Lacidipine (BioDeep_00000015131)
natural product
代谢物信息卡片
"Lacidipine (Lacipil, Motens)"
化学式: C26H33NO6 (455.23077580000006)
中文名称: 拉西地平
谱图信息:
最多检出来源 Escherichia coli(natural_products) 56.25%
分子结构信息
SMILES: C1=CC=CC(=C1C2C(=C(NC(=C2C(OCC)=O)C)C)C(OCC)=O)/C=C/C(=O)OC(C)(C)C
InChI: InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
2 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:135737
- ChEBI: CHEBI:94480
- KEGG: C71162
- KEGGdrug: D04657
- PubChem: 5311217
- Metlin: METLIN915
- DrugBank: DB09236
- ChEMBL: CHEMBL1728809
- ChEMBL: CHEMBL460291
- CAS: 103890-78-4
- MoNA: FiehnHILIC002789
- MoNA: FiehnHILIC002041
- MoNA: FiehnHILIC001288
- MoNA: FiehnHILIC000468
- MoNA: CCMSLIB00000078377
- MoNA: CCMSLIB00000078376
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ashveta Anant Dessai, Mrunali Navin Kantak, Cleona Elizabeth Mary DCruz, Lalit Kumar, Prashant Jivaji Bhide, Rupesh Kalidas Shirodkar. Formulation and Characterization of Nanoparticulate Drug Carrier System for Lacidipine.
Assay and drug development technologies.
2023 10; 21(7):309-324. doi:
10.1089/adt.2023.023. [PMID: 37831909] - Dheeraj Kataria, Ameeduzzafar Zafar, Javed Ali, Karishma Khatoon, Saba Khan, Syed Sarim Imam, Mohd Yasir, Asgar Ali. Formulation of Lipid-Based Nanocarriers of Lacidipine for Improvement of Oral Delivery: Box-Behnken Design Optimization, In Vitro, Ex Vivo, and Preclinical Assessment.
Assay and drug development technologies.
2022 01; 20(1):5-21. doi:
10.1089/adt.2021.084. [PMID: 34978917] - Kunal Khurana, Manish Kumar, Nitin Bansal. Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice.
Neurotoxicity research.
2021 Dec; 39(6):1920-1936. doi:
10.1007/s12640-021-00421-2. [PMID: 34613588] - Jian Guan, Xu Huan, Qiaoyu Liu, Liwei Jin, Haiyang Wu, Xin Zhang, Shirui Mao. Synergetic effect of nucleation and crystal growth inhibitor on in vitro-in vivo performance of supersaturable lacidipine solid dispersion.
International journal of pharmaceutics.
2019 Jul; 566(?):594-603. doi:
10.1016/j.ijpharm.2019.06.010. [PMID: 31175988] - Michele Bombelli, Mario Macchiarulo, Rita Facchetti, Davide Maggiolini, Cesare Cuspidi, Gianfranco Parati, Giuseppe Mancia, Guido Grassi. Serum uric acid and resistance to antihypertensive treatment: data from the European Lacidipine Study on Atherosclerosis.
Journal of hypertension.
2019 04; 37(4):844-850. doi:
10.1097/hjh.0000000000001951. [PMID: 30817467] - So-Yeon Jeon, Na-Ri Lee, Chang-Yeol Yim. Successful re-administration of Pazopanib in a patient with metastatic renal cell carcinoma and a history of Pazopanib-induced nephrotic syndrome: a case report.
BMC nephrology.
2019 01; 20(1):1. doi:
10.1186/s12882-018-1181-1. [PMID: 30606155] - Hao Chen, Lan Li, Shuai Song, Yan Du, Xiaoqin Jin, PeiPei Ding, Chenlin Shen, Xiaohui Huang. Determination of lacidipine in human plasma by LC-MS/MS: Application in a bioequivalence study
.
International journal of clinical pharmacology and therapeutics.
2018 Oct; 56(10):493-500. doi:
10.5414/cp203250. [PMID: 30079887] - Natesan Subramanian, Shanmugam Palaniappan Sharavanan, Ponnusamy Chandrasekar, Alagar Balakumar, Satya Priya Moulik. Lacidipine self-nanoemulsifying drug delivery system for the enhancement of oral bioavailability.
Archives of pharmacal research.
2016 Apr; 39(4):481-491. doi:
10.1007/s12272-015-0657-9. [PMID: 26362165] - Oskar González, Michael van Vliet, Carola W N Damen, Frans M van der Kloet, Rob J Vreeken, Thomas Hankemeier. Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.
Analytical chemistry.
2015 Jun; 87(12):5921-9. doi:
10.1021/ac504268y. [PMID: 25965142] - Rupesh Shirodkar, Chandrasekhar Misra, Chethan Gh, Pallavi Shetty, Zenab Attari, Srinivas Mutalik, Shaila Lewis. Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats.
TheScientificWorldJournal.
2015; 2015(?):947623. doi:
10.1155/2015/947623. [PMID: 26101786] - E Bernard, V Mialou, A Dony, N Garnier, C Renard, N Bleyzac. [Lacidipine efficacy and safety for high blood pressure treatment in pediatric oncohematology].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2014 Oct; 21(10):1101-5. doi:
10.1016/j.arcped.2014.06.028. [PMID: 25125033] - Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Scientific reports.
2014 Sep; 4(?):6437. doi:
10.1038/srep06437. [PMID: 25257666] - Yajie Geng, Longshan Zhao, Juanhang Zhao, Bei Guo, Panqin Ma, Yuanyuan Li, Tianhong Zhang. Development of a supercritical fluid chromatography-tandem mass spectrometry method for the determination of lacidipine in beagle dog plasma and its application to a bioavailability study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jan; 945-946(?):121-6. doi:
10.1016/j.jchromb.2013.11.029. [PMID: 24333769] - Sahar Mohamed Kamal. Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats.
Pakistan journal of biological sciences : PJBS.
2013 Nov; 16(21):1353-7. doi:
10.3923/pjbs.2013.1353.1357. [PMID: 24511746] - Pankaj Kisan Chatki, Kishore Kumar Hotha, Pandu Ranga Reddy Kolagatla, D Vijaya Bharathi, V Venkateswarulu. LC-MS/MS determination and pharmacokinetic study of lacidipine in human plasma.
Biomedical chromatography : BMC.
2013 Jul; 27(7):838-45. doi:
10.1002/bmc.2868. [PMID: 23460049] - Aiqi Zhang, Shuli Fu, Lan Chen, Lihong Ren, Shuqiang Qu, Yujing Zhang, Li Yao, Shufen Yang. Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 32(4):1040-9. doi:
10.1159/000354504. [PMID: 24107594] - Murat Yigiter, Abdullah Yildiz, Beyzagul Polat, Hamit Hakan Alp, Osman Nuri Keles, Ahmet Bedii Salman, Halis Suleyman. The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.
Surgery today.
2012 Nov; 42(11):1051-60. doi:
10.1007/s00595-011-0074-8. [PMID: 22202971] - Vijaya Kumari Karra, Nageswara Rao Pilli, Srinivasa Rao Polagani, Jaswanth Kumar Inamadugu, J V L N Seshagiri Rao. Liquid chromatography-tandem mass spectrometric assay for the light sensitive calcium channel antagonist lacidipine in human plasma.
Journal of pharmaceutical and biomedical analysis.
2012 Jul; 66(?):211-7. doi:
10.1016/j.jpba.2012.02.022. [PMID: 22459503] - Günay Yetik Anacak, Levent Ustünes, Ozlem Yilmaz Dilsiz, Adviye Ergul. Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure.
Vascular pharmacology.
2010 Nov; 53(5-6):193-9. doi:
10.1016/j.vph.2010.08.003. [PMID: 20709189] - Emad B Basalious, Nevine Shawky, Shaimaa M Badr-Eldin. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization.
International journal of pharmaceutics.
2010 May; 391(1-2):203-11. doi:
10.1016/j.ijpharm.2010.03.008. [PMID: 20214965] - Gannu Ramesh, Yamsani Vamshi Vishnu, Palem Chinna Reddy, Yamsani Shravan Kumar, Yamsani Madhusudan Rao. Development of high performance liquid chromatography method for lacidipine in rabbit serum: application to pharmacokinetic study.
Analytica chimica acta.
2009 Jan; 632(2):278-83. doi:
10.1016/j.aca.2008.11.018. [PMID: 19110105] - Jing Tang, Ronghua Zhu, Ruike Zhao, Gang Cheng, Wenxing Peng. Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2008 Aug; 47(4-5):923-8. doi:
10.1016/j.jpba.2008.04.018. [PMID: 18534803] - Alberto Zanchetti, Micheal Hennig, Hansjoerg Baurecht, Rong Tang, Cesare Cuspidi, Stefano Carugo, Giuseppe Mancia. Prevalence and incidence of the metabolic syndrome in the European Lacidipine Study on Atherosclerosis (ELSA) and its relation with carotid intima-media thickness.
Journal of hypertension.
2007 Dec; 25(12):2463-70. doi:
10.1097/hjh.0b013e3282f063d5. [PMID: 17984668] - Jan Kyselovic, Peter Martinka, Zuzana Batova, Andrea Gazova, Theophile Godfraind. Calcium channel blocker inhibits Western-type diet-evoked atherosclerosis development in ApoE-deficient mice.
The Journal of pharmacology and experimental therapeutics.
2005 Oct; 315(1):320-8. doi:
10.1124/jpet.105.089847. [PMID: 16020630] - D R J Kuypers, H H Neumayer, L Fritsche, K Budde, J L Rodicio, Y Vanrenterghem. Calcium channel blockade and preservation of renal graft function in cyclosporine-treated recipients: a prospective randomized placebo-controlled 2-year study.
Transplantation.
2004 Oct; 78(8):1204-11. doi:
10.1097/01.tp.0000137793.23371.42. [PMID: 15502721] - N V S Ramakrishna, K N Vishwottam, S Puran, S Manoj, M Santosh, M Koteshwara. Simple, sensitive and rapid liquid chromatographic/electrospray ionization tandem mass spectrometric method for the quantification of lacidipine in human plasma.
Journal of mass spectrometry : JMS.
2004 Jul; 39(7):824-32. doi:
10.1002/jms.664. [PMID: 15282762] - Patrizia G Cristofori, Federica A Crivellente, Ivo Faustinelli, Anna R Lanzoni, Chiara Lazzarini, Elena Vecchiato, Michela Andreoli, John A Turton, Carlo Zancanaro, Francesco M Crespi. Involvement of the nitric oxide system in the anti-atherosclerotic potential of lacidipine in the ApoE-deficient mouse: a morphological, functional, and electrochemical study.
Toxicologic pathology.
2004 Jul; 32(4):493-9. doi:
10.1080/01926230490483351. [PMID: 15223775] - Patrizia Cristofori, Federica Crivellente, Mario Campagnola, Anna Fratta Pasini, Ulisse Garbin, Anna Rigoni, Maria Tosetti, John Turton, Ivo Faustinelli, Luciano Cominacini. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice treated with lacidipine is associated with a decreased susceptibility of low-density lipoprotein to oxidation.
International journal of experimental pathology.
2004 Apr; 85(2):105-14. doi:
10.1111/j.0959-9673.2004.00375.x. [PMID: 15154916] - Germaine Escames, Hoda Khaldy, Josefa León, Luis González, Darío Acuña-Castroviejo. Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine.
Journal of hypertension.
2004 Mar; 22(3):629-35. doi:
10.1097/00004872-200403000-00027. [PMID: 15076170] - Paul L McCormack, Antona J Wagstaff. Lacidipine: a review of its use in the management of hypertension.
Drugs.
2003; 63(21):2327-56. doi:
10.2165/00003495-200363210-00008. [PMID: 14524737] - F Boffi, S Grande, S Marzi, M Dell'Ariccia, A Rosi, V Viti, A Congiu Castellano. MRS study of the interaction of dihydropyridines with lipid molecules in phosphatidylcholine vesicles.
Physiological chemistry and physics and medical NMR.
2003; 35(1):55-72. doi:
NULL. [PMID: 15139283] - Lucio Da Ros, Lisa Squassante, Stefano Milleri. Dose linearity of lacidipine pharmacokinetics after single and repeated oral doses in healthy volunteers.
Clinical pharmacokinetics.
2003; 42(1):99-106. doi:
10.2165/00003088-200342010-00004. [PMID: 12489980] - V R Kharat, K K Verma, J D Dhake. Determination of lacidipine from urine by HPTLC using off-line SPE.
Journal of pharmaceutical and biomedical analysis.
2002 May; 28(3-4):789-93. doi:
10.1016/s0731-7085(01)00584-2. [PMID: 12008159] - B L Salako, F O Finomo, S Kadiri, A Arije, A O Olatosin. Comparative effect of lisinopril and lacidipine on urinary albumin excretion in patients with type 11 diabetic nephropathy.
African journal of medicine and medical sciences.
2002 Mar; 31(1):53-7. doi:
NULL. [PMID: 12518931] - Joon-Keun Park, Anette Fiebeler, Dominik N Muller, Eero M A Mervaala, Ralf Dechend, Faikah Abou-Rebyeh, Friedrich C Luft, Hermann Haller. Lacidipine inhibits adhesion molecule and oxidase expression independent of blood pressure reduction in angiotensin-induced vascular injury.
Hypertension (Dallas, Tex. : 1979).
2002 Feb; 39(2 Pt 2):685-9. doi:
10.1161/hy0202.103482. [PMID: 11882631] - I I Lapchyns'ka, T Ie Zhurylo, M M Seliuk, A Ie Hromova. [Therapeutic efficacy of lacidipine in patients with chronic glomerulonephritis and diabetic nephropathy].
Likars'ka sprava.
2002; ?(2):116-20. doi:
NULL. [PMID: 12073241] - B A Sidorenko, T M Stetsenko, D V Preobrazhenskiĭ, M V Savchenko, A V Soplevenko, E N Shabaeva. [Third generation of calcium antagonists: focus on lacidipine].
Kardiologiia.
2002; 42(12):81-90. doi:
NULL. [PMID: 12494025] - J Kyselovic, P Krenek, M Wibo, T Godfraind. Effects of amlodipine and lacidipine on cardiac remodelling and renin production in salt-loaded stroke-prone hypertensive rats.
British journal of pharmacology.
2001 Dec; 134(7):1516-22. doi:
10.1038/sj.bjp.0704398. [PMID: 11724758] - A Benigni, E Gagliardini, A Remuzzi, D Corna, G Remuzzi. Angiotensin-converting enzyme inhibition prevents glomerular-tubule disconnection and atrophy in passive Heymann nephritis, an effect not observed with a calcium antagonist.
The American journal of pathology.
2001 Nov; 159(5):1743-50. doi:
10.1016/s0002-9440(10)63021-0. [PMID: 11696435] - S Taddei, A Virdis, L Ghiadoni, A Magagna, A F Pasini, U Garbin, L Cominacini, A Salvetti. Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients.
Journal of hypertension.
2001 Aug; 19(8):1379-86. doi:
10.1097/00004872-200108000-00005. [PMID: 11518845] - P Krenek, S Salomone, J Kyselovic, M Wibo, N Morel, T Godfraind. Lacidipine prevents endothelial dysfunction in salt-loaded stroke-prone hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2001 Apr; 37(4):1124-8. doi:
10.1161/01.hyp.37.4.1124. [PMID: 11304513] - L Ziviani, L Da Ros, L Squassante, S Milleri, M Cugola, L E Iavarone. The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects.
British journal of clinical pharmacology.
2001 Feb; 51(2):147-52. doi:
10.1111/j.1365-2125.2001.bcp119.x. [PMID: 11259986] - R Fogari, A Zoppi, L Corradi, P Preti, G D Malalamani, A Mugellini. Effects of different dihydropyridine calcium antagonists on plasma norepinephrine in essential hypertension.
Journal of hypertension.
2000 Dec; 18(12):1871-5. doi:
10.1097/00004872-200018120-00023. [PMID: 11132613] - P Cristofori, A Lanzoni, M Quartaroli, A M Pastorino, C Zancanaro, L Cominacini, G Gaviraghi, J Turton. The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse.
Journal of hypertension.
2000 Oct; 18(10):1429-36. doi:
10.1097/00004872-200018100-00010. [PMID: 11057430] - M C Armas-Padilla, M J Armas-Hernández, R Hernández-Hernández, M Velasco, B Pacheco, A R Carvajal, A Castillo-Moreno. Effect of lacidipine and nifedipine GITS on platelet function in patients with essential hypertension.
Journal of human hypertension.
2000 Apr; 14 Suppl 1(?):S91-5. doi:
10.1038/sj.jhh.1000993. [PMID: 10854087] - P Cristofori, A Lanzoni, G Gaviraghi, J Turton, A Sbarbati. Anti-atherosclerotic activity of the calcium antagonist lacidipine in cholesterol-fed hamsters.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2000 Mar; 54(2):93-9. doi:
10.1016/s0753-3322(00)88858-7. [PMID: 10759293] - J L Rodicio. Calcium antagonists and renal protection from cyclosporine nephrotoxicity: long-term trial in renal transplantation patients.
Journal of cardiovascular pharmacology.
2000; 35(3 Suppl 1):S7-11. doi:
10.1097/00005344-200000001-00002. [PMID: 11347860] - S Bellosta, F Bernini. Lipophilic calcium antagonists in antiatherosclerotic therapy.
Current atherosclerosis reports.
2000 Jan; 2(1):76-81. doi:
10.1007/s11883-000-0098-9. [PMID: 11122728] - C Napoli, S Salomone, T Godfraind, W Palinski, D M Capuzzi, G Palumbo, F P D'Armiento, R Donzelli, F de Nigris, R L Capizzi, M Mancini, J S Gonnella, A Bianchi. 1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats.
Stroke.
1999 Sep; 30(9):1907-15. doi:
10.1161/01.str.30.9.1907. [PMID: 10471444] - A Cosenzi, E Bernobich, N Plazzotta, P Seculin, G Odoni, G Bellini. Lacidipine reduces high blood pressure and the target organ damage induced by high fructose diet in rats.
Journal of hypertension.
1999 Jul; 17(7):965-71. doi:
10.1097/00004872-199917070-00013. [PMID: 10419070] - H Funato, M Watanabe, A Uemura. Therapeutic effects of a calcium antagonist, lacidipine, on stroke-prone spontaneously hypertensive rats with cerebrovascular lesions.
Japanese journal of pharmacology.
1999 Jul; 80(3):199-208. doi:
10.1254/jjp.80.199. [PMID: 10461764] - E Bonora, G Targher, M Alberiche, R C Bonadonna, F Saggiani, M B Zenere, S Uleri, M Muggeo. Effect of chronic treatment with lacidipine or lisinopril on intracellular partitioning of glucose metabolism in type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism.
1999 May; 84(5):1544-50. doi:
10.1210/jcem.84.5.5700. [PMID: 10323377] - A Cosenzi, A Sacerdote, P Seculin, G Odoni, N Plazzotta, E Bernobich, G Bellini. Lacidipine prevents the hypertension and renal and cardiac changes induced by high-fructose diet in WKY rats.
Journal of cardiovascular pharmacology.
1999 Mar; 33(3):485-91. doi:
10.1097/00005344-199903000-00020. [PMID: 10069686] - A Fassi, F Sangalli, F Colombi, N Perico, G Remuzzi, A Remuzzi. Beneficial effects of calcium channel blockade on acute glomerular hemodynamic changes induced by cyclosporine.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1999 Feb; 33(2):267-75. doi:
10.1016/s0272-6386(99)70299-4. [PMID: 10023637] - M U Naidu, K V Kumar, A A Shifow, A Prayag, K S Ratnakar. Lacidipine protects against cyclosporine-induced nephrotoxicity in rats.
Nephron.
1999 Jan; 81(1):60-6. doi:
10.1159/000045247. [PMID: 9884421] - S C Amuchastegui, N Azzollini, M Mister, A Pezzotta, N Perico, G Remuzzi. Chronic allograft nephropathy in the rat is improved by angiotensin II receptor blockade but not by calcium channel antagonism.
Journal of the American Society of Nephrology : JASN.
1998 Oct; 9(10):1948-55. doi:
10.1681/asn.v9101948. [PMID: 9773797] - Y Hamada, Y Futamura. Induction of Leydig cell tumors by lacidipine via up-regulation of the LHRH receptor on Leydig cells in rats.
The Journal of toxicological sciences.
1998 Feb; 23(1):35-52. doi:
10.2131/jts.23.35. [PMID: 9513920] - M Aiello, O Moran, M Pisciotta, F Gambale. Interaction between dihydropyridines and phospholipid bilayers: a molecular dynamics simulation.
European biophysics journal : EBJ.
1998; 27(3):211-8. doi:
10.1007/s002490050127. [PMID: 9615394] - R R Bailey, B I Shand, A H Smith, R A Robson, K L Lynn. Effect of lacidipine, a dihydropyridine calcium antagonist on renal function of hypertensive patients with renal insufficiency.
Clinical nephrology.
1997 Oct; 48(4):224-9. doi:
NULL. [PMID: 9352156] - S Liu, S Ou, Q Zheng. [Effects of lacidipine on serum oxygen free radicals and fasting levels of insulin in patients with essential hypertension].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
1997; 22(1):53-5, 58. doi:
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American journal of hypertension.
1996 Sep; 9(9):895-901. doi:
10.1016/s0895-7061(96)00177-x. [PMID: 8879346] - M R Soma, E Donetti, R Seregni, L Barberi, R Fumagalli, R Paoletti, A L Catapano. Effect of lacidipine on fatty and proliferative lesions induced in hypercholesterolaemic rabbits.
British journal of pharmacology.
1996 May; 118(2):215-9. doi:
10.1111/j.1476-5381.1996.tb15389.x. [PMID: 8735617] - P Lijnen, V Petrov. Blood pressure and cationic transport systems during combined calcium channel blocker and calcium administration in males.
Methods and findings in experimental and clinical pharmacology.
1996 May; 18(4):287-94. doi:
NULL. [PMID: 8803961] - A Zanchetti. Antiatherosclerotic effects of antihypertensive drugs: recent evidence and ongoing trials.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1996 Apr; 18(3-4):489-99. doi:
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Investigative ophthalmology & visual science.
1996 Feb; 37(2):281-9. doi:
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Experimental nephrology.
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Kidney international.
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European journal of pharmacology.
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Xenobiotica; the fate of foreign compounds in biological systems.
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