Lornoxicam (BioDeep_00000015051)
Main id: BioDeep_00000033375
natural product PANOMIX_OTCML-2023
代谢物信息卡片
Lornoxicam (Xefo)
化学式: C13H10ClN3O4S2 (370.980125)
中文名称: 氯诺昔康
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
InChI: InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AC - Oxicams
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Lornoxicam (Chlortenoxicam) is a highly active COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM respectively. It is a new non-steroidal anti-inflammatory compound.
同义名列表
4 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:31783
- KEGG: C76243
- KEGGdrug: D01866
- PubChem: 54690031
- DrugBank: DB06725
- ChEMBL: CHEMBL3188235
- ChEMBL: CHEMBL1569487
- CAS: 70374-27-5
- CAS: 70374-39-9
- MoNA: CCMSLIB00000078407
- PMhub: MS000001677
- medchemexpress: HY-B0367
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Moataz B Zewail, Gihan F Asaad, Salma M Swellam, Sama M Abd-Allah, Sahar K Hosny, Salma K Sallah, Jehan E Eissa, Salma S Mohamed, Walaa A El-Dakroury. Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation.
International journal of pharmaceutics.
2022 Jul; 624(?):122006. doi:
10.1016/j.ijpharm.2022.122006. [PMID: 35820515] - Nguyen-Thach Tung, Thi-Hoang-Yen Dong, Cao-Son Tran, Thi-Kim-Thuy Nguyen, Sang-Cheol Chi, Danh-Son Dao, Dang-Hoa Nguyen. Integration of lornoxicam nanocrystals into hydroxypropyl methylcellulose-based sustained release matrix to form a novel biphasic release system.
International journal of biological macromolecules.
2022 Jun; 209(Pt A):441-451. doi:
10.1016/j.ijbiomac.2022.04.041. [PMID: 35413313] - Sabry M El-Bahr, Rabab R Elzoghby, Mohammed A Alfattah, Mahmoud Kandeel, Ahlam F Hamouda. Aqueous Ginger (Zingiber officinale) Extract Ameliorates the Harmful Effects of High-Dose Lornoxicam in Albino Male Rats.
BioMed research international.
2022; 2022(?):1546734. doi:
10.1155/2022/1546734. [PMID: 35958816] - Mahmoud H Teaima, Khaled M Abdel-Haleem, Rewan Osama, Mohamed A El-Nabarawi, Osama S Elnahas. A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study.
Drug design, development and therapy.
2021; 15(?):4229-4242. doi:
10.2147/dddt.s332729. [PMID: 34675486] - Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh. Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Journal of medicinal chemistry.
2020 02; 63(4):1763-1774. doi:
10.1021/acs.jmedchem.0c00046. [PMID: 31995375] - V V Popov, G N Gildeeva, D V Butuzova, E A Ezhova, A V Belostotskiy, N A Bulanova. [A study of the efficacy and safety of lornoxicam in patients with acute sciatica].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2020; 120(5):42-49. doi:
10.17116/jnevro202012005142. [PMID: 32621467] - Shanshan Gao, Baocheng Tian, Jingtian Han, Jing Zhang, Yanan Shi, Qingzhi Lv, Keke Li. Enhanced transdermal delivery of lornoxicam by nanostructured lipid carrier gels modified with polyarginine peptide for treatment of carrageenan-induced rat paw edema.
International journal of nanomedicine.
2019; 14(?):6135-6150. doi:
10.2147/ijn.s205295. [PMID: 31447556] - Syed Nisar Hussain Shah, Kashif Sohail, Zeeshan Javaid, Muhammad Zaman, Ejaz Basheer. Development and validation of RP-HPLC method for determination of Lornoxicam in rabbit's plasma.
Pakistan journal of pharmaceutical sciences.
2019 Jan; 32(1(Supplementary)):333-338. doi:
NULL. [PMID: 30829212] - Ruby Christian, Vaishali Thakkar, Tushar Patel, Mukesh Gohel, Lalji Baldaniya, Purvi Shah, Tosha Pandya, Tejal Gandhi. Development of Biodegradable Injectable In situ Forming Implants for Sustained Release of Lornoxicam.
Current drug delivery.
2019; 16(1):66-78. doi:
10.2174/1567201815666180927155710. [PMID: 30264681] - Keke Li, Shanshan Gao, Baocheng Tian, Yanan Shi, Qingzhi Lv, Jingtian Han. Formulation Optimization and In-vitro and In-vivo Evaluation of Lornoxicam Ethosomal Gels with Penetration Enhancers.
Current drug delivery.
2018; 15(3):424-435. doi:
10.2174/1567201815666171207163010. [PMID: 29219057] - Mohamed Yousif Moutasim, Aliaa Nabil ElMeshad, Mohamed Ahmed El-Nabarawi. A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation.
Drug delivery and translational research.
2017 06; 7(3):450-459. doi:
10.1007/s13346-017-0367-6. [PMID: 28283842] - Sandipan Dasgupta, Subhabrata Ray, Sanjay Dey, Paulami Pal, Bhaskar Mazumder. Transdermal Lipid Nanocarriers: A Potential Delivery System for Lornoxicam.
Pharmaceutical nanotechnology.
2017; 5(1):32-43. doi:
10.2174/2211738505666170105161336. [PMID: 28948909] - Hebatullah Samy Helmy, Ayman E El-Sahar, Rabab H Sayed, Rehab Nabil Shamma, Alaa Hamed Salama, Eman Maher Elbaz. Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis.
International journal of nanomedicine.
2017; 12(?):7015-7023. doi:
10.2147/ijn.s147738. [PMID: 29026298] - Seby Elsy Varghese, Mayur K Fariya, Gopal Singh Rajawat, Frank Steiniger, Alfred Fahr, Mangal S Nagarsenker. Lecithin and PLGA-based self-assembled nanocomposite, Lecithmer: preparation, characterization, and pharmacokinetic/pharmacodynamic evaluation.
Drug delivery and translational research.
2016 08; 6(4):342-53. doi:
10.1007/s13346-016-0314-y. [PMID: 27371394] - Hande Arpacı, Faruk Metin Çomu, Ayşegül Küçük, Bahadır Kösem, Seyfi Kartal, Volkan Şıvgın, Hüseyin Cihad Turgut, Muhammed Enes Aydın, Derya Sebile Koç, Mustafa Arslan. Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats.
Drug design, development and therapy.
2016; 10(?):2477-81. doi:
10.2147/dddt.s113806. [PMID: 27536068] - Altug Tuncel, Melih Balci, Aysun Postaci, Yilmaz Aslan, Ali Atan. Comparıson of different postoperative paın managements in patients submitted to transperitoneal laparoscopic renal and adrenal surgery.
International braz j urol : official journal of the Brazilian Society of Urology.
2015 Jul; 41(4):669-75. doi:
10.1590/s1677-5538.ibju.2013.0238. [PMID: 26401858] - Ümit Gönüllü, Melike Üner, Gülgün Yener, Ecem Fatma Karaman, Zeynep Aydoğmuş. Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery.
Acta pharmaceutica (Zagreb, Croatia).
2015 Mar; 65(1):1-13. doi:
10.1515/acph-2015-0009. [PMID: 25781700] - Fei Li, Shuangshuang Song, Yingxin Guo, Qianqian Zhao, Xuemei Zhang, Weisan Pan, Xinggang Yang. Preparation and pharmacokinetics evaluation of oral self-emulsifying system for poorly water-soluble drug Lornoxicam.
Drug delivery.
2015; 22(4):487-98. doi:
10.3109/10717544.2014.885615. [PMID: 24524289] - He Liang Sun, Ying Chun Dong, Can Qin Wang, Yan Ning Qian, Zhong Yun Wang. Effects of postoperative analgesia with the combination of tramadol and lornoxicam on serum inflammatory cytokines in patients with gastric cancer.
International journal of clinical pharmacology and therapeutics.
2014 Dec; 52(12):1023-9. doi:
10.5414/cp202190. [PMID: 25295719] - Zeynep Fatma Zor, Berrin Isik, Sedat Cetiner. Efficacy of preemptive lornoxicam on postoperative analgesia after surgical removal of mandibular third molars.
Oral surgery, oral medicine, oral pathology and oral radiology.
2014 Jan; 117(1):27-31. doi:
10.1016/j.oooo.2013.08.027. [PMID: 24332324] - Junichi Shirako, Marina Kawasaki, Kotoe Komine, Yoko Kunisue, Masaru Terada, Chizuko Sasaki, Wataru Irie, Chikako Murakami, Keiko Tonooka, Koji Tomobe, Tatsuo Shinozuka. Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography-tandem mass spectrometry.
Forensic science international.
2013 Apr; 227(1-3):100-2. doi:
10.1016/j.forsciint.2012.11.016. [PMID: 23273940] - Takeki Uehara, Chiaki Kondo, Yuji Morikawa, Hiroyuki Hanafusa, Seiko Ueda, Yohsuke Minowa, Noriyuki Nakatsu, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Toxicogenomic biomarkers for renal papillary injury in rats.
Toxicology.
2013 Jan; 303(?):1-8. doi:
10.1016/j.tox.2012.09.012. [PMID: 23142791] - Nasir Idkaidek, Tawfiq Arafat. Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system.
Molecular pharmaceutics.
2012 Aug; 9(8):2358-63. doi:
10.1021/mp300250r. [PMID: 22784220] - Fatih Ozkan, Fikret Erdemir, Unal Erkorkmaz, Ziya Kaya, Yesim Senayli, Bekir S Parlaktas. Comparison of three different analgesic protocols during shockwave lithotripsy.
Journal of endourology.
2012 Jun; 26(6):691-6. doi:
10.1089/end.2011.0004. [PMID: 22050496] - Zhiyue Zhang, Guihua Huang. Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis.
Drug delivery.
2012 Jun; 19(5):255-63. doi:
10.3109/10717544.2012.700962. [PMID: 22775466] - Fang Zhao, Wenhui Zhao. Investigation on the micelle-sensitized Ce(IV)-lornoxicam-Rh B chemiluminescence system and its application.
Journal of fluorescence.
2012 Jan; 22(1):529-35. doi:
10.1007/s10895-011-0987-z. [PMID: 21968509] - Chang-Ik Choi, Mi-Jeong Kim, Choon-Gon Jang, Young-Seo Park, Jung-Woo Bae, Seok-Yong Lee. Effects of the CYP2C9*1/*13 genotype on the pharmacokinetics of lornoxicam.
Basic & clinical pharmacology & toxicology.
2011 Dec; 109(6):476-80. doi:
10.1111/j.1742-7843.2011.00751.x. [PMID: 21726410] - Shu Wang, Moses S S Chow, Zhong Zuo. An approach for rapid development of nasal delivery of analgesics--identification of relevant features, in vitro screening and in vivo verification.
International journal of pharmaceutics.
2011 Nov; 420(1):43-50. doi:
10.1016/j.ijpharm.2011.08.019. [PMID: 21871544] - Zhiyue Zhang, Xiuli Bi, Hui Li, Guihua Huang. Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration.
Drug delivery.
2011 Sep; 18(7):536-44. doi:
10.3109/10717544.2011.596584. [PMID: 21812757] - Mohamed Daabiss, Mohamed Hashish. Effects of lornoxicam on the hemodynamic and catecholamine response to laryngoscopy and tracheal intubation.
European journal of clinical pharmacology.
2011 Aug; 67(8):783-6. doi:
10.1007/s00228-011-1017-4. [PMID: 21369950] - P H Kook, C E Reusch. [Severe gastrointestinal bleeding secondary to lornoxicam in the dog].
Schweizer Archiv fur Tierheilkunde.
2011 May; 153(5):223-9. doi:
10.1024/0036-7281/a000186. [PMID: 21541911] - Reeta Punith, Ashwini H Hegde, Seetharamappa Jaldappagari. Binding of an anti-inflammatory drug lornoxicam with blood proteins: insights from spectroscopic investigations.
Journal of fluorescence.
2011 Mar; 21(2):487-95. doi:
10.1007/s10895-010-0735-9. [PMID: 20924657] - He-na Jiao, Fei Ren, Hong-wei Cai. [Effect of intravenous lornoxicam at different doses on the immune function in patients undergoing total abdominal hysterectomy].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Aug; 30(8):1844-6. doi:
NULL. [PMID: 20813681] - Burcin Bozal, Bengi Uslu. Applications of carbon based electrodes for voltammetric determination of lornoxicam in pharmaceutical dosage form and human serum.
Combinatorial chemistry & high throughput screening.
2010 Aug; 13(7):598-609. doi:
10.2174/1386207311004070599. [PMID: 20402638] - Zheng-Jie Wu, Cai-Li Zhang, Yan-Hui Zeng, Yong-Zhan Zhu, Yan Li. [Analysis of the effects of different medicines on hypercoagulability state variations of femoral shaft fracture and after its operation].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2010 Jun; 33(6):1019-23. doi:
". [PMID: 21049628] - Hena Jiao, Fei Ren. Pretreatment with lornoxicam, a cyclooxygenase inhibitor, relieves postoperative immuno-suppression after total abdominal hysterectomy.
The Tohoku journal of experimental medicine.
2009 Dec; 219(4):289-94. doi:
10.1620/tjem.219.289. [PMID: 19966527] - Deniz Ekinci, Sükrü Beydemir. Effect of some analgesics on paraoxonase-1 purified from human serum.
Journal of enzyme inhibition and medicinal chemistry.
2009 Aug; 24(4):1034-9. doi:
10.1080/14756360802608351. [PMID: 19548782] - Erdal Yilmaz. Re: Takmaz SA, et al. Analgesic effect of 8- and 16-mg lornoxicam administered before shock wave lithotripsy: a randomized, double-blind, controlled study (Urology 2008;72:282-285).
Urology.
2009 Jan; 73(1):211-2. doi:
10.1016/j.urology.2008.09.034. [PMID: 19111738] - Shi-Qing Lin, Xiao-Jian Wu, Shu Zheng, Hui Zhang, Wen-Qi Huang. [A comparison of the metabolic effect of postoperative analgesia with lornoxicam and morphine or morphine on patients undergoing gastrointestinal carcinoma operation].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery.
2008 Mar; 11(2):141-4. doi:
NULL. [PMID: 18344081] - Susanna Radhofer-Welte, Peter Dittrich, Marija Simin, Poul Erik Branebjerg. Comparative bioavailability of lornoxicam as single doses of quick-release tablet, standard tablet and intramuscular injection: a randomized, open-label, crossover phase I study in healthy volunteers.
Clinical drug investigation.
2008; 28(6):345-51. doi:
10.2165/00044011-200828060-00002. [PMID: 18479176] - Erhan Ayan, Murat Bayram Kaplan, Oguz Koksel, Lulufer Tamer, Tuba Karabacak, Lokman Ayaz, Ali Ozdulger. Efficiency of lornoxicam in lung and trachea injury caused by peroxynitrite.
Pulmonary pharmacology & therapeutics.
2008; 21(1):201-7. doi:
10.1016/j.pupt.2007.02.005. [PMID: 17467319] - Ayten Bilir, Sacit Gulec, Mehmet Turgut, Dilek Cetinkaya, Ayse Erkan, Imran Kurt. Lornoxicam in extracorporeal shock-wave lithotripsy; comparison with tenoxicam and placebo in terms of analgesic consumption.
Scandinavian journal of urology and nephrology.
2008; 42(2):143-7. doi:
10.1080/00365590701225988. [PMID: 17853036] - Young Hoon Kim, Hye Young Ji, Eun-Seok Park, Soo-Wan Chae, Hye Suk Lee. Liquid chromatography-electrospray ionization tandem mass spectrometric determination of lornoxicam in human plasma.
Archives of pharmacal research.
2007 Jul; 30(7):905-10. doi:
10.1007/bf02978844. [PMID: 17703745] - Selda Sen, Firuzan Kacan Doger, Serdar Sen, Osman N Aydin, Aslihan Karul, Turhan Dost. The protective effect of nitroglycerin on gastrointestinal and renal side effects of lornoxicam in rats.
European journal of pharmacology.
2006 Jul; 541(3):191-7. doi:
10.1016/j.ejphar.2006.05.022. [PMID: 16765342] - Ya-Li Liu, Wei Zhang, Zhi-Rong Tan, Dong-Sheng Ouyang, Chen-hui Luo, Zhao-Qian Liu, Yu Qiu, Yao Chen, Yi-Jing He, Gan Zhou, Hong-Hao Zhou. Effect of the CYP2C9*3 allele on lornoxicam metabolism.
Clinica chimica acta; international journal of clinical chemistry.
2006 Feb; 364(1-2):287-91. doi:
10.1016/j.cca.2005.07.013. [PMID: 16182270] - Yi-Fan Zhang, Xiao-Yan Chen, Ying-Jie Guo, Da-Yong Si, Hui Zhou, Da-Fang Zhong. [Impact of cytochrome P450 CYP2C9 variant allele CYP2C9 * 3 on the pharmacokinetics of glibenclamide and lornoxicam in Chinese subjects].
Yao xue xue bao = Acta pharmaceutica Sinica.
2005 Sep; 40(9):796-9. doi:
NULL. [PMID: 16342679] - T Yamamoto, H Itoga, Y Kohno, K Nagata, Y Yamazoe. Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: comparison among well-stirred, parallel-tube, distributed and dispersion models.
Xenobiotica; the fate of foreign compounds in biological systems.
2005 Jun; 35(6):627-46. doi:
10.1080/00498250500159371. [PMID: 16192112] - Yifan Zhang, Dafang Zhong, Dayong Si, Yingjie Guo, Xiaoyan Chen, Hui Zhou. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype.
British journal of clinical pharmacology.
2005 Jan; 59(1):14-7. doi:
10.1111/j.1365-2125.2005.02223.x. [PMID: 15606435] - I Kyrikou, S K Hadjikakou, D Kovala-Demertzi, K Viras, T Mavromoustakos. Effects of non-steroid anti-inflammatory drugs in membrane bilayers.
Chemistry and physics of lipids.
2004 Dec; 132(2):157-69. doi:
10.1016/j.chemphyslip.2004.06.005. [PMID: 15555602] - Dilek Memiş, Beyhan Karamanlioğlu, Alparslan Turan, Onur Koyuncu, Zafer Pamukçu. Effects of lornoxicam on the physiology of severe sepsis.
Critical care (London, England).
2004 Dec; 8(6):R474-82. doi:
10.1186/cc2969. [PMID: 15566594] - Ya-lin Zeng, Xiao-yan Chen, Yi-fan Zhang, Da-fang Zhong. [Determination of lornoxicam in human plasma by LC/MS/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 Feb; 39(2):132-5. doi:
NULL. [PMID: 15127622] - C Kohl, M Steinkellner. Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants.
Drug metabolism and disposition: the biological fate of chemicals.
2000 Feb; 28(2):161-8. doi:
NULL. [PMID: 10640513] - U P Masche, K M Rentsch, A von Felten, P J Meier, K E Fattinger. Opposite effects of lornoxicam co-administration on phenprocoumon pharmacokinetics and pharmacodynamics.
European journal of clinical pharmacology.
1999 Jan; 54(11):857-64. doi:
10.1007/s002280050567. [PMID: 10027661] - N M Skjodt, N M Davies. Clinical pharmacokinetics of lornoxicam. A short half-life oxicam.
Clinical pharmacokinetics.
1998 Jun; 34(6):421-8. doi:
10.2165/00003088-199834060-00001. [PMID: 9646006] - S Radhofer-Welte, P Dittrich. Determination of the novel non-steroidal anti-inflammatory drug lornoxicam and its main metabolite in plasma and synovial fluid.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Apr; 707(1-2):151-9. doi:
10.1016/s0378-4347(97)00597-5. [PMID: 9613944] - G Pohlmeyer-Esch, N Mehdi, D Clarke, S Radhofer-Welte. Evaluation of chronic oral toxicity and carcinogenic potential of lornoxicam in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1997 Sep; 35(9):909-22. doi:
10.1016/s0278-6915(97)00062-8. [PMID: 9409632] - S R Bareggi, V Gambaro, M Valenti, C Benvenuti. Absorption of oral lornoxicam in healthy volunteers using a granular formulation in comparison with standard tablets.
Arzneimittel-Forschung.
1997 Jun; 47(6):755-7. doi:
NULL. [PMID: 9239455] - E Atzpodien, N Mehdi, D Clarke, S Radhofer-Welte. Subacute and chronic oral toxicity of lornoxicam in cynomolgus monkeys.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1997 May; 35(5):465-74. doi:
10.1016/s0278-6915(97)00019-7. [PMID: 9216745] - T R Meling, L Aabakken, A Røseth, M Osnes. Faecal calprotectin shedding after short-term treatment with non-steroidal anti-inflammatory drugs.
Scandinavian journal of gastroenterology.
1996 Apr; 31(4):339-44. doi:
10.3109/00365529609006407. [PMID: 8726300] - K T Olkkola, A V Brunetto, M J Mattila. Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents.
Clinical pharmacokinetics.
1994 Feb; 26(2):107-20. doi:
10.2165/00003088-199426020-00004. [PMID: 8162655] - M Ravic, I Salas-Herrera, A Johnston, P Turner, K Foley, D E Rosenow. A pharmacokinetic interaction between cimetidine or ranitidine and lornoxicam.
Postgraduate medical journal.
1993 Nov; 69(817):865-6. doi:
10.1136/pgmj.69.817.865. [PMID: 8290432] - T Suwa, H Urano, Y Shinohara, J Kokatsu. Simultaneous high-performance liquid chromatographic determination of lornoxicam and its 5'-hydroxy metabolite in human plasma using electrochemical detection.
Journal of chromatography.
1993 Jul; 617(1):105-10. doi:
10.1016/0378-4347(93)80427-6. [PMID: 8376521] - T P Pruss, H Stroissnig, S Radhofer-Welte, W Wendtlandt, N Mehdi, F Takacs, H Fellier. Overview of the pharmacological properties, pharmacokinetics and animal safety assessment of lornoxicam.
Postgraduate medical journal.
1990; 66 Suppl 4(?):S18-21. doi:
NULL. [PMID: 2284216] - S J Warrington, Y Lewis, A Dawnay, A Johnston, I B Kovacs, E Lamb, M Ravic. Renal and gastrointestinal tolerability of lornoxicam, and effects on haemostasis and hepatic microsomal oxidation.
Postgraduate medical journal.
1990; 66 Suppl 4(?):S35-40. doi:
NULL. [PMID: 2284219] - P Dittrich, S Radhofer-Welte, D Magometschnigg, W R Kukovetz, S Mayerhofer, H P Ferber. The effect of concomitantly administered antacids on the bioavailability of lornoxicam, a novel highly potent NSAID.
Drugs under experimental and clinical research.
1990; 16(2):57-62. doi:
NULL. [PMID: 2401187] - P Turner, A Johnston. Clinical pharmacokinetic studies with lornoxicam.
Postgraduate medical journal.
1990; 66 Suppl 4(?):S28-9. doi:
NULL. [PMID: 2284218] - G Hitzenberger, S Radhofer-Welte, F Takacs, D Rosenow. Pharmacokinetics of lornoxicam in man.
Postgraduate medical journal.
1990; 66 Suppl 4(?):S22-7. doi:
NULL. [PMID: 2284217] - W Kullich, G Klein, G Pöllmann. Influence of lornoxicam on serum pepsinogen levels.
Postgraduate medical journal.
1990; 66 Suppl 4(?):S46-8. doi:
NULL. [PMID: 2149454] - M Ravic, A Johnston, P Turner. Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs.
Postgraduate medical journal.
1990; 66 Suppl 4(?):S30-4. doi:
NULL. [PMID: 2126624] - A Hitoglou-Makedou, M Lawson, P Turner, H P Ferber. Comparison of chlortenoxicam and indomethacin on frusemide-induced diuresis.
Postgraduate medical journal.
1989 Nov; 65(769):821-3. doi:
10.1136/pgmj.65.769.821. [PMID: 2694142] - S J Warrington, A Dawnay, A Johnston, S Saul, P Turner, H P Ferber. Chlortenoxicam and renal function of normal human volunteers.
Human toxicology.
1989 Jan; 8(1):53-4. doi:
10.1177/096032718900800110. [PMID: 2714812] - S I Ankier, A E Brimelow, P Crome, A Johnston, S J Warrington, P Turner, H P Ferber. Chlortenoxicam pharmacokinetics in young and elderly human volunteers.
Postgraduate medical journal.
1988 Oct; 64(756):752-4. doi:
10.1136/pgmj.64.756.752. [PMID: 3255915]