Dexamethasone Sodium Phosphate (BioDeep_00000015033)
代谢物信息卡片
Dexamethasone 21-phosphate disodium salt
化学式: C22H28FNa2O8P (516.1301)
中文名称: 地塞米松磷酸钠
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
InChI: /q
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:4462
- KEGG: C08175
- KEGGdrug: D00975
- PubChem: 16961
- Metlin: METLIN66841
- ChEMBL: CHEMBL2021430
- CAS: 55203-24-2
- CAS: 2392-39-4
- PubChem: 10375
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Dayle McClintock, Michaela Austel, Robert M Gogal, Frane Banovic. Oral dexamethasone sodium phosphate solution significantly reduces pruritus and clinical lesions in feline hypersensitivity dermatitis: an open-label study.
Veterinary dermatology.
2021 Oct; 32(5):497-e137. doi:
10.1111/vde.13006. [PMID: 34351657] - Selena de Wasseige, Khristine Picotte, Jean-Pierre Lavoie. Nebulized dexamethasone sodium phosphate in the treatment of horses with severe asthma.
Journal of veterinary internal medicine.
2021 May; 35(3):1604-1611. doi:
10.1111/jvim.16113. [PMID: 33817859] - Sanjukta Duarah, Manisha Sharma, Jingyuan Wen. Rapid and simultaneous determination of dexamethasone and dexamethasone sodium phosphate using HPLC-UV: Application in microneedle-assisted skin permeation and deposition studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Apr; 1170(?):122609. doi:
10.1016/j.jchromb.2021.122609. [PMID: 33713946] - Li-Juan Zhao, Ben-Sheng Dong, Hui Zhang, Dao-Fang Ding, Hua-Zong Guan, Ya-Fang Li, Guo-Hui Zhang, Shu-Yu Zhang, Kun Niu, Hong Zhang. Intermittent pressure imitating rolling manipulation ameliorates injury in skeletal muscle cells through oxidative stress and lipid metabolism signalling pathways.
Gene.
2021 Apr; 778(?):145460. doi:
10.1016/j.gene.2021.145460. [PMID: 33515727] - Dhananjay Jadhav, Pradeep Vavia. Dexamethasone Sodium Phosphate Loaded Modified Cyclodextrin Based Nanoparticles: An Efficient Treatment for Rheumatoid Arthritis.
Journal of pharmaceutical sciences.
2021 03; 110(3):1206-1218. doi:
10.1016/j.xphs.2020.10.023. [PMID: 33075379] - Heather K Knych, Daniel Weiner, Rick M Arthur, Russell Baden, Daniel S McKemie, Philip H Kass. Serum concentrations, pharmacokinetic/pharmacodynamic modeling, and effects of dexamethasone on inflammatory mediators following intravenous and oral administration to exercised horses.
Drug testing and analysis.
2020 Aug; 12(8):1087-1101. doi:
10.1002/dta.2862. [PMID: 32436346] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
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2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - S Mainguy-Seers, A Bessonnat, K Picotte, J-P Lavoie. Nebulisation of dexamethasone sodium phosphate for the treatment of severe asthmatic horses.
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2019 Sep; 51(5):641-645. doi:
10.1111/evj.13091. [PMID: 30849189] - Augusto F Schmidt, Matthew W Kemp, Mark Milad, Lisa A Miller, James P Bridges, Michael W Clarke, Paranthaman S Kannan, Alan H Jobe. Oral dosing for antenatal corticosteroids in the Rhesus macaque.
PloS one.
2019; 14(9):e0222817. doi:
10.1371/journal.pone.0222817. [PMID: 31536601] - Kongnara Papangkorn, John W Higuchi, Balbir Brar, William I Higuchi. Ocular Drug Distribution and Safety of a Noninvasive Ocular Drug Delivery System of Dexamethasone Sodium Phosphate in Rabbit.
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1989 Jan; 22(1):67-73. doi:
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1987 Dec; 48(12):1719-24. doi:
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1987 Jun; 91(6):850-4. doi:
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1987 May; 8(3):205-12. doi:
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The American journal of pathology.
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1981; 20(4):277-82. doi:
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