Nelfinavir mesylate (BioDeep_00000015070)
Volatile Flavor Compounds
代谢物信息卡片
Nelfinavir mesylate
化学式: C33H49N3O7S2 (663.3011764)
中文名称: 甲磺酸奈非那韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC=C1O)C(=O)NC(CSC2=CC=CC=C2)C(CN3CC4CCCCC4CC3C(=O)NC(C)(C)C)O.CS(=O)(=O)O
InChI: /m0./s1
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:7497
- KEGG: C73028
- KEGG: C08091
- KEGGdrug: D00899
- PubChem: 64142
- ChEMBL: CHEMBL1205
- MeSH: Nelfinavir
- CAS: 159989-65-8
- PubChem: 10291
- NIKKAJI: J710.192I
- KNApSAcK: 7497
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling, Xiangrui Jiang, Xiangyun Lu, Chuan Li, Likun Gong, Guangbo Ge, Yani Zhang, Yi Zang, Tian-Zhang Song, Xiao-Li Feng, Ren-Rong Tian, Jia Ji, Miaojin Zhu, Nanping Wu, Chunhui Wu, Zhen Wang, Yechun Xu, Cheng Peng, Min Zheng, Junling Yang, Feifei Du, Junliang Wu, Peipei Wang, Jingshan Shen, Jianliang Zhang, Yong-Tang Zheng, Hangping Yao, Weiliang Zhu. Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2.
Signal transduction and targeted therapy.
2023 04; 8(1):169. doi:
10.1038/s41392-023-01429-0. [PMID: 37095086] - Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196374. [PMID: 36234910] - Palaniyandi Umadevi, Subramanian Manivannan, Abdulkabeer Muhammed Fayad, Sreekumar Shelvy. In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection.
Journal of biomolecular structure & dynamics.
2022 07; 40(11):5053-5059. doi:
10.1080/07391102.2020.1866669. [PMID: 33372574] - Emily G Hicks, Sylvie E Kandel, Jed N Lampe. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors.
Bioorganic & medicinal chemistry letters.
2022 06; 66(?):128732. doi:
10.1016/j.bmcl.2022.128732. [PMID: 35427739] - Caroline S Foo, Rana Abdelnabi, Suzanne J F Kaptein, Xin Zhang, Sebastiaan Ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K Chatterjee, Pieter P Annaert, Patrick F Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts. HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect.
Antiviral research.
2022 06; 202(?):105311. doi:
10.1016/j.antiviral.2022.105311. [PMID: 35390430] - Jinfu Peng, Mayur K Ladumor, Jashvant D Unadkat. Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model.
Drug metabolism and disposition: the biological fate of chemicals.
2022 05; 50(5):613-623. doi:
10.1124/dmd.121.000733. [PMID: 35149540] - Desirée Bartolini, Anna Maria Stabile, Carmine Vacca, Alessandra Pistilli, Mario Rende, Antimo Gioiello, Gabriele Cruciani, Francesco Galli. Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy.
IUBMB life.
2022 01; 74(1):93-100. doi:
10.1002/iub.2537. [PMID: 34390301] - Jose Francis, Rosie Mngqibisa, Helen McIlleron, Michelle A Kendall, Xingye Wu, Kelly E Dooley, Cynthia Firnhaber, Catherine Godfrey, Susan E Cohn, Paolo Denti. A Semimechanistic Pharmacokinetic Model for Depot Medroxyprogesterone Acetate and Drug-Drug Interactions With Antiretroviral and Antituberculosis Treatment.
Clinical pharmacology and therapeutics.
2021 10; 110(4):1057-1065. doi:
10.1002/cpt.2324. [PMID: 34151439] - Lenka Besse, Andrej Besse, Sara C Stolze, Amin Sobh, Esther A Zaal, Alwin J van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J Thomas Hannich, Alex Loguinov, Bart Everts, Celia R Berkers, Marc Pilon, Hesso Farhan, Christopher D Vulpe, Herman S Overkleeft, Christoph Driessen. Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma.
Cancer research.
2021 09; 81(17):4581-4593. doi:
10.1158/0008-5472.can-20-3323. [PMID: 34158378] - Malina A Bakowski, Nathan Beutler, Karen C Wolff, Melanie G Kirkpatrick, Emily Chen, Tu-Trinh H Nguyen, Laura Riva, Namir Shaabani, Mara Parren, James Ricketts, Anil K Gupta, Kastin Pan, Peiting Kuo, MacKenzie Fuller, Elijah Garcia, John R Teijaro, Linlin Yang, Debashis Sahoo, Victor Chi, Edward Huang, Natalia Vargas, Amanda J Roberts, Soumita Das, Pradipta Ghosh, Ashley K Woods, Sean B Joseph, Mitchell V Hull, Peter G Schultz, Dennis R Burton, Arnab K Chatterjee, Case W McNamara, Thomas F Rogers. Drug repurposing screens identify chemical entities for the development of COVID-19 interventions.
Nature communications.
2021 06; 12(1):3309. doi:
10.1038/s41467-021-23328-0. [PMID: 34083527] - Bruce Schultz, Andrea Zaliani, Christian Ebeling, Jeanette Reinshagen, Denisa Bojkova, Vanessa Lage-Rupprecht, Reagon Karki, Sören Lukassen, Yojana Gadiya, Neal G Ravindra, Sayoni Das, Shounak Baksi, Daniel Domingo-Fernández, Manuel Lentzen, Mark Strivens, Tamara Raschka, Jindrich Cinatl, Lauren Nicole DeLong, Phil Gribbon, Gerd Geisslinger, Sandra Ciesek, David van Dijk, Steve Gardner, Alpha Tom Kodamullil, Holger Fröhlich, Manuel Peitsch, Marc Jacobs, Julia Hoeng, Roland Eils, Carsten Claussen, Martin Hofmann-Apitius. A method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization.
Scientific reports.
2021 05; 11(1):11049. doi:
10.1038/s41598-021-90296-2. [PMID: 34040048] - Naoki Hosogaya, Taiga Miyazaki, Yuri Fukushige, Sachiko Takemori, Shinpei Morimoto, Hiroshi Yamamoto, Makoto Hori, Tomoya Kurokawa, Yohei Kawasaki, Michiko Hanawa, Yasuhisa Fujii, Hideki Hanaoka, Shingo Iwami, Koichi Watashi, Satoshi Yamagoe, Yoshitsugu Miyazaki, Takaji Wakita, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae, Shigeru Kohno. Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial.
Trials.
2021 Apr; 22(1):309. doi:
10.1186/s13063-021-05282-w. [PMID: 33910617] - Hua Qu, Yi Zheng, Yuren Wang, Hongwei Li, Xiufei Liu, Xin Xiong, Linlin Zhang, Jing Gu, Gangyi Yang, Zhiming Zhu, Hongting Zheng, Qin Ouyang. The potential effects of clinical antidiabetic agents on SARS-CoV-2.
Journal of diabetes.
2021 Mar; 13(3):243-252. doi:
10.1111/1753-0407.13135. [PMID: 33210826] - Mohsen Sargolzaei. Effect of nelfinavir stereoisomers on coronavirus main protease: Molecular docking, molecular dynamics simulation and MM/GBSA study.
Journal of molecular graphics & modelling.
2021 03; 103(?):107803. doi:
10.1016/j.jmgm.2020.107803. [PMID: 33333424] - Nikhil Pathak, Yun-Ti Chen, Yen-Chao Hsu, Nung-Yu Hsu, Chih-Jung Kuo, Hui Ping Tsai, Jaw-Jou Kang, Chih-Heng Huang, Sui-Yuan Chang, Yu-Hsiu Chang, Po-Huang Liang, Jinn-Moon Yang. Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing.
ACS nano.
2021 01; 15(1):857-872. doi:
10.1021/acsnano.0c07383. [PMID: 33373194] - Giovanni Bolcato, Maicol Bissaro, Matteo Pavan, Mattia Sturlese, Stefano Moro. Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir.
Scientific reports.
2020 12; 10(1):20927. doi:
10.1038/s41598-020-77700-z. [PMID: 33262359] - Krzysztof Marciniec, Artur Beberok, Paweł Pęcak, Stanisław Boryczka, Dorota Wrześniok. Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis.
Pharmacological reports : PR.
2020 Dec; 72(6):1553-1561. doi:
10.1007/s43440-020-00169-0. [PMID: 33063271] - Teruhisa S Komatsu, Noriaki Okimoto, Yohei M Koyama, Yoshinori Hirano, Gentaro Morimoto, Yousuke Ohno, Makoto Taiji. Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation.
Scientific reports.
2020 10; 10(1):16986. doi:
10.1038/s41598-020-74099-5. [PMID: 33046764] - Farhana Musarrat, Vladimir Chouljenko, Achyut Dahal, Rafiq Nabi, Tamara Chouljenko, Seetharama D Jois, Konstantin G Kousoulas. The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections.
Journal of medical virology.
2020 10; 92(10):2087-2095. doi:
10.1002/jmv.25985. [PMID: 32374457] - Aleksandr Ianevski, Rouan Yao, Mona Høysæter Fenstad, Svetlana Biza, Eva Zusinaite, Tuuli Reisberg, Hilde Lysvand, Kirsti Løseth, Veslemøy Malm Landsem, Janne Fossum Malmring, Valentyn Oksenych, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Caroline H Pettersen, Tanel Tenson, Jan Egil Afset, Svein Arne Nordbø, Magnar Bjørås, Denis E Kainov. Potential Antiviral Options against SARS-CoV-2 Infection.
Viruses.
2020 06; 12(6):. doi:
10.3390/v12060642. [PMID: 32545799] - Mark Olsen, Sarah E Cook, Vanthida Huang, Niels Pedersen, Brian G Murphy. Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage.
International journal of antimicrobial agents.
2020 Jun; 55(6):105964. doi:
10.1016/j.ijantimicag.2020.105964. [PMID: 32251732] - Ashley Barlow, Kaitlin M Landolf, Brooke Barlow, Siu Yan Amy Yeung, Jason J Heavner, Cassidy W Claassen, Mojdeh S Heavner. Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019.
Pharmacotherapy.
2020 05; 40(5):416-437. doi:
10.1002/phar.2398. [PMID: 32259313] - Kafila Kousar, Arshia Majeed, Farkhanda Yasmin, Waqar Hussain, Nouman Rasool. Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum Computations.
BioMed research international.
2020; 2020(?):6237160. doi:
10.1155/2020/6237160. [PMID: 33102585] - Mehregan Safari, Mojtaba Shamsipur, Parvin Zohrabi, Homeira Ebrahimzadeh. Solid-phase extraction combined with dispersive liquid-liquid microextraction/HPLC-UV as a sensitive and efficient method for extraction, pre-concentration and simultaneous determination of antiretroviral drugs nevirapine, efavirenz and nelfinavir in pharmaceutical formulations and biological samples.
Journal of pharmaceutical and biomedical analysis.
2019 Mar; 166(?):95-104. doi:
10.1016/j.jpba.2019.01.003. [PMID: 30639934] - Ahizechukwu C Eke, Shelley A McCormack, Brookie M Best, Alice M Stek, Jiajia Wang, Regis Kreitchmann, David Shapiro, Elizabeth Smith, Lynne M Mofenson, Edmund V Capparelli, Mark Mirochnick. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum.
Journal of clinical pharmacology.
2019 03; 59(3):386-393. doi:
10.1002/jcph.1331. [PMID: 30358179] - Atsushi Kambayashi, Jennifer B Dressman. Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir.
Journal of pharmaceutical sciences.
2019 Jan; 108(1):584-591. doi:
10.1016/j.xphs.2018.11.008. [PMID: 30423339] - Tejashree Belubbi, Sukhada Shevade, Vivek Dhawan, Vinay Sridhar, Anuradha Majumdar, Rute Nunes, Francisca Araújo, Bruno Sarmento, Kalpa Nagarsenker, Frank Steiniger, Alfred Fahr, Aniket Magarkar, Alex Bunker, Mangal Nagarsenker. Lipid Architectonics for Superior Oral Bioavailability of Nelfinavir Mesylate: Comparative in vitro and in vivo Assessment.
AAPS PharmSciTech.
2018 Nov; 19(8):3584-3598. doi:
10.1208/s12249-018-1156-3. [PMID: 30209788] - Kazuki Okubo, Makoto Isono, Takako Asano, Akinori Sato. Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Anticancer research.
2018 Oct; 38(10):5615-5626. doi:
10.21873/anticanres.12896. [PMID: 30275179] - Leandro S Sangenito, Rubem F S Menna-Barreto, Ana Carolina Oliveira, Claudia M d'Avila-Levy, Marta H Branquinha, André L S Santos. Primary evidence of the mechanisms of action of HIV aspartyl peptidase inhibitors on Trypanosoma cruzi trypomastigote forms.
International journal of antimicrobial agents.
2018 Aug; 52(2):185-194. doi:
10.1016/j.ijantimicag.2018.03.021. [PMID: 29635008] - Kazuki Okubo, Akinori Sato, Makoto Isono, Takako Asano, Tomohiko Asano. Nelfinavir Induces Endoplasmic Reticulum Stress and Sensitizes Renal Cancer Cells to TRAIL.
Anticancer research.
2018 Aug; 38(8):4505-4514. doi:
10.21873/anticanres.12754. [PMID: 30061216] - Dominik Abt, Andrej Besse, Lenka Sedlarikova, Marianne Kraus, Juergen Bader, Tobias Silzle, Martina Vodinska, Ondrej Slaby, Hans-Peter Schmid, Daniel Stephan Engeler, Christoph Driessen, Lenka Besse. Improving the efficacy of proteasome inhibitors in the treatment of renal cell carcinoma by combination with the human immunodeficiency virus (HIV)-protease inhibitors lopinavir or nelfinavir.
BJU international.
2018 04; 121(4):600-609. doi:
10.1111/bju.14083. [PMID: 29161753] - A Besse, S C Stolze, L Rasche, N Weinhold, G J Morgan, M Kraus, J Bader, H S Overkleeft, L Besse, C Driessen. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.
Leukemia.
2018 02; 32(2):391-401. doi:
10.1038/leu.2017.212. [PMID: 28676669] - K Yang, C Battista, J L Woodhead, S H Stahl, J T Mettetal, P B Watkins, S Q Siler, B A Howell. Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.
Clinical pharmacology and therapeutics.
2017 04; 101(4):501-509. doi:
10.1002/cpt.619. [PMID: 28074467] - Soren Gantt, Erin Leister, Denise L Jacobsen, Isabelle Boucoiran, Meei-Li Huang, Keith R Jerome, Gonzague Jourdain, Nicole Ngo-Giang-Huong, Sandra Burchett, Lisa Frenkel. Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy.
Journal of medical virology.
2016 Jun; 88(6):1051-8. doi:
10.1002/jmv.24420. [PMID: 26519647] - Marlene Weiß, Bernd Kost, Ingrid Renner-Müller, Eckhard Wolf, Ioannis Mylonas, Ansgar Brüning. Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells.
Cardiovascular toxicology.
2016 Jan; 16(1):90-9. doi:
10.1007/s12012-015-9314-2. [PMID: 25666561] - Krishna Kattel, Ruby Evande, Chalet Tan, Goutam Mondal, Jean L Grem, Ram I Mahato. Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer.
British journal of clinical pharmacology.
2015 Aug; 80(2):267-75. doi:
10.1111/bcp.12620. [PMID: 25752914] - Z Dai, W Cai, F Hu, Y Lan, L Li, C Chung, B Caughey, K Zhang, X Tang. Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART).
Current molecular medicine.
2015; 15(10):975-9. doi:
10.2174/1566524016666151123114401. [PMID: 26592244] - Yevgeniya Kushchayeva, Kirk Jensen, Antony Recupero, John Costello, Aneeta Patel, Joanna Klubo-Gwiezdzinska, Lisa Boyle, Kenneth Burman, Vasyl Vasko. The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.
The Journal of clinical endocrinology and metabolism.
2014 May; 99(5):E734-45. doi:
10.1210/jc.2013-3369. [PMID: 24483157] - Peng Hsiao, Jashvant D Unadkat. Predicting the outer boundaries of P-glycoprotein (P-gp)-based drug interactions at the human blood-brain barrier based on rat studies.
Molecular pharmaceutics.
2014 Feb; 11(2):436-44. doi:
10.1021/mp400396k. [PMID: 24364805] - Samantha L Gerlach, Mariamawit Yeshak, Ulf Göransson, Upal Roy, Reza Izadpanah, Debasis Mondal. Cycloviolacin O2 (CyO2) suppresses productive infection and augments the antiviral efficacy of nelfinavir in HIV-1 infected monocytic cells.
Biopolymers.
2013 Sep; 100(5):471-9. doi:
10.1002/bip.22325. [PMID: 23897405] - Yu Fukuda, Kazumasa Takenaka, Alex Sparreboom, Satish B Cheepala, Chung-Pu Wu, Sean Ekins, Suresh V Ambudkar, John D Schuetz. Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Molecular pharmacology.
2013 Sep; 84(3):361-71. doi:
10.1124/mol.113.086967. [PMID: 23775562] - Muki S Shey, Eugene J Kongnyuy, Samuel M Alobwede, Charles Shey Wiysonge. Co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection and AIDS.
The Cochrane database of systematic reviews.
2013 Mar; ?(3):CD005481. doi:
10.1002/14651858.cd005481.pub3. [PMID: 23543540] - Janet Pan, Michelle Mott, Bixin Xi, Ernestine Hepner, Min Guan, Kristen Fousek, Rachel Magnusson, Raechelle Tinsley, Frances Valdes, Paul Frankel, Timothy Synold, Warren A Chow. Phase I study of nelfinavir in liposarcoma.
Cancer chemotherapy and pharmacology.
2012 Dec; 70(6):791-9. doi:
10.1007/s00280-012-1961-4. [PMID: 22983015] - Mark A Wallet, Caroline M Reist, Julie C Williams, Sofia Appelberg, Giorgio L Guiulfo, Brent Gardner, John W Sleasman, Maureen M Goodenow. The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation.
Journal of leukocyte biology.
2012 Oct; 92(4):795-805. doi:
10.1189/jlb.0911447. [PMID: 22786868] - Camille Bono, Lionel Karlin, Stephanie Harel, Enguerran Mouly, Sylvaine Labaume, Lionel Galicier, Sébastien Apcher, Hélène Sauvageon, Jean-Paul Fermand, Jean-Christophe Bories, Bertrand Arnulf. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo.
Haematologica.
2012 Jul; 97(7):1101-9. doi:
10.3324/haematol.2011.049981. [PMID: 22271897] - Brian J Kirby, Ann C Collier, Evan D Kharasch, Dale Whittington, Kenneth E Thummel, Jashvant D Unadkat. Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):610-6. doi:
10.1124/dmd.111.042705. [PMID: 22190694] - Nancy L Sheehan, Rolf P G van Heeswijk, Brian C Foster, Humayoun Akhtar, Neera Singhal, Isabelle Seguin, Lina DelBalso, Marc Bourbeau, Bobby M Chauhan, Mohammed-Rachid Boulassel, David M Burger, Richard G Lalonde, Donald William Cameron. The effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients.
Molecules (Basel, Switzerland).
2012 Jan; 17(1):688-702. doi:
10.3390/molecules17010688. [PMID: 22241465] - A Fang, S R Valluri, M-J O'Sullivan, R Maupin, T Jones, I Delke, P Clax. Safety and pharmacokinetics of nelfinavir during the second and third trimesters of pregnancy and postpartum.
HIV clinical trials.
2012 Jan; 13(1):46-59. doi:
10.1310/hct1301-046. [PMID: 22306587] - Benjamin J Grady, David C Samuels, Gregory K Robbins, Doug Selph, Jeffrey A Canter, Richard B Pollard, David W Haas, Robert Shafer, Spyros A Kalams, Deborah G Murdock, Marylyn D Ritchie, Todd Hulgan. Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384.
Journal of acquired immune deficiency syndromes (1999).
2011 Dec; 58(4):363-70. doi:
10.1097/qai.0b013e31822c688b. [PMID: 21792066] - Paul J Weidle, Clement Zeh, Amy Martin, Richard Lando, Frank Angira, Joseph Osoga, Paul Ogindo, Sonali Girde, Timothy D Minniear, Timothy K Thomas. Nelfinavir and its active metabolite, hydroxy-t-butylamidenelfinavir (M8), are transferred in small quantities to breast milk and do not reach biologically significant concentrations in breast-feeding infants whose mothers are taking nelfinavir.
Antimicrobial agents and chemotherapy.
2011 Nov; 55(11):5168-71. doi:
10.1128/aac.05273-11. [PMID: 21876052] - Yasushi Shono, Ekarat Jantratid, Jennifer B Dressman. Precipitation in the small intestine may play a more important role in the in vivo performance of poorly soluble weak bases in the fasted state: case example nelfinavir.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Oct; 79(2):349-56. doi:
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AIDS research and human retroviruses.
2011 Aug; 27(8):921-4. doi:
10.1089/aid.2010.0323. [PMID: 21114462] - Brian J Kirby, Ann C Collier, Evan D Kharasch, Dale Whittington, Kenneth E Thummel, Jashvant D Unadkat. Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jun; 39(6):1070-8. doi:
10.1124/dmd.110.037523. [PMID: 21406602] - Stéphanie Leroyer, Camille Vatier, Sarah Kadiri, Joëlle Quette, Charles Chapron, Jacqueline Capeau, Bénédicte Antoine. Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue.
Journal of lipid research.
2011 Feb; 52(2):207-20. doi:
10.1194/jlr.m000869. [PMID: 21068005] - K L Mealey, D Waiting, D L Raunig, K R Schmidt, F R Nelson. Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs.
Journal of veterinary pharmacology and therapeutics.
2010 Oct; 33(5):453-60. doi:
10.1111/j.1365-2885.2010.01170.x. [PMID: 20840389] - Li-En Hsieh, Chao-Nan Lin, Bi-Ling Su, Tong-Rong Jan, Chi-Min Chen, Ching-Ho Wang, Dah-Sheng Lin, Chung-Tien Lin, Ling-Ling Chueh. Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus.
Antiviral research.
2010 Oct; 88(1):25-30. doi:
10.1016/j.antiviral.2010.06.010. [PMID: 20603153] - Roger Paredes, Irene Cheng, Daniel R Kuritzkes, Ruth E Tuomala. Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy.
AIDS (London, England).
2010 Jan; 24(1):45-53. doi:
10.1097/qad.0b013e32832e5303. [PMID: 19915448] - Nobuyuki Sugioka, Kenta Haraya, Keizo Fukushima, Yukako Ito, Kanji Takada. Effects of obesity induced by high-fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats.
Biopharmaceutics & drug disposition.
2009 Dec; 30(9):532-41. doi:
10.1002/bdd.689. [PMID: 19862765] - Elmar Gocke, Heinrich Bürgin, Lutz Müller, Thomas Pfister. Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate.
Toxicology letters.
2009 Nov; 190(3):254-65. doi:
10.1016/j.toxlet.2009.03.016. [PMID: 19857796] - Diane Descamps, Corine Chazallon, Clive Loveday, Lee Bacheler, Ruth Goodall, Patrick Yéni, David A Cooper, Abdel Babiker, Jean-Pierre Aboulker, Francoise Brun-Vézinet. Resistance and virological response analyses in a three initial treatment strategy trial: a substudy of the INITIO trial.
HIV clinical trials.
2009 Nov; 10(6):385-93. doi:
10.1310/hct1006-385. [PMID: 20133269] - Jelena Ivanovic, Emanuele Nicastri, Maurizio M Anceschi, Paolo Ascenzi, Fabrizio Signore, Giuseppe Pisani, Cristina Vallone, Elisabetta Mattia, Stefania Notari, Massimo Tempestilli, Leopoldo P Pucillo, Pasquale Narciso. Transplacental transfer of antiretroviral drugs and newborn birth weight in HIV-infected pregnant women.
Current HIV research.
2009 Nov; 7(6):620-5. doi:
10.2174/157016209789973628. [PMID: 19929798] - Bharat D Damle, Howard Uderman, Pinaki Biswas, Penelope Crownover, Chang Lin, Paul Glue. Influence of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir and its active metabolite.
British journal of clinical pharmacology.
2009 Nov; 68(5):682-9. doi:
10.1111/j.1365-2125.2009.03499.x. [PMID: 19916992] - Huixia Zhang, Xiaohui Wu, Suresh Babu Naraharisetti, Francisco Chung, Dale Whittington, Ahmad Mirfazaelian, Jashvant D Unadkat. Pregnancy does not increase CYP3A or P-glycoprotein activity in the non-human primate, Macaca nemestrina.
The Journal of pharmacology and experimental therapeutics.
2009 Aug; 330(2):586-95. doi:
10.1124/jpet.109.153569. [PMID: 19478134] - Muki Shey, Eugene J Kongnyuy, Judith Shang, Charles Shey Wiysonge. A combination drug of abacavir-lamivudine-zidovudine (Trizivir) for treating HIV infection and AIDS.
The Cochrane database of systematic reviews.
2009 Jul; ?(3):CD005481. doi:
10.1002/14651858.cd005481.pub2. [PMID: 19588374] - K Derakhshandeh, A Sohrabi. Pharmacokinetic study and comparative bioavailability of two nelfinavir tablet formulations in Iranian healthy volunteers after a low-dose administration.
International journal of clinical pharmacology and therapeutics.
2009 Jul; 47(7):491-8. doi:
10.5414/cpp47491. [PMID: 19640357] - Ilana Kachko, Adva Maissel, Livnat Mazor, Ronit Ben-Romano, Robert T Watson, June C Hou, Jeffrey E Pessin, Nava Bashan, Assaf Rudich. Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.
Endocrinology.
2009 Jun; 150(6):2618-26. doi:
10.1210/en.2008-1205. [PMID: 19179444] - Jane M Sayer, John M Louis. Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
Proteins.
2009 May; 75(3):556-68. doi:
10.1002/prot.22271. [PMID: 18951411] - Evan D Kharasch, Alysa Walker, Dale Whittington, Christine Hoffer, Pamela Sheffels Bedynek. Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.
Drug and alcohol dependence.
2009 May; 101(3):158-68. doi:
10.1016/j.drugalcdep.2008.12.009. [PMID: 19232844] - Vijay P Singh, Gary D Bren, Alicia Algeciras-Schimnich, David Schnepple, Sarah Navina, Stacey A Rizza, Rajinder K Dawra, Ashok K Saluja, Suresh T Chari, Santhi S Vege, Andrew D Badley. Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology.
2009 May; 296(5):G1040-6. doi:
10.1152/ajpgi.90642.2008. [PMID: 19282375] - Alessia Uglietti, Giovanni Ravasi, Valeria Meroni, Pasquale Narciso, Nicoletta Ladisa, Salvatore Martini, Paolo Perini, Lucia Testa, Alessandro Masala, Lisa Malicarne, Cecilia Occhino, Elena Donadel, Francesca Genco, Guido Chichino, Renato Maserati. Nelfinavir+M8 plasma levels determined with an ELISA test in HIV infected patients with or without HCV and/or HBV coinfection: the VIRAKINETICS II study.
Current HIV research.
2009 May; 7(3):293-301. doi:
10.2174/157016209788347967. [PMID: 19442125] - Surabhi Chandra, Subramanyam N Murthy, Debasis Mondal, Krishna C Agrawal. Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats.
Canadian journal of physiology and pharmacology.
2009 Apr; 87(4):300-9. doi:
10.1139/y09-014. [PMID: 19370083] - Surabhi Chandra, Debasis Mondal, Krishna C Agrawal. HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone.
Experimental biology and medicine (Maywood, N.J.).
2009 Apr; 234(4):442-53. doi:
10.3181/0811-rm-317. [PMID: 19234050] - Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen, William F Elmquist. Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Mar; 37(3):560-70. doi:
10.1124/dmd.108.022046. [PMID: 19056916] - Nobuyuki Sugioka, Kenta Haraya, Yuta Maeda, Keizo Fukushima, Kanji Takada. Pharmacokinetics of human immunodeficiency virus protease inhibitor, nelfinavir, in poloxamer 407-induced hyperlipidemic model rats.
Biological & pharmaceutical bulletin.
2009 Feb; 32(2):269-75. doi:
10.1248/bpb.32.269. [PMID: 19182388] - Julia Kovsan, Alexander Osnis, Adva Maissel, Livnat Mazor, Tanya Tarnovscki, Liat Hollander, Shira Ovadia, Britta Meier, Johannes Klein, Nava Bashan, Assaf Rudich. Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes--relevance for partial lipodystrophy.
American journal of physiology. Endocrinology and metabolism.
2009 Feb; 296(2):E315-22. doi:
10.1152/ajpendo.90486.2008. [PMID: 19033543] - Laure Elens, Sophie Veriter, Vincent Di Fazio, Roger Vanbinst, Daniel Boesmans, Pierre Wallemacq, Vincent Haufroid. Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection.
Clinical chemistry.
2009 Jan; 55(1):170-4. doi:
10.1373/clinchem.2008.108647. [PMID: 19028822] - Lívia O Santos, Fernanda A Marinho, Ellen F Altoé, Bianca S Vitório, Carlos R Alves, Constança Britto, Maria Cristina M Motta, Marta H Branquinha, André L S Santos, Claudia M d'Avila-Levy. HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.
PloS one.
2009; 4(3):e4918. doi:
10.1371/journal.pone.0004918. [PMID: 19325703] - Chantelle Bennetto-Hood, Yvonne J Bryson, Alice Stek, Jennifer R King, Mark Mirochnick, Edward P Acosta. Zidovudine, lamivudine, and nelfinavir concentrations in amniotic fluid and maternal serum.
HIV clinical trials.
2009 Jan; 10(1):41-7. doi:
10.1310/hct1001-041. [PMID: 19362995] - J S Read, B M Best, A M Stek, C Hu, E V Capparelli, D T Holland, S K Burchett, M E Smith, E C Sheeran, W T Shearer, I Febo, M Mirochnick. Pharmacokinetics of new 625 mg nelfinavir formulation during pregnancy and postpartum.
HIV medicine.
2008 Nov; 9(10):875-82. doi:
10.1111/j.1468-1293.2008.00640.x. [PMID: 18795962] - Silvia Baroncelli, Paola Villani, Marco Floridia, Maria F Pirillo, Clementina M Galluzzo, Maria Cusato, Roberta Amici, Carmela Pinnetti, Francesca Sabbatini, Atim Molinari, Enrica Tamburrini, Mario Regazzi. Trough concentrations of lopinavir, nelfinavir, and nevirapine with standard dosing in human immunodeficiency virus-infected pregnant women receiving 3-drug combination regimens.
Therapeutic drug monitoring.
2008 Oct; 30(5):604-10. doi:
10.1097/ftd.0b013e3181867a6e. [PMID: 18728627] - Y J Bryson, M Mirochnick, A Stek, L M Mofenson, J Connor, E Capparelli, D H Watts, S Huang, M D Hughes, K Kaiser, L Purdue, Y Asfaw, M Keller, E Smith. Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353.
HIV clinical trials.
2008 Mar; 9(2):115-25. doi:
10.1310/hct0902-115. [PMID: 18474496] - C V Fletcher, R C Brundage, T Fenton, C G Alvero, C Powell, L M Mofenson, S A Spector. Pharmacokinetics and pharmacodynamics of efavirenz and nelfinavir in HIV-infected children participating in an area-under-the-curve controlled trial.
Clinical pharmacology and therapeutics.
2008 Feb; 83(2):300-6. doi:
10.1038/sj.clpt.6100282. [PMID: 17609682] - Annie F Fang, Bharat D Damle, Robert R LaBadie, Penelope H Crownover, Dial Hewlett, Paul W Glue. Significant decrease in nelfinavir systemic exposure after omeprazole coadministration in healthy subjects.
Pharmacotherapy.
2008 Jan; 28(1):42-50. doi:
10.1592/phco.28.1.42. [PMID: 18154473] - Tomasz Pawiński, Piotr Pulik, Beata Gralak, Andrzej Horban. Pharmacokinetic monitoring of HIV-1 protease inhibitors in the antiretroviral therapy.
Acta poloniae pharmaceutica.
2008 Jan; 65(1):93-100. doi:
NULL. [PMID: 18536180] - Matthias Mehling, Henning Drechsler, Jens Kuhle, Martin Hardmeier, Ruediger Doerries, Stephan Ruegg, Achim Gass. Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement.
Journal of neurovirology.
2008 Jan; 14(1):78-84. doi:
10.1080/13550280701793940. [PMID: 18300078] - Akihiko Saitoh, Terence Fenton, Carmelita Alvero, Courtney V Fletcher, Stephen A Spector. Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy.
Antimicrobial agents and chemotherapy.
2007 Dec; 51(12):4236-42. doi:
10.1128/aac.00893-07. [PMID: 17893156] - Déborah Hirt, Saïk Urien, Vincent Jullien, Ghislaine Firtion, Hélène Chappuy, Elisabeth Rey, Gérard Pons, Laurent Mandelbrot, Jean-Marc Treluyer. Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples.
British journal of clinical pharmacology.
2007 Nov; 64(5):634-44. doi:
10.1111/j.1365-2125.2007.02885.x. [PMID: 17892516] - Xavière Panhard, Mayeule Legrand, Anne-Marie Taburet, Bertrand Diquet, Cécile Goujard, France Mentré. Population pharmacokinetic analysis of lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART.
European journal of clinical pharmacology.
2007 Nov; 63(11):1019-29. doi:
10.1007/s00228-007-0337-x. [PMID: 17694300] - Roger Paredes, Irene Cheng, Daniel R Kuritzkes, Ruth E Tuomala. High prevalence of primary lamivudine and nelfinavir resistance in HIV-1-infected pregnant women in the United States, 1998-2004.
AIDS (London, England).
2007 Oct; 21(15):2103-6. doi:
10.1097/qad.0b013e3282ef3822. [PMID: 17885302] - S R Vlahakis, G D Bren, A Algeciras-Schimnich, S A Trushin, D J Schnepple, A D Badley. Flying in the face of resistance: antiviral-independent benefit of HIV protease inhibitors on T-cell survival.
Clinical pharmacology and therapeutics.
2007 Sep; 82(3):294-9. doi:
10.1038/sj.clpt.6100140. [PMID: 17361127] - Julia Kovsan, Ronit Ben-Romano, Sandra C Souza, Andrew S Greenberg, Assaf Rudich. Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis.
The Journal of biological chemistry.
2007 Jul; 282(30):21704-11. doi:
10.1074/jbc.m702223200. [PMID: 17488708] - Alessia Uglietti, Francesca Genco, Elena Donadel, Serena Rinaldi, Erica Bastiani, Renato Maserati, Valeria Meroni. Evaluation of Elisa test for therapeutic monitoring of Nelfinavir in HIV-positive patients.
The new microbiologica.
2007 Jul; 30(3):318-20. doi:
NULL. [PMID: 17802918] - George Chrysos, Sotirios Mikros, Stelios Kokkoris, Androula Pastelli, George Kontochristopoulos. Alopecia induced by lopinavir plus ritonavir therapy in an HIV patient.
Journal of drugs in dermatology : JDD.
2007 Jul; 6(7):742-3. doi:
NULL. [PMID: 17763601] - Kathryn Anastos, Dalian Lu, Qiuhu Shi, Phyllis C Tien, Robert C Kaplan, Nancy A Hessol, Steven Cole, Cheryl Vigen, Mardge Cohen, Mary Young, Jessica Justman. Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens.
Journal of acquired immune deficiency syndromes (1999).
2007 May; 45(1):34-42. doi:
10.1097/qai.0b013e318042d5fe. [PMID: 17460470] - Dennis R Weller, Richard C Brundage, Henry H Balfour, Heather E Vezina. An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Apr; 848(2):369-73. doi:
10.1016/j.jchromb.2006.10.022. [PMID: 17081812] - Sun Ok Choi, Naser L Rezk, Angela D M Kashuba. High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.
Journal of pharmaceutical and biomedical analysis.
2007 Mar; 43(4):1562-7. doi:
10.1016/j.jpba.2006.11.017. [PMID: 17236737] - S E Cohn, J-G Park, D H Watts, A Stek, J Hitti, P A Clax, S Yu, J J L Lertora. Depo-medroxyprogesterone in women on antiretroviral therapy: effective contraception and lack of clinically significant interactions.
Clinical pharmacology and therapeutics.
2007 Feb; 81(2):222-7. doi:
10.1038/sj.clpt.6100040. [PMID: 17192768] - Elina Teicher, Isabelle Vincent, Laurence Bonhomme-Faivre, Chadi Abbara, Aurélie Barrail, Alain Boissonnas, Jean-Charles Duclos-Vallée, Anne-Marie Taburet, Didier Samuel, Daniel Vittecoq. Effect of highly active antiretroviral therapy on tacrolimus pharmacokinetics in hepatitis C virus and HIV co-infected liver transplant recipients in the ANRS HC-08 study.
Clinical pharmacokinetics.
2007; 46(11):941-52. doi:
10.2165/00003088-200746110-00002. [PMID: 17922559] - David Asboe, Ian G Williams, Ruth L Goodall, Janet H Darbyshire, Malcolm H Hooker, Abdel G Babiker. A virological benefit from an induction/maintenance strategy: the Forte trial.
Antiviral therapy.
2007; 12(1):47-54. doi:
NULL. [PMID: 17503747]