Kanamycin sulfate (BioDeep_00000015097)
Chemicals and Drugs
代谢物信息卡片
Kanamycin A sulfate
化学式: C18H38N4O15S (582.2054278)
中文名称: 硫酸卡那霉素
谱图信息:
最多检出来源 () 0%
Reviewed
Last reviewed on 2024-08-12.
Cite this Page
Kanamycin sulfate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/kanamycin_sulfate (retrieved
2024-11-05) (BioDeep RN: BioDeep_00000015097). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
InChI: /m1./s1
描述信息
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:6109
- KEGG: C08046
- KEGGdrug: D00866
- KEGGdrug: D03262
- PubChem: 441374
- ChEMBL: CHEMBL1446
- MeSH: Kanamycin
- CAS: 25389-94-0
- CAS: 133-92-6
- NIKKAJI: J203.663K
- medchemexpress: HY-16566A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Analytical methods : advancing methods and applications.
2023 08; 15(34):4282-4288. doi:
10.1039/d3ay01076g. [PMID: 37599591] - Mohammad Hossein Mirzaee, Masoumeh Emadpour. Advances in the Transformation of Cyclamen persicum Mill. Through Direct Regeneration Based on an Optimized Kanamycin Selection Scheme.
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2022 12; 94(50):17567-17576. doi:
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European journal of medicinal chemistry.
2016 Sep; 120(?):329-37. doi:
10.1016/j.ejmech.2016.04.074. [PMID: 27236014] - T V Shevchuk, N S Zakharchenko, S V Tarlachkov, O V Furs, O V Dyachenko, Y I Buryanov. 35S Promoter Methylation in Kanamycin-Resistant Kalanchoe (Kalanchoe pinnata L.) Plants Expressing the Antimicrobial Peptide Cecropin P1 Transgene.
Biochemistry. Biokhimiia.
2016 Sep; 81(9):968-71. doi:
10.1134/s0006297916090054. [PMID: 27682168] - J A Dijkstra, A J Voerman, B Greijdanus, D J Touw, J W C Alffenaar. Immunoassay Analysis of Kanamycin in Serum Using the Tobramycin Kit.
Antimicrobial agents and chemotherapy.
2016 08; 60(8):4646-51. doi:
10.1128/aac.03025-15. [PMID: 27185806] - Shin-Ichi Katsumata, Maiko Fujioka, Shungo Fujii, Ken Takeda, Yoshiko Ishimi, Mariko Uehara. Kanamycin inhibits daidzein metabolism and abilities of the metabolites to prevent bone loss in ovariectomized mice.
BMC research notes.
2016 Jul; 9(?):334. doi:
10.1186/s13104-016-2139-7. [PMID: 27388904] - Sung Hwan Kim, Woonhee Jeung, Il-Dong Choi, Ji-Woong Jeong, Dong Eun Lee, Chul-Sung Huh, Geun-Bae Kim, Seong Soo Hong, Jae-Jung Shim, Jung Lyoul Lee, Jae-Hun Sim, Young-Tae Ahn. Lactic Acid Bacteria Improves Peyer's Patch Cell-Mediated Immunoglobulin A and Tight-Junction Expression in a Destructed Gut Microbial Environment.
Journal of microbiology and biotechnology.
2016 Jun; 26(6):1035-45. doi:
10.4014/jmb.1512.12002. [PMID: 26975767] - Gouranga Santra, Rudrajit Paul, Avik Karak, Somnath Mukhopadhay. Gitelman-like Syndrome with Kanamycin Toxicity.
The Journal of the Association of Physicians of India.
2016 05; 64(5):90-92. doi:
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Journal of medicinal chemistry.
2016 Apr; 59(7):3140-51. doi:
10.1021/acs.jmedchem.5b01912. [PMID: 26964758] - Vemanna S Ramu, Thavarekere N Swetha, Shekarappa H Sheela, Chandrashekar K Babitha, Sreevathsa Rohini, Malireddy K Reddy, Narendra Tuteja, Chandrashekar P Reddy, Trichi Ganesh Prasad, Makarla Udayakumar. Simultaneous expression of regulatory genes associated with specific drought-adaptive traits improves drought adaptation in peanut.
Plant biotechnology journal.
2016 Mar; 14(3):1008-20. doi:
10.1111/pbi.12461. [PMID: 26383697] - Rouhollah Barahimipour, Juliane Neupert, Ralph Bock. Efficient expression of nuclear transgenes in the green alga Chlamydomonas: synthesis of an HIV antigen and development of a new selectable marker.
Plant molecular biology.
2016 Mar; 90(4-5):403-18. doi:
10.1007/s11103-015-0425-8. [PMID: 26747175] - Kimi Ogasawara, Kenji Yamada, Noriyuki Hatsugai, Chiaki Imada, Mikio Nishimura. Hexose Oxidase-Mediated Hydrogen Peroxide as a Mechanism for the Antibacterial Activity in the Red Seaweed Ptilophora subcostata.
PloS one.
2016; 11(2):e0149084. doi:
10.1371/journal.pone.0149084. [PMID: 26867214] - Simplice B Tankeo, Pierre Tane, Victor Kuete. In vitro antibacterial and antibiotic-potentiation activities of the methanol extracts from Beilschmiedia acuta, Clausena anisata, Newbouldia laevis and Polyscias fulva against multidrug-resistant Gram-negative bacteria.
BMC complementary and alternative medicine.
2015 Nov; 15(?):412. doi:
10.1186/s12906-015-0944-5. [PMID: 26590804] - Peter Belenky, Jonathan D Ye, Caroline B M Porter, Nadia R Cohen, Michael A Lobritz, Thomas Ferrante, Saloni Jain, Benjamin J Korry, Eric G Schwarz, Graham C Walker, James J Collins. Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage.
Cell reports.
2015 Nov; 13(5):968-80. doi:
10.1016/j.celrep.2015.09.059. [PMID: 26565910] - Sang-In Park, Jaeseong Oh, Kyungho Jang, Jangsoo Yoon, Seol Ju Moon, Jong Sun Park, Jae Ho Lee, Junghan Song, In-Jin Jang, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of Second-Line Antituberculosis Drugs after Multiple Administrations in Healthy Volunteers.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4429-35. doi:
10.1128/aac.00354-15. [PMID: 25987620] - Vijayta Gupta, Laiq Ur Rahman. An efficient plant regeneration and Agrobacterium-mediated genetic transformation of Tagetes erecta.
Protoplasma.
2015 Jul; 252(4):1061-70. doi:
10.1007/s00709-014-0740-y. [PMID: 25504508] - L V Ribeiro Neto, A P Oliveira, M V Lourenço, B W Bertoni, S C França, T M Rosa-Santos, S M Zingaretti. Improving plant transformation using Agrobacterium tumefaciens.
Genetics and molecular research : GMR.
2015 Jun; 14(2):6695-8. doi:
10.4238/2015.june.18.13. [PMID: 26125878] - Min Zhao, Ying Zhuo, Ya-Qin Chai, Ruo Yuan. Au nanoparticles decorated C60 nanoparticle-based label-free electrochemiluminesence aptasensor via a novel 'on-off-on' switch system.
Biomaterials.
2015 Jun; 52(?):476-83. doi:
10.1016/j.biomaterials.2015.02.058. [PMID: 25818453] - Dong Chan Moon, Migma Dorji Tamang, Hyang-Mi Nam, Jin-Ha Jeong, Geum-Chan Jang, Suk-Chan Jung, Yong-Ho Park, Suk-Kyung Lim. Identification of livestock-associated methicillin-resistant Staphylococcus aureus isolates in Korea and molecular comparison between isolates from animal carcasses and slaughterhouse workers.
Foodborne pathogens and disease.
2015 Apr; 12(4):327-34. doi:
10.1089/fpd.2014.1868. [PMID: 25786036] - Tanmaya Joshi, Zhi Xiang Voo, Bim Graham, Leone Spiccia, Lisandra L Martin. Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D).
Biochimica et biophysica acta.
2015 Feb; 1848(2):385-91. doi:
10.1016/j.bbamem.2014.10.019. [PMID: 25450807] - J X Juan, X H Yu, X M Jiang, Z Gao, Y Zhang, W Li, Y D Duan, G Yang. Agrobacterium-mediated transformation of tomato with the ICE1 transcription factor gene.
Genetics and molecular research : GMR.
2015 Jan; 14(1):597-608. doi:
10.4238/2015.january.30.1. [PMID: 25729995] - Chunxiang Fu, Timothy Hernandez, Chuanen Zhou, Zeng-Yu Wang. Alfalfa (Medicago sativa L.).
Methods in molecular biology (Clifton, N.J.).
2015; 1223(?):213-21. doi:
10.1007/978-1-4939-1695-5_17. [PMID: 25300843] - Charles A Leslie, Sriema L Walawage, Sandra L Uratsu, Gale McGranahan, Abhaya M Dandekar. Walnut (Juglans).
Methods in molecular biology (Clifton, N.J.).
2015; 1224(?):229-41. doi:
10.1007/978-1-4939-1658-0_19. [PMID: 25416262] - Devendra Kumar Maravi, Purabi Mazumdar, Shamsher Alam, Vaibhav V Goud, Lingaraj Sahoo. Jatropha (Jatropha curcas L.).
Methods in molecular biology (Clifton, N.J.).
2015; 1224(?):25-35. doi:
10.1007/978-1-4939-1658-0_3. [PMID: 25416246] - Neda Soleimani, Mahdi Aganj, Liaqat Ali, Leili Shokoohizadeh, Türkân Sakinc. Frequency distribution of genes encoding aminoglycoside modifying enzymes in uropathogenic E. coli isolated from Iranian hospital.
BMC research notes.
2014 Nov; 7(?):842. doi:
10.1186/1756-0500-7-842. [PMID: 25424607] - Alexander Lipsky, Avner Cohen, Aurel Ion, Iris Yedidia. Genetic transformation of Ornithogalum via particle bombardment and generation of Pectobacterium carotovorum-resistant plants.
Plant science : an international journal of experimental plant biology.
2014 Nov; 228(?):150-8. doi:
10.1016/j.plantsci.2014.02.002. [PMID: 25438795] - Dobroslava Bujnakova, Eva Strakova, Vladimir Kmet. In vitro evaluation of the safety and probiotic properties of Lactobacilli isolated from chicken and calves.
Anaerobe.
2014 Oct; 29(?):118-27. doi:
10.1016/j.anaerobe.2013.10.009. [PMID: 24291759] - Supriyo Chowdhury, Arpita Basu, Surekha Kundu. A new high-frequency Agrobacterium-mediated transformation technique for Sesamum indicum L. using de-embryonated cotyledon as explant.
Protoplasma.
2014 Sep; 251(5):1175-90. doi:
10.1007/s00709-014-0625-0. [PMID: 24590594] - Sandra Rodriguez Salgueiro, Lucía González Núñez, Diana García Del Barco Herrera, Elsa Santos Febles, Dayamí Maza Ares, René Millares López, Jorge Berlanga Acosta. Role of epidermal growth factor and growth hormone-releasing peptide-6 in acceleration of renal tissue repair after kanamycin overdosing in rats.
Iranian journal of kidney diseases.
2014 Sep; 8(5):382-8. doi:
. [PMID: 25194405] - Jacob A Dijkstra, Marieke Gg Sturkenboom, Kai van Hateren, Remco A Koster, Ben Greijdanus, Jan-Willem C Alffenaar. Quantification of amikacin and kanamycin in serum using a simple and validated LC-MS/MS method.
Bioanalysis.
2014 Aug; 6(16):2125-33. doi:
10.4155/bio.14.191. [PMID: 25331857] - Xujing Wang, Qiaoling Tang, Lei Dong, Yufeng Dong, Yueyan Su, Shirong Jia, Zhixing Wang. Construction of a standard reference plasmid containing seven target genes for the detection of transgenic cotton.
Plasmid.
2014 Jul; 74(?):39-44. doi:
10.1016/j.plasmid.2014.05.005. [PMID: 24929128] - Micah E Stevens, Paula M Pijut. Agrobacterium-mediated genetic transformation and plant regeneration of the hardwood tree species Fraxinus profunda.
Plant cell reports.
2014 Jun; 33(6):861-70. doi:
10.1007/s00299-014-1562-2. [PMID: 24493252] - Alexandru Mihai Grumezescu, Cristina Daniela Ghitulica, Georgeta Voicu, Keng-Shiang Huang, Chih-Hui Yang, Anton Ficai, Bogdan Stefan Vasile, Valentina Grumezescu, Coralia Bleotu, Mariana Carmen Chifiriuc. New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections.
International journal of pharmaceutics.
2014 Mar; 463(2):170-6. doi:
10.1016/j.ijpharm.2013.07.016. [PMID: 23871740] - Sotaro Sadahiro, Toshiyuki Suzuki, Akira Tanaka, Kazutake Okada, Hiroko Kamata, Toru Ozaki, Yasuhiro Koga. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial.
Surgery.
2014 Mar; 155(3):493-503. doi:
10.1016/j.surg.2013.06.002. [PMID: 24524389] - Pal Maliga, Tarinee Tungsuchat-Huang. Plastid transformation in Nicotiana tabacum and Nicotiana sylvestris by biolistic DNA delivery to leaves.
Methods in molecular biology (Clifton, N.J.).
2014; 1132(?):147-63. doi:
10.1007/978-1-62703-995-6_8. [PMID: 24599851] - Meiyan Jiang, Qi Wang, Takatoshi Karasawa, Ja-Won Koo, Hongzhe Li, Peter S Steyger. Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides.
PloS one.
2014; 9(9):e108941. doi:
10.1371/journal.pone.0108941. [PMID: 25268124] - Stellah G Mpagama, Norah Ndusilo, Suzanne Stroup, Happiness Kumburu, Charles A Peloquin, Jean Gratz, Eric R Houpt, Gibson S Kibiki, Scott K Heysell. Plasma drug activity in patients on treatment for multidrug-resistant tuberculosis.
Antimicrobial agents and chemotherapy.
2014; 58(2):782-8. doi:
10.1128/aac.01549-13. [PMID: 24247125] - Guo-hua Liu, Yi-qing Liu, Ze-xiong Chen, Zhou-jiang Liu. [Establishment of transformation system of Lonicera macranthoides mediated by Agrobacterium tumefaciens].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2013 Dec; 36(12):1904-7. doi:
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FEBS letters.
2013 Oct; 587(20):3321-6. doi:
10.1016/j.febslet.2013.08.016. [PMID: 23994526] - Lei Deng, Yu Pan, Xuqing Chen, Guoping Chen, Zongli Hu. Small RNAs were involved in homozygous state-associated silencing of a marker gene (Neomycin phosphotransferase II: nptII) in transgenic tomato plants.
Plant physiology and biochemistry : PPB.
2013 Jul; 68(?):8-15. doi:
10.1016/j.plaphy.2013.03.022. [PMID: 23612328] - Ahmad Farhad Talebi, Masoud Tohidfar, Meisam Tabatabaei, Abdolreza Bagheri, Motahhareh Mohsenpor, Seyed Kaveh Mohtashami. Genetic manipulation, a feasible tool to enhance unique characteristic of Chlorella vulgaris as a feedstock for biodiesel production.
Molecular biology reports.
2013 Jul; 40(7):4421-8. doi:
10.1007/s11033-013-2532-4. [PMID: 23652998] - Jingli Yang, Jaeseon Yi, Chuanping Yang, Chenghao Li. Agrobacterium tumefaciens-mediated genetic transformation of Salix matsudana Koidz. using mature seeds.
Tree physiology.
2013 Jun; 33(6):628-39. doi:
10.1093/treephys/tpt038. [PMID: 23771952] - Amber Howerton, Manomita Patra, Ernesto Abel-Santos. A new strategy for the prevention of Clostridium difficile infection.
The Journal of infectious diseases.
2013 May; 207(10):1498-504. doi:
10.1093/infdis/jit068. [PMID: 23420906] - Bernhard Westermann, Simon Dörner, Sebastian Brauch, Angela Schaks, Ramona Heinke, Sebastian Stark, Floris L van Delft, Sander S van Berkel. CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.
Carbohydrate research.
2013 Apr; 371(?):61-7. doi:
10.1016/j.carres.2013.02.003. [PMID: 23507494] - Danny L Bayliss, Gilbert Shama, Michael G Kong. Restoration of antibiotic sensitivity in meticillin-resistant Staphylococcus aureus following treatment with a non-thermal atmospheric gas plasma.
International journal of antimicrobial agents.
2013 Apr; 41(4):398-9. doi:
10.1016/j.ijantimicag.2012.12.005. [PMID: 23380582] - Ayhan Ayar, Sophie Wehrkamp-Richter, Jean-Baptiste Laffaire, Samuel Le Goff, Julien Levy, Sandrine Chaignon, Hajer Salmi, Alexandra Lepicard, Christophe Sallaud, Maria E Gallego, Charles I White, Wyatt Paul. Gene targeting in maize by somatic ectopic recombination.
Plant biotechnology journal.
2013 Apr; 11(3):305-14. doi:
10.1111/pbi.12014. [PMID: 23094946]