Fluphenazine hydrochloride (BioDeep_00000015108)

   


代谢物信息卡片


Fluphenazine (dihydrochloride)

化学式: C22H28Cl2F3N3OS (509.12821340000005)
中文名称: 盐酸氟奋嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
InChI: 2*1H

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent

同义名列表

2 个代谢物同义名

Fluphenazine (dihydrochloride); Fluphenazine hydrochloride



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jilan Nazeam, Esraa Z Mohammed, Mariam Raafat, Mariam Houssein, Asmaa Elkafoury, Dina Hamdy, Lina Jamil. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS discovery : advancing life sciences R & D. 2020 12; 25(10):1123-1140. doi: 10.1177/2472555220950236. [PMID: 32804597]
  • Michał Otręba, Leon Kośmider, Anna Rzepecka-Stojko. Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review. European journal of pharmacology. 2020 Nov; 887(?):173553. doi: 10.1016/j.ejphar.2020.173553. [PMID: 32949606]
  • Sanju Sinha, Kuoyuan Cheng, Alejandro A Schäffer, Kenneth Aldape, Eyal Schiff, Eytan Ruppin. In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression. Molecular systems biology. 2020 07; 16(7):e9628. doi: 10.15252/msb.20209628. [PMID: 32729248]
  • Paulina Trombik, Katarzyna Cieślik-Boczula. Influence of phenothiazine molecules on the interactions between positively charged poly-l-lysine and negatively charged DPPC/DPPG membranes. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Feb; 227(?):117563. doi: 10.1016/j.saa.2019.117563. [PMID: 31689607]
  • Luca Menilli, Aída Nelly García-Argáez, Lisa Dalla Via, Giorgia Miolo. The neuroleptic drug fluphenazine induces a significant UVA-mediated cytotoxic effect on three human cancer cell lines through apoptosis. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2019 Sep; 18(9):2232-2239. doi: 10.1039/c9pp00023b. [PMID: 30860541]
  • Kamila Środa-Pomianek, Krystyna Michalak, Piotr Świątek, Andrzej Poła, Anna Palko-Łabuz, Olga Wesołowska. Increased lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line LoVo and its doxorubicin-resistant subline LoVo/Dx in the presence of newly synthesized phenothiazine derivatives. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):624-636. doi: 10.1016/j.biopha.2018.06.170. [PMID: 29990852]
  • Jiao-Jiao Jing, Bin Liu, Xin Wang, Xin Wang, Ling-Ling He, Xue-Yuan Guo, Ming-Ling Xu, Qian-Yu Li, Bo Gao, Bo-Yang Dong. Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food-drug interaction by spectroscopic techniques. Luminescence : the journal of biological and chemical luminescence. 2017 Sep; 32(6):1056-1065. doi: 10.1002/bio.3291. [PMID: 28374530]
  • Christopher Cottingham, Pulin Che, Wei Zhang, Hongxia Wang, Raymond X Wang, Stefanie Percival, Tana Birky, Lufang Zhou, Kai Jiao, Qin Wang. Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α2A adrenergic receptor ligands. Neuropharmacology. 2017 04; 116(?):38-49. doi: 10.1016/j.neuropharm.2016.12.004. [PMID: 27956055]
  • Anna-Maria Kreidler, Roland Benz, Holger Barth. Chloroquine derivatives block the translocation pores and inhibit cellular entry of Clostridium botulinum C2 toxin and Bacillus anthracis lethal toxin. Archives of toxicology. 2017 Mar; 91(3):1431-1445. doi: 10.1007/s00204-016-1716-9. [PMID: 27106023]
  • Larissa Finger Schaffer, Catiuscia Molz de Freitas, Ana Paula Chiapinotto Ceretta, Luis Ricardo Peroza, Elizete de Moraes Reis, Bárbara Nunes Krum, Alcindo Busanello, Aline Augusti Boligon, Jéssie Haigert Sudati, Roselei Fachinetto, Caroline Wagner. Harpagophytum Procumbens Ethyl Acetate Fraction Reduces Fluphenazine-Induced Vacuous Chewing Movements and Oxidative Stress in Rat Brain. Neurochemical research. 2016 May; 41(5):1170-84. doi: 10.1007/s11064-015-1811-y. [PMID: 26732278]
  • Matthew H Slawson, Kamisha L Johnson-Davis. Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Methods in molecular biology (Clifton, N.J.). 2016; 1383(?):49-57. doi: 10.1007/978-1-4939-3252-8_6. [PMID: 26660173]
  • Jason D Wagman, Barbara A Wolfe, Mandi W Schook. The effect of fluphenazine decanoate on glucocorticoid production, reproductive cyclicity, and the behavioral stress response in the Persian onager (Equus hemionus onager). Zoo biology. 2015 Nov; 34(6):525-34. doi: 10.1002/zoo.21250. [PMID: 26491959]
  • Joanna Petrus, Bogusława Czarnik-Matusewicz, Rafał Petrus, Katarzyna Cieślik-Boczula, Agata Jaszczyszyn, Kazimierz Gąsiorowski. Fluphenazine: from an isolated molecule to its interaction with lipid bilayers. Chemistry and physics of lipids. 2015 Feb; 186(?):51-60. doi: 10.1016/j.chemphyslip.2015.01.002. [PMID: 25595294]
  • Rachael B Weiss, Mandi W Schook, Barbara A Wolfe. Long-acting neuroleptic use for reproductive management of non-domestic ungulates using the domestic goat (Capra hircus) as a model. Zoo biology. 2014 May; 33(3):204-11. doi: 10.1002/zoo.21125. [PMID: 24644127]
  • Katarzyna Cieślik-Boczula, Piotr Swiątek, Agata Jaszczyszyn, Patrycja Zawilska, Kazimierz Gąsiorowski, Wiesław Malinka, Gottfried Köhler. Phase separation in phosphatidylcholine membrane caused by the presence of a pyrimidine analogue of fluphenazine with high anti-multidrug-resistance activity. The journal of physical chemistry. B. 2014 Apr; 118(13):3605-15. doi: 10.1021/jp410882r. [PMID: 24601791]
  • Shao-Long Zhu, Lan Yan, Yan-Xia Zhang, Zhi-Hui Jiang, Ping-Hui Gao, Yue Qiu, Liang Wang, Ming-Zhu Zhao, Ting-Jun-Hong Ni, Zhan Cai, Shu-Juan Tian, Cheng-Xu Zang, Da-Zhi Zhang, Yuan-Ying Jiang. Berberine inhibits fluphenazine-induced up-regulation of CDR1 in Candida albicans. Biological & pharmaceutical bulletin. 2014; 37(2):268-73. doi: 10.1248/bpb.b13-00734. [PMID: 24492724]
  • Lei Xu, Libo Li, Jianshe Huang, Tianyan You. Analysis of perphenazine and fluphenazine by capillary electrophoresis coupled with tris (2,2'-bipyridyl) ruthenium (II) electrochemiluminescence detection. Talanta. 2014 Jan; 118(?):1-6. doi: 10.1016/j.talanta.2013.09.048. [PMID: 24274263]
  • Sara Costello, Brendan Heffron, Lisa Taddei, Marc Benoit, Laura Hurt, Lindsay Simpson, Jennifer Bishop, Dawn Folker-Calderon, Adam Negrusz. Quantitation of fluphenazine in equine serum following fluphenazine decanoate administration. Journal of analytical toxicology. 2013 Oct; 37(8):594-9. doi: 10.1093/jat/bkt073. [PMID: 23986099]
  • Elizete M Reis, Jivago Röpke, Alcindo Busanello, Patrícia Reckziegel, Caroline Q Leal, Caroline Wagner, Aline A Boligon, Margareth L Athayde, Roselei Fachinetto. Effect of Hypericum perforatum on different models of movement disorders in rats. Behavioural pharmacology. 2013 Oct; 24(7):623-7. doi: 10.1097/fbp.0b013e3283656d68. [PMID: 23962987]
  • JoEtta M Juenke, Paul I Brown, Francis M Urry, Kamisha L Johnson-Davis, Gwendolyn A McMillin. Simultaneous UPLC-MS/MS assay for the detection of the traditional antipsychotics haloperidol, fluphenazine, perphenazine, and thiothixene in serum and plasma. Clinica chimica acta; international journal of clinical chemistry. 2013 Aug; 423(?):32-4. doi: 10.1016/j.cca.2013.04.014. [PMID: 23618971]
  • Annalisa Teutonico, Pasquale Libutti, Carlo Basile. [A case of drug-induced syndrome of inappropriate secretion of antidiuretic hormone]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. 2010 Jul; 27(4):399-403. doi: . [PMID: 20672238]
  • Katarzyna Cieślik-Boczula, Joanna Szwed, Agata Jaszczyszyn, Kazimierz Gasiorowski, Aleksander Koll. Interactions of dihydrochloride fluphenazine with DPPC liposomes: ATR-IR and 31P NMR studies. The journal of physical chemistry. B. 2009 Nov; 113(47):15495-502. doi: 10.1021/jp904805t. [PMID: 19883091]
  • Ali A Ensafi, F Hasanpour, T Khayamian. Simultaneous chemiluminescence determination of promazine and fluphenazine using support vector regression. Talanta. 2009 Jul; 79(2):534-8. doi: 10.1016/j.talanta.2009.04.023. [PMID: 19559917]
  • Cristiane L Dalla Corte, Roselei Fachinetto, Robson Puntel, Caroline Wagner, Cristina W Nogueira, Félix A Antunes Soares, João B T Rocha. Chronic treatment with fluphenazine alters parameters of oxidative stress in liver and kidney of rats. Basic & clinical pharmacology & toxicology. 2009 Jul; 105(1):51-7. doi: 10.1111/j.1742-7843.2009.00417.x. [PMID: 19486337]
  • Marcin Kolaczkowski, Anna Kolaczkowska, Noboru Motohashi, Krystyna Michalak. New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters. Antimicrobial agents and chemotherapy. 2009 Apr; 53(4):1516-27. doi: 10.1128/aac.00956-08. [PMID: 19188399]
  • Fathalla Belal, Amina El-Brashy, Nahed El-Enany, Nihal El-Bahay. Spectrofluorometric determination of olanzapine and fluphenazine hydrochloride in pharmaceutical preparations and human plasma using eosin: application to stability studies. Journal of AOAC International. 2008 Nov; 91(6):1309-17. doi: NULL. [PMID: 19202791]
  • Harpreet S Duggal, Ira Singh. Neuroleptic malignant syndrome presenting with acute renal failure. Progress in neuro-psychopharmacology & biological psychiatry. 2008 May; 32(4):1074-5. doi: 10.1016/j.pnpbp.2008.01.010. [PMID: 18281139]
  • Z Vucicevic, V Degoricija, Z Alfirevic, D Vukicevic-Badouin. Fatal hyponatremia and other metabolic disturbances associated with psychotropic drug polypharmacy. International journal of clinical pharmacology and therapeutics. 2007 May; 45(5):289-92. doi: 10.5414/cpp45289. [PMID: 17542351]
  • M Jakovljevic, N Pivac, A Mihaljevic-Peles, M Mustapic, M Relja, D Ljubicic, D Marcinko, D Muck-Seler. The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study. Progress in neuro-psychopharmacology & biological psychiatry. 2007 Mar; 31(2):399-402. doi: 10.1016/j.pnpbp.2006.10.007. [PMID: 17126974]
  • Erica Duncan, Boadie W Dunlop, William Boshoven, Sandra L Woolson, Robert M Hamer, Lawrence S Phillips. Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population. International clinical psychopharmacology. 2007 Jan; 22(1):1-11. doi: 10.1097/01.yic.0000224792.44276.20. [PMID: 17159454]
  • John D Baird, Luis G Arroyo, Modest Vengust, M Kimberly J McGurrin, Alexander Rodriguez-Palacios, Daniel G Kenney, Manickam Aravagiri, George A Maylin. Adverse extrapyramidal effects in four horse given fluphenazine decanoate. Journal of the American Veterinary Medical Association. 2006 Jul; 229(1):104-10. doi: 10.2460/javma.229.1.104. [PMID: 16817724]
  • Weifen Niu, Fei Nie, Jiuru Lu. Chemiluminescence sensor for the determination of perphenazine based on a molecular imprinted polymer. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2006 Jul; 22(7):971-5. doi: 10.2116/analsci.22.971. [PMID: 16837748]
  • A Ahmadzadeh, M A Barnes, F C Gwazdauskas, R M Akers. Dopamine antagonist alters serum cortisol and prolactin secretion in lactating Holstein cows. Journal of dairy science. 2006 Jun; 89(6):2051-5. doi: 10.3168/jds.s0022-0302(06)72272-x. [PMID: 16702268]
  • Joseph P McEvoy. Risks versus benefits of different types of long-acting injectable antipsychotics. The Journal of clinical psychiatry. 2006; 67 Suppl 5(?):15-8. doi: NULL. [PMID: 16822092]
  • Chiara Bastianon, Roberta Zanoni, Giorgia Miolo, Sergio Caffieri, Elena Reddi. Mitochondria and plasma membrane as targets of UVA-induced toxicity of neuroleptic drugs fluphenazine, perphenazine and thioridazine. The international journal of biochemistry & cell biology. 2005 Apr; 37(4):901-8. doi: 10.1016/j.biocel.2004.11.016. [PMID: 15694848]
  • Frank Orlik, Bettina Schiffler, Roland Benz. Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis. Biophysical journal. 2005 Mar; 88(3):1715-24. doi: 10.1529/biophysj.104.050336. [PMID: 15596516]
  • M Aleem, J Choudhari, V Padwal, N Balasinor, P Parte, M K Gill-Sharma. Hyperprolactinemia affects spermiogenesis in adult male rats. Journal of endocrinological investigation. 2005 Jan; 28(1):39-48. doi: 10.1007/bf03345528. [PMID: 15816370]
  • Deanna L Kelly, Robert R Conley. Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. The Journal of clinical psychiatry. 2005 Jan; 66(1):80-4. doi: 10.4088/jcp.v66n0111. [PMID: 15669892]
  • Thai-Yen Ling, Chun-Lin Chen, Yen-Hua Huang, I-Hua Liu, Shuan Shian Huang, Jung San Huang. Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1. The Journal of biological chemistry. 2004 Sep; 279(37):38736-48. doi: 10.1074/jbc.m310537200. [PMID: 15226301]
  • Amal Abou El Ela, Sebastian Härtter, Ulrich Schmitt, Christoph Hiemke, Hildegard Spahn-Langguth, Peter Langguth. Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. The Journal of pharmacy and pharmacology. 2004 Aug; 56(8):967-75. doi: 10.1211/0022357043969. [PMID: 15285840]
  • Christoph Bachmeyer, Frank Orlik, Holger Barth, Klaus Aktories, Roland Benz. Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis. Journal of molecular biology. 2003 Oct; 333(3):527-40. doi: 10.1016/j.jmb.2003.08.044. [PMID: 14556742]
  • M K Gill-Sharma, M Aleem, G Sethi, J Choudhary, V Padwal, S D'Souza, N Balasinor, P Parte, H S Juneja. Antifertility effects of fluphenazine in adult male rats. Journal of endocrinological investigation. 2003 Apr; 26(4):316-26. doi: 10.1007/bf03345179. [PMID: 12841539]
  • Boadie W Dunlop, Maya Sternberg, Lawrence S Phillips, Judy Andersen, Erica Duncan. Disturbed glucose metabolism among patients taking olanzapine and typical antipsychotics. Psychopharmacology bulletin. 2003; 37(3):99-117. doi: NULL. [PMID: 14608243]
  • Rudiger Gröning, Jörg Breitkreutz, Volker Baroth, Rotraut Stephanie Müller. Nanoparticles in plant extracts: influence of drugs on the formation of nanoparticles and precipitates in black tea infusions. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2002 Mar; 15(2):149-55. doi: 10.1016/s0928-0987(01)00194-4. [PMID: 11849911]
  • S R Marder, M Aravagiri, W C Wirshing, D A Wirshing, M Lebell, J Mintz. Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate. Schizophrenia research. 2002 Jan; 53(1-2):25-30. doi: 10.1016/s0920-9964(00)00184-5. [PMID: 11728835]
  • S Moses, K Dreja, A Lindqvist, C Lövdahl, P Hellstrand, A Hultgårdh-Nilsson. Smooth muscle cell response to mechanical injury involves intracellular calcium release and ERK1/ERK2 phosphorylation. Experimental cell research. 2001 Sep; 269(1):88-96. doi: 10.1006/excr.2001.5308. [PMID: 11525642]
  • P L Ryan, K Bennett-Wimbush, W E Vaala, C A Bagnell. Systemic relaxin in pregnant pony mares grazed on endophyte-infected fescue: effects of fluphenazine treatment. Theriogenology. 2001 Aug; 56(3):471-83. doi: 10.1016/s0093-691x(01)00578-7. [PMID: 11516126]
  • G S Linn, K Lifshitz, R T O'Keeffe, K Lee, J Camp-Lifshitz. Increased incidence of dyskinesias and other behavioral effects of re-exposure to neuroleptic treatment in social colonies of Cebus apella monkeys. Psychopharmacology. 2001 Jan; 153(3):285-94. doi: 10.1007/s002130000572. [PMID: 11271400]
  • M J Gitlin, K H Nuechterlein, J Mintz, D Fogelson, G Bartzokis, J Ventura, K Subotnik, M Aravagiri. Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: relation to side effects, psychosocial function and depression. Psychopharmacology. 2000 Mar; 148(4):350-4. doi: 10.1007/s002130050062. [PMID: 10928306]
  • H Yang, J M Daun, J R Rose, W J Christ, F Gusovsky, J C Chow. Examination of chlorpromazine and other amphipathic drugs on the activity of lipopolysaccharide antagonists, E5564 and E5531. Journal of endotoxin research. 2000; 6(6):447-52. doi: 10.1179/096805100101532405. [PMID: 11521069]
  • J W Hubbard, S Hadad, J P Luo, G McKay, K K Midha. Pharmacokinetics of fluphenazine, a highly lipophilic drug, estimated from a pulse dose of a stable isotopomer in dogs at steady state. Journal of pharmaceutical sciences. 1999 Sep; 88(9):918-21. doi: 10.1021/js980440c. [PMID: 10479354]
  • C I Bak, J W Huh, S Hong, B J Song. Noncompetitive, Ca(2+)-independent inhibition of pyruvate dehydrogenase phosphatase by fluphenazine. Biochemistry and molecular biology international. 1999 Jun; 47(6):1029-37. doi: 10.1080/15216549900202153. [PMID: 10410249]
  • D A Wirshing, G Bartzokis, J M Pierre, W C Wirshing, A Sun, T A Tishler, S R Marder. Tardive dyskinesia and serum iron indices. Biological psychiatry. 1998 Sep; 44(6):493-8. doi: 10.1016/s0006-3223(97)00453-8. [PMID: 9777182]
  • J P Luo, J W Hubbard, K K Midha. The roles of depot injection sites and proximal lymph nodes in the presystemic absorption of fluphenazine decanoate and fluphenazine: ex vivo experiments in rats. Pharmaceutical research. 1998 Sep; 15(9):1485-9. doi: 10.1023/a:1011978327504. [PMID: 9755905]
  • L Chayet, L Collados, A M Kettlun, E Campos, A Traverso-Cori, L García, M A Valenzuela. Human placental ecto-enzymes: studies on the plasma membrane anchorage and effect of inhibitors of ATP-metabolizing enzymes. Research communications in molecular pathology and pharmacology. 1997 Apr; 96(1):14-24. doi: NULL. [PMID: 9178364]
  • L Braghiroli, A Ponzianelli, M Fiani, G De Feo, C Y Cheng, G Mazzanti. Effect of clozapine on dopamine-induced inhibition of prolactin release from cultured rat pituitary cells. Pharmacological research. 1997 Mar; 35(3):173-5. doi: 10.1006/phrs.1996.0102. [PMID: 9229404]
  • J P Luo, J W Hubbard, K K Midha. Sensitive method for the simultaneous measurement of fluphenazine decanoate and fluphenazine in plasma by high-performance liquid chromatography with coulometric detection. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jan; 688(2):303-8. doi: 10.1016/s0378-4347(96)00287-3. [PMID: 9061468]
  • M T Bunker, P A Marken, M E Schneiderhan, V L Ruehter. Attenuation of antipsychotic-induced hyperprolactinemia with clozapine. Journal of child and adolescent psychopharmacology. 1997; 7(1):65-9. doi: 10.1089/cap.1997.7.65. [PMID: 9192542]
  • U Heresco-Levy, D Greenberg, B Lerer, D C Javitt, W A Brown. Serum neuroleptic levels during reduced dose fluphenazine decanoate maintenance therapy. The Israel journal of psychiatry and related sciences. 1997; 34(4):281-9. doi: NULL. [PMID: 9409085]
  • D J Pabis, P G Dorson, M L Crismon. Evaluation of inpatient depot antipsychotic prescribing. The Annals of pharmacotherapy. 1996 Dec; 30(12):1381-6. doi: 10.1177/106002809603001203. [PMID: 8968447]
  • M C Oliveira, J T Moraes, H M Barros, L M Barbosa-Coutinho. Effect of estrogen and neuroleptics on prolactin secretion and immunoreactive prolactin cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1996 Apr; 29(4):521-5. doi: NULL. [PMID: 8736119]
  • F J Gómez-Pérez, R Choza, J M Ríos, A Reza, E Huerta, C A Aguilar, J A Rull. Nortriptyline-fluphenazine vs. carbamazepine in the symptomatic treatment of diabetic neuropathy. Archives of medical research. 1996; 27(4):525-9. doi: NULL. [PMID: 8987189]
  • K Akiyama, K Tsuchida, A Kanzaki, H Ujike, T Hamamura, K Kondo, S Mutoh, K Miyanagi, S Kuroda, S Otsuki. Plasma homovanillic acid levels and therapeutic outcome in schizophrenics: comparisons of neuroleptic-naive first-episode patients and patients with disease exacerbation due to neuroleptic discontinuance. Biological psychiatry. 1995 Nov; 38(10):639-48. doi: 10.1016/0006-3223(94)00383-1. [PMID: 8555375]
  • M Aravagiri, S R Marder, A Yuwiler, K K Midha, N S Kula, R J Baldessarini. Distribution of fluphenazine and its metabolites in brain regions and other tissues of the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1995 Nov; 13(3):235-47. doi: 10.1016/0893-133x(95)00070-t. [PMID: 8602896]
  • E C de Ferreyra, A S Bernacchi, M F San Martin, G D Castro, J A Castro. Late protective effects of the anticalmodulin drug fluphenazine on carbon tetrachloride-induced liver necrosis. Biomedical and environmental sciences : BES. 1995 Sep; 8(3):218-25. doi: ". [PMID: 8561921]
  • H He, G McKay, B Wirshing, K K Midha. Development and application of a specific and sensitive radioimmunoassay for trihexyphenidyl to a pharmacokinetic study in humans. Journal of pharmaceutical sciences. 1995 May; 84(5):561-7. doi: 10.1002/jps.2600840509. [PMID: 7658345]
  • D F Levinson, G M Simpson, E S Lo, T B Cooper, H Singh, K Yadalam, M J Stephanos. Fluphenazine plasma levels, dosage, efficacy, and side effects. The American journal of psychiatry. 1995 May; 152(5):765-71. doi: 10.1176/ajp.152.5.765. [PMID: 7726317]
  • R S Miller, G M Peterson, S McLean, T T Westhead, P Gillies. Monitoring plasma levels of fluphenazine during chronic therapy with fluphenazine decanoate. Journal of clinical pharmacy and therapeutics. 1995 Apr; 20(2):55-62. doi: 10.1111/j.1365-2710.1995.tb00629.x. [PMID: 7650075]
  • D C Goff, K K Midha, O Sarid-Segal, J W Hubbard, E Amico. A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia. Psychopharmacology. 1995 Feb; 117(4):417-23. doi: 10.1007/bf02246213. [PMID: 7604142]
  • P Saha, M Singh. Characterization of a winged bean (Psophocarpus tetragonolobus) protein kinase with calmodulin-like domain: regulation by autophosphorylation. The Biochemical journal. 1995 Jan; 305 ( Pt 1)(?):205-10. doi: 10.1042/bj3050205. [PMID: 7826330]
  • P Merlob, B Stahl, E Maltz. Is fluphenazine a teratogen?. American journal of medical genetics. 1994 Aug; 52(2):231-2. doi: 10.1002/ajmg.1320520221. [PMID: 7802015]
  • K K Midha, J W Hubbard, S R Marder, B D Marshall, T Van Putten. Impact of clinical pharmacokinetics on neuroleptic therapy in patients with schizophrenia. Journal of psychiatry & neuroscience : JPN. 1994 Jul; 19(4):254-64. doi: . [PMID: 7918346]
  • M Aravagiri, S R Marder, T Van Putten, E M Hawes, G McKay, K K Midha. Radioimmunoassay for 7-hydroxy metabolite of fluphenazine and its application to plasma level monitoring in schizophrenic patients treated long term with oral and depot fluphenazine. Therapeutic drug monitoring. 1994 Feb; 16(1):21-9. doi: 10.1097/00007691-199402000-00003. [PMID: 8160250]
  • A R Koreen, J Lieberman, J Alvir, M Chakos, A Loebel, T Cooper, J Kane. Relation of plasma fluphenazine levels to treatment response and extrapyramidal side effects in first-episode schizophrenic patients. The American journal of psychiatry. 1994 Jan; 151(1):35-9. doi: 10.1176/ajp.151.1.35. [PMID: 8267132]
  • M A Burke, J P McEvoy, J C Ritchie. A pilot study of a structured interview addressing sexual function in men with schizophrenia. Biological psychiatry. 1994 Jan; 35(1):32-5. doi: 10.1016/0006-3223(94)91164-9. [PMID: 8167201]
  • S Baruah, R Waziri, A Sherman. Neuroleptic effects on serine and glycine metabolism. Biological psychiatry. 1993 Oct; 34(8):544-50. doi: 10.1016/0006-3223(93)90197-l. [PMID: 7903868]
  • R E Litman, W W Hong, E M Weissman, T P Su, W Z Potter, D Pickar. Idazoxan, an alpha 2 antagonist, augments fluphenazine in schizophrenic patients: a pilot study. Journal of clinical psychopharmacology. 1993 Aug; 13(4):264-7. doi: . [PMID: 8104200]
  • R R Owen, R Gutierrez-Esteinou, J Hsiao, K Hadd, C Benkelfat, B A Lawlor, D L Murphy, D Pickar. Effects of clozapine and fluphenazine treatment on responses to m-chlorophenylpiperazine infusions in schizophrenia. Archives of general psychiatry. 1993 Aug; 50(8):636-44. doi: 10.1001/archpsyc.1993.01820200046005. [PMID: 8343034]
  • K K Midha, S R Marder, T J Jaworski, G McKay, J W Hubbard, E M Hawes, T Van Putten, W C Wirshing, M Aravagiri. Clinical perspectives of some neuroleptics through development and application of their assays. Therapeutic drug monitoring. 1993 Jun; 15(3):179-89. doi: 10.1097/00007691-199306000-00001. [PMID: 8101398]
  • F Jouen, P Verité, D André, L Colonna, P Boucly. Plasma fluphenazine levels measured by high-performance liquid chromatography in patients treated with depot injections. Arzneimittel-Forschung. 1993 May; 43(5):509-11. doi: NULL. [PMID: 8328993]
  • A C Altamura. A multidimensional (pharmacokinetic and clinical-biological) approach to neuroleptic response in schizophrenia. With particular reference to drug resistance. Schizophrenia research. 1993 Jan; 8(3):187-98. doi: 10.1016/0920-9964(93)90017-d. [PMID: 8094628]
  • W M Glazer, L T Friedhoff, S R Marder, W A Brown. The determination of the steady-state pharmacokinetic profile of fluphenazine decanoate by gas chromatography/mass spectrometry detection. Schizophrenia research. 1992 Dec; 8(2):111-7. doi: 10.1016/0920-9964(92)90026-2. [PMID: 1457388]
  • B Kirkpatrick, W T Carpenter, K Maeda, R W Buchanan, A Breier, C A Tamminga. Plasma prolactin as a predictor of relapse in drug-free schizophrenic outpatients. Biological psychiatry. 1992 Dec; 32(11):1049-54. doi: 10.1016/0006-3223(92)90067-a. [PMID: 1467385]
  • R E See, M A Chapman, C E Murray, M Aravagiri. Regional differences in chronic neuroleptic effects on extracellular dopamine activity. Brain research bulletin. 1992 Sep; 29(3-4):473-8. doi: 10.1016/0361-9230(92)90085-c. [PMID: 1382815]
  • D Pickar, R R Owen, R E Litman, E Konicki, R Gutierrez, M H Rapaport. Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine. Archives of general psychiatry. 1992 May; 49(5):345-53. doi: 10.1001/archpsyc.1992.01820050009001. [PMID: 1375019]
  • C A Peabody, M D Warner, M Griffin, N N Boutros, I G Worsley, H G Friesen. Prolactin bioassay in schizophrenia before and after neuroleptics. Psychiatry research. 1992 Mar; 41(3):249-55. doi: 10.1016/0165-1781(92)90006-o. [PMID: 1594711]
  • D Pickar. Plasma homovanillic acid and other predictors of clozapine response. Clinical neuropharmacology. 1992; 15 Suppl 1 Pt A(?):516A-517A. doi: 10.1097/00002826-199201001-00268. [PMID: 1498935]
  • K Rásky, S Losonczy, M Pátfalusi. Radioimmunoassay for a new phenothiazine derivative and its application. Acta physiologica Hungarica. 1992; 79(1):103-11. doi: NULL. [PMID: 1363169]
  • S D Soni, M Brownlee. Alcohol abuse in chronic schizophrenics: implications for management in the community. Acta psychiatrica Scandinavica. 1991 Sep; 84(3):272-6. doi: 10.1111/j.1600-0447.1991.tb03143.x. [PMID: 1950628]
  • S Robinson, P Rosca, R Durst, U Shai, C Ghinea, U Schmidt, I Nir. Serum melatonin levels in schizophrenic and schizoaffective hospitalized patients. Acta psychiatrica Scandinavica. 1991 Sep; 84(3):221-4. doi: 10.1111/j.1600-0447.1991.tb03133.x. [PMID: 1950621]
  • S R Marder, K K Midha, T Van Putten, M Aravagiri, E M Hawes, J W Hubbard, G McKay, J Mintz. Plasma levels of fluphenazine in patients receiving fluphenazine decanoate. Relationship to clinical response. The British journal of psychiatry : the journal of mental science. 1991 May; 158(?):658-65. doi: 10.1192/bjp.158.5.658. [PMID: 1860020]
  • J Alvarez, M Montero, J García-Sancho. Cytochrome P-450 may link intracellular Ca2+ stores with plasma membrane Ca2+ influx. The Biochemical journal. 1991 Feb; 274 ( Pt 1)(?):193-7. doi: 10.1042/bj2740193. [PMID: 2001232]
  • T Van Putten, S R Marder, W C Wirshing, M Aravagiri, N Chabert. Neuroleptic plasma levels. Schizophrenia bulletin. 1991; 17(2):197-216. doi: 10.1093/schbul/17.2.197. [PMID: 1679251]
  • K Lifshitz, R T O'Keeffe, K L Lee, G S Linn, D Mase, J Avery, E S Lo, T B Cooper. Effect of extended depot fluphenazine treatment and withdrawal on social and other behaviors of Cebus apella monkeys. Psychopharmacology. 1991; 105(4):492-500. doi: 10.1007/bf02244369. [PMID: 1771217]
  • T Van Putten, M Aravagiri, S R Marder, W C Wirshing, J Mintz, N Chabert. Plasma fluphenazine levels and clinical response in newly admitted schizophrenic patients. Psychopharmacology bulletin. 1991; 27(2):91-6. doi: NULL. [PMID: 1924666]
  • P E Konicki, R R Owen, R E Litman, D Pickar. The acute effects of central- and peripheral-acting dopamine antagonists on plasma HVA in schizophrenic patients. Life sciences. 1991; 48(14):1411-6. doi: 10.1016/0024-3205(91)90438-h. [PMID: 2008157]
  • B Mann, M L Grayeski. Evaluation of peroxyoxalate chemiluminescence postcolumn detection of fluphenazine in urine and blood plasma using high performance liquid chromatography. Biomedical chromatography : BMC. 1991 Jan; 5(1):47-52. doi: 10.1002/bmc.1130050111. [PMID: 2032022]
  • G M Simpson, K G Yadalam, D F Levinson, M J Stephanos, E S Lo, T B Cooper. Single-dose pharmacokinetics of fluphenazine after fluphenazine decanoate administration. Journal of clinical psychopharmacology. 1990 Dec; 10(6):417-21. doi: 10.1097/00004714-199010060-00007. [PMID: 2286711]
  • R J Srám, B Binková, J Topinka, I Fojtíková. Inhibition of DNA repair synthesis in the rat by in vivo exposure to psychotropic drugs and reversal of the effect by co-administration with alpha-tocopherol. Mutation research. 1990 Aug; 244(4):331-5. doi: 10.1016/0165-7992(90)90081-t. [PMID: 2385247]