Chlorpheniramine maleate (BioDeep_00000015098)

   

natural product


代谢物信息卡片


Chlorpheniramine maleate

化学式: C20H23ClN2O4 (390.13462680000004)
中文名称: 马来酸氯苯那敏
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(=CC=CC(=N1)C(CCN(C)C)C2=CC=C(C=C2)Cl).C(/C=C\C(O)=O)(O)=O
InChI: 2-1-

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents
Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM[1][2][3].

同义名列表

3 个代谢物同义名

Chlorpheniramine maleate; Chlorphenamine maleate; Chlorpheniramine (maleate)



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ting Yang, Xiang Li, Lili Lan, Dandan Gong, Fan Zhang, Xinrong Liu, Guixia Ling, Guoxiang Sun. Quality evaluation of Keteling capsules based on fingerprinting, multicomponent quantification, and quantitative prediction. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Aug; 303(?):123274. doi: 10.1016/j.saa.2023.123274. [PMID: 37603975]
  • Qingqing Guo, Hao Lin, Jiandong Lin. Chlorpheniramine poisoning as a potential cause of rhabdomyolysis. The American journal of emergency medicine. 2022 07; 57(?):236.e1-236.e3. doi: 10.1016/j.ajem.2022.04.010. [PMID: 35459564]
  • Swann Geoffroy, Alexis Fremery, Yann Lambert, Christian Marty, Narcisse Elenga. Case Report: Acute Kidney Failure due to Massive Envenomation of a Two-Year-Old Child Caused by Killer Bee Stings. The American journal of tropical medicine and hygiene. 2021 05; 105(1):222-224. doi: 10.4269/ajtmh.20-1276. [PMID: 33970887]
  • Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry. Angewandte Chemie (International ed. in English). 2020 12; 59(51):23162-23168. doi: 10.1002/anie.202006481. [PMID: 32869436]
  • Bernard Ho, Abhishek Ray. A case for palliative dermatology: COVID-19-related dermatoses. Clinics in dermatology. 2020 Nov; 38(6):768-769. doi: 10.1016/j.clindermatol.2020.06.001. [PMID: 33341213]
  • Khalid Hassan. Urticaria and angioedema as a prodromal cutaneous manifestation of SARS-CoV-2 (COVID-19) infection. BMJ case reports. 2020 Jul; 13(7):. doi: 10.1136/bcr-2020-236981. [PMID: 32641443]
  • Kave Moulaee, Mohammad Reza Ganjali, Parviz Norouzi, Hadi Beitollahi. Facile electrochemical preparation of overoxidizedpolypyrrole/RGO composite for ds-DNA immobilization: a novel signal amplified sensing platform for electrochemical determination of chlorpheniramine. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2020 Jun; 28(1):57-64. doi: 10.1007/s40199-019-00314-y. [PMID: 31808068]
  • Yao-Te Yen, Yin-Jue Chang, Pin-Jung Lai, Chi-Lun Chang, Ting-Yueh Chen, San-Chong Chyueh. A Study of Opiate, Opiate Metabolites and Antihistamines in Urine after Consumption of Cold Syrups by LC-MS/MS. Molecules (Basel, Switzerland). 2020 Feb; 25(4):. doi: 10.3390/molecules25040972. [PMID: 32098143]
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  • Takashige Yamada, Takeshi Suzuki, Reiko Murase, Hiromasa Nagata, Shizuko Kosugi. Anaphylactic Reactions to Native and Light-Exposed Sugammadex Suggested by Basophil Activation Test: A Report of 2 Cases. A&A practice. 2018 Oct; 11(7):181-183. doi: 10.1213/xaa.0000000000000774. [PMID: 29672323]
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  • Weijie Xu, Jiagang Deng, Yiyun Qian, Xiao-Tao Hou, Zhenhua Zhu, Ming Zhao, Erxin Shang, Dawei Qian, Huiting Zeng, Hanqing Pang, Jinao Duan. Simultaneous determination of kaempferol, quercetin, mangiferin, gallic acid, p-hydroxybenzoic acid and chlorpheniramine maleate in rat plasma after oral administration of Mang-Guo-Zhi-Ke tablets by UHPLC-MS/MS and its application to pharmacokinetics. Biomedical chromatography : BMC. 2018 Apr; 32(4):. doi: 10.1002/bmc.4155. [PMID: 29169211]
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  • Yaqi Yao, Li Zhou, Meng Li, Xingjie Guo. The cation-selective exhaustive injection and sweeping capillary electrophoresis method for the analysis of chlorpheniramine enantiomers in rat plasma. Journal of pharmaceutical and biomedical analysis. 2018 Jan; 148(?):142-148. doi: 10.1016/j.jpba.2017.09.021. [PMID: 29024852]
  • Lamis Beshir, Babiker Kaballo, Donald Young. Attempted suicide by ingestion of hair dye containing p-phenylenediamine: a case report. Annals of clinical biochemistry. 2017 Jul; 54(4):507-510. doi: 10.1177/0004563216685117. [PMID: 27923888]
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  • Na Zhang. Letter to the editor regarding 'Development and validation of a sensitive UHPLC-MS/MS method for simultaneous analysis of tramadol, dextromethorphan chlorpheniramine and their major metabolites in human plasma in forensic context: application to pharmacokinetics'. Biomedical chromatography : BMC. 2016 Apr; 30(4):663-4. doi: 10.1002/bmc.3603. [PMID: 26332009]
  • Hala M Heneedak, Ismail Salama, Samia Mostafa, Ehab El-Kady, Mohamed El-Sadek. Development and validation of a sensitive UHPLC-MS/MS method for the simultaneous analysis of tramadol, dextromethorphan chlorpheniramine and their major metabolites in human plasma in forensic context: application to pharmacokinetics. Biomedical chromatography : BMC. 2015 Jul; 29(7):998-1007. doi: 10.1002/bmc.3384. [PMID: 25417559]
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  • Aravindhan Thiruputkuzhi Ranganathan, Chitraa R Chandran, Priya Prabhakar, Mahalingam Lakshmiganthan, Thakkalapati Parthasaradhi. Plasma cell gingivitis: treatment with chlorpheniramine maleate. The International journal of periodontics & restorative dentistry. 2015 May; 35(3):411-3. doi: 10.11607/prd.2111. [PMID: 25909529]
  • Eleonora Veglia, Cristina Grange, Alessandro Pini, Aldo Moggio, Cecilia Lanzi, Giovanni Camussi, Paul L Chazot, Arianna Carolina Rosa. Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2015 Apr; 64(3-4):261-70. doi: 10.1007/s00011-015-0807-z. [PMID: 25725698]
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  • Ying Ding, Kai Huang, Lan Chen, Jie Yang, Wen-Yan Xu, Xue-Jiao Xu, Ru Duan, Jing Zhang, Qing He. Simultaneous quantitative analysis of dextromethorphan, dextrorphan and chlorphenamine in human plasma by liquid chromatography-electrospray tandem mass spectrometry. Biomedical chromatography : BMC. 2014 Mar; 28(3):446-52. doi: 10.1002/bmc.3054. [PMID: 24254834]
  • Taisuke Kuroda, Shun-ichi Nagata, Yoshimasa Takizawa, Norihisa Tamura, Kanichi Kusano, Fumiaki Mizobe, Kazuhisa Hariu. Pharmacokinetics and pharmacodynamics of d-chlorpheniramine following intravenous and oral administration in healthy Thoroughbred horses. Veterinary journal (London, England : 1997). 2013 Aug; 197(2):433-7. doi: 10.1016/j.tvjl.2013.02.003. [PMID: 23489843]
  • Can Peng, Mengying Lv, Jixin Tian, Yin Huang, Yuan Tian, Zunjian Zhang. Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats. The Journal of pharmacy and pharmacology. 2013 Jul; 65(7):1064-72. doi: 10.1111/jphp.12069. [PMID: 23738734]
  • J Scheele, K Diergarten, J Drevs, F R Niazi. A phase I trial assessing the safety, tolerability, pharmacokinetic and pharmacodynamic characteristics of single-dose Auron Misheil therapy in healthy male subjects. Journal of clinical pharmacy and therapeutics. 2013 Feb; 38(1):3-11. doi: 10.1111/j.1365-2710.2009.01087.x. [PMID: 23281770]
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  • Homeira Ebrahimzadeh, Nafiseh Shekari, Zahra Saharkhiz, Ali Akbar Asgharinezhad. Simultaneous determination of chloropheniramine maleate and dextromethorphan hydrobromide in plasma sample by hollow fiber liquid phase microextraction and high performance liquid chromatography with the aid of chemometrics. Talanta. 2012 May; 94(?):77-83. doi: 10.1016/j.talanta.2012.02.054. [PMID: 22608417]
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  • Ziyan Hu, Qiaogen Zou, Jixin Tian, Lili Sun, Zunjian Zhang. Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Dec; 879(32):3937-42. doi: 10.1016/j.jchromb.2011.11.001. [PMID: 22119507]
  • Yun-Qing Huang, Jing-Qing You, Junsheng Zhang, Wenjian Sun, Li Ding, Yu-Qi Feng. Coupling frontal elution paper chromatography with desorption corona beam ionization mass spectrometry for rapid analysis of chlorphenamine in herbal medicines and dietary supplements. Journal of chromatography. A. 2011 Oct; 1218(41):7371-6. doi: 10.1016/j.chroma.2011.08.067. [PMID: 21899852]
  • Mohammad Hossein Boskabady, Hengameh Tabanfar. Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains. Indian journal of experimental biology. 2011 Sep; 49(9):679-83. doi: ". [PMID: 21941941]
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  • Jürgen Scheele, Marion Mappes, Annette Dorn, Faiz Niazi. Effects of Auron-Misheil-Therapy in human in vitro skin models. The Journal of dermatology. 2011 May; 38(5):456-64. doi: 10.1111/j.1346-8138.2010.00994.x. [PMID: 21352344]
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