Cariprazine (BioDeep_00000015063)
代谢物信息卡片
化学式: C21H32Cl2N4O (426.19530419999995)
中文名称: 卡利拉嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl
InChI: InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics
Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:90933
- KEGG: C76682
- KEGGdrug: D09997
- PubChem: 11154555
- DrugBank: DB06016
- ChEMBL: CHEMBL2028019
- ChEMBL: CHEMBL3085826
- CAS: 839712-12-8
- medchemexpress: HY-14763
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Judy Hope, Nicholas A Keks. Cariprazine: A new partial dopamine agonist with a familiar profile.
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists.
2022 06; 30(3):382-385. doi:
10.1177/10398562211064254. [PMID: 35156402] - Radomir Juza, Iveta Vojtechova, Kristyna Stefkova-Mazochova, Wim Dehaen, Tomas Petrasek, Lukas Prchal, Tereza Kobrlova, Jiri Janousek, Premysl Vlcek, Eva Mezeiova, Daniel Svozil, Jana Zdarova Karasova, Jaroslav Pejchal, Holger Stark, Grzegorz Satala, Andrzej J Bojarski, Monika Kubacka, Szczepan Mogilski, Alena Randakova, Kamil Musilek, Ondrej Soukup, Jan Korabecny. Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment.
European journal of medicinal chemistry.
2022 Mar; 232(?):114193. doi:
10.1016/j.ejmech.2022.114193. [PMID: 35176563] - Thanh Thuy Truong, Benjamin Li. Case Series: Cariprazine for treatment of methamphetamine use disorder.
The American journal on addictions.
2022 01; 31(1):85-88. doi:
10.1111/ajad.13241. [PMID: 34713943] - Thiago C Genaro-Mattos, Allison Anderson, Luke B Allen, Keri A Tallman, Ned A Porter, Zeljka Korade, Károly Mirnics. Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis.
Molecular psychiatry.
2020 11; 25(11):2685-2694. doi:
10.1038/s41380-020-0801-x. [PMID: 32504050] - Antonia Periclou, Susan Willavize, David Jaworowicz, Julie Passarell, Timothy Carrothers, Parviz Ghahramani, Suresh Durgam, Willie Earley, Margit Kapás, Tatiana Khariton. Relationship Between Plasma Concentrations and Clinical Effects of Cariprazine in Patients With Schizophrenia or Bipolar Mania.
Clinical and translational science.
2020 03; 13(2):362-371. doi:
10.1111/cts.12720. [PMID: 31664765] - Thiago C Genaro-Mattos, Keri A Tallman, Luke B Allen, Allison Anderson, Karoly Mirnics, Zeljka Korade, Ned A Porter. Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis.
Toxicology and applied pharmacology.
2018 06; 349(?):21-28. doi:
10.1016/j.taap.2018.04.029. [PMID: 29698737] - Ragy R Girgis, Mark Slifstein, Deepak D'Souza, Yih Lee, Antonia Periclou, Parviz Ghahramani, István Laszlovszky, Suresh Durgam, Nika Adham, Nabeel Nabulsi, Yiyun Huang, Richard E Carson, Béla Kiss, Margit Kapás, Anissa Abi-Dargham, Ashok Rakhit. Preferential binding to dopamine D3 over D2 receptors by cariprazine in patients with schizophrenia using PET with the D3/D2 receptor ligand [(11)C]-(+)-PHNO.
Psychopharmacology.
2016 Oct; 233(19-20):3503-12. doi:
10.1007/s00213-016-4382-y. [PMID: 27525990] - Terence A Ketter, Po W Wang, Shefali Miller. Bipolar therapeutics update 2014: A tale of 3 treatments.
The Journal of clinical psychiatry.
2015 Jan; 76(1):69-70. doi:
10.4088/jcp.14ac09649. [PMID: 25650673] - István Gyertyán, Béla Kiss, Katalin Sághy, Judit Laszy, Györgyi Szabó, Tamás Szabados, Larisza I Gémesi, Gabriella Pásztor, Mária Zájer-Balázs, Margit Kapás, Eva Ágai Csongor, György Domány, Károly Tihanyi, Zsolt Szombathelyi. Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents.
Neurochemistry international.
2011 Nov; 59(6):925-35. doi:
10.1016/j.neuint.2011.07.002. [PMID: 21767587] - Gerhard Gründer. Cariprazine, an orally active D2/D3 receptor antagonist, for the potential treatment of schizophrenia, bipolar mania and depression.
Current opinion in investigational drugs (London, England : 2000).
2010 Jul; 11(7):823-32. doi:
NULL. [PMID: 20571978] - Gabriella Pásztor Mészáros, Eva Agai-Csongor, Margit Kapás. Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine.
Journal of pharmaceutical and biomedical analysis.
2008 Sep; 48(2):388-97. doi:
10.1016/j.jpba.2007.12.016. [PMID: 18242914]