DexChlorpheniramine Maleate (BioDeep_00000015105)
代谢物信息卡片
化学式: C20H23ClN2O4 (390.13462680000004)
中文名称: 右泛醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
InChI: /m0./s1
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Dexchlorpheniramine maleate is an antihistamine with anticholinergic properties used in the study of allergic diseases.
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:4465
- KEGG: C07783
- KEGGdrug: D00668
- PubChem: 5281070
- DrugBank: DB09555
- ChEMBL: CHEMBL1200927
- CAS: 2438-32-6
- PubChem: 9985
- medchemexpress: HY-B1062
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Swann Geoffroy, Alexis Fremery, Yann Lambert, Christian Marty, Narcisse Elenga. Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings.
The American journal of tropical medicine and hygiene.
2021 05; 105(1):222-224. doi:
10.4269/ajtmh.20-1276. [PMID: 33970887] - Mariele Gobo-Oliveira, Vitória G Pigari, Matheus Sp Ogata, Hélio A Miot, Daniela Ponce, Luciana Pf Abbade. Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial.
European journal of dermatology : EJD.
2018 Aug; 28(4):488-495. doi:
10.1684/ejd.2018.3356. [PMID: 29976533] - Alberto Alvarez-Perea, Alicia Prieto García, Alejandro La Rotta Hernández, Manuel de Barrio, María Luisa Baeza. Urticaria due to aloe vera: a new sensitizer?.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2010 Nov; 105(5):404-5. doi:
10.1016/j.anai.2010.09.016. [PMID: 21055672] - Ronilson Agnaldo Moreno, Diogo Oliveira-Silva, Carlos Eduardo Sverdloff, Bruno Carter Borges, Paulo Alexandre Rebelo Galvinas, Rafael Barrientos Astigarraga, Ney Carter Borges. Determination of chlorpheniramine in human plasma by HPLC-ESI-MS/MS: application to a dexchlorpheniramine comparative bioavailability study.
Biomedical chromatography : BMC.
2010 Jul; 24(7):774-81. doi:
10.1002/bmc.1362. [PMID: 19924675] - J Montoro, N Freixenet, A Lozano, F Bertomeu. An unusual adverse drug reaction?.
Allergologia et immunopathologia.
2005 Jul; 33(4):235-7. doi:
10.1157/13077751. [PMID: 16045865] - O Cáceres Calle, M Fernández-Benítez. Allergy to dexchlorpheniramine. Study of a case.
Allergologia et immunopathologia.
2004 Sep; 32(5):306-9. doi:
10.1016/s0301-0546(04)79259-9. [PMID: 15456628] - T H Bui, C Fernandez, K Vu, K H Nguyen, A Thuillier, R Farinotti, P Arnaud, F Gimenez. Stereospecific versus nonstereospecific assessments for the bioequivalence of two formulations of racemic chlorpheniramine.
Chirality.
2000 Aug; 12(8):599-605. doi:
10.1002/1520-636x(2000)12:8<599::aid-chir1>3.0.co;2-s. [PMID: 10897096] - B T Hiep, F Gimenez, V U Khanh, N K Hung, A Thuillier, R Farinotti, C Fernandez. Binding of chlorpheniramine enantiomers to human plasma proteins.
Chirality.
1999; 11(5-6):501-4. doi:
10.1002/(sici)1520-636x(1999)11:5/6<501::aid-chir24>3.0.co;2-k. [PMID: 10368923] - A Sabbah, S Hassoun, J Le Sellin, C André, H Sicard. A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract.
Allergy.
1994 May; 49(5):309-13. doi:
10.1111/j.1398-9995.1994.tb02273.x. [PMID: 8092425] - P Chiodera, R Volpi, R Delsignore, L Ippolito, G Rossi, L Camellini, C Marchesi, A Gnudi, V Coiro. Muscarinic cholinergic and histaminergic H1 and H2 receptors are not involved in the LH response to naloxone in man.
Hormone research.
1987; 25(2):120-4. doi:
10.1159/000180642. [PMID: 3570149] - G Albertini, R Davalli, P Moroni, V Oberhauser. Clinical pharmacology of tritoqualine: a comparative study against dexchlorpheniramine in allergic rhinitis.
International journal of clinical pharmacology research.
1986; 6(2):113-8. doi:
NULL. [PMID: 2873107] - V Coiro, P Chiodera, R Volpi, G Salati, P Ferrari, A Caiazza, G Rossi. Histaminergic H1 and H2 receptors do not mediate cortisol release in response to naloxone in normal men.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
1984; 38(7):358-60. doi:
NULL. [PMID: 6098319] - S M Huang, N K Athanikar, K Sridhar, Y C Huang, W L Chiou. Pharmacokinetics of chlorpheniramine after intravenous and oral administration in normal adults.
European journal of clinical pharmacology.
1982; 22(4):359-65. doi:
10.1007/bf00548406. [PMID: 7106172]