Oxibendazole (BioDeep_00000015053)
Secondary id: BioDeep_00000181975
natural product
代谢物信息卡片
化学式: C12H15N3O3 (249.1113)
中文名称: 奥苯达唑
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: C1(=CC=C2C(=C1)NC(=N2)NC(OC)=O)OCCC
InChI: InChI=1S/C12H15N3O3/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:92907
- KEGG: C73898
- KEGGdrug: D05293
- PubChem: 4622
- Metlin: METLIN44351
- DrugBank: DB04910
- ChEMBL: CHEMBL1087630
- CAS: 20559-55-1
- MoNA: CCMSLIB00000078315
- PMhub: MS000003412
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Rafael Paranhos de Mendonça, Daniela Oliveira Carneiro, Eliane Marucci Baccin, Márcia Richena Pirágine, Sara Menegatti Zoca, Luis Augusto Ferreira Rossa, Guilherme Cecílio Lima, Francismar Barbosa de Oliveira, Istanlei Soares Costa, Gabriel Nunes de Oliveira, Sabrina Nathália Louzada Nogueira, Thaís Rabelo Dos Santos-Doni. Anthelmintic efficacy of oxibendazole against gastrointestinal nematodes in swine.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria.
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Cell reports.
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International journal for parasitology. Drugs and drug resistance.
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Molecular pharmacology.
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Veterinary parasitology.
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Scientific reports.
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. [PMID: 22961681] - Eugene T Lyons, Sharon C Tolliver, Tetiana A Kuzmina, Sandra S Collins. Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010).
Parasitology research.
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. [PMID: 21499750] - Laura Ceballos, Laura Moreno, Luis Alvarez, Laura Shaw, Ian Fairweather, Carlos Lanusse. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.
BMC veterinary research.
2010 Feb; 6(?):8. doi:
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. [PMID: 20128898] - Donato Traversa, Raffaella Iorio, Domenico Otranto, Annunziata Giangaspero, Piermarino Milillo, Thomas R Klei. Species-specific identification of equine cyathostomes resistant to fenbendazole and susceptible to oxibendazole and moxidectin by macroarray probing.
Experimental parasitology.
2009 Jan; 121(1):92-5. doi:
10.1016/j.exppara.2008.10.001
. [PMID: 18950625] - E T Lyons, S C Tolliver, M Ionita, S S Collins. Evaluation of parasiticidal activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007.
Parasitology research.
2008 Jul; 103(2):287-91. doi:
10.1007/s00436-008-0966-8
. [PMID: 18470536] - E T Lyons, S C Tolliver, M Ionita, A Lewellen, S S Collins. Field studies indicating reduced activity of ivermectin on small strongyles in horses on a farm in Central Kentucky.
Parasitology research.
2008 Jun; 103(1):209-15. doi:
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. [PMID: 18389281] - E T Lyons, S C Tolliver, R A Rathgeber, S S Collins. Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically.
Parasitology research.
2007 Feb; 100(3):473-8. doi:
10.1007/s00436-006-0289-6
. [PMID: 17013652] - E T Lyons, S C Tolliver, S S Collins. Field studies on endoparasites of Thoroughbred foals on seven farms in central Kentucky in 2004.
Parasitology research.
2006 Apr; 98(5):496-500. doi:
10.1007/s00436-005-0091-x
. [PMID: 16385405] - Titus A M Msagati, Mathew Muzi Nindi. Comparative study of sample preparation methods; supported liquid membrane and solid phase extraction in the determination of benzimidazole anthelmintics in biological matrices by liquid chromatography-electrospray-mass spectrometry.
Talanta.
2006 Mar; 69(1):243-50. doi:
10.1016/j.talanta.2005.10.002
. [PMID: 18970561] - Ray M Kaplan, Thomas R Klei, Eugene T Lyons, Guy Lester, Charles H Courtney, Dennis D French, Sharon C Tolliver, Anand N Vidyashankar, Ying Zhao. Prevalence of anthelmintic resistant cyathostomes on horse farms.
Journal of the American Veterinary Medical Association.
2004 Sep; 225(6):903-10. doi:
10.2460/javma.2004.225.903
. [PMID: 15485051] - R Tandon, R M Kaplan. Evaluation of a larval development assay (DrenchRite) for the detection of anthelmintic resistance in cyathostomin nematodes of horses.
Veterinary parasitology.
2004 May; 121(1-2):125-42. doi:
10.1016/j.vetpar.2003.09.016
. [PMID: 15110410] - Eugene Lyons. Population-S benzimidazole- and tetrahydropyrimidine-resistant small strongyles in a pony herd in Kentucky (1977-1999): effects of anthelmintic treatment on the parasites as determined in critical tests.
Parasitology research.
2003 Nov; 91(5):407-11. doi:
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. [PMID: 14530968] - M L Mottier, L I Alvarez, M A Pis, C E Lanusse. Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol-water partition coefficients.
Experimental parasitology.
2003 Jan; 103(1-2):1-7. doi:
10.1016/s0014-4894(03)00060-2
. [PMID: 12810040] - S Matthee, F H Dreyer, W A Hoffmann, F E van Niekerk. An introductory survey of helminth control practices in south africa and anthelmintic resistance on Thoroughbred stud farms in the Western Cape Province.
Journal of the South African Veterinary Association.
2002 Dec; 73(4):195-200. doi:
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. [PMID: 12665133] - Dennis Kitzman, Kuei-Ju Cheng, Lawrence Fleckenstein. HPLC assay for albendazole and metabolites in human plasma for clinical pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2002 Oct; 30(3):801-13. doi:
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2002 Jul; 106(4):331-43. doi:
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. [PMID: 12079739] - C Gokbulut, A M Nolan, Q A McKellar. Plasma disposition, faecal excretion and in vitro metabolism of oxibendazole following oral administration in horses.
Research in veterinary science.
2002 Feb; 72(1):11-5. doi:
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. [PMID: 12002632] - P F Rolfe, K L Dawson, M Holm-Martin. Efficacy of moxidectin and other anthelmintics against small strongyles in horses.
Australian veterinary journal.
1998 May; 76(5):332-4. doi:
10.1111/j.1751-0813.1998.tb12361.x
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The veterinary quarterly.
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. [PMID: 9563164] - S K Katiyar, T D Edlind. In vitro susceptibilities of the AIDS-associated microsporidian Encephalitozoon intestinalis to albendazole, its sulfoxide metabolite, and 12 additional benzimidazole derivatives.
Antimicrobial agents and chemotherapy.
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10.1128/aac.41.12.2729
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Antimicrobial agents and chemotherapy.
1995 Jun; 39(6):1265-8. doi:
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Australian veterinary journal.
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1992 Jul; 201(1):51-5. doi:
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