Lomefloxacin hydrochloride (BioDeep_00000015065)

   

natural product Volatile Flavor Compounds


代谢物信息卡片


Lomefloxacin hydrochloride (Maxaquin)

化学式: C17H20ClF2N3O3 (387.1161184)
中文名称: 盐酸洛美沙星
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(=C(C=C2C(=C1F)N(C=C(C2=O)C(=O)O)CC)F)N3(CCNC(C3)C).Cl
InChI: 1H

描述信息

The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for the treatment of otitis externa and otitis media.
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors

同义名列表

3 个代谢物同义名

Lomefloxacin hydrochloride; Lomefloxacin hydrochloride (Maxaquin); Lomefloxacin hydrochloride



数据库引用编号

12 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Tamer Z Attia, Mahmoud A Omar, Deena A M Nour El-Deen, Asmaa Mohamed Abbas, Abobakr A Mohamed. A novel spectrofluorimetric method for determination of lomefloxacin adopting on zinc(II) chelation strategy: Application in human plasma. Luminescence : the journal of biological and chemical luminescence. 2022 Feb; 37(2):255-262. doi: 10.1002/bio.4168. [PMID: 34806313]
  • Kamal Ahmed El-Shazly, Amera Abd El-Latif, Walied Abdo, Ahmed El-Morsey, Magdy Ibrahim Abd El-Aziz, Heba El-Mogazy. The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens. Parasitology research. 2020 Jun; 119(6):1955-1968. doi: 10.1007/s00436-020-06692-6. [PMID: 32399722]
  • Sima Beigoli, Atena Sharifi Rad, Azam Askari, Reza Assaran Darban, Jamshidkhan Chamani. Isothermal titration calorimetry and stopped flow circular dichroism investigations of the interaction between lomefloxacin and human serum albumin in the presence of amino acids. Journal of biomolecular structure & dynamics. 2019 Jun; 37(9):2265-2282. doi: 10.1080/07391102.2018.1491421. [PMID: 30047851]
  • Shereen A Boltia, Aya T Soudi, Eman S Elzanfaly, Hala E Zaazaa. Analytical Eco-Scale for Assessing the Greenness of a Developed Potentiometric Method for Lomefloxacin Hydrochloride Determination in its Different Dosage Forms, Plasma, and Dissolution Medium. Journal of AOAC International. 2019 May; 102(3):794-800. doi: 10.5740/jaoacint.18-0217. [PMID: 30446018]
  • Ren San, Weidong Yue, Surong Hasi. Effects of CYP1A enzyme specific inhibitor on pharmacokinetics of para-acetaminophen in Bactrian camel. Journal of veterinary science. 2019 May; 20(3):e12. doi: 10.4142/jvs.2019.20.e12. [PMID: 31161735]
  • Tianlie Luo, Jingwen Chen, Xuehua Li, Shuying Zhang, Hongye Yao, Willie J G M Peijnenburg. Effects of lomefloxacin on survival, growth and reproduction of Daphnia magna under simulated sunlight radiation. Ecotoxicology and environmental safety. 2018 Dec; 166(?):63-70. doi: 10.1016/j.ecoenv.2018.09.067. [PMID: 30248562]
  • Mengmeng Gao, Lili Li, Suxiang Lu, Qiang Liu, Hua He. Silver nanoparticles for the visual detection of lomefloxacin in the presence of cystine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Dec; 205(?):72-78. doi: 10.1016/j.saa.2018.05.072. [PMID: 30007902]
  • Lei Sha, Xiaoyan Tang, Dengyong Liu, Yongping Xu, Y U Ding, Feng Ding. Detection and Quantitation of Lomefloxacin and Pefloxacin Residues in the Organ Tissues and Eggs of Laying Hens. Journal of food protection. 2018 05; 81(5):810-814. doi: 10.4315/0362-028x.jfp-17-422. [PMID: 29637810]
  • Yutaka Yonezawa, Taishi Miyashita, Hiroko Ashizawa, Kazuto Hashimoto, Hiroaki Nejishima, Haruko Ogawa. Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats. The Journal of toxicological sciences. 2017; 42(2):145-157. doi: 10.2131/jts.42.145. [PMID: 28321041]
  • Urszula K Komarnicka, Radosław Starosta, Agnieszka Kyzioł, Michał Płotek, Małgorzata Puchalska, Małgorzata Jeżowska-Bojczuk. New copper(I) complexes bearing lomefloxacin motif: Spectroscopic properties, in vitro cytotoxicity and interactions with DNA and human serum albumin. Journal of inorganic biochemistry. 2016 12; 165(?):25-35. doi: 10.1016/j.jinorgbio.2016.09.015. [PMID: 27764707]
  • Xiao-hu Dai, Yong-gang Xue, Hua-jie Liu, Ling-ling Dai, Han Yan, Ning Li. [Development of Determination Method of Fluoroquinolone Antibiotics in Sludge Based on Solid Phase Extraction and HPLC-Fluorescence Detection Analysis]. Huan jing ke xue= Huanjing kexue. 2016 Apr; 37(4):1553-61. doi: ". [PMID: 27548982]
  • Mitra Amoli-Diva, Kamyar Pourghazi, Somayeh Hajjaran. Dispersive micro-solid phase extraction using magnetic nanoparticle modified multi-walled carbon nanotubes coupled with surfactant-enhanced spectrofluorimetry for sensitive determination of lomefloxacin and ofloxacin from biological samples. Materials science & engineering. C, Materials for biological applications. 2016 Mar; 60(?):30-36. doi: 10.1016/j.msec.2015.11.013. [PMID: 26706503]
  • Sonia Soldevila, M Consuelo Cuquerella, Francisco Bosca. Understanding of the photoallergic properties of fluoroquinolones: photoreactivity of lomefloxacin with amino acids and albumin. Chemical research in toxicology. 2014 Apr; 27(4):514-23. doi: 10.1021/tx400377s. [PMID: 24528107]
  • Zohreh Sattar, Mohammad Reza Saberi, Jamshidkhan Chamani. Determination of LMF binding site on a HSA-PPIX complex in the presence of human holo transferrin from the viewpoint of drug loading on proteins. PloS one. 2014; 9(1):e84045. doi: 10.1371/journal.pone.0084045. [PMID: 24392106]
  • Zohreh Sattar, Hediye Iranfar, Ahmad Asoodeh, Mohammad Reza Saberi, Mahboobeh Mazhari, Jamshidkhan Chamani. Interaction between holo transferrin and HSA-PPIX complex in the presence of lomefloxacin: an evaluation of PPIX aggregation in protein-protein interactions. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Nov; 97(?):1089-100. doi: 10.1016/j.saa.2012.07.034. [PMID: 22925987]
  • N A Nozdrachev, A I Neĭmark, B A Neĭmark. [Administration of vitaprost plus for prevention of infectious-inflammatory complications of transurethral prostatic resection in patients with prostatic adenoma]. Urologiia (Moscow, Russia : 1999). 2011 Jul; ?(4):55, 57-60. doi: NULL. [PMID: 22066244]
  • Joana Sousa, Gilberto Alves, Ana Fortuna, Angelina Pena, Celeste Lino, Amílcar Falcão. Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma. Biomedical chromatography : BMC. 2011 May; 25(5):535-41. doi: 10.1002/bmc.1480. [PMID: 20641047]
  • JamshidKhan Chamani, Hanif Vahedian-Movahed, Mohammad Reza Saberi. Lomefloxacin promotes the interaction between human serum albumin and transferrin: a mechanistic insight into the emergence of antibiotic's side effects. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 55(1):114-24. doi: 10.1016/j.jpba.2010.12.029. [PMID: 21273024]
  • H Vahedian-Movahed, M R Saberi, J Chamani. Comparison of binding interactions of lomefloxacin to serum albumin and serum transferrin by resonance light scattering and fluorescence quenching methods. Journal of biomolecular structure & dynamics. 2011 Feb; 28(4):483-502. doi: 10.1080/07391102.2011.10508590. [PMID: 21142219]
  • M I Davidov. [Treatment of prostatic adenoma with concomitant chronic bacterial prostatitis]. Urologiia (Moscow, Russia : 1999). 2011 Jan; ?(1):21-8. doi: . [PMID: 21500490]
  • M G Chesnokova, A I Novikov, Iu A Novikov, V N Kabanov, T D Solov'eva. [Characteristics of microbiological diagnosis of chronic bacterial prostatitis]. Urologiia (Moscow, Russia : 1999). 2010 Nov; ?(6):47-50. doi: . [PMID: 21427995]
  • Maria Rambla-Alegre, Josep Esteve-Romero, Samuel Carda-Broch. Validation of a MLC method with fluorescence detection for the determination of quinolones in urine samples by direct injection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):3975-81. doi: 10.1016/j.jchromb.2009.10.007. [PMID: 19854116]
  • Sevgi Tatar Ulu. Highly sensitive spectrofluorimetric determination of lomefloxacin in spiked human plasma, urine and pharmaceutical preparations. European journal of medicinal chemistry. 2009 Sep; 44(9):3402-5. doi: 10.1016/j.ejmech.2009.02.019. [PMID: 19359067]
  • Hanwen Sun, Peiyun Chen, Fei Wang, Haifang Wen. Investigation on enhanced chemiluminescence reaction systems with bis(hydrogenperiodato) argentate(III) complex anion for fluoroquinolones synthetic antibiotics. Talanta. 2009 Jul; 79(2):134-40. doi: 10.1016/j.talanta.2009.03.008. [PMID: 19559854]
  • N A Lopatkin, A A Kamalov, E B Mazo, A S Kozdoba, S V Popov, E A Efremov, S D Dorofeev, Ia I Mel'nik, D A Okhobotov. [Vitaprost plus in the treatment of chronic bacterial prostatitis]. Urologiia (Moscow, Russia : 1999). 2009 May; ?(3):54-61. doi: NULL. [PMID: 19670818]
  • Jahye Kim, Hisakazu Ohtani, Masayuki Tsujimoto, Yasufumi Sawada. Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. Drug metabolism and pharmacokinetics. 2009; 24(2):167-74. doi: 10.2133/dmpk.24.167. [PMID: 19430173]
  • Sabry M Attia. Abatement by naringin of lomefloxacin-induced genomic instability in mice. Mutagenesis. 2008 Nov; 23(6):515-21. doi: 10.1093/mutage/gen045. [PMID: 18755759]
  • Shoulian Wei, Jiesheng Lin, Haifang Li, Jin-Ming Lin. Separation of seven fluoroquinolones by microemulsion electrokinetic chromatography and application to ciprofloxacin, lomefloxacin determination in urine. Journal of chromatography. A. 2007 Sep; 1163(1-2):333-6. doi: 10.1016/j.chroma.2007.06.052. [PMID: 17658537]
  • Jian-Quan Lu, Fen Jin, Ting-Quan Sun, Xing-Wang Zhou. Multi-spectroscopic study on interaction of bovine serum albumin with lomefloxacin-copper(II) complex. International journal of biological macromolecules. 2007 Mar; 40(4):299-304. doi: 10.1016/j.ijbiomac.2006.08.010. [PMID: 17030362]
  • Seiji Hori, Junko Kizu, Masahiro Kawamura. Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2006 Apr; 12(2):109-11. doi: 10.1007/s10156-006-0429-z. [PMID: 16648952]
  • Hua He, Hai-ying Ye, Li Dai, Qing-cai Jiao, Pham-huy Chuong. [Study on the interaction of lomefloxacin terbium complex and bovine serum albumin by fluorescence spectra]. Guang pu xue yu guang pu fen xi = Guang pu. 2006 Mar; 26(3):480-3. doi: NULL. [PMID: 16830760]
  • M A El Ries, A A Wassel, N T Abdel Ghani, M A El-Shall. Electrochemical adsorptive behavior of some fluoroquinolones at carbon paste electrode. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 Oct; 21(10):1249-54. doi: 10.2116/analsci.21.1249. [PMID: 16270589]
  • Li-Hua Nie, Hui-Chun Zhao, Xu Wang, Lin Yi, Yan Lu, Lin-Pei Jin, Hui-Min Ma. Determination of lomefloxacin by terbium sensitized chemiluminescence method. Analytical and bioanalytical chemistry. 2002 Dec; 374(7-8):1187-90. doi: 10.1007/s00216-002-1553-y. [PMID: 12474083]
  • Shailesh A Shah, Ishwarsinh S Rathod, Shrinivas S Savale, Dharmesh B Patel. Determination of bioequivalence of lomefloxacin tablets using urinary excretion data. Journal of pharmaceutical and biomedical analysis. 2002 Nov; 30(4):1319-29. doi: 10.1016/s0731-7085(02)00453-3. [PMID: 12408922]
  • Mineko Nagasawa, Shozo Nakamura, Miyono Miyazaki, Yasuyuki Nojima, Hiroyoshi Hayakawa, Yasuhito Kawamura. [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies]. The Japanese journal of antibiotics. 2002 Jun; 55(3):259-69. doi: . [PMID: 12199110]
  • Qing-qin Xu, Li-ming Du, Jing-ping Wang. [Study on the direct determination of lomefloxacin in urine by derivative-synchronous fluorescence]. Guang pu xue yu guang pu fen xi = Guang pu. 2002 Jun; 22(3):444-5. doi: . [PMID: 12938329]
  • Mehdi Shakibaei, Irmela Baumann-Wilschke, Marcus Rücker, Ralf Stahlmann. Ultrastructural characterization of murine limb buds after in vitro exposure to grepafloxacin and other fluoroquinolones. Archives of toxicology. 2002 Jan; 75(11-12):725-33. doi: 10.1007/s00204-001-0293-7. [PMID: 11876506]
  • A S Melani, M Pirrelli, F Sarlo, V Cantoni. Safety and effectiveness of lomefloxacin in patients with acute exacerbation of chronic bronchitis (AECB) chronically treated with oral theophyllines. Journal of chemotherapy (Florence, Italy). 2001 Dec; 13(6):628-34. doi: 10.1179/joc.2001.13.6.628. [PMID: 11806624]
  • M Cazzola, M G Matera, M A Tufano, P Catalanotti, M Polverino, V Cantoni, F Fici, F Sarlo, F Rossi. Pulmonary disposition of lomefloxacin in patients with acute exacerbation of chronic obstructive pulmonary disease. A multiple-dose study. Journal of chemotherapy (Florence, Italy). 2001 Aug; 13(4):407-12. doi: 10.1179/joc.2001.13.4.407. [PMID: 11589484]
  • J L Vílchez, L Araujo, A Prieto, A Navalón. Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxacin. Journal of pharmaceutical and biomedical analysis. 2001 Aug; 26(1):23-9. doi: 10.1016/s0731-7085(01)00391-0. [PMID: 11451639]
  • M T Maya, N J Gonçalves, N B Silva, J A Morais. Simple high-performance liquid chromatographic assay for the determination of ciprofloxacin in human plasma with ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications. 2001 May; 755(1-2):305-9. doi: 10.1016/s0378-4347(01)00126-8. [PMID: 11393718]
  • A Alvarez-Lueje, C López, L J Núñez-Vergara, J A Squella. Voltammetric behavior and analytical applications of lomefloxacin, an antibacterial fluorquinolone. Journal of AOAC International. 2001 May; 84(3):649-58. doi: 10.1093/jaoac/84.3.649. [PMID: 11417626]
  • S Scelzi, F Travaglini, S Nerozzi, A Dominici, R Ponchietti, A Novelli, M Rizzo. The role of lomefloxacin in the treatment of chronic prostatitis. Journal of chemotherapy (Florence, Italy). 2001 Feb; 13(1):82-7. doi: 10.1179/joc.2001.13.1.82. [PMID: 11233805]
  • H de Vries, G M van Henegouwen. Photochemical decomposition of lomefloxacin in vitro and in vivo. Journal of photochemistry and photobiology. B, Biology. 2000 Oct; 58(1):6-12. doi: 10.1016/s1011-1344(00)00103-2. [PMID: 11195854]
  • K Shimoda, T Ikeda, S Okawara, M Kato. Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice. Toxicological sciences : an official journal of the Society of Toxicology. 2000 Aug; 56(2):290-6. doi: 10.1093/toxsci/56.2.290. [PMID: 10910986]
  • K A Al-Rashood, K I Al-Khamis, Y M El-Sayed, S Al-Bella, M A Al-Yamani, S M Alam, R Dham. Bioequivalence evaluation of lomefloxacin 400 mg tablets (Lomax versus Maxaquin in healthy human volunteers. Biopharmaceutics & drug disposition. 1999 Dec; 20(9):407-10. doi: 10.1002/1099-081x(199912)20:9<407::aid-bdd199>3.0.co;2-f. [PMID: 10951428]
  • A Kawada, K Hatanaka, H Gomi, I Matsuo. In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. Photodermatology, photoimmunology & photomedicine. 1999 Dec; 15(6):226-30. doi: 10.1111/j.1600-0781.1999.tb00094.x. [PMID: 10599972]
  • H Sasabe, Y Kato, T Terasaki, A Tsuji, Y Sugiyama. Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacin and lomefloxacin, in the rat. Biopharmaceutics & drug disposition. 1999 Apr; 20(3):151-8. doi: 10.1002/(sici)1099-081x(199904)20:3<151::aid-bdd168>3.0.co;2-p. [PMID: 10211868]
  • M Zhao, S Jiang, R Wang. [The serum bactericidal activity of domestic fleroxacin and lomefloxacin]. Zhonghua nei ke za zhi. 1999 Feb; 38(2):98-100. doi: NULL. [PMID: 11798634]
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