Trifluoperazine hydrochloride (BioDeep_00000015102)
代谢物信息卡片
Trifluoperazine dihydrochloride
化学式: C21H26Cl2F3N3S (479.1176492000001)
中文名称: 三氟拉嗪二盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl
InChI: 2*1H
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:9710
- KEGG: C75189
- KEGGdrug: D00799
- PubChem: 66064
- ChEMBL: CHEMBL1257040
- MeSH: Trifluoperazine
- CAS: 440-17-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qianqian Jiang, Renyan Mao, Yongcai Li, Yang Bi, Yongxiang Liu, Miao Zhang, Rong Li, Yangyang Yang, Dov B Prusky. AaCaM is required for infection structure differentiation and secondary metabolites in pear fungal pathogen Alternaria alternata.
Journal of applied microbiology.
2022 Oct; 133(4):2631-2641. doi:
10.1111/jam.15732. [PMID: 35870147] - Ahmed E Goda, Amr M Elenany, Alaa E Elsisi. Novel in vivo potential of trifluoperazine to ameliorate doxorubicin-induced cardiotoxicity involves suppression of NF-κB and apoptosis.
Life sciences.
2021 Oct; 283(?):119849. doi:
10.1016/j.lfs.2021.119849. [PMID: 34343539] - Rodrigo R R Duarte, Dennis C Copertino, Luis P Iñiguez, Jez L Marston, Yaron Bram, Yuling Han, Robert E Schwartz, Shuibing Chen, Douglas F Nixon, Timothy R Powell. Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry.
Molecular medicine (Cambridge, Mass.).
2021 09; 27(1):105. doi:
10.1186/s10020-021-00356-6. [PMID: 34503440] - Nicole J Sylvain, Mootaz M Salman, M Jake Pushie, Huishu Hou, Vedashree Meher, Rasmus Herlo, Lissa Peeling, Michael E Kelly. The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model.
Biochimica et biophysica acta. Biomembranes.
2021 05; 1863(5):183573. doi:
10.1016/j.bbamem.2021.183573. [PMID: 33561476] - Ruimei Zhou, Jiashun Liao, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lü, Shi-You Chen, Wei-Bing Xie. Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial-mesenchymal transition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 03; 35(3):e21381. doi:
10.1096/fj.202000926rr. [PMID: 33617091] - Anmao Li, Xuanxin Chen, Zizi Jing, Jianbin Chen. Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma.
FEBS open bio.
2020 10; 10(10):2097-2106. doi:
10.1002/2211-5463.12960. [PMID: 32810364] - Arumugam Sangili, Rajalakshmi Sakthivel, Shen Ming Chen. Cost-effective single-step synthesis of flower-like cerium-ruthenium-sulfide for the determination of antipsychotic drug trifluoperazine in human urine samples.
Analytica chimica acta.
2020 Sep; 1131(?):35-44. doi:
10.1016/j.aca.2020.07.032. [PMID: 32928478] - Amir Kiani, Shadi Heydari Nik, Adineh Khodadoost, Ahmad Salimi, Jalal Pourahmad. Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity.
Drug research.
2020 Jun; 70(6):265-272. doi:
10.1055/a-1154-8672. [PMID: 32365382] - Qi Ding, Ferzin Sethna, Xue-Ting Wu, Zhuang Miao, Ping Chen, Yueqi Zhang, Hua Xiao, Wei Feng, Yue Feng, Xuan Li, Hongbing Wang. Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model.
Communications biology.
2020 03; 3(1):127. doi:
10.1038/s42003-020-0833-4. [PMID: 32179850] - Darpan Raghav, Susobhan Mahanty, Krishnan Rathinasamy. Characterizing the interactions of the antipsychotic drug trifluoperazine with bovine serum albumin: Probing the drug-protein and drug-drug interactions using multi-spectroscopic approaches.
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International journal of molecular medicine.
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DNA and cell biology.
2017 10; 36(10):813-821. doi:
10.1089/dna.2017.3790. [PMID: 28876084] - Baodong Wang, Xiaoshuang Zhou, Yanqin Wang, Rongshan Li. Trifluoperazine Inhibits Mesangial Cell Proliferation by Arresting Cell Cycle-Dependent Mechanisms.
Medical science monitor : international medical journal of experimental and clinical research.
2017 Jul; 23(?):3461-3469. doi:
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2017 07; 185(?):80-87. doi:
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Pharmacological research.
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Life sciences.
2016 Jul; 156(?):21-29. doi:
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Toxicology and applied pharmacology.
2016 06; 301(?):42-9. doi:
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2016 Jun; 68(3):649-53. doi:
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TSitologiia i genetika.
2016 Jan; 50(1):3-11. doi:
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Biological & pharmaceutical bulletin.
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Journal of neuropathology and experimental neurology.
2014 Nov; 73(11):1078-90. doi:
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Journal of proteomics.
2014 Sep; 109(?):38-49. doi:
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Analytical and bioanalytical chemistry.
2012 Apr; 402(10):3211-8. doi:
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PloS one.
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1486-94. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1522-8. doi:
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Molecular membrane biology.
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Journal of separation science.
2011 Jan; 34(1):90-7. doi:
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Plant physiology and biochemistry : PPB.
2010 Oct; 48(10-11):860-5. doi:
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Plant & cell physiology.
2010 Oct; 51(10):1788-99. doi:
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Journal of the science of food and agriculture.
2010 Mar; 90(4):669-75. doi:
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Indian journal of experimental biology.
2009 Jun; 47(6):480-8. doi:
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BMC plant biology.
2009 May; 9(?):64. doi:
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Plant & cell physiology.
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2004 Aug; 126(31):9478-9. doi:
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The Biochemical journal.
2004 Aug; 381(Pt 3):929-39. doi:
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2004 Jul; 49(1):28-31. doi:
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The Journal of antimicrobial chemotherapy.
2004 Jun; 53(6):1072-5. doi:
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Biophysical chemistry.
2004 Apr; 109(1):85-104. doi:
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Journal of cell science.
2004 Mar; 117(Pt 8):1469-80. doi:
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2003 Jul; 89(4):800-7. doi:
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Experimental & molecular medicine.
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2001 Nov; 53(6):629-34. doi:
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2001 Sep; 60(3):944-56. doi:
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2001 Jul; 69(8):863-77. doi:
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2001 Jun; 83(1):111-20. doi:
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