Procarbazine hydrochloride (BioDeep_00000015068)

   


代谢物信息卡片


Procarbazine hydrochloride

化学式: C12H20ClN3O (257.129482)
中文名称: 盐酸甲基苄肼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
InChI: 1H

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents

同义名列表

1 个代谢物同义名

Procarbazine hydrochloride



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Brendan O'Kelly, Padraig McGettrick, Daniel Angelov, Michael Fay, Tara McGinty, Aoife G Cotter, Gerard Sheehan, John S Lambert. Outcome of a patient with refractory Hodgkin lymphoma on pembrolizumab, infected with SARS-CoV-2. British journal of haematology. 2020 Jul; 190(1):e1-e3. doi: 10.1111/bjh.16798. [PMID: 32379903]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rikang Wang, Chao Zhang, Chaojun Zheng, Huilan Li, Xinshu Xie, Yi Jin, Zhijun Liu, Heru Chen. Introduction of Z-GP scaffold into procarbazine reduces spermatoxicity and myelosuppression. Bioorganic chemistry. 2019 03; 83(?):461-467. doi: 10.1016/j.bioorg.2018.11.011. [PMID: 30448724]
  • Gaofeng Chen, Hairuo Wen, Zhihui Mao, Jie Song, Hua Jiang, Weifan Wang, Ying Yang, Yufa Miao, Chao Wang, Zhiying Huang, Xue Wang. Assessment of the Pig-a, micronucleus, and comet assay endpoints in rats treated by acute or repeated dosing protocols with procarbazine hydrochloride and ethyl carbamate. Environmental and molecular mutagenesis. 2019 01; 60(1):56-71. doi: 10.1002/em.22227. [PMID: 30240497]
  • Lisanne S Rigter, Manon C W Spaander, Leon M Moons, Tanya M Bisseling, Berthe M P Aleman, Jan Paul de Boer, Pieternella J Lugtenburg, Cecile P M Janus, Eefke J Petersen, Judith M Roesink, John M M Raemaekers, Richard W M van der Maazen, Annemieke Cats, Eveline M A Bleiker, Petur Snaebjornsson, Beatriz Carvalho, Iris Lansdorp-Vogelaar, Katarzyna Jóźwiak, Hein Te Riele, Gerrit A Meijer, Flora E van Leeuwen, Monique E van Leerdam. Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: study design. BMC cancer. 2017 Feb; 17(1):112. doi: 10.1186/s12885-017-3089-8. [PMID: 28173773]
  • Yoshitaka Kikukawa, Ayako Yamamura-Fujimoto, Shinya Endo, Eiko Miyagawa, Yawara Kawano, Shikiko Ueno, Hiroaki Mitsuya, Hiroyuki Hata, Yutaka Okuno. Successful Treatment of Bing-Neel Syndrome Accompanying Waldenström's Macroglobulinemia with R-MPV: A Case Report. Journal of clinical and experimental hematopathology : JCEH. 2015; 55(2):113-9. doi: 10.3960/jslrt.55.113. [PMID: 26490525]
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  • Stuart A Grossman, Kathryn A Carson, Tracy T Batchelor, Glenn Lesser, Tom Mikkelsen, Jane B Alavi, Surasak Phuphanich, Tarek Hammour, Joy D Fisher, Jeffrey G Supko. The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Sep; 12(17):5174-81. doi: 10.1158/1078-0432.ccr-06-0932. [PMID: 16951236]
  • Xiao-Hong Fu, Shu-Sen Wang, Yan Huang, Bo Wang, Hui-Qiang Huang, Li Zhang, Xiao-Fei Sun, Rui-Hua Xu, Tong-Yu Lin. [Feasibility study of application of international prognostic score on prediction of prognosis for advanced Hodgkin's lymphoma]. Ai zheng = Aizheng = Chinese journal of cancer. 2006 Aug; 25(8):1013-8. doi: NULL. [PMID: 16965685]
  • Beate Strandberg, Jørgen A Axelsen, Marianne Bruus Pedersen, John Jensen, Martin J Attrill. Effect of a copper gradient on plant community structure. Environmental toxicology and chemistry. 2006 Mar; 25(3):743-53. doi: 10.1897/04-582r.1. [PMID: 16566159]
  • Rainer Preiss, Frank Baumann, Ralf Regenthal, Michael Matthias. Plasma kinetics of procarbazine and azo-procarbazine in humans. Anti-cancer drugs. 2006 Jan; 17(1):75-80. doi: 10.1097/01.cad.0000181591.85476.aa. [PMID: 16317293]
  • Maria Alice Neves Bordallo, Marília Martins Guimarães, Cencita Hosanha C N Pessoa, Maria Kadma Carriço, Trude Dimetz, Helena Mussi Gazolla, Jane Dobbin, Ilda Akemi Muramoto Alves Castilho. Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence. Journal of pediatric endocrinology & metabolism : JPEM. 2004 Jun; 17(6):879-87. doi: 10.1515/jpem.2004.17.6.879. [PMID: 15270406]
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  • X He, T T Batchelor, S Grossman, J G Supko. Determination of procarbazine in human plasma by liquid chromatography with electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jan; 799(2):281-91. doi: 10.1016/j.jchromb.2003.10.061. [PMID: 14670747]
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  • R Zanotti, A Trolese, A Ambrosetti, G Nadali, C Visco, M M Ricetti, F Benedetti, G Pizzolo. Serum levels of soluble CD30 improve International Prognostic Score in predicting the outcome of advanced Hodgkin's lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology. 2002 Dec; 13(12):1908-14. doi: 10.1093/annonc/mdf333. [PMID: 12453859]
  • Chang-Ki Min, Dong Wook Kim, Jong Wook Lee, Chi Wha Han, Woo Sung Min, Chun Choo Kim. Supplemental peripheral blood stem cells to decrease marrow rejection in adult patients with severe aplastic anemia. American journal of hematology. 2002 Jan; 69(1):15-22. doi: 10.1002/ajh.10015. [PMID: 11835325]
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