Trimethobenzamide hydrochloride (BioDeep_00000015029)

   


代谢物信息卡片


N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide;hydrochloride

  化学式: C21H29ClN2O5 (424.1765)
中文名称: 盐酸三甲苯甲酰胺
  谱图信息: 最多检出来源 not specific(not specific) %

分子结构信息

SMILES: CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C(=C2)OC)OC)OC.Cl
InChI: InChI=1S/C21H28N2O5.ClH/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4


描述信息

D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

同义名列表

55 个代谢物同义名

Trimethobenzamide hydrochloride; WLN: 1OR BO1 CO1 EVM1R DO2N1&1 &GH; Ro 2-9578; Trimethobenzamide (hydrochloride); 4-(2-Dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine hydrochloride; 4-[(2-Dimethylamino)ethoxy]-N-(3,5-trimethoxybenzoyl)benzylamine hydrochloride; Ametik hydrochloride; Anaus; Benzamide, N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxy-, monohydrochloride; Benzamide, N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-, hydrochloride; Benzamide, N-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-, monohydrochloride; Benzamide,4,5-trimethoxy-, hydrochloride; Benzamide,4,5-trimethoxy-, monohydrochloride; Benzamide,N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-,monohydrochloride; Ibikin; N-({4-[2-(dimethylamino)ethoxy]phenyl}methyl)-3,4,5-trimethoxybenzamide hydrochloride; N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide hydrochloride; N-(p-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide hydrochloride; N-(p-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide monohydrochloride; N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide Monohydrochloride; N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide;hydrochloride; N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide Hydrochloride; N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,5-trimethoxybenzamide hydrochloride; N-{[4-(2-dimethylaminoethoxy)phenyl]methyl}-3,4,5-trimethoxy-benzamide hydrochloride; Nauseton; Poligerim; T-Gen; Tebamide; Ticon; Tigan; TIGAN(R) (TRIMETHOBENZAMIDE HYDROCHLORIDE); Tox21_110465; Tox21_110465_1; Tribenzagan Hydrochloride; trimethobenzamide; Trimethobenzamide (hydrochloride) (Standard); Trimethobenzamide HCL; TRIMETHOBENZAMIDE HYDROCHLORIDE (MART.); TRIMETHOBENZAMIDE HYDROCHLORIDE (USP MONOGRAPH); TRIMETHOBENZAMIDE HYDROCHLORIDE (USP-RS); Trimethobenzamide hydrochloride (USP); TRIMETHOBENZAMIDE HYDROCHLORIDE [MART.]; TRIMETHOBENZAMIDE HYDROCHLORIDE [MI]; TRIMETHOBENZAMIDE HYDROCHLORIDE [ORANGE BOOK]; TRIMETHOBENZAMIDE HYDROCHLORIDE [USP MONOGRAPH]; TRIMETHOBENZAMIDE HYDROCHLORIDE [USP-RS]; Trimethobenzamide hydrochloride [USP]; TRIMETHOBENZAMIDE HYDROCHLORIDE [VANDF]; TRIMETHOBENZAMIDE HYDROCHLORIDE [WHO-DD]; Trimethobenzamide Hydrochloride Preservative Free; trimethobenzamide monohydrochloride; TrimethobenzamideHCL; UNII-WDQ5P1SX7Q; WDQ5P1SX7Q; WIIZEEPFHXAUND-UHFFFAOYSA-N



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Z Fazliogullari, A K Karabulut, I I Uysal, N Unver Dogan, H Acar. Investigation of developmental toxicity and teratogenicity of antiemetics on rat embryos cultured in vitro. Anatomia, histologia, embryologia. 2013 Aug; 42(4):239-46. doi: 10.1111/ahe.12007. [PMID: 23002952]
  • R Pohjanvirta, M Unkila, J Tuomisto. TCDD-induced hypophagia is not explained by nausea. Pharmacology, biochemistry, and behavior. 1994 Feb; 47(2):273-82. doi: 10.1016/0091-3057(94)90010-8. [PMID: 8146218]
  • R Jones, K Klette, J J Kuhlman, B Levine, M L Smith, C V Watson, C M Selavka. Trimethobenzamide cross-reacts in immunoassays of amphetamine/methamphetamine. Clinical chemistry. 1993 Apr; 39(4):699-700. doi: . [PMID: 8472376]
  • T A Robert, E A Daigneault, P Hinton, A N Hagardorn. The relationship between serum and saliva trimethobenzamide concentrations in man. Journal of clinical pharmacology. 1982 Jan; 22(1):53-8. doi: 10.1002/j.1552-4604.1982.tb05708.x. [PMID: 7061726]