthipong, Chatchai Muanprasat. Pranlukast inhibits renal epithelial cyst progression via activation of AMP-activated protein kinase.
European journal of pharmacology.
2014 Feb; 724(?):67-76. doi:
10.1016/j.ejphar.2013.12.013. [PMID: 24360935] - Yukitoshi Takahashi, Katsumi Imai, Hitoshi Ikeda, Yuko Kubota, Etsuko Yamazaki, Fuminobu Susa. Open study of pranlukast add-on therapy in intractable partial epilepsy.
Brain & development.
2013 Mar; 35(3):236-44. doi:
10.1016/j.braindev.2012.04.001. [PMID: 22571867] - Myoung-Ki Baek, Jong-Hwa Lee, Young-Ho Cho, Hak-Hyung Kim, Gye-Won Lee. Self-microemulsifying drug-delivery system for improved oral bioavailability of pranlukast hemihydrate: preparation and evaluation.
International journal of nanomedicine.
2013; 8(?):167-76. doi:
10.2147/ijn.s37338. [PMID: 23326192] - San-hua Fang, Ka-na Lin, Xue-qin Huang, Yun-bi Lu, Wei-ping Zhang, Er-qing Wei. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells.
Acta pharmacologica Sinica.
2012 Dec; 33(12):1511-7. doi:
10.1038/aps.2012.101. [PMID: 23085741] - H Hirata, M Arima, Y Fukushima, K Honda, K Sugiyama, T Tokuhisa, T Fukuda. Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2011 Aug; 41(8):1133-42. doi:
10.1111/j.1365-2222.2011.03720.x. [PMID: 21429049] - H Taki, K Shinoda, H Hounoki, R Ogawa, S Ishizawa, E Sugiyama, K Tobe. Serum interleukin-5 levels correlate with disease activity of Churg-Strauss syndrome in a patient treated with a leucotriene receptor antagonist, pranlukast, and inhaled corticosteroid.
Scandinavian journal of rheumatology.
2010 Aug; 39(4):341-3. doi:
10.3109/03009740903270573. [PMID: 20560805] - Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Koichi Noguchi. Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.
Glia.
2010 Apr; 58(5):599-610. doi:
10.1002/glia.20948. [PMID: 19908283] - Yoko Yamakawa, Yoshikazu Ohtsuka, Kiyotaka Ohtani, Tohru Fujii, Satoru Nagata, Yuichiro Yamashiro, Toshiaki Shimizu. Effects of leukotriene receptor antagonists on peripheral eosinophil counts and serum IgE levels in children with food allergy.
Drugs in R&D.
2010; 10(3):147-54. doi:
10.2165/11586150-000000000-00000. [PMID: 20945945] - Hironori Sagara, Tatsuo Yukawa, Ryuichi Kashima, Takenori Okada, Takeshi Fukuda. Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Allergology international : official journal of the Japanese Society of Allergology.
2009 Jun; 58(2):277-87. doi:
10.2332/allergolint.08-oa-0058. [PMID: 19390239] - Susumu Nakade, Akinori Yamauchi, Junji Komaba, Tomoya Ohno, Junsaku Kitagawa, Naoki Honda, Chihiro Hasegawa, Kazuhiro Yoneda, Yasuo Kodama, Kuninobu Yasuda, Junichi Azuma, Yasuyuki Miyata. Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers.
Drug metabolism and pharmacokinetics.
2008; 23(6):428-33. doi:
10.2133/dmpk.23.428. [PMID: 19122337] - Takuto Mizoe, Tetsuya Ozeki, Hiroaki Okada. Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms.
Journal of controlled release : official journal of the Controlled Release Society.
2007 Sep; 122(1):10-5. doi:
10.1016/j.jconrel.2007.06.001. [PMID: 17655963] - Takahiko Horiguchi, Soichi Tachikawa, Rieko Kondo, Junichi Miyazaki, Mamoru Shiga, Masahiro Hirose, Kashin Kobayashi, Nobuyuki Hayashi, Daisuke Ohira, Toshinori Nasu, Yoichiro Otake, Hideharu Hata. Comparative evaluation of the leukotriene receptor antagonist pranlukast versus the steroid inhalant fluticasone in the therapy of aged patients with mild bronchial asthma.
Arzneimittel-Forschung.
2007; 57(2):87-91. doi:
10.1055/s-0031-1296588. [PMID: 17396618] - Kazutaka Tokita, Yasuhiro Uchida, Tetsuro Yamamoto. Roles of leukocytosis and cysteinyl leukotriene in polymorphonuclear leukocyte-dependent plasma extravasation.
Journal of leukocyte biology.
2006 Dec; 80(6):1308-19. doi:
10.1189/jlb.0805488. [PMID: 16940329] - Fumiaki Yamashita, Hisakazu Ohtani, Noriko Koyabu, Fumihiko Ushigome, Hiroki Satoh, Hideyasu Murakami, Takeshi Uchiumi, Takanori Nakamura, Michihiko Kuwano, Masayuki Tsujimoto, Yasufumi Sawada. Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
The Journal of pharmacy and pharmacology.
2006 Nov; 58(11):1499-505. doi:
10.1211/jpp.58.11.0011. [PMID: 17132213] - Hideaki Shirasaki, Etsuko Kanaizumi, Nobuhiko Seki, Megumi Kikuchi, Kazumasa Watanabe, Nobuhiro Konno, Tetsuo Himi. Distribution of specific binding sites for cysteinyl leukotriene 1 receptor antagonist in human nasal mucosa.
Acta oto-laryngologica.
2006 Sep; 126(9):948-51. doi:
10.1080/00016480500540493. [PMID: 16864492] - Susumu Nakade, Shinya Ueda, Tomoya Ohno, Kazuki Nakayama, Yasuyuki Miyata, Eiji Yukawa, Shun Higuchi. Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.
Drug metabolism and pharmacokinetics.
2006 Apr; 21(2):133-9. doi:
10.2133/dmpk.21.133. [PMID: 16702733] - Liaman Mamedova, Valérie Capra, Maria Rosa Accomazzo, Zhan-Guo Gao, Silvia Ferrario, Marta Fumagalli, Maria P Abbracchio, G Enrico Rovati, Kenneth A Jacobson. CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors.
Biochemical pharmacology.
2005 Dec; 71(1-2):115-25. doi:
10.1016/j.bcp.2005.10.003. [PMID: 16280122] - Toshishige Shibamoto, Zonghai Ruan, Sen Cui, Wei Liu, Yasutaka Kurata. Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers.
Prostaglandins & other lipid mediators.
2005 Dec; 78(1-4):218-30. doi:
10.1016/j.prostaglandins.2005.08.003. [PMID: 16303618] - Kyung S Lee, So R Kim, Hee S Park, Gong Y Jin, Yong C Lee. Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression.
The Journal of allergy and clinical immunology.
2004 Nov; 114(5):1093-9. doi:
10.1016/j.jaci.2004.07.039. [PMID: 15536415] - Yasutomo Nakanishi, Takeshi Nabe, Nobuaki Mizutani, Hiroshi Takenaka, Shigekatsu Kohno. Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs.
Prostaglandins & other lipid mediators.
2004 Oct; 74(1-4):125-37. doi:
10.1016/j.prostaglandins.2004.07.006. [PMID: 15560121] - Y Tsuji, Y Abe, M Hisano, T Sakai. Urinary leukotriene E4 in Henoch-Schonlein purpura.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2004 Aug; 34(8):1259-61. doi:
10.1111/j.1365-2222.2004.02029.x. [PMID: 15298567] - Takahiko Horiguchi, Rieko Kondo, Junici Miyazaki, Mamoru Shiga, Masahiro Sugiyama, Masahiro Hirose, Soichi Tachikawa. [Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society.
2003 Oct; 41(10):696-703. doi:
NULL. [PMID: 14584388] - Anna M Feldweg, Daniel S Friend, Joseph S Zhou, Yoshihide Kanaoka, Massoud Daheshia, Lin Li, K Frank Austen, Howard R Katz. gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo.
European journal of immunology.
2003 Aug; 33(8):2262-8. doi:
10.1002/eji.200323978. [PMID: 12884301] - Takahiko Horiguchi, Soichi Tachikawa, Rieko Kondo, Mamoru Shiga, Masahiro Hirose, Tomohiro Ito. Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma.
Arzneimittel-Forschung.
2003; 53(10):714-21. doi:
10.1055/s-0031-1299817. [PMID: 14650364] - James P Kemp. Recent advances in the management of asthma using leukotriene modifiers.
American journal of respiratory medicine : drugs, devices, and other interventions.
2003; 2(2):139-56. doi:
10.1007/bf03256645. [PMID: 14720013] - Takeshi Terashima, Kazuhisa Amakawa, Akiko Matsumaru, Kazuhiro Yamaguchi. Correlation between cysteinyl leukotriene release from leukocytes and clinical response to a leukotriene inhibitor.
Chest.
2002 Nov; 122(5):1566-70. doi:
10.1378/chest.122.5.1566. [PMID: 12426254] - Kenji Baba, Ayako Sakakibara, Takeo Yagi, Sayaka Niwa, Hideo Wakayama, Kenzo Takagi. Long-term observations of the clinical course after step down of corticosteroid inhalation therapy in adult chronic asthmatics: correlation with serum levels of eosinophil cationic protein.
Respirology (Carlton, Vic.).
2002 Sep; 7(3):255-66. doi:
10.1046/j.1440-1843.2002.00389.x. [PMID: 12153692] - T Nabe, K Yamashita, M Miura, T Kawai, S Kohno. Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2002 Apr; 32(4):633-40. doi:
10.1046/j.0954-7894.2002.01329.x. [PMID: 11972613] - Yasushi Obase, Terufumi Shimoda, Shin-ya Tomari, Kazuko Mitsuta, Tetsuya Kawano, Hiroto Matsuse, Shigeru Kohno. Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.
Chest.
2002 Jan; 121(1):143-50. doi:
10.1378/chest.121.1.143. [PMID: 11796443] - Masato Horikawa, Yukio Kato, Charles A Tyson, Yuichi Sugiyama. The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
Drug metabolism and pharmacokinetics.
2002; 17(1):23-33. doi:
10.2133/dmpk.17.23. [PMID: 15618649] - Y Obase, T Shimoda, S Tomari, K Mitsuta, C Fukushima, T Kawano, H Matsuse, S Kohno. Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2001 Jul; 87(1):74-9. doi:
10.1016/s1081-1206(10)62328-9. [PMID: 11476469] - M Hashimoto, T Fujishima, H Tanaka, H Kon, T Saikai, A Suzuki, M Nakatsugawa, S Abe. Churg-Strauss syndrome after reduction of inhaled corticosteroid in a patient treated with pranlukast for asthma.
Internal medicine (Tokyo, Japan).
2001 May; 40(5):432-4. doi:
10.2169/internalmedicine.40.432. [PMID: 11393418] - N Takahashi, Y Ishibashi, Y Murakami, H Shimizu, Y Ohta, T Asanuma, H Katoh, K Sano, T Shimada. Beneficial effect of combination therapy with ozagrel and pranlukast in exercise-induced asthma demonstrated by krypton-81 m ventilation scintigraphy--a case report.
Annals of the Academy of Medicine, Singapore.
2000 Nov; 29(6):766-9. doi:
NULL. [PMID: 11269987] - M Kodani, N Sakata, Y Takano, H Kamiya, T Katsuragi, T E Hugli, M Abe. Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes.
Immunopharmacology.
2000 Sep; 49(3):263-74. doi:
10.1016/s0162-3109(00)00240-x. [PMID: 10996024] - Y Arakida, K Ohga, Y Okada, H Morio, K Suwa, M Yokota, T Yamada. Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs.
European journal of pharmacology.
2000 Sep; 403(1-2):169-79. doi:
10.1016/s0014-2999(00)00583-5. [PMID: 10969159] - H Suguro, T Majima, T Hattori, K Ichimura, N Hashimoto, T Horie. [Effect of a leukotriene antagonist, pranlukast hydrate, on exercise-induced asthma for 14 days].
Arerugi = [Allergy].
2000 Aug; 49(8):646-52. doi:
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Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2000 Jul; 30(7):1008-14. doi:
10.1046/j.1365-2222.2000.00834.x. [PMID: 10848924] - Y Arakida, K Ohga, K Suwa, Y Okada, H Morio, M Yokota, K Miyata, T Yamada, K Honda. Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyper-responsiveness in guinea pigs.
Japanese journal of pharmacology.
2000 Apr; 82(4):287-94. doi:
10.1254/jjp.82.287. [PMID: 10875747] - S Yoshida, H Sakamoto, Y Ishizaki, K Onuma, T Shoji, H Nakagawa, H Hasegawa, M Nakabayashi, H Amayasu. Efficacy of leukotriene receptor antagonist in bronchial hyperresponsiveness and hypersensitivity to analgesic in aspirin-intolerant asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2000 Jan; 30(1):64-70. doi:
10.1046/j.1365-2222.2000.00797.x. [PMID: 10606932] - M Fujimura, M Abo, Y Kamio, S Myou, Y Ishiura, T Hashimoto, T Matsuda. Effect of leukotriene and thromboxane antagonist on propranolol-induced bronchoconstriction.
American journal of respiratory and critical care medicine.
1999 Dec; 160(6):2100-3. doi:
10.1164/ajrccm.160.6.9902110. [PMID: 10588635] - S Ishioka, S Hozawa, Y Haruta, K Hiyama, A Maeda, M Yamakido. Pranlukast, a cysteinyl leukotriene antagonist, reduces serum eosinophil cationic protein levels in patients with asthma.
Hiroshima journal of medical sciences.
1999 Dec; 48(4):105-10. doi:
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The Journal of pharmacology and experimental therapeutics.
1999 Sep; 290(3):1285-91. doi:
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Molecular pharmacology.
1999 Sep; 56(3):657-63. doi:
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The Journal of allergy and clinical immunology.
1999 Sep; 104(3 Pt 1):585-8. doi:
10.1016/s0091-6749(99)70327-1. [PMID: 10482831] - H Tanaka, T Saito, K Kurokawa, S Teramoto, N Miyazaki, S Kaneko, M Hashimoto, S Abe. Leukotriene (LT)-receptor antagonist is more effective in asthmatic patients with a low baseline ratio of urinary LTE4 to 2,3-dinor-6-keto-prostaglandin (PG)F1alpha.
Allergy.
1999 May; 54(5):489-94. doi:
10.1034/j.1398-9995.1999.00011.x. [PMID: 10380781] - G Bannenberg, S E Dahlén, M Luijerink, G Lundqvist, R Morgenstern. Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers.
The Journal of biological chemistry.
1999 Jan; 274(4):1994-9. doi:
10.1074/jbc.274.4.1994. [PMID: 9890956] - T Horiguchi, S Tachikawa, J Kasahara, M Doi, M Shiga. Effects of pranlukast hydrate on serum eosinophil cationic protein levels in patients with adult bronchial asthma.
Arzneimittel-Forschung.
1999 Jan; 49(1):35-7. doi:
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Pharmaceutical research.
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