Nelfinavir mesylate (BioDeep_00000015070)
代谢物信息卡片
化学式: C33H49N3O7S2 (663.3011764)
中文名称: 甲磺酸奈非那韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O.CS(=O)(=O)O
InChI: /m0./s1
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:7497
- KEGG: C73028
- KEGG: C08091
- KEGGdrug: D00899
- PubChem: 64142
- ChEMBL: CHEMBL1205
- MeSH: Nelfinavir
- CAS: 159989-65-8
- PubChem: 10291
- NIKKAJI: J710.192I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling, Xiangrui Jiang, Xiangyun Lu, Chuan Li, Likun Gong, Guangbo Ge, Yani Zhang, Yi Zang, Tian-Zhang Song, Xiao-Li Feng, Ren-Rong Tian, Jia Ji, Miaojin Zhu, Nanping Wu, Chunhui Wu, Zhen Wang, Yechun Xu, Cheng Peng, Min Zheng, Junling Yang, Feifei Du, Junliang Wu, Peipei Wang, Jingshan Shen, Jianliang Zhang, Yong-Tang Zheng, Hangping Yao, Weiliang Zhu. Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2.
Signal transduction and targeted therapy.
2023 04; 8(1):169. doi:
10.1038/s41392-023-01429-0
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Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196374
. [PMID: 36234910] - Palaniyandi Umadevi, Subramanian Manivannan, Abdulkabeer Muhammed Fayad, Sreekumar Shelvy. In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection.
Journal of biomolecular structure & dynamics.
2022 07; 40(11):5053-5059. doi:
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Bioorganic & medicinal chemistry letters.
2022 06; 66(?):128732. doi:
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Antiviral research.
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Drug metabolism and disposition: the biological fate of chemicals.
2022 05; 50(5):613-623. doi:
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IUBMB life.
2022 01; 74(1):93-100. doi:
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Clinical pharmacology and therapeutics.
2021 10; 110(4):1057-1065. doi:
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Cancer research.
2021 09; 81(17):4581-4593. doi:
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Nature communications.
2021 06; 12(1):3309. doi:
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Scientific reports.
2021 05; 11(1):11049. doi:
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Trials.
2021 Apr; 22(1):309. doi:
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. [PMID: 33910617] - Hua Qu, Yi Zheng, Yuren Wang, Hongwei Li, Xiufei Liu, Xin Xiong, Linlin Zhang, Jing Gu, Gangyi Yang, Zhiming Zhu, Hongting Zheng, Qin Ouyang. The potential effects of clinical antidiabetic agents on SARS-CoV-2.
Journal of diabetes.
2021 Mar; 13(3):243-252. doi:
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Journal of molecular graphics & modelling.
2021 03; 103(?):107803. doi:
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ACS nano.
2021 01; 15(1):857-872. doi:
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Scientific reports.
2020 12; 10(1):20927. doi:
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2020 10; 10(1):16986. doi:
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Viruses.
2020 06; 12(6):. doi:
10.3390/v12060642
. [PMID: 32545799] - Mark Olsen, Sarah E Cook, Vanthida Huang, Niels Pedersen, Brian G Murphy. Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage.
International journal of antimicrobial agents.
2020 Jun; 55(6):105964. doi:
10.1016/j.ijantimicag.2020.105964
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Pharmacotherapy.
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BioMed research international.
2020; 2020(?):6237160. doi:
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Journal of pharmaceutical and biomedical analysis.
2019 Mar; 166(?):95-104. doi:
10.1016/j.jpba.2019.01.003
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Journal of clinical pharmacology.
2019 03; 59(3):386-393. doi:
10.1002/jcph.1331
. [PMID: 30358179] - Atsushi Kambayashi, Jennifer B Dressman. Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir.
Journal of pharmaceutical sciences.
2019 Jan; 108(1):584-591. doi:
10.1016/j.xphs.2018.11.008
. [PMID: 30423339] - Tejashree Belubbi, Sukhada Shevade, Vivek Dhawan, Vinay Sridhar, Anuradha Majumdar, Rute Nunes, Francisca Araújo, Bruno Sarmento, Kalpa Nagarsenker, Frank Steiniger, Alfred Fahr, Aniket Magarkar, Alex Bunker, Mangal Nagarsenker. Lipid Architectonics for Superior Oral Bioavailability of Nelfinavir Mesylate: Comparative in vitro and in vivo Assessment.
AAPS PharmSciTech.
2018 Nov; 19(8):3584-3598. doi:
10.1208/s12249-018-1156-3
. [PMID: 30209788] - Kazuki Okubo, Makoto Isono, Takako Asano, Akinori Sato. Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Anticancer research.
2018 Oct; 38(10):5615-5626. doi:
10.21873/anticanres.12896
. [PMID: 30275179] - Leandro S Sangenito, Rubem F S Menna-Barreto, Ana Carolina Oliveira, Claudia M d'Avila-Levy, Marta H Branquinha, André L S Santos. Primary evidence of the mechanisms of action of HIV aspartyl peptidase inhibitors on Trypanosoma cruzi trypomastigote forms.
International journal of antimicrobial agents.
2018 Aug; 52(2):185-194. doi:
10.1016/j.ijantimicag.2018.03.021
. [PMID: 29635008] - Kazuki Okubo, Akinori Sato, Makoto Isono, Takako Asano, Tomohiko Asano. Nelfinavir Induces Endoplasmic Reticulum Stress and Sensitizes Renal Cancer Cells to TRAIL.
Anticancer research.
2018 Aug; 38(8):4505-4514. doi:
10.21873/anticanres.12754
. [PMID: 30061216] - Dominik Abt, Andrej Besse, Lenka Sedlarikova, Marianne Kraus, Juergen Bader, Tobias Silzle, Martina Vodinska, Ondrej Slaby, Hans-Peter Schmid, Daniel Stephan Engeler, Christoph Driessen, Lenka Besse. Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir.
BJU international.
2018 04; 121(4):600-609. doi:
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. [PMID: 29161753] - A Besse, S C Stolze, L Rasche, N Weinhold, G J Morgan, M Kraus, J Bader, H S Overkleeft, L Besse, C Driessen. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.
Leukemia.
2018 02; 32(2):391-401. doi:
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Clinical pharmacology and therapeutics.
2017 04; 101(4):501-509. doi:
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. [PMID: 28074467] - Soren Gantt, Erin Leister, Denise L Jacobsen, Isabelle Boucoiran, Meei-Li Huang, Keith R Jerome, Gonzague Jourdain, Nicole Ngo-Giang-Huong, Sandra Burchett, Lisa Frenkel. Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy.
Journal of medical virology.
2016 Jun; 88(6):1051-8. doi:
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Cardiovascular toxicology.
2016 Jan; 16(1):90-9. doi:
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British journal of clinical pharmacology.
2015 Aug; 80(2):267-75. doi:
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Current molecular medicine.
2015; 15(10):975-9. doi:
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The Journal of clinical endocrinology and metabolism.
2014 May; 99(5):E734-45. doi:
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Molecular pharmaceutics.
2014 Feb; 11(2):436-44. doi:
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Biopolymers.
2013 Sep; 100(5):471-9. doi:
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Molecular pharmacology.
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Cancer chemotherapy and pharmacology.
2012 Dec; 70(6):791-9. doi:
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Journal of leukocyte biology.
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Haematologica.
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):610-6. doi:
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Molecules (Basel, Switzerland).
2012 Jan; 17(1):688-702. doi:
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Antimicrobial agents and chemotherapy.
2011 Nov; 55(11):5168-71. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Oct; 79(2):349-56. doi:
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AIDS research and human retroviruses.
2011 Aug; 27(8):921-4. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Jun; 39(6):1070-8. doi:
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Journal of lipid research.
2011 Feb; 52(2):207-20. doi:
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Journal of veterinary pharmacology and therapeutics.
2010 Oct; 33(5):453-60. doi:
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Antiviral research.
2010 Oct; 88(1):25-30. doi:
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AIDS (London, England).
2010 Jan; 24(1):45-53. doi:
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Biopharmaceutics & drug disposition.
2009 Dec; 30(9):532-41. doi:
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Toxicology letters.
2009 Nov; 190(3):254-65. doi:
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HIV clinical trials.
2009 Nov; 10(6):385-93. doi:
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Current HIV research.
2009 Nov; 7(6):620-5. doi:
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British journal of clinical pharmacology.
2009 Nov; 68(5):682-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Aug; 330(2):586-95. doi:
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The Cochrane database of systematic reviews.
2009 Jul; ?(3):CD005481. doi:
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International journal of clinical pharmacology and therapeutics.
2009 Jul; 47(7):491-8. doi:
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Endocrinology.
2009 Jun; 150(6):2618-26. doi:
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Proteins.
2009 May; 75(3):556-68. doi:
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Drug and alcohol dependence.
2009 May; 101(3):158-68. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2009 May; 296(5):G1040-6. doi:
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Current HIV research.
2009 May; 7(3):293-301. doi:
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Canadian journal of physiology and pharmacology.
2009 Apr; 87(4):300-9. doi:
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Experimental biology and medicine (Maywood, N.J.).
2009 Apr; 234(4):442-53. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2009 Mar; 37(3):560-70. doi:
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Biological & pharmaceutical bulletin.
2009 Feb; 32(2):269-75. doi:
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American journal of physiology. Endocrinology and metabolism.
2009 Feb; 296(2):E315-22. doi:
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Clinical chemistry.
2009 Jan; 55(1):170-4. doi:
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PloS one.
2009; 4(3):e4918. doi:
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HIV clinical trials.
2009 Jan; 10(1):41-7. doi:
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HIV medicine.
2008 Nov; 9(10):875-82. doi:
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Therapeutic drug monitoring.
2008 Oct; 30(5):604-10. doi:
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HIV clinical trials.
2008 Mar; 9(2):115-25. doi:
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Clinical pharmacology and therapeutics.
2008 Feb; 83(2):300-6. doi:
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Pharmacotherapy.
2008 Jan; 28(1):42-50. doi:
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Acta poloniae pharmaceutica.
2008 Jan; 65(1):93-100. doi:
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Journal of neurovirology.
2008 Jan; 14(1):78-84. doi:
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Antimicrobial agents and chemotherapy.
2007 Dec; 51(12):4236-42. doi:
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British journal of clinical pharmacology.
2007 Nov; 64(5):634-44. doi:
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European journal of clinical pharmacology.
2007 Nov; 63(11):1019-29. doi:
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AIDS (London, England).
2007 Oct; 21(15):2103-6. doi:
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Clinical pharmacology and therapeutics.
2007 Sep; 82(3):294-9. doi:
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. [PMID: 17361127] - Julia Kovsan, Ronit Ben-Romano, Sandra C Souza, Andrew S Greenberg, Assaf Rudich. Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis.
The Journal of biological chemistry.
2007 Jul; 282(30):21704-11. doi:
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The new microbiologica.
2007 Jul; 30(3):318-20. doi:
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Journal of drugs in dermatology : JDD.
2007 Jul; 6(7):742-3. doi:
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Journal of acquired immune deficiency syndromes (1999).
2007 May; 45(1):34-42. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Apr; 848(2):369-73. doi:
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. [PMID: 17081812] - Sun Ok Choi, Naser L Rezk, Angela D M Kashuba. High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.
Journal of pharmaceutical and biomedical analysis.
2007 Mar; 43(4):1562-7. doi:
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Clinical pharmacology and therapeutics.
2007 Feb; 81(2):222-7. doi:
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. [PMID: 17192768] - Elina Teicher, Isabelle Vincent, Laurence Bonhomme-Faivre, Chadi Abbara, Aurélie Barrail, Alain Boissonnas, Jean-Charles Duclos-Vallée, Anne-Marie Taburet, Didier Samuel, Daniel Vittecoq. Effect of highly active antiretroviral therapy on tacrolimus pharmacokinetics in hepatitis C virus and HIV co-infected liver transplant recipients in the ANRS HC-08 study.
Clinical pharmacokinetics.
2007; 46(11):941-52. doi:
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. [PMID: 17922559] - David Asboe, Ian G Williams, Ruth L Goodall, Janet H Darbyshire, Malcolm H Hooker, Abdel G Babiker. A virological benefit from an induction/maintenance strategy: the Forte trial.
Antiviral therapy.
2007; 12(1):47-54. doi:
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