DL-Homocystine (BioDeep_00000015061)

   

PANOMIX_OTCML-2023


代谢物信息卡片


4,4-Dithiobis[2-aminobutyric Acid]

化学式: C8H16N2O4S2 (268.0551456)
中文名称: DL-高胱氨酸, 同型半胱氨酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 10.69%

分子结构信息

SMILES: C(CSSCCC(C(=O)O)N)C(C(=O)O)N
InChI: InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)

描述信息

4,4'-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite.
DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia.

同义名列表

3 个代谢物同义名

4,4-Dithiobis[2-aminobutyric Acid]; DL-Homocystine; 4,4'-Disulfanediylbis(2-aminobutanoic acid)



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qingjie Fu, Ruxin Liu, Xiaoqian Cui, Yuqi Zhao, Hui Chi, Yongzhuang Lu, Qiang Fei, Guodong Feng, Hongyan Shan, Yanfu Huan. A Fast Dual-responsive OFF-ON Fluorescent Probe for Cysteine and Glutathione without Interference from Homocysteine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2021 Nov; 37(11):1541-1546. doi: 10.2116/analsci.21p088. [PMID: 33896881]
  • Laurent Ouerdane, Eszter Borbála Both, Jiqian Xiang, Hongqing Yin, Yu Kang, Shuxun Shao, Katalin Kiszelák, Zsuzsa Jókai, Mihály Dernovics. Water soluble selenometabolome of Cardamine violifolia. Metallomics : integrated biometal science. 2020 12; 12(12):2032-2048. doi: 10.1039/d0mt00216j. [PMID: 33165451]
  • Zheng Zhou, Mario Vailati-Riboni, Daniel N Luchini, Juan J Loor. Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status. Nutrients. 2016 Dec; 9(1):. doi: 10.3390/nu9010010. [PMID: 28036059]
  • M Stojanovic, V Zivkovic, I Srejovic, V Jakovljevic, N Jeremic, D Djuric. The role of hydrogen sulfide in homocysteine-induced cardiodynamic effects and oxidative stress markers in the isolated rat heart. Physiology international. 2016 Dec; 103(4):428-438. doi: 10.1556/2060.103.2016.4.3. [PMID: 28229626]
  • Emre Kumral, Gülsüm Saruhan, Dilara Aktert, Mehmet Orman. Association of Hyperhomocysteinemia with Stroke Recurrence after Initial Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2016 Aug; 25(8):2047-54. doi: 10.1016/j.jstrokecerebrovasdis.2016.05.008. [PMID: 27260368]
  • Wayne R Leifert, Tori Nguyen, Alan Rembach, Ralph Martins, Stephanie Rainey-Smith, Colin L Masters, David Ames, Christopher C Rowe, S Lance Macaulay, Maxime François, Michael F Fenech. Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk. Journal of Alzheimer's disease : JAD. 2015; 48(2):443-52. doi: 10.3233/jad-150330. [PMID: 26402008]
  • Hyung-Min Kwon, Yong-Seok Lee, Hee-Joon Bae, Dong-Wha Kang. Homocysteine as a predictor of early neurological deterioration in acute ischemic stroke. Stroke. 2014 Mar; 45(3):871-3. doi: 10.1161/strokeaha.113.004099. [PMID: 24448992]
  • Lijuan Zhang, Biqi Lu, Chao Lu, Jin-Ming Lin. Determination of cysteine, homocysteine, cystine, and homocystine in biological fluids by HPLC using fluorosurfactant-capped gold nanoparticles as postcolumn colorimetric reagents. Journal of separation science. 2014 Jan; 37(1-2):30-6. doi: 10.1002/jssc.201300998. [PMID: 24302617]
  • Evangelia Kararizou, George Paraskevas, Nikolaos Triantafyllou, George Koutsis, Maria E Evangelopoulos, Dimitrios Mandellos, Constantinos Sfagos, Elisabeth Kapaki. Plasma homocysteine levels in patients with multiple sclerosis in the Greek population. Journal of the Chinese Medical Association : JCMA. 2013 Nov; 76(11):611-4. doi: 10.1016/j.jcma.2013.07.002. [PMID: 23933346]
  • Zhuo Huang, Lian-shu Han, Jun Ye, Wen-juan Qiu, Hui-wen Zhang, Xiao-lan Gao, Yu Wang, Wen-jun Ji, Xiao-yan Li, Xue-fan Gu. [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2013 Mar; 51(3):194-8. doi: NULL. [PMID: 23751581]
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  • R Bieżanowska-Kopeć, T Leszczyńska. The effect of methionine supplementation of the AIN-93G semi-synthetic diet on the levels of homocysteine and lipids in experimental rats. The journal of nutrition, health & aging. 2012 Apr; 16(4):395-400. doi: 10.1007/s12603-012-0049-5. [PMID: 22499465]
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  • M O Ebesunun, H U Eruvulobi, T Olagunju, O A Owoeye. Elevated plasma homocysteine in association with decreased vitamin B(12), folate, serotonin, lipids and lipoproteins in depressed patients. African journal of psychiatry. 2012 Jan; 15(1):25-9. doi: 10.4314/ajpsy.v15i1.3. [PMID: 22344759]
  • Rosanna Capasso, Irene Sambri, Amelia Cimmino, Sofia Salemme, Cinzia Lombardi, Filomena Acanfora, Ersilia Satta, Donald L Puppione, Alessandra F Perna, Diego Ingrosso. Homocysteinylated albumin promotes increased monocyte-endothelial cell adhesion and up-regulation of MCP1, Hsp60 and ADAM17. PloS one. 2012; 7(2):e31388. doi: 10.1371/journal.pone.0031388. [PMID: 22319627]
  • Rafał Głowacki, Kamila Borowczyk, Edward Bald. Fast analysis of wine for total homocysteine content by high-performance liquid chromatography. Amino acids. 2012 Jan; 42(1):247-51. doi: 10.1007/s00726-010-0509-3. [PMID: 22209913]
  • Peng Jiang, Weixing Dai, Shikai Yan, Zhongliang Chen, Ruilin Xu, Jianmi Ding, Li Xiang, Shuping Wang, Runhui Liu, Weidong Zhang. Biomarkers in the early period of acute myocardial infarction in rat serum and protective effects of Shexiang Baoxin Pill using a metabolomic method. Journal of ethnopharmacology. 2011 Nov; 138(2):530-6. doi: 10.1016/j.jep.2011.09.049. [PMID: 22001859]
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  • Tao Huang, Jusheng Zheng, Ying Chen, Bin Yang, Mark L Wahlqvist, Duo Li. High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized, placebo-controlled trials. Nutrition (Burbank, Los Angeles County, Calif.). 2011 Sep; 27(9):863-7. doi: 10.1016/j.nut.2010.12.011. [PMID: 21501950]
  • Camila Simioni Vanzin, Giovana Brondani Biancini, Angela Sitta, Carlos Alberto Yasin Wayhs, Izabela Netto Pereira, Francieli Rockenbach, Solange Cristina Garcia, Angela Terezinha de Souza Wyse, Ida Vanessa Doederlein Schwartz, Moacir Wajner, Carmen Regla Vargas. Experimental evidence of oxidative stress in plasma of homocystinuric patients: a possible role for homocysteine. Molecular genetics and metabolism. 2011 Sep; 104(1-2):112-7. doi: 10.1016/j.ymgme.2011.06.013. [PMID: 21742526]
  • Bjanka Vuksan-Ćusa, Miro Jakovljević, Marina Sagud, Alma Mihaljević Peleš, Darko Marčinko, Radmila Topić, Sanea Mihaljević, Jadranka Sertić. Metabolic syndrome and serum homocysteine in patients with bipolar disorder and schizophrenia treated with second generation antipsychotics. Psychiatry research. 2011 Aug; 189(1):21-5. doi: 10.1016/j.psychres.2010.11.021. [PMID: 21216014]
  • Preethi S Ganapathy, Richard E White, Yonju Ha, B Renee Bozard, Paul L McNeil, R William Caldwell, Sanjiv Kumar, Stephen M Black, Sylvia B Smith. The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. Investigative ophthalmology & visual science. 2011 Jul; 52(8):5515-24. doi: 10.1167/iovs.10-6870. [PMID: 21436276]
  • James B Adams, Tapan Audhya, Sharon McDonough-Means, Robert A Rubin, David Quig, Elizabeth Geis, Eva Gehn, Melissa Loresto, Jessica Mitchell, Sharon Atwood, Suzanne Barnhouse, Wondra Lee. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & metabolism. 2011 Jun; 8(1):34. doi: 10.1186/1743-7075-8-34. [PMID: 21651783]
  • Rima Obeid, Jennifer Schlundt, Natalia Umanskaya, Wolfgang Herrmann, Markus Herrmann. Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain. Journal of neurochemistry. 2011 Jun; 117(6):1047-54. doi: 10.1111/j.1471-4159.2011.07280.x. [PMID: 21517845]
  • Rino Donghi, Plinio Amendola, Gabriele Pellicciotta, Pierfelice Bertuzzi. [Cardiovascular disease prevention: results from Programma FASEN - H San Raffaele]. Giornale italiano di medicina del lavoro ed ergonomia. 2011 Apr; 33(2 Suppl):48-50. doi: NULL. [PMID: 22187925]
  • David S Wald, Joan K Morris, Nicholas J Wald. Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis. PloS one. 2011 Feb; 6(2):e16473. doi: 10.1371/journal.pone.0016473. [PMID: 21311765]
  • Sabri Aydin, Bashar Abuzayed, Figen Varlibas, Hulya Apaydin, Murat Mengi, Baris Kucukyuruk, Hakan Hanimoglu, Selin Yagci, Osman Kizilkilic, Murat Hanci. Treatment of homocystinuria-related dystonia with deep brain stimulation: a case report. Stereotactic and functional neurosurgery. 2011; 89(4):210-3. doi: 10.1159/000325703. [PMID: 21597311]
  • Jian-bo Li, Yu-ze Cheng, Min Shi, Hong-man Zhang, Qing Dai, Yu Zhang, Yan-juan Wang, Ji-wen Chen, Hong-xing Wang, Jia-wei Chen. [The relationship between plasma homocysteine levels and diabetic peripheral neuropathy]. Zhonghua nei ke za zhi. 2011 Jan; 50(1):14-7. doi: NULL. [PMID: 21418881]
  • Chie Shimmura, Shiro Suda, Kenji J Tsuchiya, Kenji Hashimoto, Koji Ohno, Hideo Matsuzaki, Keiko Iwata, Kaori Matsumoto, Tomoyasu Wakuda, Yosuke Kameno, Katsuaki Suzuki, Masatsugu Tsujii, Kazuhiko Nakamura, Nori Takei, Norio Mori. Alteration of plasma glutamate and glutamine levels in children with high-functioning autism. PloS one. 2011; 6(10):e25340. doi: 10.1371/journal.pone.0025340. [PMID: 21998651]
  • Alireza Javadzadeh, Amir Ghorbanihaghjo, Elham Bahreini, Nadereh Rashtchizadeh, Hassan Argani, Samira Alizadeh. Plasma oxidized LDL and thiol-containing molecules in patients with exudative age-related macular degeneration. Molecular vision. 2010 Dec; 16(?):2578-84. doi: NULL. [PMID: 21151596]
  • Soujatya Dhar, Sumana Chatterjee, Saumitra Ray, Anjanlal Dutta, Bani Sengupta, Shila Chakrabarti. Polymorphisms of methylenetetrahydrofolate reductase gene as the genetic predispositions of coronary artery diseases in eastern India. Journal of cardiovascular disease research. 2010 Jul; 1(3):152-7. doi: 10.4103/0975-3583.70922. [PMID: 21187870]
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  • Yoshiro Tsuji, Takahiro Mikami, Yasumi Anan, Yasumitsu Ogra. Comparison of selenohomolanthionine and selenomethionine in terms of selenium distribution and toxicity in rats by bolus administration. Metallomics : integrated biometal science. 2010 Jun; 2(6):412-8. doi: 10.1039/c004026f. [PMID: 21072388]
  • Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric disease and treatment. 2010 May; 6(?):159-95. doi: 10.2147/ndt.s6564. [PMID: 20505848]
  • In-Uk Song, Young-Do Kim, Joong-Seok Kim, Kwang-Soo Lee, Sung-Woo Chung. Can high-sensitivity C-reactive protein and plasma homocysteine levels independently predict the prognosis of patients with functional disability after first-ever ischemic stroke?. European neurology. 2010; 64(5):304-10. doi: 10.1159/000321415. [PMID: 21051895]
  • Vadamalai Vivek, Sunil Bhandari. Prevalence of modifiable cardiovascular risk factors in long-term renal transplant patients. International journal of nephrology and renovascular disease. 2010; 3(?):175-82. doi: 10.2147/ijnrd.s13866. [PMID: 21694943]
  • Bruno Casetta. Determination of total homocysteine in plasma using liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):253-60. doi: 10.1007/978-1-60761-459-3_23. [PMID: 20077076]
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