Triflupromazine hydrochloride (BioDeep_00000015087)
代谢物信息卡片
Triflupromazine hydrochloride
化学式: C18H20ClF3N2S (388.0988)
中文名称: 三氟丙嗪盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F.Cl
InChI: 1H
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:9712
- KEGG: C71345
- KEGGdrug: D00800
- PubChem: 66069
- ChEMBL: CHEMBL1201102
- MeSH: Triflupromazine
- CAS: 1098-60-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Chun-Lin Chen, Wei-Hsien Hou, I-Hua Liu, George Hsiao, Shuan Shian Huang, Jung San Huang. Inhibitors of clathrin-dependent endocytosis enhance TGFbeta signaling and responses.
Journal of cell science.
2009 Jun; 122(Pt 11):1863-71. doi:
10.1242/jcs.038729. [PMID: 19461075] - Keisuke Kitamura, Ahmed Ahmed Omran, Chieyo Nagata, Yoshiko Kamijima, Rumi Tanaka, Shigehiko Takegami, Tatsuya Kitade. Effects of inorganic ions on the binding of triflupromazine and chlorpromazine to bovine serum albumin studied by spectrometric methods.
Chemical & pharmaceutical bulletin.
2006 Jul; 54(7):972-6. doi:
10.1248/cpb.54.972. [PMID: 16819214] - Shigehiko Takegami, Keisuke Kitamura, Tatsuya Kitade, Miwa Takashima, Mika Ito, Eiko Nakagawa, Midori Sone, Rie Sumitani, Yumiko Yasuda. Effects of phosphatidylserine and phosphatidylethanolamine content on partitioning of triflupromazine and chlorpromazine between phosphatidylcholine-aminophospholipid bilayer vesicles and water studied by second-derivative spectrophotometry.
Chemical & pharmaceutical bulletin.
2005 Jan; 53(1):147-50. doi:
10.1248/cpb.53.147. [PMID: 15635254] - Keisuke Kitamura, Manabu Kume, Masayoshi Yamamoto, Shigehiko Takegami, Tatsuya Kitade. 19F NMR spectroscopic study on the binding of triflupromazine to bovine and human serum albumins.
Journal of pharmaceutical and biomedical analysis.
2004 Oct; 36(2):411-4. doi:
10.1016/j.jpba.2004.06.027. [PMID: 15496337] - Keisuke Kitamura, Shigehiko Takegami, Takumi Kobayashi, Kumi Makihara, Chie Kotani, Tatsuya Kitade, Maki Moriguchi, Yuki Inoue, Tomoko Hashimoto, Midori Takeuchi. Dissociation constants of phenothiazine drugs incorporated in phosphatidylcholine bilayer of small unilamellar vesicles as determined by carbon-13 nuclear magnetic resonance spectrometric titration.
Biochimica et biophysica acta.
2004 Feb; 1661(1):61-7. doi:
10.1016/j.bbamem.2003.11.017. [PMID: 14967475] - M Tatsumi, K Jansen, R D Blakely, E Richelson. Pharmacological profile of neuroleptics at human monoamine transporters.
European journal of pharmacology.
1999 Mar; 368(2-3):277-83. doi:
10.1016/s0014-2999(99)00005-9. [PMID: 10193665] - H W Hagedorn, S Zuck, R Schulz. Prothipendyl: detection and elimination in the horse--a case report.
DTW. Deutsche tierarztliche Wochenschrift.
1996 Apr; 103(4):125-7. doi:
NULL. [PMID: 8925772] - E C de Ferreyra, A S Bernacchi, M F San Martin, G D Castro, J A Castro. Trifluopromazine late preventive effects on carbon tetrachloride-induced liver necrosis.
Experimental and molecular pathology.
1995 Apr; 62(2):75-82. doi:
10.1006/exmp.1995.1009. [PMID: 8549698] - S Ogura. [Phenothiazine derivatives, chlorpromazine and triflupromazine, produce different effects on sympathetic nerve activity in urethane-anesthetized rabbits].
Masui. The Japanese journal of anesthesiology.
1994 Aug; 43(8):1179-90. doi:
NULL. [PMID: 7933499] - I Ginsburg, R S Mitra, D F Gibbs, J Varani, R Kohen. Killing of endothelial cells and release of arachidonic acid. Synergistic effects among hydrogen peroxide, membrane-damaging agents, cationic substances, and proteinases and their modulation by inhibitors.
Inflammation.
1993 Jun; 17(3):295-319. doi:
10.1007/bf00918992. [PMID: 8330929] - M A Jandreski, W E Vanderslice. Clinical measurement of serum amiodarone and desethylamiodarone by using solid-phase extraction followed by HPLC with a high-carbon reversed-phase column.
Clinical chemistry.
1993 Mar; 39(3):496-500. doi:
10.1093/clinchem/39.3.496. [PMID: 8448863] - P K Peshin, D Sharifi, D B Patil, S Singh, H Singh, J Singh, A P Singh, D K Murthy. Evaluation of triflupromazine as a sedative in camels (Camelus dromedarius).
Zentralblatt fur Veterinarmedizin. Reihe A.
1991 Oct; 38(8):580-4. doi:
10.1111/j.1439-0442.1991.tb01052.x. [PMID: 1771979] - R K Kale, S L Sitasawad. Modification of radiation induced lipid peroxidation by calmodulin antagonists.
Indian journal of experimental biology.
1990 Aug; 28(8):757-61. doi:
". [PMID: 2253969] - W Tolksdorf, J Berlin, N Petrakis, E R Rey, R Schmidt. [Stress reduction by i.m. premedication with 6 different single substances].
Anasthesie, Intensivtherapie, Notfallmedizin.
1984 Feb; 19(1):1-7. doi:
NULL. [PMID: 6370028] - M Kawamura, T Inagami. Calmodulin antagonists stimulate renin release from isolated rat glomeruli.
Endocrinology.
1983 May; 112(5):1857-9. doi:
10.1210/endo-112-5-1857. [PMID: 6187563] - T Gopal, F W Oehme, S Omer. Influence of dietary protein on the effect of coumaphos and triflupromazine interaction in sheep.
American journal of veterinary research.
1976 Oct; 37(10):1143-52. doi:
NULL. [PMID: 984539] - P C Huang, S Gabay. Examination of phenothiazine-albumin interaction by ultraviolet difference spectrophotometry.
Biochemical pharmacology.
1974 Mar; 23(5):957-72. doi:
10.1016/0006-2952(74)90026-4. [PMID: 4156471] - U Breyer, H J Gaertner, A Prox. Formation of identical metabolites from piperazine- and dimethylamino-substituted phenothiazine drugs in man, rat and dog.
Biochemical pharmacology.
1974 Jan; 23(2):313-22. doi:
10.1016/0006-2952(74)90422-5. [PMID: 4813348] - M Shostak. Immunological properties of some phenothiazines.
Advances in biochemical psychopharmacology.
1974; 9(0):365-77. doi:
NULL. [PMID: 4836213] - H H Wieck, G Ulrich. [Therapy of severe purulent menigitides].
Deutsche medizinische Wochenschrift (1946).
1973 Apr; 98(15):776-8. doi:
10.1055/s-0028-1106904. [PMID: 4695763] - J Krieglstein, W Meiler, J Staab. Hydrophobic and ionic interactions of phenothiazine derivatives with bovine serum albumin.
Biochemical pharmacology.
1972 Apr; 21(7):985-97. doi:
10.1016/0006-2952(72)90403-0. [PMID: 5064735] - L A Hadwiger, A R Martin. Induced formation of phenylalanine ammonia lyase and pisatin by chlorpromazine and other phenothiazine derivatives.
Biochemical pharmacology.
1971 Dec; 20(12):3255-61. doi:
10.1016/0006-2952(71)90430-8. [PMID: 5167294] - M S Aronoff, R S Epstein. Factors associated with poor response to lithium carbonate: a clinical study.
The American journal of psychiatry.
1970 Oct; 127(4):472-80. doi:
10.1176/ajp.127.4.472. [PMID: 4918114] - C L Huang, J Z Yeh, I A Muni. Comparative distribution, excretion, and metabolism of 14C-labeled quaternary ammonium compounds of promazine, chlorpromazine, and triflupromazine.
Journal of pharmaceutical sciences.
1970 Aug; 59(8):1114-8. doi:
10.1002/jps.2600590811. [PMID: 5457327] - M T Moore, M H Book. Sudden death in phenothiazine therapy. (A clinicopathologic study of 12 cases).
The Psychiatric quarterly.
1970; 44(3):389-402. doi:
10.1007/bf01562983. [PMID: 5514886] - H Glasser, J Krieglstein. [Protein binding of some psychoactive drugs with a tricyclic ring system, as a function of their chemical constitution].
Naunyn-Schmiedebergs Archiv fur Pharmakologie.
1970; 265(4):321-34. doi:
NULL. [PMID: 4244609] - P Haux, S Natelson. A practical method for the assay of phenothiazines in biologic fluids.
American journal of clinical pathology.
1970 Jan; 53(1):77-83. doi:
10.1093/ajcp/53.1.77. [PMID: 5460616] - J Staab, J Krieglstein. [Participation of the basic side-chain of phenothiazine derivatives in their albumin binding].
Naunyn-Schmiedebergs Archiv fur Pharmakologie.
1970; 266(4):456-7. doi:
NULL. [PMID: 4253875] - M A Mahju, R P Maickel. Accumulation of phenothiazine tranquilizers in rat brain and plasma after repeated dosage.
Biochemical pharmacology.
1969 Oct; 18(10):2701-10. doi:
10.1016/0006-2952(69)90178-6. [PMID: 5404004] - D Maroske, I Staib. [Circulatory studies following premedication agents and plasma expanders].
Der Anaesthesist.
1969 Jun; 18(6):185-9. doi:
NULL. [PMID: 4903315] - B Pal, J J Ghosh. Phenothiazine tranquillizers: effect on in vivo monoamine oxidase activity in rats.
Indian journal of biochemistry.
1969 Mar; 6(1):42-3. doi:
NULL. [PMID: 4257195] - J Krieglstein, G Kuschinsky. [Interaction of phenothiazine derivatives with bovine serum albumin].
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie.
1969; 262(1):1-16. doi:
NULL. [PMID: 4237039] - H Lange, B Miller. ['Payquil convulsions' as a differential diagnosis in organic brain seizures in the terminal state of chronic kidney insufficiency].
Medizinische Klinik.
1968 Jan; 63(1):12-4. doi:
NULL. [PMID: 5668744] - J Krieglstein, G Kuschinsky. [Binding of some phenothiazine derivatives to bovine serum albumin].
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie.
1968; 260(2):160-1. doi:
NULL. [PMID: 4239198] - J Ghaye-Roquet, S Jousse, P Ganter. [Prevention of experimental hypertension in the rat by prolonged administration of a combination of antihypertensive agents].
Archives internationales de pharmacodynamie et de therapie.
1967 Mar; 166(1):65-78. doi:
NULL. [PMID: 6034330] - I STAIB, D MAROSKE, P DRINGS, H OEHMIG. [CHANGES IN THE HEART MINUTE VOLUME (HMV) AFTER MANY MEDICATIONS AND PLASMA EXTENDERS].
Langenbecks Archiv fur klinische Chirurgie ... vereinigt mit Deutsche Zeitschrift fur Chirurgie.
1964 Nov; 308(?):848-51. doi:
NULL. [PMID: 14347793] - H EBERHARDT, O W LERBS, K J FREUNDT. [THE DEMONSTRATION OF PSYCHOTROPIC PHENOTHIAZINE DERIVATIVES AND THEIR EXCRETION PRODUCTS WITH THE AID OF THIN LAYER CHROMATOGRAPHY].
Arzneimittel-Forschung.
1963 Sep; 13(?):804-5. doi:
NULL. [PMID: 14117736] - H S POSNER, J LEVINE. Inability to validate the urinary FPN test for phenothiazine drugs: suggestions as to the cause of the discrepancy.
The Journal of nervous and mental disease.
1963 Jun; 136(?):591-3. doi:
10.1097/00005053-196306000-00011. [PMID: 13985660] - F M FORREST, I S FORREST, A S MASON. A rapid urine color test for triflupromazine (vesprin).
The American journal of psychiatry.
1959 Jun; 115(12):1114-5. doi:
10.1176/ajp.115.12.1114. [PMID: 13649968]
