CLORSULON (BioDeep_00000015058)

 

Secondary id: BioDeep_00000177588


代谢物信息卡片


CLORSULON

化学式: C8H8Cl3N3O4S2 (378.9021818)
中文名称: 氯舒隆
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl
InChI: InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides

同义名列表

1 个代谢物同义名

CLORSULON



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Martínez-Valladares, C Cordero-Pérez, F A Rojo-Vázquez. Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon. Experimental parasitology. 2014 Jan; 136(?):59-62. doi: 10.1016/j.exppara.2013.10.010. [PMID: 24211419]
  • M Escribano, M I San Andrés, J J de Lucas, A González-Canga. Ivermectin residue depletion in food producing species and its presence in animal foodstuffs with a view to human safety. Current pharmaceutical biotechnology. 2012 May; 13(6):987-98. doi: 10.2174/138920112800399121. [PMID: 22039793]
  • Laura Ceballos, Laura Moreno, Luis Alvarez, Laura Shaw, Ian Fairweather, Carlos Lanusse. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes. BMC veterinary research. 2010 Feb; 6(?):8. doi: 10.1186/1746-6148-6-8. [PMID: 20128898]
  • Bülent Elitok, Ozgül Mukaddes Elitok, Mustafa Kabu. Field trial on comparative efficacy of four fasciolicides against natural liver fluke infection in cattle. Veterinary parasitology. 2006 Feb; 135(3-4):279-85. doi: 10.1016/j.vetpar.2005.10.008. [PMID: 16289862]
  • M Meaney, I Fairweather, G P Brennan, A B Forbes. Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitology research. 2004 Feb; 92(3):232-41. doi: 10.1007/s00436-003-1036-x. [PMID: 14714178]
  • Y Vera Montenegro, F Ibarra Velarde, H Quiroz Romero, A Hernández Campos, R Castillo. Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle. Parasitology research. 2003 Sep; 91(1):1-4. doi: 10.1007/s00436-003-0901-y. [PMID: 12844256]
  • A F Loyacano, J C Williams, J Gurie, A A DeRosa. Effect of gastrointestinal nematode and liver fluke infections on weight gain and reproductive performance of beef heifers. Veterinary parasitology. 2002 Aug; 107(3):227-34. doi: 10.1016/s0304-4017(02)00130-9. [PMID: 12127252]
  • A F Loyacano, T L Skogerboe, J C Williams, A A DeRosa, J A Gurie, V K Shostrom. Effects of parenteral administration of doramectin or a combination of ivermectin and clorsulon on control of gastrointestinal nematode and liver fluke infections and on growth performance in cattle. Journal of the American Veterinary Medical Association. 2001 May; 218(9):1465-8. doi: 10.2460/javma.2001.218.1465. [PMID: 11345312]
  • P Sibille, C Calléja, F Carreras, K Bigot, P Galtier, C Boulard. Fasciola hepatica: influence of gender and liver biotransformations on flukicide treatment efficacy of rats infested and cured with either clorsulon/ivermectin or triclabendazole. Experimental parasitology. 2000 Apr; 94(4):227-37. doi: 10.1006/expr.2000.4501. [PMID: 10831390]
  • S F Sundlof, T W Whitlock. Clorsulon pharmacokinetics in sheep and goats following oral and intravenous administration. Journal of veterinary pharmacology and therapeutics. 1992 Sep; 15(3):282-91. doi: 10.1111/j.1365-2885.1992.tb01018.x. [PMID: 1433492]
  • G R Lankas, C P Peter. Induction of reversible urothelial cell hyperplasia in rats by clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1992 Apr; 30(4):297-306. doi: 10.1016/0278-6915(92)90007-8. [PMID: 1628865]
  • T A Wehner, J S Wood, R Walker, G V Downing, W J Vandenheuvel. Confirmation of clorsulon residues in cattle kidney by capillary gas chromatography-negative-ion chemical-ionization mass spectrometry. Journal of chromatography. 1987 Jul; 399(?):251-8. doi: 10.1016/s0021-9673(00)96127-2. [PMID: 3654857]
  • G L Zimmerman, D H Wallace, D J Schons, E P Hoberg. Efficacy of clorsulon against mature, naturally acquired Fasciola hepatica infections in cattle and sheep. American journal of veterinary research. 1986 Aug; 47(8):1665-7. doi: NULL. [PMID: 3752673]
  • C H Courtney, J K Shearer, R E Plue. Efficacy and safety of clorsulon used concurrently with ivermectin for control of Fasciola hepatica in Florida beef cattle. American journal of veterinary research. 1985 Jun; 46(6):1245-6. doi: NULL. [PMID: 3839640]
  • S H Chiu, E Sestokas, R Taub, R W Walker, A Y Lu. Application of carbonic anhydrase affinity chromatography in study of tissue-bound residue of 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide (MK-401, clorsulon). Drug metabolism and disposition: the biological fate of chemicals. 1985 May; 13(3):374-6. doi: NULL. [PMID: 2862000]
  • J B Malone, R T Ramsey, A F Loyacano. Efficacy of clorsulon for treatment of mature naturally acquired and 8-week-old experimentally induced Fasciola hepatica infections in cattle. American journal of veterinary research. 1984 May; 45(5):851-4. doi: NULL. [PMID: 6732013]
  • M D Schulman, D Valentino, S Cifelli, D A Ostlind. Dose-dependent pharmacokinetics and efficacy of MK-401 against old, and young-mature infections of Fasciola hepatica in the rat. The Journal of parasitology. 1982 Aug; 68(4):603-8. doi: NULL. [PMID: 7119988]