Chlorpromazine hydrochloride (BioDeep_00000015081)
Volatile Flavor Compounds
代谢物信息卡片
Chlorpromazine hydrochloride
化学式: C17H20Cl2N2S (354.072418)
中文名称: 盐酸氯丙嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
InChI: 1H
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:3649
- KEGG: C07952
- KEGGdrug: D00789
- KEGGdrug: D89519
- PubChem: 6240
- ChEMBL: CHEMBL1713
- MeSH: Chlorpromazine
- CAS: 69-09-0
- PubChem: 10153
- NIKKAJI: J237.634B
- KNApSAcK: 3649
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinxia Dai, Hui Lin, Yuning Pan, Yanmin Sun, Ye Wang, Jun-Qin Qiao, Hong-Zhen Lian, Chun-Xiang Xu. Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis.
Food chemistry.
2023 Mar; 403(?):134298. doi:
10.1016/j.foodchem.2022.134298. [PMID: 36182851] - Lijuan Li, Xiaohu Liu, Yunxia Cui, Yang Chen, Huiwen Wu, Jing Wang, Xiaodi Gong, Xiaoyan Gao, Linlin Yang, Jian Li, Xiao Sun, Fei Mao, Yudong Wang. Novel chlorpromazine derivatives as anti-endometrial carcinoma agents with reduced extrapyramidal side effects.
Bioorganic chemistry.
2022 10; 127(?):106008. doi:
10.1016/j.bioorg.2022.106008. [PMID: 35868106] - Xuemei Liu, Tao Fan, Jinshuai Guan, Ai Luo, Yan Yu, Daohong Chen, Bing Mao, Hongli Jiang, Wei Liu. Dopamine relieves inflammatory responses through the D2 receptor after electroacupuncture at ST36 in a mouse model of chronic obstructive pulmonary disease.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2022 Jul; ?(?):9645284221107684. doi:
10.1177/09645284221107684. [PMID: 35775581] - Iwona Karwaciak, Kaja Karaś, Anna Sałkowska, Joanna Pastwińska, Marcin Ratajewski. Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes.
Molecules (Basel, Switzerland).
2022 Jun; 27(12):. doi:
10.3390/molecules27123651. [PMID: 35744777] - Katia Sayyed, Ibrahim Hdayed, Mohamad Tabcheh, Ziad Abdel-Razzak, Hoda El-Bitar. Antioxidant properties of the Lebanese plant Iris x germanica L. crude extracts and antagonism of chlorpromazine toxicity on Saccharomyces cerevisiae.
Drug and chemical toxicology.
2022 May; 45(3):1168-1179. doi:
10.1080/01480545.2020.1810261. [PMID: 32847432] - Chinedu Ifeanyi Atama, Excellence Chidera Nnaji, Ifeanyi Christian Ezeoyili, Faith Okwukwe Udeani, Chioma Juliet Onovo, Nelson Ike Ossai, Ifeanyi Oscar Aguzie, Christopher Didigwu Nwani. Neuromodulatory and oxidative stress evaluations in African catfish Clarias gariepinus exposed to antipsychotic drug chlorpromazine.
Drug and chemical toxicology.
2022 May; 45(3):1318-1324. doi:
10.1080/01480545.2020.1822391. [PMID: 32957809] - Cong Hu, Hong-Wei Li, Jia-Qun Ke, Xue-Chun Yu, Mei-Yu Zhao, Xin-Yue Shi, Lin-Jing Wu, Xi-Lan Tang, Yin-Hua Xiong. Metabolic profiling of lysophosphatidylcholines in chlorpromazine hydrochloride- and N-acetyl-p-amino-phenoltriptolide-induced liver injured rats based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221108320. doi:
10.1177/09603271221108320. [PMID: 35722787] - Yejin Ahn, Sung Hee Han, Min Guk Kim, Ki-Bae Hong, Woo Jung Kim, Hyung Joo Suh, Kyungae Jo. Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model.
Pharmaceutical biology.
2021 Dec; 59(1):998-1007. doi:
10.1080/13880209.2021.1949356. [PMID: 34362287] - M T Yakubu, H T Fayemo. Anti-hyperprolactinemic activities of aqueous extract of Uvaria chamae (P. Beauv) roots and associated biochemical changes in chlorpromazine-induced hyperprolactinemic female Wistar rats.
Journal of ethnopharmacology.
2021 May; 271(?):113863. doi:
10.1016/j.jep.2021.113863. [PMID: 33485972] - Akbar Dorgalaleh, Ali Dabbagh, Shadi Tabibian, Mehran Bahraini, Hassan Rafieemehr. Persistent hiccups in a patient with mild congenital factor V deficiency and COVID-19; clinical and laboratory finding of a rare bleeding disorder.
International journal of laboratory hematology.
2021 04; 43(2):e87-e88. doi:
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The American journal of tropical medicine and hygiene.
2021 Apr; 104(5):1713-1715. doi:
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International journal of antimicrobial agents.
2021 Mar; 57(3):106274. doi:
10.1016/j.ijantimicag.2020.106274. [PMID: 33387629] - Masaki Morishita, Maho Horita, Ayaka Higuchi, Maho Marui, Hidemasa Katsumi, Akira Yamamoto. Characterizing Different Probiotic-Derived Extracellular Vesicles as a Novel Adjuvant for Immunotherapy.
Molecular pharmaceutics.
2021 03; 18(3):1080-1092. doi:
10.1021/acs.molpharmaceut.0c01011. [PMID: 33554596] - Nicolas Hoertel, Marina Sánchez-Rico, Raphaël Vernet, Anne-Sophie Jannot, Antoine Neuraz, Carlos Blanco, Cédric Lemogne, Guillaume Airagnes, Nicolas Paris, Christel Daniel, Alexandre Gramfort, Guillaume Lemaitre, Mélodie Bernaux, Ali Bellamine, Nathanaël Beeker, Frédéric Limosin. Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19.
Clinical drug investigation.
2021 Mar; 41(3):221-233. doi:
10.1007/s40261-021-01001-0. [PMID: 33559821] - Markus Blaess, Lars Kaiser, Oliver Sommerfeld, René Csuk, Hans-Peter Deigner. Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041797. [PMID: 33670304] - Adeleke Opeyemi, Oyewopo Adeoye, Akingbade Adebanji, Johnson Olawumi. CREM, PRM I and II gene expression in Wistar rats testes treated with antipsychotic drugs: Chlorpromazine, Rauwolfia vomitoria and co-administration of reserpine, zinc and ascorbic acid.
JBRA assisted reproduction.
2021 02; 25(1):97-103. doi:
10.5935/1518-0557.20200058. [PMID: 32960520] - Michał Otręba, Leon Kośmider, Anna Rzepecka-Stojko. Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review.
European journal of pharmacology.
2020 Nov; 887(?):173553. doi:
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Journal of clinical psychopharmacology.
2020 Nov; 40(6):641-642. doi:
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Medical hypotheses.
2020 11; 144(?):110011. doi:
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Drug and chemical toxicology.
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Journal of virology.
2020 10; 94(21):. doi:
10.1128/jvi.01218-20. [PMID: 32817221] - Emmanuel Stip. Psychiatry and COVID-19: The Role of Chlorpromazine.
Canadian journal of psychiatry. Revue canadienne de psychiatrie.
2020 10; 65(10):739-740. doi:
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Pakistan journal of pharmaceutical sciences.
2020 Sep; 33(5):1945-1953. doi:
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Schizophrenia research.
2020 09; 223(?):373-375. doi:
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The FEBS journal.
2020 09; 287(17):3664-3671. doi:
10.1111/febs.15369. [PMID: 32428379] - George Mihai Nitulescu, Horia Paunescu, Sterghios A Moschos, Dimitrios Petrakis, Georgiana Nitulescu, George Nicolae Daniel Ion, Demetrios A Spandidos, Taxiarchis Konstantinos Nikolouzakis, Nikolaos Drakoulis, Aristidis Tsatsakis. Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review).
International journal of molecular medicine.
2020 Aug; 46(2):467-488. doi:
10.3892/ijmm.2020.4608. [PMID: 32468014] - M Plaze, D Attali, A-C Petit, M Blatzer, E Simon-Loriere, F Vinckier, A Cachia, F Chrétien, R Gaillard. Repurposing chlorpromazine to treat COVID-19: The reCoVery study.
L'Encephale.
2020 Jun; 46(3):169-172. doi:
10.1016/j.encep.2020.05.006. [PMID: 32425222] - M Plaze, D Attali, A-C Petit, M Blatzer, E Simon-Loriere, F Vinckier, A Cachia, F Chrétien, R Gaillard. [Repurposing of chlorpromazine in COVID-19 treatment: the reCoVery study].
L'Encephale.
2020 Jun; 46(3S):S35-S39. doi:
10.1016/j.encep.2020.04.010. [PMID: 32387014] - Richard Bouley, Naofumi Yui, Abby Terlouw, Pui W Cheung, Dennis Brown. Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells.
Cells.
2020 04; 9(4):. doi:
10.3390/cells9041057. [PMID: 32340337] - Shi-Cheng Ling, Mei-Qin Zhuo, Dian-Guang Zhang, Heng-Yang Cui, Zhi Luo. Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.
International journal of molecular sciences.
2020 Feb; 21(5):. doi:
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Molecules (Basel, Switzerland).
2020 Feb; 25(5):. doi:
10.3390/molecules25051090. [PMID: 32121158] - Paulina Trombik, Katarzyna Cieślik-Boczula. Influence of phenothiazine molecules on the interactions between positively charged poly-l-lysine and negatively charged DPPC/DPPG membranes.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Feb; 227(?):117563. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Feb; 226(?):117652. doi:
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Central nervous system agents in medicinal chemistry.
2020; 20(1):13-25. doi:
10.2174/1871524920666200120142508. [PMID: 31987026] - Yan-Jie Han, Zhi-Guang Ren, Xin-Xin Li, Ji-Liang Yan, Chun-Yan Ma, Dong-Dong Wu, Xin-Ying Ji. Advances and challenges in the prevention and treatment of COVID-19.
International journal of medical sciences.
2020; 17(12):1803-1810. doi:
10.7150/ijms.47836. [PMID: 32714083] - Neethu Sebastian, Wan-Chin Yu, Yu-Chung Hu, Deepak Balram, Yuan-Hsiang Yu. Sonochemical synthesis of iron-graphene oxide/honeycomb-like ZnO ternary nanohybrids for sensitive electrochemical detection of antipsychotic drug chlorpromazine.
Ultrasonics sonochemistry.
2019 Dec; 59(?):104696. doi:
10.1016/j.ultsonch.2019.104696. [PMID: 31430655] - Thapanan Jatuyosporn, Pasunee Laohawutthichai, Premruethai Supungul, Rogerio R Sotelo-Mundo, Adrian Ochoa-Leyva, Anchalee Tassanakajon, Kuakarun Krusong. Role of Clathrin Assembly Protein-2 Beta Subunit during White Spot Syndrome Virus Infection in Black Tiger Shrimp Penaeus monodon.
Scientific reports.
2019 09; 9(1):13489. doi:
10.1038/s41598-019-49852-0. [PMID: 31530841] - Kanae Nishimura, Noboru Okamura, Tetsutaro Kimachi, Jun Haginaka. Evaluation of molecularly imprinted polymers for chlorpromazine and bromopromazine prepared by multi-step swelling and polymerization method-The application for the determination of chlorpromazine and its metabolites in rat plasma by column-switching LC.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):248-255. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Sep; 131(?):110537. doi:
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ACS medicinal chemistry letters.
2019 Aug; 10(8):1128-1133. doi:
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Medicina (Kaunas, Lithuania).
2019 May; 55(5):. doi:
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Clinical nutrition ESPEN.
2019 04; 30(?):89-93. doi:
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Microbial pathogenesis.
2019 Apr; 129(?):250-256. doi:
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The Science of the total environment.
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Molecules (Basel, Switzerland).
2019 Jan; 24(2):. doi:
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Current drug discovery technologies.
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The journal of physical chemistry. B.
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Scientific reports.
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Journal of separation science.
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Journal of virological methods.
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Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2018 08; 31(4):561-570. doi:
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Virology journal.
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Therapeutic drug monitoring.
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Neuroscience.
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2018 Feb; 40(2):138-140. doi:
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Journal of bioenergetics and biomembranes.
2018 02; 50(1):59-69. doi:
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Nature communications.
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