Salsalate (BioDeep_00000015057)
Main id: BioDeep_00000024262
Volatile Flavor Compounds
代谢物信息卡片
Salsalate
化学式: C14H10O5 (258.052821)
中文名称: 双水杨酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O
InChI: InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
描述信息
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BA - Salicylic acid and derivatives
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018501 - Antirheumatic Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:9014
- KEGG: C75590
- KEGGdrug: D00428
- PubChem: 5161
- Metlin: METLIN43330
- DrugBank: DB01399
- ChEMBL: CHEMBL154111
- CAS: 552-94-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hesham Shamshoum, Kyle D Medak, Greg L McKie, Stewart Jeromson, Margaret K Hahn, David C Wright. Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115671. doi:
10.1016/j.biopha.2023.115671. [PMID: 37839107] - Jochen Kressler, Armando Mendez, Luisa Betancourt, Mark Nash. Salsalate Improves Postprandial Glycemic and Some Lipid Responses in Persons With Tetraplegia: A Randomized Clinical Pilot Trial With Crossover Design.
Topics in spinal cord injury rehabilitation.
2023; 29(3):1-13. doi:
10.46292/sci22-00033. [PMID: 38076289] - Eric M Desjardins, Brennan K Smith, Gregory R Steinberg, Russell E Brown. Sevoflurane-induced hyperglycemia is attenuated by salsalate in obese insulin-resistant mice.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2021 07; 68(7):972-979. doi:
10.1007/s12630-021-01935-1. [PMID: 33580878] - S Trifilio, L Gordon, H Rubin, N Grosshans, J Mehta. The non-steroidal anti-inflammatory drug salsalate provides safe and effective control of mucositis-unrelated pain during autologous and allogeneic hematopoietic stem cell transplantation.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2021 Jul; 29(7):3643-3648. doi:
10.1007/s00520-020-05664-x. [PMID: 33179136] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Gregory E Bigford, Angela Szeto, John Kimball, Edward E Herderick, Armando J Mendez, Mark S Nash. Cardiometabolic risks and atherosclerotic disease in ApoE knockout mice: Effect of spinal cord injury and Salsalate anti-inflammatory pharmacotherapy.
PloS one.
2021; 16(2):e0246601. doi:
10.1371/journal.pone.0246601. [PMID: 33626069] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Wouter N Leonhard, Xuewen Song, Anish A Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R Steinberg, Dorien J M Peters, York Pei. Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.
EBioMedicine.
2019 Sep; 47(?):436-445. doi:
10.1016/j.ebiom.2019.08.041. [PMID: 31473186] - Ninad Salastekar, Tanvi Desai, Thomas Hauser, Ernst J Schaefer, Kristen Fowler, Stacey Joseph, Steven E Shoelson, Allison B Goldfine. Salsalate improves glycaemia in overweight persons with diabetes risk factors of stable statin-treated cardiovascular disease: A 30-month randomized placebo-controlled trial.
Diabetes, obesity & metabolism.
2017 10; 19(10):1458-1462. doi:
10.1111/dom.12940. [PMID: 28295931] - Li Nie, Xin-Lu Yuan, Ke-Tao Jiang, Yu-Hui Jiang, Jin Yuan, Lan Luo, Shi-Wei Cui, Cheng Sun. Salsalate Activates Skeletal Muscle Thermogenesis and Protects Mice from High-Fat Diet Induced Metabolic Dysfunction.
EBioMedicine.
2017 Sep; 23(?):136-145. doi:
10.1016/j.ebiom.2017.08.004. [PMID: 28801239] - Jaroslava Trnovská, Jan Šilhavý, Ondřej Kuda, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Vojtěch Škop, Olena Oliyarnyk, Ludmila Kazdová, Martin Haluzík, Michal Pravenec. Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls.
PloS one.
2017; 12(6):e0179063. doi:
10.1371/journal.pone.0179063. [PMID: 28586387] - Brennan K Smith, Rebecca J Ford, Eric M Desjardins, Alex E Green, Meghan C Hughes, Vanessa P Houde, Emily A Day, Katarina Marcinko, Justin D Crane, Emilio P Mottillo, Christopher G R Perry, Bruce E Kemp, Mark A Tarnopolsky, Gregory R Steinberg. Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1.
Diabetes.
2016 Nov; 65(11):3352-3361. doi:
10.2337/db16-0564. [PMID: 27554471] - Mishaela R Rubin, Allison B Goldfine, Donald J McMahon, Daniel S Donovan, Serge Cremers, Elzbieta Dworakowski, Ernst J Schaefer, Steven E Shoelson, Shonni J Silverberg. Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus.
Endocrine.
2015 Nov; 50(2):504-7. doi:
10.1007/s12020-015-0535-8. [PMID: 25636441] - Wen Liang, Lars Verschuren, Petra Mulder, José W A van der Hoorn, Joanne Verheij, Andrea D van Dam, Mariette R Boon, Hans M G Princen, Louis M Havekes, Robert Kleemann, Anita M van den Hoek. Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes.
British journal of pharmacology.
2015 Nov; 172(22):5293-305. doi:
10.1111/bph.13315. [PMID: 26292849] - Danit Ariel, Sun H Kim, Alice Liu, Fahim Abbasi, Cindy A Lamendola, Kaylene Grove, Vanessa Tomasso, Gerald M Reaven. Salsalate-induced changes in lipid, lipoprotein, and apoprotein concentrations in overweight or obese, insulin-resistant, nondiabetic individuals.
Journal of clinical lipidology.
2015 Sep; 9(5):658-63. doi:
10.1016/j.jacl.2015.06.009. [PMID: 26350812] - Wenfeng Liu, Yonlian Li, Yuan Yue, Kun Zhang, Qian Chen, Huaqian Wang, Yujing Lu, Mou-Tuan Huang, Xi Zheng, Zhiyun Du. Synthesis and biological evaluation of curcumin derivatives containing NSAIDs for their anti-inflammatory activity.
Bioorganic & medicinal chemistry letters.
2015 Aug; 25(15):3044-51. doi:
10.1016/j.bmcl.2015.04.077. [PMID: 26048786] - A Penesova, J Koska, E Ortega, J C Bunt, C Bogardus, B de Courten. Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo-controlled trial in subjects without diabetes.
Diabetes, obesity & metabolism.
2015 Jun; 17(6):608-612. doi:
10.1111/dom.12450. [PMID: 25683256] - Andrea D van Dam, Kimberly J Nahon, Sander Kooijman, Susan M van den Berg, Anish A Kanhai, Takuya Kikuchi, Mattijs M Heemskerk, Vanessa van Harmelen, Marc Lombès, Anita M van den Hoek, Menno P J de Winther, Esther Lutgens, Bruno Guigas, Patrick C N Rensen, Mariëtte R Boon. Salsalate activates brown adipose tissue in mice.
Diabetes.
2015 May; 64(5):1544-54. doi:
10.2337/db14-1125. [PMID: 25475439] - Tanya L Alderete, Fred R Sattler, Joyce M Richey, Hooman Allayee, Steven D Mittelman, Xia Sheng, Jonathan Tucci, Lauren E Gyllenhammer, Edward G Grant, Michael I Goran. Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics.
Obesity (Silver Spring, Md.).
2015 Mar; 23(3):543-51. doi:
10.1002/oby.20991. [PMID: 25644856] - Sun H Kim, Alice Liu, Danit Ariel, Fahim Abbasi, Cindy Lamendola, Kaylene Grove, Vanessa Tomasso, Hector Ochoa, Gerald Reaven. Effect of salsalate on insulin action, secretion, and clearance in nondiabetic, insulin-resistant individuals: a randomized, placebo-controlled study.
Diabetes care.
2014 Jul; 37(7):1944-50. doi:
10.2337/dc13-2977. [PMID: 24963111] - Joshua I Barzilay, Kathleen A Jablonski, Vivian Fonseca, Steven E Shoelson, Allison B Goldfine, Christopher Strauch, Vincent M Monnier. The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.
Diabetes care.
2014 Apr; 37(4):1083-91. doi:
10.2337/dc13-1527. [PMID: 24255104] - Tae Woo Jung, Byung-Soo Youn, Hae Yoon Choi, So Young Lee, Ho Cheol Hong, Sae Jeong Yang, Hye Jin Yoo, Baek-Hui Kim, Sei Hyun Baik, Kyung Mook Choi. Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A.
Biochemical pharmacology.
2013 Oct; 86(7):960-9. doi:
10.1016/j.bcp.2013.07.034. [PMID: 23948064] - Elham Faghihimani, Ashraf Aminorroaya, Hassan Rezvanian, Peyman Adibi, Faramarz Ismail-Beigi, Masoud Amini. Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes.
Acta diabetologica.
2013 Aug; 50(4):537-43. doi:
10.1007/s00592-011-0329-2. [PMID: 21938543] - Allison B Goldfine, Vivian Fonseca, Kathleen A Jablonski, Yii-Der Ida Chen, Laura Tipton, Myrlene A Staten, Steven E Shoelson. Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.
Annals of internal medicine.
2013 Jul; 159(1):1-12. doi:
10.7326/0003-4819-159-1-201307020-00003. [PMID: 23817699] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Elham Faghihimani, Ashraf Aminorroaya, Hassan Rezvanian, Peyman Adibi, Faramarz Ismail-Beigi, Masoud Amini. Reduction of insulin resistance and plasma glucose level by salsalate treatment in persons with prediabetes.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2012 Nov; 18(6):826-33. doi:
10.4158/ep12064.or. [PMID: 22784842] - Simon A Hawley, Morgan D Fullerton, Fiona A Ross, Jonathan D Schertzer, Cyrille Chevtzoff, Katherine J Walker, Mark W Peggie, Darya Zibrova, Kevin A Green, Kirsty J Mustard, Bruce E Kemp, Kei Sakamoto, Gregory R Steinberg, D Grahame Hardie. The ancient drug salicylate directly activates AMP-activated protein kinase.
Science (New York, N.Y.).
2012 May; 336(6083):918-22. doi:
10.1126/science.1215327. [PMID: 22517326] - Mark F McCarty. Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease.
Medical hypotheses.
2011 Oct; 77(4):550-6. doi:
10.1016/j.mehy.2011.06.029. [PMID: 21764223] - Weidong Chai, Jia Liu, Linda A Jahn, Dale E Fowler, Eugene J Barrett, Zhenqi Liu. Salsalate attenuates free fatty acid-induced microvascular and metabolic insulin resistance in humans.
Diabetes care.
2011 Jul; 34(7):1634-8. doi:
10.2337/dc10-2345. [PMID: 21617098] - Ruth C R Meex, Esther Phielix, Esther Moonen-Kornips, Patrick Schrauwen, Matthijs K C Hesselink. Stimulation of human whole-body energy expenditure by salsalate is fueled by higher lipid oxidation under fasting conditions and by higher oxidative glucose disposal under insulin-stimulated conditions.
The Journal of clinical endocrinology and metabolism.
2011 May; 96(5):1415-23. doi:
10.1210/jc.2010-1816. [PMID: 21289240] - Jan Westerink, Frank L J Visseren. Pharmacological and non-pharmacological interventions to influence adipose tissue function.
Cardiovascular diabetology.
2011 Jan; 10(?):13. doi:
10.1186/1475-2840-10-13. [PMID: 21276223] - Kristen L Jablonski, Michel Chonchol, Gary L Pierce, Ashley E Walker, Douglas R Seals. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults.
Hypertension (Dallas, Tex. : 1979).
2011 Jan; 57(1):63-9. doi:
10.1161/hypertensionaha.110.160929. [PMID: 21115878] - Viviane Zorzanelli Rocha, Eduardo J Folco. Inflammatory concepts of obesity.
International journal of inflammation.
2011; 2011(?):529061. doi:
10.4061/2011/529061. [PMID: 21837268] - Subramanyam N Murthy, Cyrus V Desouza, Neal W Bost, Rose-Claire St Hilaire, David B Casey, Adeleke M Badejo, Jasdeep S Dhaliwal, Jennifer McGee, Dennis B McNamara, Philip J Kadowitz, Vivian A Fonseca. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats.
Diabetes.
2010 Dec; 59(12):3240-6. doi:
10.2337/db09-1761. [PMID: 20876710] - Martha M Rumore, Katelynn S Kim. Potential role of salicylates in type 2 diabetes.
The Annals of pharmacotherapy.
2010 Jul; 44(7-8):1207-21. doi:
10.1345/aph.1m483. [PMID: 20516365] - Patrick L West, B Zane Horowitz. Delayed recrudescence to toxic salicylate concentrations after salsalate overdose.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2010 Jun; 6(2):150-4. doi:
10.1007/s13181-010-0070-1. [PMID: 20405267] - Allison B Goldfine, Vivian Fonseca, Kathleen A Jablonski, Laura Pyle, Myrlene A Staten, Steven E Shoelson. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial.
Annals of internal medicine.
2010 Mar; 152(6):346-57. doi:
10.7326/0003-4819-152-6-201003160-00004. [PMID: 20231565] - Zaichang Yang, Yule Niu, Yi Le, Xiaoyan Ma, Chong Qiao. Beta-lactamase inhibitory component from the roots of Fissistigma cavaleriei.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Feb; 17(2):139-41. doi:
10.1016/j.phymed.2009.08.003. [PMID: 19747808] - Ran Meng, Da-Long Zhu, Yan Bi, Dong-Hui Yang, Ya-Ping Wang. Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice.
Mediators of inflammation.
2010; 2010(?):858735. doi:
10.1155/2010/858735. [PMID: 21403905] - Jean-Philippe Lafrance, Donald R Miller. Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury.
Pharmacoepidemiology and drug safety.
2009 Oct; 18(10):923-31. doi:
10.1002/pds.1798. [PMID: 19585463] - Yaël Mamane, Chi Chung Chan, Genevieve Lavallee, Nicolas Morin, Li-Jing Xu, JingQi Huang, Robert Gordon, Winston Thomas, John Lamb, Eric E Schadt, Brian P Kennedy, Joseph A Mancini. The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation.
Diabetes.
2009 Sep; 58(9):2006-17. doi:
10.2337/db09-0323. [PMID: 19581423] - Gary L Pierce, Lisa A Lesniewski, Brooke R Lawson, Stacy D Beske, Douglas R Seals. Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.
Circulation.
2009 Mar; 119(9):1284-92. doi:
10.1161/circulationaha.108.804294. [PMID: 19237660] - J Koska, E Ortega, J C Bunt, A Gasser, J Impson, R L Hanson, J Forbes, B de Courten, J Krakoff. The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study.
Diabetologia.
2009 Mar; 52(3):385-93. doi:
10.1007/s00125-008-1239-x. [PMID: 19104769] - Allison B Goldfine, Robert Silver, Waleed Aldhahi, Dongsheng Cai, Elizabeth Tatro, Jongsoon Lee, Steven E Shoelson. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes.
Clinical and translational science.
2008 May; 1(1):36-43. doi:
10.1111/j.1752-8062.2008.00026.x. [PMID: 19337387] - Amy Fleischman, Steven E Shoelson, Raquel Bernier, Allison B Goldfine. Salsalate improves glycemia and inflammatory parameters in obese young adults.
Diabetes care.
2008 Feb; 31(2):289-94. doi:
10.2337/dc07-1338. [PMID: 17959861] - Mark F McCarty, Keith I Block. Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy.
Integrative cancer therapies.
2006 Sep; 5(3):252-68. doi:
10.1177/1534735406291499. [PMID: 16880431] - R Wang, J C Nelson, R B Wilcox. Salsalate and salicylate binding to and their displacement of thyroxine from thyroxine-binding globulin, transthyrin, and albumin.
Thyroid : official journal of the American Thyroid Association.
1999 Apr; 9(4):359-64. doi:
10.1089/thy.1999.9.359. [PMID: 10319941] - R J McConnell. Changes in thyroid function tests during short-term salsalate use.
Metabolism: clinical and experimental.
1999 Apr; 48(4):501-3. doi:
10.1016/s0026-0495(99)90111-7. [PMID: 10206445] - J A Pulgarín, L F Bermejo. Simultaneous determination of salicylamide and salsalate in serum and urine by first derivative variable-angle synchronous fluorescence spectrometry.
Analytical biochemistry.
1998 Dec; 265(2):331-9. doi:
10.1006/abio.1998.2936. [PMID: 9882411] - R Wang, J C Nelson, R B Wilcox. Salsalate administration--a potential pharmacological model of the sick euthyroid syndrome.
The Journal of clinical endocrinology and metabolism.
1998 Sep; 83(9):3095-9. doi:
10.1210/jcem.83.9.5124. [PMID: 9745409] - N Chalasani, J Roman, R L Jurado. Systemic inflammatory response syndrome caused by chronic salicylate intoxication.
Southern medical journal.
1996 May; 89(5):479-82. doi:
10.1097/00007611-199605000-00005. [PMID: 8638172] - G Casadevall, J J Moreno, M A Franch, J Queralt. N-acetyl-beta-D-glucosaminidase (NAG) and alanine aminopeptidase (AAP) excretion after acute administration of acetaminophen, salsalate and aspirin in rats.
Research communications in chemical pathology and pharmacology.
1993 Jul; 81(1):77-89. doi:
NULL. [PMID: 8105522] - J R Lisse, J P Lavery, N E Goeken. Salsalate-induced pancytopenia in a patient with systemic lupus erythematosus.
Annals of allergy.
1993 Mar; 70(3):206-9. doi:
NULL. [PMID: 8452314] - B B Latham, E Horst, H Nankin, T Lin, J Osterman. Case report: abnormal thyroid function tests in a patient and two normal volunteers treated with salsalate.
The American journal of the medical sciences.
1993 Feb; 305(2):111-3. doi:
10.1097/00000441-199302000-00010. [PMID: 8427292] - L I Harrison, D J Riedel, K E Armstrong, M B Goldlust, B P Ekholm. Effect of food on salsalate absorption.
Therapeutic drug monitoring.
1992 Apr; 14(2):87-91. doi:
10.1097/00007691-199204000-00002. [PMID: 1585407] - R J McConnell. Abnormal thyroid function test results in patients taking salsalate.
JAMA.
1992 Mar; 267(9):1242-3. doi:
NULL. [PMID: 1538562] - J D Sweeney, L A Hoernig. Hemostatic effects of salsalate in normal subjects and patients with hemophilia A.
Thrombosis research.
1991 Jan; 61(1):23-7. doi:
10.1016/0049-3848(91)90165-s. [PMID: 2020937] - B Cryer, M Goldschmiedt, J S Redfern, M Feldman. Comparison of salsalate and aspirin on mucosal injury and gastroduodenal mucosal prostaglandins.
Gastroenterology.
1990 Dec; 99(6):1616-21. doi:
10.1016/0016-5085(90)90465-d. [PMID: 2227277] - J M Scheiman, E M Behler, R R Berardi, G H Elta. Salicylsalicylic acid causes less gastroduodenal mucosal damage than enteric-coated aspirin. An endoscopic comparison.
Digestive diseases and sciences.
1989 Feb; 34(2):229-32. doi:
10.1007/bf01536056. [PMID: 2914543] - K S Kleinman, S Schweitzer, A R Nissenson. Accidental salicylate intoxication in a hemodialysis patient.
Archives of internal medicine.
1988 Oct; 148(10):2277-8. doi:
NULL. [PMID: 3178384] - P A Abraham, M T Stillman. Salsalate exacerbation of chronic renal insufficiency. Relation to inhibition of prostaglandin synthesis.
Archives of internal medicine.
1987 Sep; 147(9):1674-6. doi:
NULL. [PMID: 3477131] - M E Williams, M Weinblatt, R M Rosa, V L Griffin, M B Goldlust, S F Shang, L I Harrison, R S Brown. Salsalate kinetics in patients with chronic renal failure undergoing hemodialysis.
Clinical pharmacology and therapeutics.
1986 Apr; 39(4):420-4. doi:
10.1038/clpt.1986.65. [PMID: 3956057] - H G Morris, N A Sherman, C McQuain, M B Goldlust, S F Chang, L I Harrison. Effects of salsalate (nonacetylated salicylate) and aspirin on serum prostaglandins in humans.
Therapeutic drug monitoring.
1985; 7(4):435-8. doi:
10.1097/00007691-198512000-00012. [PMID: 3866409] - S H Dromgoole, D E Furst, H E Paulus. Metabolism of salsalate in normal subjects.
Journal of pharmaceutical sciences.
1984 Nov; 73(11):1657-9. doi:
10.1002/jps.2600731147. [PMID: 6520777] - S H Dromgoole, S Cassell, D E Furst, H E Paulus. Availability of salicylate from salsalate and aspirin.
Clinical pharmacology and therapeutics.
1983 Oct; 34(4):539-45. doi:
10.1038/clpt.1983.211. [PMID: 6617077] - L I Harrison, M L Funk, O N Ré, R E Ober. Absorption, biotransformation, and pharmacokinetics of salicylsalicylic acid in humans.
Journal of clinical pharmacology.
1981 Oct; 21(10):401-4. doi:
10.1002/j.1552-4604.1981.tb01740.x. [PMID: 7309902] - H Mielants, E M Veys, G Verbruggen, Schelstraete. Comparison of serum salicylate levels and gastro-intestinal blood loss between salsalate (Disalcid)and other forms of salicylates.
Scandinavian journal of rheumatology.
1981; 10(3):169-73. doi:
10.3109/03009748109095292. [PMID: 7027430] - L I Harrison, M L Funk, R E Ober. High-pressure liquid chromatographic determination of salicylsalicylic acid, aspirin, and salicylic acid in human plasma and urine.
Journal of pharmaceutical sciences.
1980 Nov; 69(11):1268-71. doi:
10.1002/jps.2600691109. [PMID: 7452454] - F Fazarinc, S N Steen. Long-term management of rheumatoid arthritis with disalcid.
The Journal of international medical research.
1980; 8(5):339-42. doi:
10.1177/030006058000800506. [PMID: 6774903] - M M Lubran, S N Steen, R L Smith. Measurement of salicylsalicylic acid and salicylic acid in plasma by high pressure liquid chromatography.
Annals of clinical and laboratory science.
1979 Nov; 9(6):501-10. doi:
NULL. [PMID: 518013] - O N Ré. Salicylsalicylic acid revisited: a multicentre study.
The Journal of international medical research.
1979; 7(1):90-5. doi:
10.1177/030006057900700114. [PMID: 421967] - S P Liyanage, P K Tambar. Comparative study of salsalate and aspirin in osteoarthrosis of the hip or knee.
Current medical research and opinion.
1978; 5(6):450-3. doi:
10.1185/03007997809111914. [PMID: 350497] - H S RUBIN. SERUM SALICYLATE LEVELS IN OSTEOARTHRITIS FOLLOWING ORAL ADMINISTRATION OF A PREPARATION CONTAINING SALICYLSALICYLIC ACID.
The American journal of the medical sciences.
1964 Jul; 248(?):31-6. doi:
10.1097/00000441-196407000-00006. [PMID: 14177937] - G BOLLAND, K THALMANN. [Comparative experiments on blood level, protein absorption & renal excretion of tetrahydro-1, 4-oxazine-salicyl & sodium salicylate with & without para aminobenzoic acid].
Arzneimittel-Forschung.
1957 May; 7(5):309-11. doi:
NULL. [PMID: 13445547] - P BASTIDE. [Hydrolysis and in vivo elimination of various salicylate derivatives: salicylsalicylic acid and succinyldisalicylic acid; determination of hemicresis and protorrhea].
Therapie.
1955; 10(5):700-7. doi:
NULL. [PMID: 13299223]