colestipol (BioDeep_00000015040)
代谢物信息卡片
Tetraethylenepentamine crosslinked with epichlorohydrin
化学式: C11H28ClN5O (281.1982268)
中文名称: 考来替泊, 蛇根混合碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(O1)CCl.C(CNCCNCCNCCN)N
InChI: 3H,1-2H2
描述信息
It is used as a food additive .
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AC - Bile acid sequestrants
D019995 - Laboratory Chemicals > D007475 - Ion Exchange Resins > D000837 - Anion Exchange Resins
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
D001697 - Biomedical and Dental Materials
D064449 - Sequestering Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 62816
- MeSH: Secologanin Tryptamine Alkaloids
- foodb: FDB010378
- CAS: 26658-42-4
- CAS: 50925-79-6
- CAS: 8001-95-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Thalya Soares Ribeiro Nogueira, Milena Gonçalves Curcino Vieira, Renata Rodrigues da Silva Robaina, Raimundo Braz-Filho, Douglas da Costa Gontijo, Alaíde Braga de Oliveira, Ivo José Curcino Vieira. An update review on monoterpene indole alkaloids and biological activities of Tabernaemontana species occurring in Brazil.
Journal of ethnopharmacology.
2024 Jun; 328(?):117921. doi:
10.1016/j.jep.2024.117921. [PMID: 38369065] - Alice Ameline, Laurie Gheddar, Nadia Arbouche, Adeline Blanchot, Jean-Sebastien Raul, Pascal Kintz. Testing for Kratom alkaloids in fingernail clippings - not only mitragynine.
Journal of pharmaceutical and biomedical analysis.
2024 Jun; 243(?):116078. doi:
10.1016/j.jpba.2024.116078. [PMID: 38489958] - Jia-Xu Qin, Yang Hong, Lu-Yi Zhao, Chao-Qun Wang, Xin Fang, Shuang Liang. The basic chemical substances of total alkaloids of Uncaria rhynchophylla and their anti-neuroinflammatory activities.
Journal of Asian natural products research.
2024 Jun; 26(6):765-771. doi:
10.1080/10286020.2024.2315211. [PMID: 38373226] - Yusuke Hirasawa, Yusuke Kakizoe, Takahiro Tougan, Nahoko Uchiyama, Toshihiro Horii, Hiroshi Morita. Vincarostine A, a novel anti-malarial trimeric monoterpenoid indole alkaloid from Catharanthus roseus.
Journal of natural medicines.
2024 Jun; 78(3):768-773. doi:
10.1007/s11418-024-01795-1. [PMID: 38564155] - Samuel A Bradley, Frederik G Hansson, Beata J Lehka, Daniela Rago, Pedro Pinho, Huadong Peng, Khem B Adhikari, Ahmad K Haidar, Lea G Hansen, Daria Volkova, Maxence Holtz, Sergi Muyo Abad, Xin Ma, Konstantinos Koudounas, Sébastien Besseau, Nicolas Gautron, Céline Mélin, Jillian Marc, Caroline Birer Williams, Vincent Courdavault, Emil D Jensen, Jay D Keasling, Jie Zhang, Michael K Jensen. Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine.
ACS synthetic biology.
2024 May; 13(5):1498-1512. doi:
10.1021/acssynbio.4c00039. [PMID: 38635307] - Lauren F Cole-Osborn, Shannon A McCallan, Olga Prifti, Rafay Abu, Virginie Sjoelund, Carolyn W T Lee-Parsons. The role of the Golden2-like (GLK) transcription factor in regulating terpenoid indole alkaloid biosynthesis in Catharanthus roseus.
Plant cell reports.
2024 May; 43(6):141. doi:
10.1007/s00299-024-03208-9. [PMID: 38743349] - Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda-Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah E O'Connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai. Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus.
The New phytologist.
2024 May; 242(3):1156-1171. doi:
10.1111/nph.19662. [PMID: 38513692] - Asep Bayu, Siti Irma Rahmawati, Firmansyah Karim, Jonathan Ardhianto Panggabean, Dasilva Primarindu Nuswantari, Dwi Wahyu Indriani, Peni Ahmadi, Rendi Witular, Ni Luh Putu Indi Dharmayanti, Masteria Yunovilsa Putra. An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061404. [PMID: 38543040] - Mengxia Zhang, Bingrun Yang, Yanyan Wang, Fang Yu. CrJAT1 Regulates Endogenous JA Signaling for Modulating Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus.
Genes.
2024 Mar; 15(3):. doi:
10.3390/genes15030324. [PMID: 38540383] - Marilyn A Huestis, Martin A Brett, John Bothmer, Ramsey Atallah. Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder.
Molecules (Basel, Switzerland).
2024 Feb; 29(5):. doi:
10.3390/molecules29050984. [PMID: 38474495] - Matthew D DeMars, Sarah E O'Connor. Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America.
2024 Feb; 121(7):e2318586121. doi:
10.1073/pnas.2318586121. [PMID: 38319969] - Yingying Shao, Yu Zhou, Li Yang, Detian Mu, Iain W Wilson, Yao Zhang, Lina Zhu, Xinghui Liu, Ling Luo, Jialong He, Deyou Qiu, Qi Tang. Genome-wide identification of GATA transcription factor family and the effect of different light quality on the accumulation of terpenoid indole alkaloids in Uncaria rhynchophylla.
Plant molecular biology.
2024 Feb; 114(1):15. doi:
10.1007/s11103-023-01400-1. [PMID: 38329633] - Kaicheng Du, Yanan Liang, Zihao Song, Changwei Zheng, Lantao Lai, Kunqi Zong, Yumeng Wang, Dali Meng. Monoterpenoid indole alkaloids from Melodinus axillaris W.T.Wang exhibit anti-inflammatory activities by inhibiting the NF-κB signaling pathways.
Journal of ethnopharmacology.
2024 Jan; 324(?):117771. doi:
10.1016/j.jep.2024.117771. [PMID: 38242218] - Sarah Szwarc, Adrien Jagora, Séverine Derbré, Karine Leblanc, Somia Rharrabti, Charifat Said-Hassane, Chaker El Kalamouni, Jean-François Gallard, Pierre Le Pogam, Mehdi A Beniddir. Combination of Machine Learning and Empirical Computation for the Structural Validation of Trirosaline, a Natural Trimeric Monoterpene Indole Alkaloid from Catharanthus roseus.
Organic letters.
2024 Jan; 26(1):274-279. doi:
10.1021/acs.orglett.3c03972. [PMID: 38134219] - Moriel J Dror, Joshua Misa, Danielle A Yee, Angela M Chu, Rachel K Yu, Bradley B Chan, Lauren S Aoyama, Anjali P Chaparala, Sarah E O'Connor, Yi Tang. Engineered biosynthesis of plant heteroyohimbine and corynantheine alkaloids in Saccharomyces cerevisiae.
Journal of industrial microbiology & biotechnology.
2024 Jan; 51(?):. doi:
10.1093/jimb/kuad047. [PMID: 38140980] - Jawad Ahmed, Yasar Sajjad, Aasia Latif, Mohammad Saeed Lodhi, Muhammad Huzafa, Chen Situ, Raza Ahmad, Muhammad Maroof Shah, Amjad Hassan. Genome-wide identification and characterization of wall-associated kinases, molecular docking and polysaccharide elicitation of monoterpenoid indole alkaloids in micro-propagated Catharanthus roseus.
Journal of plant research.
2024 Jan; 137(1):125-142. doi:
10.1007/s10265-023-01504-1. [PMID: 37962734] - Bin-Yuan Hu, Yun-Li Zhao, Ying-Jie He, Yan Qin, Xiao-Dong Luo. Undescribed indole lactones from Alstonia scholaris protecting hepatic cell damage.
Phytochemistry.
2024 Jan; 217(?):113926. doi:
10.1016/j.phytochem.2023.113926. [PMID: 37981062] - Joana G Guedes, Rogério Ribeiro, Inês Carqueijeiro, Ana Luísa Guimarães, Cláudia Bispo, John Archer, Herlander Azevedo, Nuno A Fonseca, Mariana Sottomayor. The leaf idioblastome of the medicinal plant Catharanthus roseus is associated with stress resistance and alkaloid metabolism.
Journal of experimental botany.
2024 Jan; 75(1):274-299. doi:
10.1093/jxb/erad374. [PMID: 37804484] - Sachin Kumar Verma, Danswrang Goyary, Amit Kumar Singh, Sivalingam Anandhan, Soom Nath Raina, Sadanand Pandey, Shailesh Kumar, Neeraj Khare. Modulation of terpenoid indole alkaloid pathway via elicitation with phytosynthesized silver nanoparticles for the enhancement of ajmalicine, a pharmaceutically important alkaloid.
Planta.
2023 Dec; 259(2):30. doi:
10.1007/s00425-023-04311-z. [PMID: 38150044] - Lin Wang, Siyu Chen, Xun Gao, Xiao Liang, Weichen Lv, Dongfang Zhang, Xin Jin. Recent progress in chemistry and bioactivity of monoterpenoid indole alkaloids from the genus gelsemium: a comprehensive review.
Journal of enzyme inhibition and medicinal chemistry.
2023 Dec; 38(1):2155639. doi:
10.1080/14756366.2022.2155639. [PMID: 36629436] - Deniz Etit, Ólafur Ögmundarson, Jie Zhang, Michael Krogh Jensen, Sumesh Sukumara. Early-stage economic and environmental impact assessment for optimized bioprocess development: Monoterpenoid indole alkaloids.
Bioresource technology.
2023 Nov; 391(Pt B):130005. doi:
10.1016/j.biortech.2023.130005. [PMID: 37952588] - Rahni Hossain, Abida Sultana, Manit Nuinoon, Kunwadee Noonong, Jitbanjong Tangpong, Kazi Helal Hossain, Md Atiar Rahman. A Critical Review of the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural Compounds.
Molecules (Basel, Switzerland).
2023 Oct; 28(21):. doi:
10.3390/molecules28217372. [PMID: 37959790] - Thomas Shi, Jennifer L Shea. A case of fatal overdose involving both hydromorphone and kratom.
Journal of forensic sciences.
2023 Sep; ?(?):. doi:
10.1111/1556-4029.15394. [PMID: 37753815] - Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Fei Wang, Guolin Zhang, Yinggang Luo. Hunteriasines A - D, tryptamine-derived alkaloids from Hunteria umbellata.
Phytochemistry.
2023 Sep; 213(?):113752. doi:
10.1016/j.phytochem.2023.113752. [PMID: 37330032] - Yan Qin, Ying-Jie He, Yun-Li Zhao, Zhong-Shun Zhou, Zhao-Jie Wang, Yan-Yan Zhu, Xiao-Dong Luo. Targeted quantitative analysis of monoterpenoid indole alkaloids in Alstonia scholaris by ultra-high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry.
Journal of separation science.
2023 Sep; 46(17):e2200843. doi:
10.1002/jssc.202200843. [PMID: 37349854] - Yinan Wu, Chang Liu, Anna Koganitsky, Franklin Gong, Sijin Li. Discovering Dynamic Plant Enzyme Complexes in Yeast for Kratom Alkaloid Pathway Identification.
Angewandte Chemie (International ed. in English).
2023 Aug; ?(?):e202307995. doi:
10.1002/anie.202307995. [PMID: 37549372] - Kyunghee Kim, Mohammadamin Shahsavarani, Jorge Jonathan Oswaldo Garza-García, Jack Edward Carlisle, Jun Guo, Vincenzo De Luca, Yang Qu. Biosynthesis of kratom opioids.
The New phytologist.
2023 Jul; ?(?):. doi:
10.1111/nph.19162. [PMID: 37518950] - Guido Huisman, Maximilian Menke, Oliver Grundmann, Rudy Schreiber, Natasha Mason. Examining the Psychoactive Differences between Kratom Strains.
International journal of environmental research and public health.
2023 07; 20(14):. doi:
10.3390/ijerph20146425. [PMID: 37510657] - M E González-Trujano, N Páez-Martínez, F Krengel, D Martínez-Vargas, M León-Santiago, B Cruz-López, J M Puentes-Guerrero, J K Díaz-Cantón, R Reyes-Chilpa, S L Guzmán-Gutiérrez. Central nervous system activity of a Tabernaemontana arborea alkaloid extract involves serotonergic and opioidergic neurotransmission in murine models.
Fitoterapia.
2023 Jul; ?(?):105602. doi:
10.1016/j.fitote.2023.105602. [PMID: 37423501] - Zhi-Wen Liu, Min Song, Jun-Ya Wang, De-Zhi Wang, Biao Sun, Lei Shi, Ren-Wang Jiang, Min Ma, Xiao-Qi Zhang. Monoterpenoid indole alkaloid adducts and dimers from Melodinus fusiformis.
Phytochemistry.
2023 Jul; 211(?):113678. doi:
10.1016/j.phytochem.2023.113678. [PMID: 37059289] - Daniel J Farkas, Saadet Inan, Laila N Heydari, Clare T Johnson, Pingwei Zhao, Heather B Bradshaw, Sara Jane Ward, Scott M Rawls. Cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid mitragynine against neuropathic, but not inflammatory pain.
Life sciences.
2023 Jun; 328(?):121878. doi:
10.1016/j.lfs.2023.121878. [PMID: 37392779] - Oliver Grundmann, Katherine Hill, Everest Al Barzanji, Nilofar Ghulam Hazrat, Gurnoor Kaur, Ryan Einstein Negeve, Soren Shade, Sam Weber, Charles A Veltri. Correlations of kratom (Mitragyna speciosa Korth.) tea bag preparations and reported pharmacological effects.
Journal of ethnopharmacology.
2023 Jun; 317(?):116779. doi:
10.1016/j.jep.2023.116779. [PMID: 37364801] - Wu Hao, Qin Ma-Long, Fan Kun, Gao Wen, Guo Rui-Rong, Yin Shan-Ze, Hu Wei-Yan, Zhang Lan-Chun, Zhang Rong-Ping, Yu Hao-Fei, Li Yu-Peng, Ding Cai-Feng. Two new antimicrobial monoterpenoid indole alkaloids from the roots of Rauvolfia yunnanensis.
Journal of Asian natural products research.
2023 May; 25(5):429-437. doi:
10.1080/10286020.2022.2104258. [PMID: 35930443] - Hossam S El-Beltagi, Salwa M El-Sayed, Ahmed N Abdelhamid, Karim M Hassan, Walaa A Elshalakany, Mona Ibrahim Nossier, Nadiyah M Alabdallah, Nadi Awad Al-Harbi, Salem Mesfir Al-Qahtani, Doaa Bahaa Eldin Darwish, Zahid Khorshid Abbas, Hemmat A Ibrahim. Potentiating Biosynthesis of Alkaloids and Polyphenolic Substances in Catharanthus roseus Plant Using ĸ-Carrageenan.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083642. [PMID: 37110876] - Katherine Hill, Stephen Gibson, Oliver Grundmann, Kirsten E Smith, Jonathan Ballard, Corneliu N Stanciu. Evaluating health information provided to kratom consumers by good manufacturing practice-qualified vendors.
Substance abuse treatment, prevention, and policy.
2023 04; 18(1):21. doi:
10.1186/s13011-023-00531-4. [PMID: 37041624] - Chen Chen, Xiao Ding, Lingling Han, Wentao Zhu, Kepu Huang, Xiaojiang Hao, Yu Zhang. Two new monoterpenoid indole alkaloids from the kernels of Kopsia arborea.
Natural product research.
2023 Apr; 37(7):1047-1052. doi:
10.1080/14786419.2021.1984911. [PMID: 34583594] - Rana Khudhair Jasim, Darshan Singh, Lay-Harn Gam. Development and validation of ELISA for screening of Kratom (Mitragyna speciosa) habitual users using urinary AZ122 biomarker.
Biotechnology and applied biochemistry.
2023 Apr; 70(2):707-715. doi:
10.1002/bab.2392. [PMID: 35931067] - Larissa C Laforest, Michelle A Kuntz, Siva Rama Raju Kanumuri, Sushobhan Mukhopadhyay, Abhisheak Sharma, Sarah E O'Connor, Christopher R McCurdy, Satya Swathi Nadakuduti. Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition.
Journal of natural products.
2023 Mar; ?(?):. doi:
10.1021/acs.jnatprod.3c00092. [PMID: 36913648] - Da Song, Jia-Jun Liang, Shi-Biao Pu, Pan-Pan Zhang, Yun-Lin Peng, Xia Liu, Ting-Ting Feng, Xiang Pu, Ying Zhou, Xiong-Wei Liu, Xin Wei. Structural Elucidation and Cytotoxic Activity of New Monoterpenoid Indoles from Gelsemium elegans.
Molecules (Basel, Switzerland).
2023 Mar; 28(6):. doi:
10.3390/molecules28062531. [PMID: 36985503] - Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T Dang, Larissa C Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R McCurdy, Sarah E O'Connor. Directed Biosynthesis of Mitragynine Stereoisomers.
Journal of the American Chemical Society.
2023 Mar; 145(9):4957-4963. doi:
10.1021/jacs.2c13644. [PMID: 36883326] - Manish L Raorane, Christina Manz, Sarah Hildebrandt, Marion Mielke, Marc Thieme, Judith Keller, Mirko Bunzel, Peter Nick. Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus.
Protoplasma.
2023 Mar; 260(2):349-369. doi:
10.1007/s00709-022-01781-y. [PMID: 35697946] - Marcus Daniel Brandbjerg Bohn Lorensen, Nanna Bjarnholt, Benoit St-Pierre, Vincent Courdavault, Sarah Heinicke, Sarah O'Connor, Christian Janfelt. Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging.
Phytochemistry.
2023 Feb; ?(?):113620. doi:
10.1016/j.phytochem.2023.113620. [PMID: 36863602] - Yuanjian Yang, Liuyu Ding, Ying Zhou, Zizheng Guo, Rongmin Yu, Jianhua Zhu. Establishment of recombinant Catharanthus roseus stem cells stably overexpressing ORCA4 for terpenoid indole alkaloids biosynthesis.
Plant physiology and biochemistry : PPB.
2023 Feb; 196(?):783-792. doi:
10.1016/j.plaphy.2023.02.039. [PMID: 36848864] - Anders Helander, Alexia Rylski. Drug testing for mitragynine and kratom: Analytical challenges and medico-legal considerations.
Drug testing and analysis.
2023 Feb; 15(2):213-219. doi:
10.1002/dta.3391. [PMID: 36258649] - Purin Candra Purnama, Leonardo Castellanos Hernandez, Robert Verpoorte. Do Fungicides Affect Alkaloid Production in Catharanthus roseus (L.) G. Don. Seedlings?.
Molecules (Basel, Switzerland).
2023 Feb; 28(3):. doi:
10.3390/molecules28031405. [PMID: 36771067] - Kirsten Elin Smith, Abhisheak Sharma, Oliver Grundmann, Christopher R McCurdy. Kratom Alkaloids: A Blueprint?.
ACS chemical neuroscience.
2023 01; 14(2):195-197. doi:
10.1021/acschemneuro.2c00704. [PMID: 36594896] - Sheng Li, Ling-Ling Han, Ke-Pu Huang, Ye-Han Ma, Ling-Li Guo, Yarong Guo, Xiaoqian Ran, Yong-Gang Yao, Xiao-Jiang Hao, Rongcan Luo, Yu Zhang. New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217).
International journal of molecular sciences.
2023 Jan; 24(2):. doi:
10.3390/ijms24021487. [PMID: 36675001] - ". Dissecting the spatial distribution of specialized metabolism at single-cell resolution.
Nature plants.
2023 01; 9(1):11-12. doi:
10.1038/s41477-022-01292-x. [PMID: 36539598] - Rubashiny Veeramohan, Arief Izzairy Zamani, Kamalrul Azlan Azizan, Hoe-Han Goh, Wan Mohd Aizat, Mohd Fauzi Abd Razak, Nur Sabrina Mohd Yusof, Sharif Mahsufi Mansor, Syarul Nataqain Baharum, Chyan Leong Ng. Comparative metabolomics analysis reveals alkaloid repertoires in young and mature Mitragyna speciosa (Korth.) Havil. Leaves.
PloS one.
2023; 18(3):e0283147. doi:
10.1371/journal.pone.0283147. [PMID: 36943850] - Qi Chen, Yan Jin, Xiaorui Guo, Mingyuan Xu, Guanyun Wei, Xueyan Lu, Zhonghua Tang. Metabolomic responses to the mechanical wounding of Catharanthus roseus' upper leaves.
PeerJ.
2023; 11(?):e14539. doi:
10.7717/peerj.14539. [PMID: 36968002] - Sijie Sun, Xiaofeng Shen, Yi Li, Ying Li, Shu Wang, Rucan Li, Huibo Zhang, Guoan Shen, Baolin Guo, Jianhe Wei, Jiang Xu, Benoit St-Pierre, Shilin Chen, Chao Sun. Single-cell RNA sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism.
Nature plants.
2023 01; 9(1):179-190. doi:
10.1038/s41477-022-01291-y. [PMID: 36522449] - Rima Atria Japarin, Norsyifa Harun, Zurina Hassan, Mohammed Shoaib. Mitragynine, a primary constituent of kratom reinstates morphine-seeking behaviour in rats.
Behavioural pharmacology.
2022 Dec; ?(?):. doi:
10.1097/fbp.0000000000000715. [PMID: 36752325] - Jack E Henningfield, Joseph V Rodricks, Aaron M Magnuson, Marilyn A Huestis. Respiratory effects of oral mitragynine and oxycodone in a rodent model.
Psychopharmacology.
2022 Dec; 239(12):3793-3804. doi:
10.1007/s00213-022-06244-z. [PMID: 36308562] - Fanfan Li, Stephen Bordeleau, Kyung Hee Kim, Jonathan Turcotte, Benjamin Davis, Lan Liu, Stéphane Bayen, Vincenzo De Luca, Mehran Dastmalchi. A lesion-mimic mutant of Catharanthus roseus accumulates the opioid agonist, akuammicine.
Phytochemistry.
2022 Nov; 203(?):113422. doi:
10.1016/j.phytochem.2022.113422. [PMID: 36055422] - Chen Chen, Jian-Wen Liu, Ling-Li Guo, Feng Xiong, Xiao-Qian Ran, Ya-Rong Guo, Yong-Gang Yao, Xiao-Jiang Hao, Rong-Can Luo, Yu Zhang. Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylation.
Phytochemistry.
2022 Nov; 203(?):113392. doi:
10.1016/j.phytochem.2022.113392. [PMID: 36030903] - M Ahmadzadeh, A H Keshtkar, K Moslemkhany, M Ahmadzadeh. Effect of the plant probiotic bacteria on terpenoid indole alkaloid biosynthesis pathway gene expression profiling, vinblastine and vincristine content in the root of Catharanthus roseus.
Molecular biology reports.
2022 Nov; 49(11):10357-10365. doi:
10.1007/s11033-022-07841-z. [PMID: 36097118] - Xiao-Ying Cai, Na Li, Yong Li, Rui-Jia Zhang, Ping Lin, Ling Liu, Hao-Yu Ye, Wen-Shuang Wu, Min Zhao. An epigenetic modifier enhances the generation of anti-phytopathogenic compounds from the endophytic fungus Chaetomium globosporum of Euphorbia humifusa.
Phytochemistry.
2022 Nov; 203(?):113426. doi:
10.1016/j.phytochem.2022.113426. [PMID: 36084856] - Narges Soltani, Farhad Nazarian Firouzabadi, Alireza Shafeinia, Masoud Shirali, Ayeh Sadat Sadr. De Novo transcriptome assembly and differential expression analysis of catharanthus roseus in response to salicylic acid.
Scientific reports.
2022 10; 12(1):17803. doi:
10.1038/s41598-022-20314-4. [PMID: 36280677] - Yu-Jie Li, Juan Li, Lan Xie, Jun-Yu Zhou, Qiu-Xuan Li, Rui-Yuan Yang, Yan-Ping Liu, Yan-Hui Fu. Monoterpenoid indole alkaloids with potential neuroprotective activities from the stems and leaves of Melodinus cochinchinensis.
Natural product research.
2022 Oct; 36(20):5181-5188. doi:
10.1080/14786419.2021.1922406. [PMID: 33960216] - Lan Zhou, Pian-Chou Gongpan, Qing-Fei Fan, Zhi Na, Feng-Mei Huang, Kai-Long Ji, Qi-Shi Song. Two new monoterpenoid indole alkaloids from Mappianthus iodoides stems.
Natural product research.
2022 Oct; 36(20):5235-5240. doi:
10.1080/14786419.2021.1928119. [PMID: 34018432] - Dylan Levac, Paulo Cázares Flores, Vincenzo De Luca. Molecular and biochemical characterization of Catharanthus roseus perivine-Nβ-methyltransferase.
Phytochemistry.
2022 Sep; 201(?):113266. doi:
10.1016/j.phytochem.2022.113266. [PMID: 35671807] - Qin Yan, Jianfeng Jiang, Jingbo Xie, Shengbo Jiang, Yunting Bai. Inhibition of osteosarcoma cell proliferation in vitro and tumor growth in vivo in mice model by alstonine through AMPK-activation and PGC-1α/TFAM up-regulation.
Acta biochimica Polonica.
2022 Aug; 69(3):543-549. doi:
10.18388/abp.2020_5769. [PMID: 35975969] - Radhiahtul Raehan Mustafa, Rashidah Sukor, Siti Mariam Mohd Nor, Nazamid Saari. Methyl ester and aromatic ether modification of mitragynine for generation of mitragynine-specific polyclonal antibodies.
Journal of immunological methods.
2022 Aug; 507(?):113291. doi:
10.1016/j.jim.2022.113291. [PMID: 35640723] - Preston K Manwill, Laura Flores-Bocanegra, Manead Khin, Huzefa A Raja, Nadja B Cech, Nicholas H Oberlies, Daniel A Todd. Kratom (Mitragyna speciosa) Validation: Quantitative Analysis of Indole and Oxindole Alkaloids Reveals Chemotypes of Plants and Products.
Planta medica.
2022 Aug; 88(9-10):838-857. doi:
10.1055/a-1795-5876. [PMID: 35468648] - Abhijit Dey, Debleena Roy, Vikas Moreshwar Mohture, Mimosa Ghorai, Md Habibur Rahman, Uttpal Anand, Saikat Dewanjee, Radha, Manoj Kumar, Dorairaj Arvind Prasanth, Niraj Kumar Jha, Saurabh Kumar Jha, Mahipal S Shekhawat, Devendra Kumar Pandey. Biotechnological interventions and indole alkaloid production in Rauvolfia serpentina.
Applied microbiology and biotechnology.
2022 Aug; 106(13-16):4867-4883. doi:
10.1007/s00253-022-12040-8. [PMID: 35819514] - Yee Shan Sim, Zan Yang Chong, Juzaili Azizi, Choon Fu Goh. Development and validation of a gradient HPLC-UV method for mitragynine following in vitro skin permeation studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Jul; 1204(?):123316. doi:
10.1016/j.jchromb.2022.123316. [PMID: 35700649] - Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hájíček, Vincenzo De Luca, Yang Qu. A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis.
Nature communications.
2022 06; 13(1):3335. doi:
10.1038/s41467-022-31100-1. [PMID: 35680936] - George S Behonick, Christina Vu, Larry Czarnecki, Maisie El-Ters, Kevin G Shanks. Two Single-Drug Fatal Intoxications by Mitragynine.
Journal of analytical toxicology.
2022 May; 46(5):e110-e114. doi:
10.1093/jat/bkac016. [PMID: 35285475] - Tengfei Liu, Yuanwei Gou, Bei Zhang, Rui Gao, Chang Dong, Mingming Qi, Lihong Jiang, Xuanwei Ding, Chun Li, Jiazhang Lian. Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast.
Biotechnology and bioengineering.
2022 05; 119(5):1314-1326. doi:
10.1002/bit.28040. [PMID: 35060115] - Vyoma Mistry, Siddhi Darji, Pragya Tiwari, Abhishek Sharma. Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast.
Applied microbiology and biotechnology.
2022 Apr; 106(7):2337-2347. doi:
10.1007/s00253-022-11883-5. [PMID: 35333954] - Rana Khudhair Jasim, Zurina Hassan, Darshan Singh, Edward Boyer, Lay-Harn Gam. Characterization of urinary protein profile in regular kratom (Mitragyna speciosa korth.) users in Malaysia.
Journal of addictive diseases.
2022 Apr; 40(2):235-246. doi:
10.1080/10550887.2021.1981122. [PMID: 34747343] - Bianka Várnai, Ferenc Zsila, Zoltán Szakács, Zsófia Garádi, Milo Malanga, Szabolcs Béni. Sulfobutylation of Beta-Cyclodextrin Enhances the Complex Formation with Mitragynine: An NMR and Chiroptical Study.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073844. [PMID: 35409208] - Norsyifa Harun, Nur Azzalia Kamaruzaman, Zarif Mohamed Sofian, Zurina Hassan. Mini review: Potential therapeutic values of mitragynine as an opioid substitution therapy.
Neuroscience letters.
2022 03; 773(?):136500. doi:
10.1016/j.neulet.2022.136500. [PMID: 35114335] - Natasha Tobarran, Carl Wolf, Kirk L Cumpston, Brandon K Wills. Pressure Necrosis Requiring Fasciotomy After Kratom Overdose.
Journal of addiction medicine.
2022 Mar; 16(2):252-253. doi:
10.1097/adm.0000000000000873. [PMID: 34001773] - Kun Fan, Lan-Chun Zhang, Wei-Yan Hu, Shi-Yu Deng, Hao Wu, Bang-Yin Tan, Rong-Ping Zhang, Cai-Feng Ding, Hao-Fei Yu. Tabernaecorymine A, an 18-normonoterpenoid indole alkaloid with antibacterial activity from Tabernaemontana corymbosa.
Fitoterapia.
2022 Mar; 157(?):105129. doi:
10.1016/j.fitote.2022.105129. [PMID: 35051555] - Xiao-Feng Wang, Ren-Jie Wei, Qiang-Qiang Fang, Wan-Ying He, Kun Jiang, Shi-Jin Qu, Jun-Jie Tan, Chang-Heng Tan. Monoterpene indole alkaloids from Melodinus cochinchinensis (Lour.) Merr.
Fitoterapia.
2022 Mar; 157(?):105118. doi:
10.1016/j.fitote.2021.105118. [PMID: 34974140] - Qiong Jin, Yun-Li Zhao, Ya-Ping Liu, Ruo-Song Zhang, Pei-Feng Zhu, Lan-Qin Zhao, Xu-Jie Qin, Xiao-Dong Luo. Anti-inflammatory and analgesic monoterpenoid indole alkaloids of Kopsia officinalis.
Journal of ethnopharmacology.
2022 Mar; 285(?):114848. doi:
10.1016/j.jep.2021.114848. [PMID: 34798159] - Kai Yue, Jonathan L Katz, Xiji Shu. Physiological dependence to mitragynine indicated by a rapid cross-dependence procedure with heroin-dependent mice.
Psychopharmacology.
2022 Mar; 239(3):897-908. doi:
10.1007/s00213-022-06080-1. [PMID: 35107609] - Xiaolan Zhao, Xiaodi Hu, Kunxi OuYang, Jing Yang, Qingmin Que, Jianmei Long, Jianxia Zhang, Tong Zhang, Xue Wang, Jiayu Gao, Xinquan Hu, Shuqi Yang, Lisu Zhang, Shufen Li, Wujun Gao, Benping Li, Wenkai Jiang, Erik Nielsen, Xiaoyang Chen, Changcao Peng. Chromosome-level assembly of the Neolamarckia cadamba genome provides insights into the evolution of cadambine biosynthesis.
The Plant journal : for cell and molecular biology.
2022 02; 109(4):891-908. doi:
10.1111/tpj.15600. [PMID: 34807496] - Chayapol Tungphatthong, Thatree Phadungcharoen, Thongchai Sooksawate, Suchada Sukrong. PCR combined with lateral flow immunochromatographic assay to differentiate the narcotic Mitragyna speciosa from related species and detect it in forensic evidence.
Forensic science international.
2022 Feb; 331(?):111149. doi:
10.1016/j.forsciint.2021.111149. [PMID: 34933184] - Nurul H M Yusoff, Zurina Hassan, Vikneswaran Murugaiyah, Christian P Müller. The effect of mitragynine on extracellular activity of brain dopamine and its metabolites.
Brain research bulletin.
2022 01; 178(?):1-8. doi:
10.1016/j.brainresbull.2021.11.002. [PMID: 34774992] - Elisabeth Prevete, Kim Paula Colette Kuypers, Eef Lien Theunissen, Ornella Corazza, Giuseppe Bersani, Johannes Gerardus Ramaekers. A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans.
Human psychopharmacology.
2022 01; 37(1):e2805. doi:
10.1002/hup.2805. [PMID: 34309900] - Mengzi Zhang, Abhisheak Sharma, Francisco León, Bonnie Avery, Roger Kjelgren, Christopher R McCurdy, Brian J Pearson. Plant growth and phytoactive alkaloid synthesis in kratom [Mitragyna speciosa (Korth.)] in response to varying radiance.
PloS one.
2022; 17(4):e0259326. doi:
10.1371/journal.pone.0259326. [PMID: 35472200] - Mohammadamin Shahsavarani, Maisha Farzana, Vincenzo De Luca, Yang Qu. Generating an EMS Mutant Population and Rapid Mutant Screening by Thin-Layer Chromatography Enables the Studies of Monoterpenoid Indole Alkaloids Biosynthesis in Catharanthus Roseus.
Methods in molecular biology (Clifton, N.J.).
2022; 2505(?):181-190. doi:
10.1007/978-1-0716-2349-7_13. [PMID: 35732945] - Sanjay K Singh, Barunava Patra, Joshua J Singleton, Yongliang Liu, Priyanka Paul, Xueyi Sui, Nitima Suttipanta, Sitakanta Pattanaik, Ling Yuan. Identification and Characterization of Transcription Factors Regulating Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus.
Methods in molecular biology (Clifton, N.J.).
2022; 2505(?):203-221. doi:
10.1007/978-1-0716-2349-7_15. [PMID: 35732947] - Samuel Mortensen, Lauren F Cole, Diana Bernal-Franco, Suphinya Sathitloetsakun, Erin J Cram, Carolyn W T Lee-Parsons. EASI Transformation Protocol: An Agrobacterium-Mediated Transient Transformation Protocol for Catharanthus roseus Seedlings.
Methods in molecular biology (Clifton, N.J.).
2022; 2505(?):249-262. doi:
10.1007/978-1-0716-2349-7_18. [PMID: 35732950] - Barunava Patra, Yongliang Liu, Joshua J Singleton, Sanjay Kumar Singh, Sitakanta Pattanaik, Ling Yuan. Virus-Induced Gene Silencing as a Tool to Study Regulation of Alkaloid Biosynthesis in Medicinal Plants.
Methods in molecular biology (Clifton, N.J.).
2022; 2469(?):155-164. doi:
10.1007/978-1-0716-2185-1_13. [PMID: 35508837] - Xin Wei, Rui Guo, Xiao Wang, Jia-Jun Liang, Hao-Fei Yu, Cai-Feng Ding, Ting-Ting Feng, Li-Yan Zhang, Xia Liu, Xin-Yue Hu, Ying Zhou. New Monoterpenoid Indoles with Osteoclast Activities from Gelsemium elegans.
Molecules (Basel, Switzerland).
2021 Dec; 26(24):. doi:
10.3390/molecules26247457. [PMID: 34946539] - Sheng-Yuan Zhang, Zi-Wei Li, Jie Xu, Qiu-Ling Chen, Min Song, Qing-Wen Zhang. Discovery of Three New Monoterpenoid Indole Alkaloids from the Leaves of Gardneria multiflora and Their Vasorelaxant and AChE Inhibitory Activities.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237191. [PMID: 34885772] - Soumen Chakraborty, Rajendra Uprety, Samuel T Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L Wilson, Brittany Scouller, Amy F Alder, Andrew C Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O Eans, Amanda Hunkele, Abdullah Allaoa, Sanjay Kalra, Jin Xu, Ying Xian Pan, John Pintar, Bronwyn M Kivell, Gavril W Pasternak, Michael D Cameron, Jay P McLaughlin, Dalibor Sames, Susruta Majumdar. Oxidative Metabolism as a Modulator of Kratom's Biological Actions.
Journal of medicinal chemistry.
2021 11; 64(22):16553-16572. doi:
10.1021/acs.jmedchem.1c01111. [PMID: 34783240] - Yongliang Liu, Barunava Patra, Sanjay Kumar Singh, Priyanka Paul, Yan Zhou, Yongqing Li, Ying Wang, Sitakanta Pattanaik, Ling Yuan. Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering.
Biotechnology letters.
2021 Nov; 43(11):2085-2103. doi:
10.1007/s10529-021-03179-x. [PMID: 34564757] - Illa S Johari, Norsyifa Harun, Zarif M Sofian, Mohammed Shoaib. Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats.
Psychopharmacology.
2021 Nov; 238(11):3183-3191. doi:
10.1007/s00213-021-05934-4. [PMID: 34333672] - Kotaro Yamamoto, Dagny Grzech, Konstantinos Koudounas, Emily Amor Stander, Lorenzo Caputi, Tetsuro Mimura, Vincent Courdavault, Sarah E O'Connor. Improved virus-induced gene silencing allows discovery of a serpentine synthase gene in Catharanthus roseus.
Plant physiology.
2021 10; 187(2):846-857. doi:
10.1093/plphys/kiab285. [PMID: 34608956] - Soumen Chakraborty, Jeffrey F DiBerto, Abdelfattah Faouzi, Sarah M Bernhard, Anna M Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N F Nelson, Wesley B Asher, Shainnel O Eans, Lisa L Wilson, Satyanarayana M Chintala, Marta Filizola, Richard M van Rijn, Elyssa B Margolis, Bryan L Roth, Jay P McLaughlin, Tao Che, Dalibor Sames, Jonathan A Javitch, Susruta Majumdar. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
Journal of medicinal chemistry.
2021 09; 64(18):13873-13892. doi:
10.1021/acs.jmedchem.1c01273. [PMID: 34505767] - Jie Zhou, Si-Yu Du, Zhong-Ying Fang, Jin-Hong Feng. Melognine, a novel monoterpenoid indole alkaloid from Melodinus fusiformis that induce apoptosis in BT549 cells.
Natural product research.
2021 Sep; 35(18):3004-3010. doi:
10.1080/14786419.2019.1682579. [PMID: 31674840] - Veronika Konečná, Sian Bray, Jakub Vlček, Magdalena Bohutínská, Doubravka Požárová, Rimjhim Roy Choudhury, Anita Bollmann-Giolai, Paulina Flis, David E Salt, Christian Parisod, Levi Yant, Filip Kolář. Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles.
Nature communications.
2021 08; 12(1):4979. doi:
10.1038/s41467-021-25256-5. [PMID: 34404804] - Sarah E Voelker, Sara E Kern, Travis M Falconer, Michael D Thatcher, David M Skelton, Kirk W Gaston, Adam C Lanzarotta, Lisa M Lorenz, JaCinta S Batson, Jonathan J Litzau. Evaluation of four field portable devices for the rapid detection of mitragynine in suspected kratom products.
Journal of pharmaceutical and biomedical analysis.
2021 Jul; 201(?):114104. doi:
10.1016/j.jpba.2021.114104. [PMID: 33964724] - Rahimah Hassan, Nurulhasanah Othman, Sharif M Mansor, Christian P Müller, Zurina Hassan. Proteomic analysis reveals brain Rab35 as a potential biomarker of mitragynine withdrawal in rats.
Brain research bulletin.
2021 07; 172(?):139-150. doi:
10.1016/j.brainresbull.2021.04.018. [PMID: 33901587] - Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C Kruegel, John E Pintar, Susruta Majumdar, Jonathan A Javitch, Dalibor Sames. Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy.
Nature communications.
2021 06; 12(1):3858. doi:
10.1038/s41467-021-23736-2. [PMID: 34158473]