Chlorpheniramine maleate (BioDeep_00000015098)
natural product Volatile Flavor Compounds
代谢物信息卡片
Chlorpheniramine maleate
化学式: C20H23ClN2O4 (390.13462680000004)
中文名称: 马来酸氯苯那敏
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=CC(=N1)C(CCN(C)C)C2=CC=C(C=C2)Cl).C(/C=C\C(O)=O)(O)=O
InChI: 2-1-
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents
Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:3645
- KEGG: C07780
- KEGGdrug: D70131
- KEGGdrug: D00665
- PubChem: 5281068
- ChEMBL: CHEMBL1659
- MeSH: Chlorpheniramine
- CAS: 113-92-8
- CAS: 113-92-8,132-22-9 (free base)
- MoNA: CCMSLIB00000078302
- MoNA: CCMSLIB00000078301
- PubChem: 9982
- medchemexpress: HY-B0286A
- KNApSAcK: 3645
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ting Yang, Xiang Li, Lili Lan, Dandan Gong, Fan Zhang, Xinrong Liu, Guixia Ling, Guoxiang Sun. Quality evaluation of Keteling capsules based on fingerprinting, multicomponent quantification, and quantitative prediction.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 Aug; 303(?):123274. doi:
10.1016/j.saa.2023.123274. [PMID: 37603975] - Qingqing Guo, Hao Lin, Jiandong Lin. Chlorpheniramine poisoning as a potential cause of rhabdomyolysis.
The American journal of emergency medicine.
2022 07; 57(?):236.e1-236.e3. doi:
10.1016/j.ajem.2022.04.010. [PMID: 35459564] - Swann Geoffroy, Alexis Fremery, Yann Lambert, Christian Marty, Narcisse Elenga. Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings.
The American journal of tropical medicine and hygiene.
2021 05; 105(1):222-224. doi:
10.4269/ajtmh.20-1276. [PMID: 33970887] - Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry.
Angewandte Chemie (International ed. in English).
2020 12; 59(51):23162-23168. doi:
10.1002/anie.202006481. [PMID: 32869436] - Bernard Ho, Abhishek Ray. A case for palliative dermatology: COVID-19-related dermatoses.
Clinics in dermatology.
2020 Nov; 38(6):768-769. doi:
10.1016/j.clindermatol.2020.06.001. [PMID: 33341213] - Khalid Hassan. Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection.
BMJ case reports.
2020 Jul; 13(7):. doi:
10.1136/bcr-2020-236981. [PMID: 32641443] - Kave Moulaee, Mohammad Reza Ganjali, Parviz Norouzi, Hadi Beitollahi. Facile electrochemical preparation of overoxidizedpolypyrrole/RGO composite for ds-DNA immobilization: a novel signal amplified sensing platform for electrochemical determination of chlorpheniramine.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2020 Jun; 28(1):57-64. doi:
10.1007/s40199-019-00314-y. [PMID: 31808068] - Yao-Te Yen, Yin-Jue Chang, Pin-Jung Lai, Chi-Lun Chang, Ting-Yueh Chen, San-Chong Chyueh. A Study of Opiate, Opiate Metabolites and Antihistamines in Urine after Consumption of Cold Syrups by LC-MS/MS.
Molecules (Basel, Switzerland).
2020 Feb; 25(4):. doi:
10.3390/molecules25040972. [PMID: 32098143] - Iason Thomas, Leonard Q C Siew, Timothy J Watts, Rubaiyat Haque. Seaweed allergy.
The journal of allergy and clinical immunology. In practice.
2019 Feb; 7(2):714-715. doi:
10.1016/j.jaip.2018.11.009. [PMID: 30471363] - Yuan Su, Hang Jie, Qing Zhu, Xiaoling Zhao, Yan Wang, Huadong Yin, Shailendra Kumar Mishra, Diyan Li. Effect of Bitter Compounds on the Expression of Bitter Taste Receptor T2R7 Downstream Signaling Effectors in cT2R7/pDisplay-Gα16/gust44/pcDNA3.1 (+) Cells.
BioMed research international.
2019; 2019(?):6301915. doi:
10.1155/2019/6301915. [PMID: 31781630] - Takashige Yamada, Takeshi Suzuki, Reiko Murase, Hiromasa Nagata, Shizuko Kosugi. Anaphylactic Reactions to Native and Light-Exposed Sugammadex Suggested by Basophil Activation Test: A Report of 2 Cases.
A&A practice.
2018 Oct; 11(7):181-183. doi:
10.1213/xaa.0000000000000774. [PMID: 29672323] - Tomoe Nishimura, Osamu Kaminuma, Mayumi Saeki, Noriko Kitamura, Minoru Gotoh, Akio Mori, Takachika Hiroi. Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis.
Allergology international : official journal of the Japanese Society of Allergology.
2018 Sep; 67S(?):S25-S31. doi:
10.1016/j.alit.2018.05.002. [PMID: 29910099] - Mariele Gobo-Oliveira, Vitória G Pigari, Matheus Sp Ogata, Hélio A Miot, Daniela Ponce, Luciana Pf Abbade. Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial.
European journal of dermatology : EJD.
2018 Aug; 28(4):488-495. doi:
10.1684/ejd.2018.3356. [PMID: 29976533] - Weijie Xu, Jiagang Deng, Yiyun Qian, Xiao-Tao Hou, Zhenhua Zhu, Ming Zhao, Erxin Shang, Dawei Qian, Huiting Zeng, Hanqing Pang, Jinao Duan. Simultaneous determination of kaempferol, quercetin, mangiferin, gallic acid, p-hydroxybenzoic acid and chlorpheniramine maleate in rat plasma after oral administration of Mang-Guo-Zhi-Ke tablets by UHPLC-MS/MS and its application to pharmacokinetics.
Biomedical chromatography : BMC.
2018 Apr; 32(4):. doi:
10.1002/bmc.4155. [PMID: 29169211] - Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson. Brompheniramine and Chlorpheniramine Pharmacokinetics Following Single-Dose Oral Administration in Children Aged 2 to 17 Years.
Journal of clinical pharmacology.
2018 04; 58(4):494-503. doi:
10.1002/jcph.1037. [PMID: 29136286] - Yaqi Yao, Li Zhou, Meng Li, Xingjie Guo. The cation-selective exhaustive injection and sweeping capillary electrophoresis method for the analysis of chlorpheniramine enantiomers in rat plasma.
Journal of pharmaceutical and biomedical analysis.
2018 Jan; 148(?):142-148. doi:
10.1016/j.jpba.2017.09.021. [PMID: 29024852] - Lamis Beshir, Babiker Kaballo, Donald Young. Attempted suicide by ingestion of hair dye containing p-phenylenediamine: a case report.
Annals of clinical biochemistry.
2017 Jul; 54(4):507-510. doi:
10.1177/0004563216685117. [PMID: 27923888] - Natsumi Hama, Yutaka Shimomura, Hiroshi Arinami, Ryoko Maruyama, Riichiro Abe. Localized heat urticaria: Positive reaction of preheated autologous serum skin test.
The Journal of dermatology.
2016 Sep; 43(9):1099-100. doi:
10.1111/1346-8138.13356. [PMID: 26970386] - Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism.
Journal of separation science.
2016 May; 39(9):1766-75. doi:
10.1002/jssc.201501026. [PMID: 26935589] - Na Zhang. Letter to the editor regarding 'Development and validation of a sensitive UHPLC-MS/MS method for simultaneous analysis of tramadol, dextromethorphan chlorpheniramine and their major metabolites in human plasma in forensic context: application to pharmacokinetics'.
Biomedical chromatography : BMC.
2016 Apr; 30(4):663-4. doi:
10.1002/bmc.3603. [PMID: 26332009] - Hala M Heneedak, Ismail Salama, Samia Mostafa, Ehab El-Kady, Mohamed El-Sadek. Development and validation of a sensitive UHPLC-MS/MS method for the simultaneous analysis of tramadol, dextromethorphan chlorpheniramine and their major metabolites in human plasma in forensic context: application to pharmacokinetics.
Biomedical chromatography : BMC.
2015 Jul; 29(7):998-1007. doi:
10.1002/bmc.3384. [PMID: 25417559] - Sameer Nadaf, Petra Nnamani, Namdeo Jadhav. Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation.
AAPS PharmSciTech.
2015 Jun; 16(3):716-29. doi:
10.1208/s12249-014-0256-y. [PMID: 25523143] - Aravindhan Thiruputkuzhi Ranganathan, Chitraa R Chandran, Priya Prabhakar, Mahalingam Lakshmiganthan, Thakkalapati Parthasaradhi. Plasma cell gingivitis: treatment with chlorpheniramine maleate.
The International journal of periodontics & restorative dentistry.
2015 May; 35(3):411-3. doi:
10.11607/prd.2111. [PMID: 25909529] - Eleonora Veglia, Cristina Grange, Alessandro Pini, Aldo Moggio, Cecilia Lanzi, Giovanni Camussi, Paul L Chazot, Arianna Carolina Rosa. Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2015 Apr; 64(3-4):261-70. doi:
10.1007/s00011-015-0807-z. [PMID: 25725698] - Tingting Hong, Cuijie Chi, Yibing Ji. Pepsin-modified chiral monolithic column for affinity capillary electrochromatography.
Journal of separation science.
2014 Nov; 37(22):3377-83. doi:
10.1002/jssc.201400424. [PMID: 25146884] - Ying Ding, Kai Huang, Lan Chen, Jie Yang, Wen-Yan Xu, Xue-Jiao Xu, Ru Duan, Jing Zhang, Qing He. Simultaneous quantitative analysis of dextromethorphan, dextrorphan and chlorphenamine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Biomedical chromatography : BMC.
2014 Mar; 28(3):446-52. doi:
10.1002/bmc.3054. [PMID: 24254834] - Taisuke Kuroda, Shun-ichi Nagata, Yoshimasa Takizawa, Norihisa Tamura, Kanichi Kusano, Fumiaki Mizobe, Kazuhisa Hariu. Pharmacokinetics and pharmacodynamics of d-chlorpheniramine following intravenous and oral administration in healthy Thoroughbred horses.
Veterinary journal (London, England : 1997).
2013 Aug; 197(2):433-7. doi:
10.1016/j.tvjl.2013.02.003. [PMID: 23489843] - Can Peng, Mengying Lv, Jixin Tian, Yin Huang, Yuan Tian, Zunjian Zhang. Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats.
The Journal of pharmacy and pharmacology.
2013 Jul; 65(7):1064-72. doi:
10.1111/jphp.12069. [PMID: 23738734] - J Scheele, K Diergarten, J Drevs, F R Niazi. A phase I trial assessing the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of single-dose Auron Misheil therapy in healthy male subjects.
Journal of clinical pharmacy and therapeutics.
2013 Feb; 38(1):3-11. doi:
10.1111/j.1365-2710.2009.01087.x. [PMID: 23281770] - Mohammad Hossein Boskabady, Hengameh Tabanfar, Zahra Gholamnezhad, Hamid Reza Sadeghnia. Inhibitory effect of Zataria multiflora Boiss and carvacrol on histamine (H(1) ) receptors of guinea-pig tracheal chains.
Fundamental & clinical pharmacology.
2012 Oct; 26(5):609-20. doi:
10.1111/j.1472-8206.2011.00971.x. [PMID: 21806678] - Wenhua Gao, Yunsheng Chen, Gaopan Chen, Jing Xi, Yaowen Chen, Jianying Yang, Ning Xu. Trace analysis of three antihistamines in human urine by on-line single drop liquid-liquid-liquid microextraction coupled to sweeping micellar electrokinetic chromatography and its application to pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Sep; 904(?):121-7. doi:
10.1016/j.jchromb.2012.07.032. [PMID: 22902104] - Homeira Ebrahimzadeh, Nafiseh Shekari, Zahra Saharkhiz, Ali Akbar Asgharinezhad. Simultaneous determination of chloropheniramine maleate and dextromethorphan hydrobromide in plasma sample by hollow fiber liquid phase microextraction and high performance liquid chromatography with the aid of chemometrics.
Talanta.
2012 May; 94(?):77-83. doi:
10.1016/j.talanta.2012.02.054. [PMID: 22608417] - Warren C Rodrigues, Catherine Castro, Philip Catbagan, Christine Moore, Guohong Wang. Immunoassay screening of diphenhydramine (Benadryl®) in urine and blood using a newly developed assay.
Journal of analytical toxicology.
2012 Mar; 36(2):123-9. doi:
10.1093/jat/bkr015. [PMID: 22337782] - Derong Zhu, Xia Li, Jinying Sun, Tianyan You. Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.
Talanta.
2012 Jan; 88(?):265-71. doi:
10.1016/j.talanta.2011.10.040. [PMID: 22265497] - Ziyan Hu, Qiaogen Zou, Jixin Tian, Lili Sun, Zunjian Zhang. Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Dec; 879(32):3937-42. doi:
10.1016/j.jchromb.2011.11.001. [PMID: 22119507] - Yun-Qing Huang, Jing-Qing You, Junsheng Zhang, Wenjian Sun, Li Ding, Yu-Qi Feng. Coupling frontal elution paper chromatography with desorption corona beam ionization mass spectrometry for rapid analysis of chlorphenamine in herbal medicines and dietary supplements.
Journal of chromatography. A.
2011 Oct; 1218(41):7371-6. doi:
10.1016/j.chroma.2011.08.067. [PMID: 21899852] - Mohammad Hossein Boskabady, Hengameh Tabanfar. Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains.
Indian journal of experimental biology.
2011 Sep; 49(9):679-83. doi:
". [PMID: 21941941] - Caterina Foti, Nicoletta Cassano, Gianni Mistrello, Stefano Amato, Paolo Romita, Gino Antonio Vena. Contact urticaria to raw arugula and parsley.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2011 May; 106(5):447-8. doi:
10.1016/j.anai.2011.01.029. [PMID: 21530883] - Jürgen Scheele, Marion Mappes, Annette Dorn, Faiz Niazi. Effects of Auron-Misheil-Therapy in human in vitro skin models.
The Journal of dermatology.
2011 May; 38(5):456-64. doi:
10.1111/j.1346-8138.2010.00994.x. [PMID: 21352344] - Mohammad Hossein Boskabady, Mahbobaeh Ghasemzadeh Rahbardar, Zahra Jafari. The effect of safranal on histamine (H(1)) receptors of guinea pig tracheal chains.
Fitoterapia.
2011 Mar; 82(2):162-7. doi:
10.1016/j.fitote.2010.08.017. [PMID: 20804826] - Naruo Shoji, Kazuhito Asano, Atsuko Furuta, Kojiro Hirano, Harumi Suzaki. Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.
International archives of allergy and immunology.
2011; 155(1):38-51. doi:
10.1159/000318720. [PMID: 21109747] - Andrew A Monte, Ryan Chuang, Michael Bodmer. Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review.
British journal of clinical pharmacology.
2010 Dec; 70(6):794-8. doi:
10.1111/j.1365-2125.2010.03747.x. [PMID: 21175434] - Omnia A Ismaiel, Tianyi Zhang, Rand G Jenkins, H Thomas Karnes. Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography/mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Dec; 878(31):3303-16. doi:
10.1016/j.jchromb.2010.10.012. [PMID: 21056019] - T Hattori, S Watanabe, M Kano, M Kanazawa, S Fukudo. Differential responding of autonomic function to histamine H₁ antagonism in irritable bowel syndrome.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2010 Dec; 22(12):1284-91, e335. doi:
10.1111/j.1365-2982.2010.01568.x. [PMID: 20667004] - Alberto Alvarez-Perea, Alicia Prieto García, Alejandro La Rotta Hernández, Manuel de Barrio, María Luisa Baeza. Urticaria due to aloe vera: a new sensitizer?.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2010 Nov; 105(5):404-5. doi:
10.1016/j.anai.2010.09.016. [PMID: 21055672] - Lawrence Asamoah Adutwum, Naoya Kishikawa, Kaname Ohyama, Shiro Harada, Kenichiro Nakashima, Naotaka Kuroda. Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence-labeled chlorpheniramine with Suzuki coupling reaction.
Analytical and bioanalytical chemistry.
2010 Sep; 398(2):823-9. doi:
10.1007/s00216-010-3932-0. [PMID: 20582691] - Ronilson Agnaldo Moreno, Diogo Oliveira-Silva, Carlos Eduardo Sverdloff, Bruno Carter Borges, Paulo Alexandre Rebelo Galvinas, Rafael Barrientos Astigarraga, Ney Carter Borges. Determination of chlorpheniramine in human plasma by HPLC-ESI-MS/MS: application to a dexchlorpheniramine comparative bioavailability study.
Biomedical chromatography : BMC.
2010 Jul; 24(7):774-81. doi:
10.1002/bmc.1362. [PMID: 19924675] - Naoko Nakaigawa, Kotoe Kamata, Ryu Komatsu, Makoto Ozaki. [Perioperative management of a patient complicated with Quincke's edema].
Masui. The Japanese journal of anesthesiology.
2010 Apr; 59(4):501-3. doi:
. [PMID: 20420145] - M H Boskabady, M Ghasemzadeh Rahbardar, H Nemati, M Esmaeilzadeh. Inhibitory effect of Crocus sativus (saffron) on histamine (H1) receptors of guinea pig tracheal chains.
Die Pharmazie.
2010 Apr; 65(4):300-5. doi:
". [PMID: 20432629] - Hao Li, Chao Zhang, Jiang Wang, Yao Jiang, J Paul Fawcett, Jingkai Gu. Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2010 Feb; 51(3):716-22. doi:
10.1016/j.jpba.2009.10.009. [PMID: 19879084] - Marcello Caballero, Jürgen Scheele, Ute Zirrgiebel, Norbert Esser, Christoph Schächtele, Jens Soltau, Jochen Rentschler, Klaus Diergarten, Joachim Drevs. Anti-tumor effects of AMT in the renal cell carcinoma model.
Oncology reports.
2010 Jan; 23(1):205-10. doi:
. [PMID: 19956883] - Jürgen Scheele, Faiz Niazi, Joachim Drevs, Klaus Diergarten, Papa Toure. A pilot study of Auron Misheil Therapy in patients with advanced cervical cancer: tumor response and its correlation with clinical benefit response, and preliminary quality of life data.
Oncology reports.
2009 Oct; 22(4):877-83. doi:
10.3892/or_00000512. [PMID: 19724868] - Mathew George, Lincy Joseph, Ramaswamy. Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2009 Jul; 6(4):554-9. doi:
10.4314/ajtcam.v6i4.57206. [PMID: 20606777] - Faiz Niazi, Joachim Drevs, Klaus Diergarten, Annette Dorn, Armin Maier, Heinz Herbert Fiebig, Eddy Bruyns, Jürgen Scheele. AMT: preclinical pharmacology studies.
International journal of oncology.
2009 May; 34(5):1341-52. doi:
. [PMID: 19360346] - Shudan Feng, Yuan Tian, Zunjian Zhang, Jingjing Zhang, Meihua Huang, Yun Chen. Rapid simultaneous determination of paracetamol, amantadine hydrochloride, caffeine and chlorpheniramine maleate in human plasma by liquid chromatography/tandem mass spectrometry.
Arzneimittel-Forschung.
2009; 59(2):86-95. doi:
10.1055/s-0031-1296369. [PMID: 19338139] - Omnia A Ismaiel, Matthew S Halquist, Magda Y Elmamly, Abdalla Shalaby, H Thomas Karnes. Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Nov; 875(2):333-43. doi:
10.1016/j.jchromb.2008.08.032. [PMID: 18926779] - Marina Martinengo, Diego Fabio Ardenghi, Gino Tripodi, Giorgio Reali. The first case of drug-induced immune hemolytic anemia due to hydrocortisone.
Transfusion.
2008 Sep; 48(9):1925-9. doi:
10.1111/j.1537-2995.2008.01797.x. [PMID: 18565121] - Gianluigi Tanda, Theresa A Kopajtic, Jonathan L Katz. Cocaine-like neurochemical effects of antihistaminic medications.
Journal of neurochemistry.
2008 Jul; 106(1):147-57. doi:
10.1111/j.1471-4159.2008.05361.x. [PMID: 18363822] - T G Madsen, D R Trout, S R L Cieslar, N G Purdie, M O Nielsen, J P Cant. The histamine H1 receptor is not involved in local control of mammary blood flow in dairy cows.
Journal of dairy science.
2008 Jun; 91(6):2461-8. doi:
10.3168/jds.2007-0845. [PMID: 18487669] - G O Gbotosho, C T Happi, A Sijuade, O A T Ogundahunsi, A Sowunmi, A M J Oduola. Comparative study of interactions between chloroquine and chlorpheniramine or promethazine in healthy volunteers: a potential combination-therapy phenomenon for resuscitating chloroquine for malaria treatment in Africa.
Annals of tropical medicine and parasitology.
2008 Jan; 102(1):3-9. doi:
10.1179/136485908x252179. [PMID: 18186973] - Michael Ganetsky, Kavita M Babu, Edward W Boyer. Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy.
Pediatric emergency care.
2007 Nov; 23(11):829-31. doi:
10.1097/pec.0b013e31815a0667. [PMID: 18007217] - Maria del Mar Ramirez Fernandez, Marleen Laloup, Michelle Wood, Gert De Boeck, Manuel Lopez-Rivadulla, Pierre Wallemacq, Nele Samyn. Liquid chromatography-tandem mass spectrometry method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and metabolites, in urine.
Journal of analytical toxicology.
2007 Oct; 31(8):497-504. doi:
10.1093/jat/31.8.497. [PMID: 17988464] - A Gupta, M Gillard, B Christophe, P Chatelain, R Massingham, M Hammarlund-Udenaes. Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig.
British journal of pharmacology.
2007 Aug; 151(7):1129-36. doi:
10.1038/sj.bjp.0707318. [PMID: 17558437] - María Amparo Martínez-Gómez, Rosa M Villanueva-Camañas, Salvador Sagrado, María José Medina-Hernández. Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE.
Electrophoresis.
2007 Aug; 28(15):2635-43. doi:
10.1002/elps.200600742. [PMID: 17605150] - Md Ashequr Rahman, Toshio Inoue, Takashi Ishikawa, Rie Yatsuzuka, Hiroshi Ohtsu, Chiaki Kamei. Involvement of chemical mediators in nasal allergic responses of HDC-KO mice.
European journal of pharmacology.
2007 Jul; 567(3):245-51. doi:
10.1016/j.ejphar.2007.01.082. [PMID: 17543300] - Huan-Xiang Zeng, Gang Cheng, Wei-San Pan, Guo-Ping Zhong, Min Huang. Preparation of codeine-resinate and chlorpheniramine-resinate sustained-release suspension and its pharmacokinetic evaluation in beagle dogs.
Drug development and industrial pharmacy.
2007 Jun; 33(6):649-65. doi:
10.1080/03639040601050221. [PMID: 17613029] - G O Gbotosho, O A Ogundahunsi, C T Happi, D E Kyle, L Gerena, W K Milhous, A Sowunmi, A M J Oduola, L A Salako. The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum.
Annals of tropical medicine and parasitology.
2006 Oct; 100(7):571-8. doi:
10.1179/136485906x118486. [PMID: 16989682] - Yingju Liu, Wuyi Zhou. Determination of chlorpheniramine and its binding with human serum albumin by capillary electrophoresis with tris(2,2'-bipyridyl)ruthenium(II) electrochemiluminescence detection.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2006 Jul; 22(7):999-1003. doi:
10.2116/analsci.22.999. [PMID: 16837753] - Shuang Ren, Xiao-yan Chen, Xiao-tao Duan, Da-fang Zhong. [Simultaneous determination of ephedrine and chlorpheniramine in human plasma by a highly sensitive liquid chromatography-tandem mass spectrometric method].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Feb; 41(2):188-92. doi:
NULL. [PMID: 16671554] - Zhen Qin, Chao Chen. Synergistic action of famotidine and chlorpheniramine on acetic acid-induced chronic gastric ulcer in rats.
World journal of gastroenterology.
2005 Dec; 11(45):7203-7. doi:
10.3748/wjg.v11.i45.7203. [PMID: 16437673] - Anthony A Attama, Megg O Nkemnele. In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus.
International journal of pharmaceutics.
2005 Nov; 304(1-2):4-10. doi:
10.1016/j.ijpharm.2005.08.018. [PMID: 16198521] - M Bhalla, G P Thami. Acute urticaria following 'gomutra' (cow's urine) gargles.
Clinical and experimental dermatology.
2005 Nov; 30(6):722-3. doi:
10.1111/j.1365-2230.2005.01890.x. [PMID: 16197405] - Richard H Schwartz. Adolescent abuse of dextromethorphan.
Clinical pediatrics.
2005 Sep; 44(7):565-8. doi:
10.1177/000992280504400702. [PMID: 16151560] - Hideo Umeuchi, Yumi Kawashima, Christopher A Aoki, Takahiro Kurokawa, Kaoru Nakao, Masatoshi Itoh, Kentaro Kikuchi, Takashi Kato, Kiyoshi Okano, M Eric Gershwin, Hiroshi Miyakawa. Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride.
European journal of pharmacology.
2005 Aug; 518(2-3):133-9. doi:
10.1016/j.ejphar.2005.06.019. [PMID: 16055114] - J Montoro, N Freixenet, A Lozano, F Bertomeu. An unusual adverse drug reaction?.
Allergologia et immunopathologia.
2005 Jul; 33(4):235-7. doi:
10.1157/13077751. [PMID: 16045865] - Tomohiro Okuda, Yukiko Ito, Naoto Nakagawa, Takanori Hishinuma, Hiroki Tsukamoto, Kentaro Iwabuchi, Takehiko Watanabe, Kiyoyuki Kitaichi, Junichi Goto, Kazuhiko Yanai. Drug interaction between methamphetamine and antihistamines: behavioral changes and tissue concentrations of methamphetamine in rats.
European journal of pharmacology.
2004 Nov; 505(1-3):135-44. doi:
10.1016/j.ejphar.2004.10.022. [PMID: 15556146] - Hui Xu, Xiaodong Yu, Hongyuan Chen. Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2004 Oct; 20(10):1409-13. doi:
10.2116/analsci.20.1409. [PMID: 15524192] - O Cáceres Calle, M Fernández-Benítez. Allergy to dexchlorpheniramine. Study of a case.
Allergologia et immunopathologia.
2004 Sep; 32(5):306-9. doi:
10.1016/s0301-0546(04)79259-9. [PMID: 15456628] - Yi-qing Mao, Zhi-xin Mu, Yue-fei Zhang. [Experimental study on the pharmacology of 999 ganmaoling, a compound recipe of Chinese and Western materia medica].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 Aug; 24(8):726-30. doi:
". [PMID: 15366599] - Xiaoyan Chen, Yong Zhang, Dafang Zhong. Simultaneous determination of chlorpheniramine and pseudoephedrine in human plasma by liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2004 May; 18(4):248-53. doi:
10.1002/bmc.311. [PMID: 15162387] - Qing-hua Ge, Zhen Zhou, Xiao-jin Zhi, Hao Wang. [Simultaneous determination of pseudoephedrine and chlorpheniramine in human plasma by HPLC-UV detection method].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 Apr; 39(4):281-4. doi:
NULL. [PMID: 15303659] - Indika Bandara Gawarammana, S Abeysingha M Kularatne, Wasantha P Dissanayake, Ranjith P V Kumarasiri, Nimal Senanayake, H Ariyasena. Parallel infusion of hydrocortisone +/- chlorpheniramine bolus injection to prevent acute adverse reactions to antivenom for snakebites.
The Medical journal of Australia.
2004 Jan; 180(1):20-3. doi:
10.5694/j.1326-5377.2004.tb05768.x. [PMID: 14709123] - M H Boskabady, M Ramazani, T Tabei. Relaxant effects of different fractions of essential oil from Carum copticum on guinea pig tracheal chains.
Phytotherapy research : PTR.
2003 Dec; 17(10):1145-9. doi:
10.1002/ptr.1238. [PMID: 14669246] - Nalini P Sadagopan, Wenlin Li, Jack A Cook, Betsy Galvan, David L Weller, Scott T Fountain, Lucinda H Cohen. Investigation of EDTA anticoagulant in plasma to improve the throughput of liquid chromatography/tandem mass spectrometric assays.
Rapid communications in mass spectrometry : RCM.
2003; 17(10):1065-70. doi:
10.1002/rcm.1023. [PMID: 12720287] - F Estelle R Simons, Norman A Silver, Xiaochen Gu, Keith J Simons. Clinical pharmacology of H1-antihistamines in the skin.
The Journal of allergy and clinical immunology.
2002 Nov; 110(5):777-83. doi:
10.1067/mai.2002.129123. [PMID: 12417888] - Takeshi Takagaki, Michiaki Matsuda, Yasuyuki Mizuki, Yoshiaki Terauchi. Simple and sensitive method for the determination of chlorpheniramine maleate in human plasma using liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Sep; 776(2):169-76. doi:
10.1016/s1570-0232(02)00315-x. [PMID: 12137998] - Atsuko Fukada, Hideyuki Saito, Ken-Ichi Inui. Transport mechanisms of nicotine across the human intestinal epithelial cell line Caco-2.
The Journal of pharmacology and experimental therapeutics.
2002 Aug; 302(2):532-8. doi:
10.1124/jpet.102.034629. [PMID: 12130712] - Sally Usdin Yasuda, Peter Zannikos, Andrea E Young, Karen M Fried, Irving W Wainer, Raymond L Woosley. The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine.
British journal of clinical pharmacology.
2002 May; 53(5):519-25. doi:
10.1046/j.1365-2125.2002.01578.x. [PMID: 11994058] - Masaru Kato, Kumiko Sakai-Kato, Nozomi Matsumoto, Toshimasa Toyo'oka. A protein-encapsulation technique by the sol-gel method for the preparation of monolithic columns for capillary electrochromatography.
Analytical chemistry.
2002 Apr; 74(8):1915-21. doi:
10.1021/ac0112162. [PMID: 11985326] - Masaaki Tagawa, Michiko Kano, Nobuyuki Okamura, Makoto Higuchi, Michiaki Matsuda, Yasuyuki Mizuki, Hiroyuki Arai, Toshihiko Fujii, Sadao Komemushi, Masatoshi Itoh, Hidetada Sasaki, Takehiko Watanabe, Kazuhiko Yanai. Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration.
British journal of clinical pharmacology.
2002 Mar; 53(3):296-304. doi:
10.1046/j.0306-5251.2001.01183.x. [PMID: 11874393] - Nu He, Wen-Qi Zhang, Dolores Shockley, Timi Edeki. Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes.
European journal of clinical pharmacology.
2002 Feb; 57(12):847-51. doi:
10.1007/s00228-001-0399-0. [PMID: 11936702] - Karen M Fried, Andrea E Young, Sally Usdin Yasuda, Irving W Wainer. The enantioselective determination of chlorpheniramine and its major metabolites in human plasma using chiral chromatography on a beta-cyclodextrin chiral stationary phase and mass spectrometric detection.
Journal of pharmaceutical and biomedical analysis.
2002 Jan; 27(3-4):479-88. doi:
10.1016/s0731-7085(01)00570-2. [PMID: 11755749] - F Moriya, Y Hashimoto. Postmortem diffusion of drugs from the bladder into femoral venous blood.
Forensic science international.
2001 Dec; 123(2-3):248-53. doi:
10.1016/s0379-0738(01)00530-8. [PMID: 11728758] - M Tagawa, M Kano, N Okamura, M Higuchi, M Matsuda, Y Mizuki, H Arai, R Iwata, T Fujii, S Komemushi, T Ido, M Itoh, H Sasaki, T Watanabe, K Yanai. Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.
British journal of clinical pharmacology.
2001 Nov; 52(5):501-9. doi:
10.1046/j.1365-2125.2001.01471.x. [PMID: 11736858] - H Inoue, K I Hisamatsu, M Yamauchi, N Kumagai. Rapid and simple determination of histamine-N-methyl transferase activity by high-performance liquid chromatography with UV detection.
Mediators of inflammation.
2001 Oct; 10(5):273-7. doi:
10.1080/09629350120093759. [PMID: 11759112] - K Hayashi, H Sato, T Kaise, K Ohmori, A Ishii, J Sano, A Karasawa. Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats.
European journal of pharmacology.
2001 Aug; 425(3):219-27. doi:
10.1016/s0014-2999(01)01177-3. [PMID: 11513841] - S Morita, Y Ueda, N Yokoyama. Painless thyroiditis induced by the cessation of betamethasone.
Internal medicine (Tokyo, Japan).
2001 Aug; 40(8):744-6. doi:
10.2169/internalmedicine.40.744. [PMID: 11518115] - B S Van Toor, A Buchwald, E Stengele, D Trenk, C Gercek, C M de Mey. Systemic bioavailability of nasally applied chlorphenamine maleate (0.4\% nasal spray) relative to tablets administered perorally.
International journal of clinical pharmacology and therapeutics.
2001 Apr; 39(4):173-8. doi:
10.5414/cpp39173. [PMID: 11332874] - T H Bui, C Fernandez, K Vu, K H Nguyen, A Thuillier, R Farinotti, P Arnaud, F Gimenez. Stereospecific versus nonstereospecific assessments for the bioequivalence of two formulations of racemic chlorpheniramine.
Chirality.
2000 Aug; 12(8):599-605. doi:
10.1002/1520-636x(2000)12:8<599::aid-chir1>3.0.co;2-s. [PMID: 10897096]