Quinapril hydrochloride (BioDeep_00000015023)
natural product Volatile Flavor Compounds
代谢物信息卡片
化学式: C25H31ClN2O5 (474.1921386)
中文名称: 盐酸喹那普利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=CC(=C1)CC[C@H](N[C@H](C(N2[C@@H](CC3=C(C2)C=CC=C3)C(O)=O)=O)C)C(OCC)=O).Cl
InChI: /m0./s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:8714
- KEGG: C07340
- KEGGdrug: D00459
- PubChem: 54891
- ChEMBL: CHEMBL1201011
- MeSH: Quinapril
- CAS: 82586-55-8
- MoNA: CCMSLIB00000078518
- PubChem: 9547
- NIKKAJI: J400.159A
- KNApSAcK: 8714
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Majid Jaberi-Douraki, Emma Meyer, Jim Riviere, Nuwan Indika Millagaha Gedara, Jessica Kawakami, Gerald J Wyckoff, Xuan Xu. Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity.
Scientific reports.
2021 06; 11(1):13349. doi:
10.1038/s41598-021-92734-7
. [PMID: 34172790] - A Gromotowicz-Poplawska, A Stankiewicz, J Mikita, M Aleksiejczuk, N Marcinczyk, J Szemraj, E Chabielska. Beneficial effect of combined spironolactone and quinapril treatment on thrombosis and hemostasis in 2K1C hypertensive rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2018 Apr; 69(2):. doi:
10.26402/jpp.2018.2.10
. [PMID: 29980144] - Shuangjiao Sun, Yanfen Wei, Hao Wang, Yupin Cao, Biyang Deng. A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma.
Talanta.
2018 Mar; 179(?):213-220. doi:
10.1016/j.talanta.2017.10.050
. [PMID: 29310224] - Jie-Hua Shi, Dong-Qi Pan, Min Jiang, Ting-Ting Liu, Qi Wang. In vitro study on binding interaction of quinapril with bovine serum albumin (BSA) using multi-spectroscopic and molecular docking methods.
Journal of biomolecular structure & dynamics.
2017 Aug; 35(10):2211-2223. doi:
10.1080/07391102.2016.1213663
. [PMID: 27418394] - Gábor Kökény, Lilla Fang, Csaba Révész, Miklós M Mózes, Péter Vörös, Gábor Szénási, László Rosivall. The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats.
Kidney & blood pressure research.
2017; 42(1):109-122. doi:
10.1159/000471915
. [PMID: 28359068] - Marzena Wojewodzka-Zelezniakowicz, Wioleta Kisiel, Karol Kramkowski, Anna Gromotowicz-Poplawska, Agnieszka Zakrzeska, Adrian Stankiewicz, Patrycjusz Kolodziejczyk, Janusz Szemraj, Jerzy Robert Ladny, Ewa Chabielska. Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2016 Apr; 17(2):1470320316647239. doi:
10.1177/1470320316647239
. [PMID: 27169890] - E Katriina Tarkiainen, Aleksi Tornio, Mikko T Holmberg, Terhi Launiainen, Pertti J Neuvonen, Janne T Backman, Mikko Niemi. Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.
British journal of clinical pharmacology.
2015 Nov; 80(5):1131-8. doi:
10.1111/bcp.12667
. [PMID: 25919042] - A A Nagornaya, S Magomedov, N A Gorchakova, I F Belenichev, I S Ghekman, T A Kuzub. [INFLUENCE OF QUINAPRIL IN COMBINATION WITH ANGIOLINE ON THE CONNECTIVE TISSUE COMPONENTS IN THE RATS SERUM WITH EXPERIMENTAL HYPERTENSION].
Likars'ka sprava.
2015 Jul; ?(5-6):116-20. doi:
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2014 Dec; 15(4):487-90. doi:
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. [PMID: 23380567] - J L Davis, K Kruger, D H LaFevers, B M Barlow, J M Schirmer, B A Breuhaus. Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses.
Equine veterinary journal.
2014 Nov; 46(6):729-33. doi:
10.1111/evj.12206
. [PMID: 24175935] - Anna M D Watson, Jiaze Li, Dian Samijono, Angelika Bierhaus, Merlin C Thomas, Karin A M Jandeleit-Dahm, Mark E Cooper. Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.
Atherosclerosis.
2014 Aug; 235(2):444-8. doi:
10.1016/j.atherosclerosis.2014.05.945
. [PMID: 24945577] - Charalambos Koumaras, Konstantinos Tziomalos, Eirini Stavrinou, Niki Katsiki, Vasilios G Athyros, Dimitri P Mikhailidis, Asterios Karagiannis. Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness.
Journal of the American Society of Hypertension : JASH.
2014 Feb; 8(2):74-82. doi:
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Diabetes.
2012 Aug; 61(8):2105-13. doi:
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Thrombosis research.
2012 Jul; 130(1):99-103. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 Jun; 341(3):626-33. doi:
10.1124/jpet.111.187732
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(26):2688-94. doi:
10.1016/j.jchromb.2011.07.026
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American journal of physiology. Heart and circulatory physiology.
2010 Apr; 298(4):H1177-81. doi:
10.1152/ajpheart.00866.2009
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The American journal of cardiology.
2010 Jan; 105(1):54-8. doi:
10.1016/j.amjcard.2009.08.648
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Diabetologia.
2010 Jan; 53(1):192-203. doi:
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. [PMID: 19862499] - . Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT).
BMC pediatrics.
2009 Dec; 9(?):79. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Dec; 24(12):3640-51. doi:
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. [PMID: 19666910] - Haodan Yuan, Bo Feng, Ying Yu, Jonathan Chupka, Jenny Y Zheng, Timothy G Heath, Brian R Bond. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.
The Journal of pharmacology and experimental therapeutics.
2009 Jul; 330(1):191-7. doi:
10.1124/jpet.108.149476
. [PMID: 19349522] - Bhavesh Dasandi, Sanjay Shah. Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry.
Biomedical chromatography : BMC.
2009 May; 23(5):492-8. doi:
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. [PMID: 19016233] - Felicio Savioli Neto, Hélio M Magalhães, Michel Batlouni, Leopoldo S Piegas. ACE inhibitors and plasma B-type natriuretic peptide levels in elderly patients with heart failure.
Arquivos brasileiros de cardiologia.
2009 May; 92(5):320-6, 336. doi:
10.1590/s0066-782x2009000500003
. [PMID: 19629285] - Iulia Sora, Elena Cristea, Florin Albu, Stefan Udrescu, Victor David, Andrei Medvedovici. LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation.
Bioanalysis.
2009 Apr; 1(1):71-86. doi:
10.4155/bio.09.5
. [PMID: 21083190] - Tokihiko Sawada, Yasuo Ishii, Ichiro Nakajima, Shohei Fuchinoue, Keiichi Kubota, Satoshi Teraoka. An experimental model of encapsulating peritoneal sclerosis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2009 Feb; 29 Suppl 2(?):S49-50. doi:
10.1177/089686080902902s09
. [PMID: 19270231] - Iu I Nesterov, I N Bondareva, A T Tepliakov, O V Poltavtseva. [Combined antihypertensive treatment of patients with hypertension and type 2 diabetes mellitus].
Terapevticheskii arkhiv.
2009; 81(2):75-9. doi:
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. [PMID: 19334497] - Iu I Nesterov, O V Poltavtseva, I N Bondareva, A T Tepliakov. [Combined antihypertensive therapy in patients with arterial hypertension and type 2 diabetes].
Klinicheskaia meditsina.
2009; 87(8):29-32. doi:
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. [PMID: 19827527] - Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H H Neubert, Hannelore Daniel, Matthias Brandsch. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.
The Journal of pharmacology and experimental therapeutics.
2008 Nov; 327(2):432-41. doi:
10.1124/jpet.108.143339
. [PMID: 18713951] - Sagar A Parekh, Ashutosh Pudage, Santosh S Joshi, Vikas V Vaidya, Noel A Gomes, Sudhir S Kamat. Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 873(1):59-69. doi:
10.1016/j.jchromb.2008.07.046
. [PMID: 18723407] - Noppamas Rojanasthien, Nayada Nasangiam, Boonyium Kumsorn, Sukit Roongapinun, Apiwat Jengjareon. Pharmacokinetics and bioequivalence study of the two 20-mg quinapril hydrochloride tablet formulations in healthy Thai male volunteers.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2008 May; 91(5):739-46. doi:
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. [PMID: 18672641] - Jie Ren, Han Li, Barry M Prior, H T Yang. Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion.
The American journal of the medical sciences.
2008 Mar; 335(3):177-87. doi:
10.1097/maj.0b013e318142b978
. [PMID: 18344690] - Saniye Sen, Sen Saniye, Mehmet Kanter, Kanter Mehmet, Sedat Ustundag, Ustundag Sedat, Cevat Aktas, Aktas Cevat, Haluk Dogutan, Omer Yalcin, Yalcin Omer. Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on streptozotocin-induced diabetic nephropathy.
Renal failure.
2008; 30(10):1023-33. doi:
10.1080/08860220802495248
. [PMID: 19016156] - Katalin Farkas, Emília Fábián, Lajos Nagy. Quinapril improves endothelial function in postmenopausal hypertensive patients.
Kidney & blood pressure research.
2008; 31(4):226-33. doi:
10.1159/000141927
. [PMID: 18587241] - Lucy H Clerk, Michelle A Vincent, Eugene J Barrett, Miles F Lankford, Jonathan R Lindner. Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition.
American journal of physiology. Endocrinology and metabolism.
2007 Dec; 293(6):E1804-9. doi:
10.1152/ajpendo.00498.2007
. [PMID: 17911341] - Marvin Sinsakul, Mohammed Sika, Roger Rodby, John Middleton, Yu Shyr, Heidi Chen, Ernest Han, Ruediger Lehrich, Stephen Clyne, Gerald Schulman, Raymond Harris, Julia Lewis. A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2007 Dec; 50(6):946-51. doi:
10.1053/j.ajkd.2007.09.005
. [PMID: 18037095] - Marcel Ruzicka, Elizabeth Coletta, Frans H H Leenen. Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients?.
American journal of hypertension.
2007 Nov; 20(11):1202-8. doi:
10.1016/j.amjhyper.2007.05.014
. [PMID: 17954368] - A E Gliddon, C J Doré, C M Black, N McHugh, R Moots, C P Denton, A Herrick, T Barnes, J Camilleri, K Chakravarty, P Emery, B Griffiths, N D Hopkinson, P Hickling, P Lanyon, C Laversuch, T Lawson, R Mallya, M Nisar, C Rhys-Dillon, T Sheeran, P J Maddison. Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril.
Arthritis and rheumatism.
2007 Nov; 56(11):3837-46. doi:
10.1002/art.22965
. [PMID: 17968938] - Samira Ubaid-Girioli, Sílvia Elaine Ferreira-Melo, Leoní Adriana Souza, Eduardo Arantes Nogueira, Juan Carlos Yugar-Toledo, Antonio Coca, Heitor Moreno. Aldosterone escape with diuretic or angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker combination therapy in patients with mild to moderate hypertension.
Journal of clinical hypertension (Greenwich, Conn.).
2007 Oct; 9(10):770-4. doi:
10.1111/j.1751-7176.2007.tb00091.x
. [PMID: 17917504] - Dariusz Andrzejczak, Dorota Górska, Elzbieta Czarnecka. Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1 beta, IL-6 in spontaneously hypertensive rats (SHR).
Pharmacological reports : PR.
2007 Jul; 59(4):437-46. doi:
. [PMID: 17901573]
- S-C Lim, A F Y Koh, S K Goh, C-L Chua, B-L Heng, T Subramaniam, C-F Sum. Angiotensin receptor antagonist vs. angiotensin-converting enzyme inhibitor in Asian subjects with type 2 diabetes and albuminuria - a randomized crossover study.
Diabetes, obesity & metabolism.
2007 Jul; 9(4):477-82. doi:
10.1111/j.1463-1326.2006.00623.x
. [PMID: 17587389] - Jesus Egido, Marta Ruiz-Ortega. Anti-inflammatory actions of quinapril.
Cardiovascular drugs and therapy.
2007 Jun; 21(3):211-20. doi:
10.1007/s10557-007-6019-1
. [PMID: 17404826] - Magdalena Gibas, Jolanta Miszczak-Smiałek, Edyta Madry, Jerzy Głuszek, Henryk Witmanowski, Janusz Piotrowski. Influence of preventive therapy with quinapril on IL-6 level in patients with chronic stable angina.
Pharmacological reports : PR.
2007 May; 59(3):330-8. doi:
. [PMID: 17652834]
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Preventive cardiology.
2007; 10(4):204-9. doi:
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. [PMID: 17917517] - Toshihiko Ishimitsu, Takeaki Honda, Satoshi Ohta, Akira Akashiba, Toshiaki Takahashi, Tomoko Kameda, Masayoshi Yoshii, Junichi Minami, Masaki Takahashi, Hidehiko Ono, Hiroaki Matsuoka. Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats.
American journal of hypertension.
2006 Dec; 19(12):1233-40. doi:
10.1016/j.amjhyper.2006.05.019
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Journal of nephrology.
2006 Nov; 19(6):725-31. doi:
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. [PMID: 17173244] - Julio Gallego-Delgado, Alberto Lazaro, Dulcenombre Gomez-Garre, Julio I Osende, Maria L Gonzalez-Rubio, Marta Herraiz, Félix Manzarbeitia, José Fortes, Arturo Fernandez-Cruz, Jesús Egido. Long-term organ protection by doxazosin and/or quinapril as antihypertensive therapy.
Journal of nephrology.
2006 Sep; 19(5):588-98. doi:
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European journal of heart failure.
2006 Aug; 8(5):451-9. doi:
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. [PMID: 16325470] - M Wojewódzka-Zelezniakowicz, E Chabielska, A Mogielnicki, K Kramkowski, A Karp, A Opadczuk, T Domaniewski, M Malinowska-Zaprzałka, W Buczko. Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2006 Jun; 57(2):231-45. doi:
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Journal of thrombosis and haemostasis : JTH.
2006 May; 4(5):1029-36. doi:
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European journal of heart failure.
2006 Mar; 8(2):122-30. doi:
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Transplantation proceedings.
2006 Mar; 38(2):483-6. doi:
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Terapevticheskii arkhiv.
2006; 78(8):14-20. doi:
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Terapevticheskii arkhiv.
2006; 78(9):61-71. doi:
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Thrombosis research.
2006; 117(5):557-61. doi:
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European journal of heart failure.
2005 Dec; 7(7):1085-94. doi:
10.1016/j.ejheart.2004.12.002
. [PMID: 16326361] - Karin Jandeleit-Dahm, Markus Lassila, Belinda J Davis, Riccardo Candido, Colin I Johnston, Terri J Allen, Louise M Burrell, Mark E Cooper. Anti-atherosclerotic and renoprotective effects of combined angiotensin-converting enzyme and neutral endopeptidase inhibition in diabetic apolipoprotein E-knockout mice.
Journal of hypertension.
2005 Nov; 23(11):2071-82. doi:
10.1097/01.hjh.0000184747.41565.a1
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The Journal of rheumatology.
2005 Nov; 32(11):2095-101. doi:
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Antioxidants & redox signaling.
2005 Sep; 7(9-10):1285-93. doi:
10.1089/ars.2005.7.1285
. [PMID: 16115034] - Arantxa Ortega, David Rámila, Adriana Izquierdo, Laura González, Antonio Barat, Rosa Gazapo, Ricardo J Bosch, Pedro Esbrit. Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat.
Journal of the American Society of Nephrology : JASN.
2005 Apr; 16(4):939-49. doi:
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2005 Apr; 45(4):295-300. doi:
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American journal of hypertension.
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2005 Jan; ?(93):S10-4. doi:
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The American journal of pathology.
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Clinical and experimental pharmacology & physiology.
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The Journal of clinical endocrinology and metabolism.
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American journal of hypertension.
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American journal of hypertension.
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Transplant international : official journal of the European Society for Organ Transplantation.
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The Canadian journal of cardiology.
2003 May; 19(6):701-4. doi:
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Clinical and experimental pharmacology & physiology.
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