Quinapril hydrochloride (BioDeep_00000015023)
natural product
代谢物信息卡片
Quinapril hydrochloride (Accupril)
化学式: C25H31ClN2O5 (474.1921386)
中文名称: 盐酸喹那普利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=CC(=C1)CC[C@H](N[C@H](C(N2[C@@H](CC3=C(C2)C=CC=C3)C(O)=O)=O)C)C(OCC)=O).Cl
InChI: /m0./s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:8714
- KEGG: C07340
- KEGGdrug: D00459
- PubChem: 54891
- ChEMBL: CHEMBL1201011
- MeSH: Quinapril
- CAS: 82586-55-8
- MoNA: CCMSLIB00000078518
- PubChem: 9547
- NIKKAJI: J400.159A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Majid Jaberi-Douraki, Emma Meyer, Jim Riviere, Nuwan Indika Millagaha Gedara, Jessica Kawakami, Gerald J Wyckoff, Xuan Xu. Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity.
Scientific reports.
2021 06; 11(1):13349. doi:
10.1038/s41598-021-92734-7. [PMID: 34172790] - A Gromotowicz-Poplawska, A Stankiewicz, J Mikita, M Aleksiejczuk, N Marcinczyk, J Szemraj, E Chabielska. Beneficial effect of combined spironolactone and quinapril treatment on thrombosis and hemostasis in 2K1C hypertensive rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2018 Apr; 69(2):. doi:
10.26402/jpp.2018.2.10. [PMID: 29980144] - Shuangjiao Sun, Yanfen Wei, Hao Wang, Yupin Cao, Biyang Deng. A novel electrochemiluminescence sensor coupled with capillary electrophoresis for simultaneous determination of quinapril hydrochloride and its metabolite quinaprilat hydrochloride in human plasma.
Talanta.
2018 Mar; 179(?):213-220. doi:
10.1016/j.talanta.2017.10.050. [PMID: 29310224] - Jie-Hua Shi, Dong-Qi Pan, Min Jiang, Ting-Ting Liu, Qi Wang. In vitro study on binding interaction of quinapril with bovine serum albumin (BSA) using multi-spectroscopic and molecular docking methods.
Journal of biomolecular structure & dynamics.
2017 Aug; 35(10):2211-2223. doi:
10.1080/07391102.2016.1213663. [PMID: 27418394] - Gábor Kökény, Lilla Fang, Csaba Révész, Miklós M Mózes, Péter Vörös, Gábor Szénási, László Rosivall. The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats.
Kidney & blood pressure research.
2017; 42(1):109-122. doi:
10.1159/000471915. [PMID: 28359068] - Marzena Wojewodzka-Zelezniakowicz, Wioleta Kisiel, Karol Kramkowski, Anna Gromotowicz-Poplawska, Agnieszka Zakrzeska, Adrian Stankiewicz, Patrycjusz Kolodziejczyk, Janusz Szemraj, Jerzy Robert Ladny, Ewa Chabielska. Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2016 Apr; 17(2):1470320316647239. doi:
10.1177/1470320316647239. [PMID: 27169890] - E Katriina Tarkiainen, Aleksi Tornio, Mikko T Holmberg, Terhi Launiainen, Pertti J Neuvonen, Janne T Backman, Mikko Niemi. Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril.
British journal of clinical pharmacology.
2015 Nov; 80(5):1131-8. doi:
10.1111/bcp.12667. [PMID: 25919042] - A A Nagornaya, S Magomedov, N A Gorchakova, I F Belenichev, I S Ghekman, T A Kuzub. [INFLUENCE OF QUINAPRIL IN COMBINATION WITH ANGIOLINE ON THE CONNECTIVE TISSUE COMPONENTS IN THE RATS SERUM WITH EXPERIMENTAL HYPERTENSION].
Likars'ka sprava.
2015 Jul; ?(5-6):116-20. doi:
. [PMID: 27089728] - Su Chi Lim, Jian-Jun Liu, Tavintharan Subramaniam, Chee Fang Sum. Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2014 Dec; 15(4):487-90. doi:
10.1177/1470320313475905. [PMID: 23380567] - J L Davis, K Kruger, D H LaFevers, B M Barlow, J M Schirmer, B A Breuhaus. Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses.
Equine veterinary journal.
2014 Nov; 46(6):729-33. doi:
10.1111/evj.12206. [PMID: 24175935] - Anna M D Watson, Jiaze Li, Dian Samijono, Angelika Bierhaus, Merlin C Thomas, Karin A M Jandeleit-Dahm, Mark E Cooper. Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.
Atherosclerosis.
2014 Aug; 235(2):444-8. doi:
10.1016/j.atherosclerosis.2014.05.945. [PMID: 24945577] - Charalambos Koumaras, Konstantinos Tziomalos, Eirini Stavrinou, Niki Katsiki, Vasilios G Athyros, Dimitri P Mikhailidis, Asterios Karagiannis. Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness.
Journal of the American Society of Hypertension : JASH.
2014 Feb; 8(2):74-82. doi:
10.1016/j.jash.2013.09.001. [PMID: 24139833] - Anna M D Watson, Stephen P Gray, Li Jiaze, Aino Soro-Paavonen, Benedict Wong, Mark E Cooper, Angelika Bierhaus, Raelene Pickering, Christos Tikellis, Despina Tsorotes, Merlin C Thomas, Karin A M Jandeleit-Dahm. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice.
Diabetes.
2012 Aug; 61(8):2105-13. doi:
10.2337/db11-1546. [PMID: 22698914] - Marek Rajzer, Wiktoria Wojciechowska, Kalina Kawecka-Jaszcz, Anetta Undas. Plasma fibrin clot properties in arterial hypertension and their modification by antihypertensive medication.
Thrombosis research.
2012 Jul; 130(1):99-103. doi:
10.1016/j.thromres.2011.08.022. [PMID: 21917299] - Tomoe Fujita, Kazuhiko Ishihara, Shuichi Yasuda, Tomomi Nakamura, Mika Maeda, Mami Kobayashi, Kunihiko Sahashi, Yasuhiko Ikeda, Yuji Kumagai, Masataka Majima. In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats.
The Journal of pharmacology and experimental therapeutics.
2012 Jun; 341(3):626-33. doi:
10.1124/jpet.111.187732. [PMID: 22389425] - Chi-Yu Lu, Fei-Tsui Liu, Chia-Hsien Feng. Quantitation of quinapril in human plasma by matrix-assisted laser desorption ionization time-of-flight mass spectrometry with quinolone matrix additives.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(26):2688-94. doi:
10.1016/j.jchromb.2011.07.026. [PMID: 21868293] - Dinko Susic, Jasmina Varagic, Edward D Frohlich. Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess.
American journal of physiology. Heart and circulatory physiology.
2010 Apr; 298(4):H1177-81. doi:
10.1152/ajpheart.00866.2009. [PMID: 20118410] - Spyridon Deftereos, Georgios Giannopoulos, Charalampos Kossyvakis, Andreas Kaoukis, Konstantin Raisakis, Metaxia Driva, Vasiliki Panagopoulou, Spyridon Lappos, Ilias Rentoukas, Vlasios Pyrgakis, Martin A Alpert. Effect of quinapril on in-stent restenosis and relation to plasma apoptosis signaling molecules.
The American journal of cardiology.
2010 Jan; 105(1):54-8. doi:
10.1016/j.amjcard.2009.08.648. [PMID: 20102890] - A M D Watson, J Li, C Schumacher, M de Gasparo, B Feng, M C Thomas, T J Allen, M E Cooper, K A M Jandeleit-Dahm. The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice.
Diabetologia.
2010 Jan; 53(1):192-203. doi:
10.1007/s00125-009-1540-3. [PMID: 19862499] - . Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT).
BMC pediatrics.
2009 Dec; 9(?):79. doi:
10.1186/1471-2431-9-79. [PMID: 20017932] - Zalan Nemeth, Gabor Kokeny, Maria Godo, Miklós Mózes, László Rosivall, Marie-Luise Gross, Eberhard Ritz, Péter Hamar. Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Dec; 24(12):3640-51. doi:
10.1093/ndt/gfp371. [PMID: 19666910] - Haodan Yuan, Bo Feng, Ying Yu, Jonathan Chupka, Jenny Y Zheng, Timothy G Heath, Brian R Bond. Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.
The Journal of pharmacology and experimental therapeutics.
2009 Jul; 330(1):191-7. doi:
10.1124/jpet.108.149476. [PMID: 19349522] - Bhavesh Dasandi, Sanjay Shah. Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry.
Biomedical chromatography : BMC.
2009 May; 23(5):492-8. doi:
10.1002/bmc.1143. [PMID: 19016233] - Felicio Savioli Neto, Hélio M Magalhães, Michel Batlouni, Leopoldo S Piegas. ACE inhibitors and plasma B-type natriuretic peptide levels in elderly patients with heart failure.
Arquivos brasileiros de cardiologia.
2009 May; 92(5):320-6, 336. doi:
10.1590/s0066-782x2009000500003. [PMID: 19629285] - Iulia Sora, Elena Cristea, Florin Albu, Stefan Udrescu, Victor David, Andrei Medvedovici. LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation.
Bioanalysis.
2009 Apr; 1(1):71-86. doi:
10.4155/bio.09.5. [PMID: 21083190] - Tokihiko Sawada, Yasuo Ishii, Ichiro Nakajima, Shohei Fuchinoue, Keiichi Kubota, Satoshi Teraoka. An experimental model of encapsulating peritoneal sclerosis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2009 Feb; 29 Suppl 2(?):S49-50. doi:
10.1177/089686080902902s09. [PMID: 19270231] - Iu I Nesterov, I N Bondareva, A T Tepliakov, O V Poltavtseva. [Combined antihypertensive treatment of patients with hypertension and type 2 diabetes mellitus].
Terapevticheskii arkhiv.
2009; 81(2):75-9. doi:
". [PMID: 19334497] - Iu I Nesterov, O V Poltavtseva, I N Bondareva, A T Tepliakov. [Combined antihypertensive therapy in patients with arterial hypertension and type 2 diabetes].
Klinicheskaia meditsina.
2009; 87(8):29-32. doi:
". [PMID: 19827527] - Ilka Knütter, Claudia Wollesky, Gabor Kottra, Martin G Hahn, Wiebke Fischer, Katja Zebisch, Reinhard H H Neubert, Hannelore Daniel, Matthias Brandsch. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.
The Journal of pharmacology and experimental therapeutics.
2008 Nov; 327(2):432-41. doi:
10.1124/jpet.108.143339. [PMID: 18713951] - Sagar A Parekh, Ashutosh Pudage, Santosh S Joshi, Vikas V Vaidya, Noel A Gomes, Sudhir S Kamat. Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Sep; 873(1):59-69. doi:
10.1016/j.jchromb.2008.07.046. [PMID: 18723407] - Noppamas Rojanasthien, Nayada Nasangiam, Boonyium Kumsorn, Sukit Roongapinun, Apiwat Jengjareon. Pharmacokinetics and bioequivalence study of the two 20-mg quinapril hydrochloride tablet formulations in healthy Thai male volunteers.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2008 May; 91(5):739-46. doi:
NULL. [PMID: 18672641] - Jie Ren, Han Li, Barry M Prior, H T Yang. Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion.
The American journal of the medical sciences.
2008 Mar; 335(3):177-87. doi:
10.1097/maj.0b013e318142b978. [PMID: 18344690] - Saniye Sen, Sen Saniye, Mehmet Kanter, Kanter Mehmet, Sedat Ustundag, Ustundag Sedat, Cevat Aktas, Aktas Cevat, Haluk Dogutan, Omer Yalcin, Yalcin Omer. Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on streptozotocin-induced diabetic nephropathy.
Renal failure.
2008; 30(10):1023-33. doi:
10.1080/08860220802495248. [PMID: 19016156] - Katalin Farkas, Emília Fábián, Lajos Nagy. Quinapril improves endothelial function in postmenopausal hypertensive patients.
Kidney & blood pressure research.
2008; 31(4):226-33. doi:
10.1159/000141927. [PMID: 18587241] - Lucy H Clerk, Michelle A Vincent, Eugene J Barrett, Miles F Lankford, Jonathan R Lindner. Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition.
American journal of physiology. Endocrinology and metabolism.
2007 Dec; 293(6):E1804-9. doi:
10.1152/ajpendo.00498.2007. [PMID: 17911341] - Marvin Sinsakul, Mohammed Sika, Roger Rodby, John Middleton, Yu Shyr, Heidi Chen, Ernest Han, Ruediger Lehrich, Stephen Clyne, Gerald Schulman, Raymond Harris, Julia Lewis. A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2007 Dec; 50(6):946-51. doi:
10.1053/j.ajkd.2007.09.005. [PMID: 18037095] - Marcel Ruzicka, Elizabeth Coletta, Frans H H Leenen. Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients?.
American journal of hypertension.
2007 Nov; 20(11):1202-8. doi:
10.1016/j.amjhyper.2007.05.014. [PMID: 17954368] - A E Gliddon, C J Doré, C M Black, N McHugh, R Moots, C P Denton, A Herrick, T Barnes, J Camilleri, K Chakravarty, P Emery, B Griffiths, N D Hopkinson, P Hickling, P Lanyon, C Laversuch, T Lawson, R Mallya, M Nisar, C Rhys-Dillon, T Sheeran, P J Maddison. Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril.
Arthritis and rheumatism.
2007 Nov; 56(11):3837-46. doi:
10.1002/art.22965. [PMID: 17968938] - Samira Ubaid-Girioli, Sílvia Elaine Ferreira-Melo, Leoní Adriana Souza, Eduardo Arantes Nogueira, Juan Carlos Yugar-Toledo, Antonio Coca, Heitor Moreno. Aldosterone escape with diuretic or angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker combination therapy in patients with mild to moderate hypertension.
Journal of clinical hypertension (Greenwich, Conn.).
2007 Oct; 9(10):770-4. doi:
10.1111/j.1751-7176.2007.tb00091.x. [PMID: 17917504] - Dariusz Andrzejczak, Dorota Górska, Elzbieta Czarnecka. Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1 beta, IL-6 in spontaneously hypertensive rats (SHR).
Pharmacological reports : PR.
2007 Jul; 59(4):437-46. doi:
. [PMID: 17901573] - S-C Lim, A F Y Koh, S K Goh, C-L Chua, B-L Heng, T Subramaniam, C-F Sum. Angiotensin receptor antagonist vs. angiotensin-converting enzyme inhibitor in Asian subjects with type 2 diabetes and albuminuria - a randomized crossover study.
Diabetes, obesity & metabolism.
2007 Jul; 9(4):477-82. doi:
10.1111/j.1463-1326.2006.00623.x. [PMID: 17587389] - Jesus Egido, Marta Ruiz-Ortega. Anti-inflammatory actions of quinapril.
Cardiovascular drugs and therapy.
2007 Jun; 21(3):211-20. doi:
10.1007/s10557-007-6019-1. [PMID: 17404826] - Magdalena Gibas, Jolanta Miszczak-Smiałek, Edyta Madry, Jerzy Głuszek, Henryk Witmanowski, Janusz Piotrowski. Influence of preventive therapy with quinapril on IL-6 level in patients with chronic stable angina.
Pharmacological reports : PR.
2007 May; 59(3):330-8. doi:
. [PMID: 17652834] - Sameer Nagamia, Anbu Pandian, Faiz Cheema, Rama Natarajan, Qamar A Khan, Amar D Patel, Nadya Merchant, Srikanth Sola, Bobby V Khan. The role of quinapril in the presence of a weight loss regimen: endothelial function and markers of obesity in patients with the metabolic syndrome.
Preventive cardiology.
2007; 10(4):204-9. doi:
10.1111/j.1520-037x.2007.06556.x. [PMID: 17917517] - Toshihiko Ishimitsu, Takeaki Honda, Satoshi Ohta, Akira Akashiba, Toshiaki Takahashi, Tomoko Kameda, Masayoshi Yoshii, Junichi Minami, Masaki Takahashi, Hidehiko Ono, Hiroaki Matsuoka. Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats.
American journal of hypertension.
2006 Dec; 19(12):1233-40. doi:
10.1016/j.amjhyper.2006.05.019. [PMID: 17161768] - Vanesa Esteban, Julio Gallego-Delgado, Alberto Lazaro, Julio Osende, Sergio Mezzano, Jesus Egido, Marta Ruiz-Ortega. Long-term treatment with an ACE inhibitor or an AT1 antagonist avoids hypertension-induced inflammation in the kidney.
Journal of nephrology.
2006 Nov; 19(6):725-31. doi:
NULL. [PMID: 17173244] - Julio Gallego-Delgado, Alberto Lazaro, Dulcenombre Gomez-Garre, Julio I Osende, Maria L Gonzalez-Rubio, Marta Herraiz, Félix Manzarbeitia, José Fortes, Arturo Fernandez-Cruz, Jesús Egido. Long-term organ protection by doxazosin and/or quinapril as antihypertensive therapy.
Journal of nephrology.
2006 Sep; 19(5):588-98. doi:
. [PMID: 17136686] - Imre Kovacs, Janos Toth, Jeno Tarjan, Akos Koller. Correlation of flow mediated dilation with inflammatory markers in patients with impaired cardiac function. Beneficial effects of inhibition of ACE.
European journal of heart failure.
2006 Aug; 8(5):451-9. doi:
10.1016/j.ejheart.2005.10.011. [PMID: 16325470] - M Wojewódzka-Zelezniakowicz, E Chabielska, A Mogielnicki, K Kramkowski, A Karp, A Opadczuk, T Domaniewski, M Malinowska-Zaprzałka, W Buczko. Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2006 Jun; 57(2):231-45. doi:
. [PMID: 16845228] - A Undas, M Celinska-Löwenhoff, T Löwenhoff, A Szczeklik. Statins, fenofibrate, and quinapril increase clot permeability and enhance fibrinolysis in patients with coronary artery disease.
Journal of thrombosis and haemostasis : JTH.
2006 May; 4(5):1029-36. doi:
10.1111/j.1538-7836.2006.01882.x. [PMID: 16689755] - Bart Westendorp, Regien G Schoemaker, Hendrik Buikema, Frans Boomsma, Dirk J van Veldhuisen, Wiek H van Gilst. Progressive left ventricular hypertrophy after withdrawal of long-term ACE inhibition following experimental myocardial infarction.
European journal of heart failure.
2006 Mar; 8(2):122-30. doi:
10.1016/j.ejheart.2005.04.014. [PMID: 16084760] - H Deniz, B Oğütmen, F Cakalağaoğlu, S Tuğlular, C Ozener, E Akoğlu. Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats.
Transplantation proceedings.
2006 Mar; 38(2):483-6. doi:
10.1016/j.transproceed.2005.12.056. [PMID: 16549154] - A A Skvortsov, V Iu Mareev, S N Nasonova, A V Sychev, G N Arbolishvili, N A Baklanova, V P Masenko, Iu N Belenkov. [Is triple combination of different neurohormonal modulators recommended for treatment of mild-to-moderate congestive heart failure patients? (Results of Sadko-CHF study)].
Terapevticheskii arkhiv.
2006; 78(8):14-20. doi:
NULL. [PMID: 17078211] - A A Skvortsov, V Iu Mareev, S N Nasonova, A V Sychev, G N Arbolishvili, N A Baklanova, V P Masenko, Iu N Belenkov. [Is triple combination of different neurohormonal modulators recommended for treatment of mild-to-moderate congestive heart failure patients? (Results of SADKO-CHF study). Part 2].
Terapevticheskii arkhiv.
2006; 78(9):61-71. doi:
. [PMID: 17076227] - Karol Kramkowski, Andrzej Mogielnicki, Ewa Chabielska, Dorota Cylwik, Włodzimierz Buczko. The effect of 'tissue' and 'plasma' angiotensin converting enzyme inhibitors on overall haemostatic potentials in rats.
Thrombosis research.
2006; 117(5):557-61. doi:
10.1016/j.thromres.2005.05.014. [PMID: 15985287] - Bart Westendorp, Regien G Schoemaker, Hendrik Buikema, Dick de Zeeuw, Frans Boomsma, Wiek H van Gilst, Dirk J van Veldhuisen. Beneficial effects of add-on hydrochlorothiazide in rats with myocardial infarction optimally treated with quinapril.
European journal of heart failure.
2005 Dec; 7(7):1085-94. doi:
10.1016/j.ejheart.2004.12.002. [PMID: 16326361] - Karin Jandeleit-Dahm, Markus Lassila, Belinda J Davis, Riccardo Candido, Colin I Johnston, Terri J Allen, Louise M Burrell, Mark E Cooper. Anti-atherosclerotic and renoprotective effects of combined angiotensin-converting enzyme and neutral endopeptidase inhibition in diabetic apolipoprotein E-knockout mice.
Journal of hypertension.
2005 Nov; 23(11):2071-82. doi:
10.1097/01.hjh.0000184747.41565.a1. [PMID: 16208151] - Canan Tikiz, Ozan Utuk, Timur Pirildar, Ozgur Bayturan, Petek Bayindir, Fatma Taneli, Hakan Tikiz, Cigdem Tuzun. Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis.
The Journal of rheumatology.
2005 Nov; 32(11):2095-101. doi:
. [PMID: 16265685] - Alberto Lazaro, Julio Gallego-Delgado, Pilar Justo, Vanesa Esteban, Julio Osende, Sergio Mezzano, Alberto Ortiz, Jesus Egido. Long-term blood pressure control prevents oxidative renal injury.
Antioxidants & redox signaling.
2005 Sep; 7(9-10):1285-93. doi:
10.1089/ars.2005.7.1285. [PMID: 16115034] - Arantxa Ortega, David Rámila, Adriana Izquierdo, Laura González, Antonio Barat, Rosa Gazapo, Ricardo J Bosch, Pedro Esbrit. Role of the renin-angiotensin system on the parathyroid hormone-related protein overexpression induced by nephrotoxic acute renal failure in the rat.
Journal of the American Society of Nephrology : JASN.
2005 Apr; 16(4):939-49. doi:
10.1681/asn.2004040328. [PMID: 15728788] - Daniel R Pomaro, Silvia S M Ihara, Leonor E S A Pinto, Ivete Ueda, Dulce E Casarini, Fabiana Ebihara, Andreza O Santos, Maria C O Izar, Francisco A H Fonseca. High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits.
Journal of cardiovascular pharmacology.
2005 Apr; 45(4):295-300. doi:
10.1097/01.fjc.0000155384.64350.45. [PMID: 15772516] - Sandra Blanco, Manuel Vaquero, Carmen Gómez-Guerrero, Dolores López, Jesús Egido, Ramón Romero. Potential role of angiotensin-converting enzyme inhibitors and statins on early podocyte damage in a model of type 2 diabetes mellitus, obesity, and mild hypertension.
American journal of hypertension.
2005 Apr; 18(4 Pt 1):557-65. doi:
10.1016/j.amjhyper.2004.10.034. [PMID: 15831368] - Mark S MacGregor, Christopher J Deighan, R Stuart C Rodger, J Michael Boulton-Jones. A prospective open-label randomised trial of quinapril and/or amlodipine in progressive non-diabetic renal failure.
Nephron. Clinical practice.
2005; 101(3):c139-49. doi:
10.1159/000086714. [PMID: 16015004] - Yoko Uchiyama-Tanaka, Yasukiyo Mori, Noriko Kishimoto, Masayoshi Fukui, Atsuko Nose, Yasuaki Kijima, Hideki Yamahara, Takamasa Hasegawa, Atsushi Kosaki, Hiroaki Matsubara, Toshiji Iwasaka. Comparison of the effects of quinapril and losartan on carotid artery intima-media thickness in patients with mild-to-moderate arterial hypertension.
Kidney & blood pressure research.
2005; 28(2):111-6. doi:
10.1159/000084254. [PMID: 15741734] - Sandra Blanco, Josep Bonet, Dolores López, Irma Casas, Ramón Romero. ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis.
Kidney international. Supplement.
2005 Jan; ?(93):S10-4. doi:
10.1111/j.1523-1755.2005.09303.x. [PMID: 15613060] - Adriaan A Voors, Peter P van Geel, Margreeth Oosterga, Hendrik Buikema, Dirk J van Veldhuisen, Wiek H van Gilst. Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2004 Sep; 5(3):130-4. doi:
10.3317/jraas.2004.029. [PMID: 15526248] - Russell Chesney. The changing face of childhood nephrotic syndrome.
Kidney international.
2004 Sep; 66(3):1294-302. doi:
10.1111/j.1523-1755.2004.00885.x. [PMID: 15327442] - Bobby V Khan, Srikanth Sola, Wright B Lauten, Rama Natarajan, W Craig Hooper, Rekha G Menon, Stamatios Lerakis, Tarek Helmy. Quinapril, an ACE inhibitor, reduces markers of oxidative stress in the metabolic syndrome.
Diabetes care.
2004 Jul; 27(7):1712-5. doi:
10.2337/diacare.27.7.1712. [PMID: 15220251] - Karina Soto, Dulcenombre Gómez-Garre, Raquel Largo, Julio Gallego-Delgado, Nuria Tejera, Marina P Catalán, Alberto Ortiz, Juan José Plaza, Covadonga Alonso, Jesús Egido. Tight blood pressure control decreases apoptosis during renal damage.
Kidney international.
2004 Mar; 65(3):811-22. doi:
10.1111/j.1523-1755.2004.00455.x. [PMID: 14871401] - Naoyuki Sata, Yasuhiro Tanaka, Syusaku Suzuki, Ryouzou Kamimura, Hiroharu Mifune, Kazuo Nakamura, Kenkichi Miyahara, Terukatsu Arima. Effectiveness of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker on atrial natriuretic peptide.
Circulation journal : official journal of the Japanese Circulation Society.
2003 Dec; 67(12):1053-8. doi:
10.1253/circj.67.1053. [PMID: 14639023] - M Pilar Oubiña, Natalia de las Heras, Eva Cediel, David Sanz-Rosa, Paloma Aragoncillo, Cristina Díaz, Gonzalo Hernández, Vicente Lahera, Victoria Cachofeiro. Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits.
Clinical science (London, England : 1979).
2003 Dec; 105(6):655-62. doi:
10.1042/cs20030127. [PMID: 12848617] - Monica Rupérez, Marta Ruiz-Ortega, Vanesa Esteban, Oscar Lorenzo, Sergio Mezzano, Juan Jose Plaza, Jesús Egido. Angiotensin II increases connective tissue growth factor in the kidney.
The American journal of pathology.
2003 Nov; 163(5):1937-47. doi:
10.1016/s0002-9440(10)63552-3. [PMID: 14578193] - F A H Fonseca, S S M Ihara, M C O Izar, E P Silva, N Kasinski, I E L Lopes, L E S A Pinto, T B Paiva, S Tufik, A A V de Paola, A C C Carvalho. Hydrochlorothiazide abolishes the anti-atherosclerotic effect of quinapril.
Clinical and experimental pharmacology & physiology.
2003 Oct; 30(10):779-85. doi:
10.1046/j.1440-1681.2003.03911.x. [PMID: 14516418] - Paresh Dandona, Vikramjeet Kumar, Ahmad Aljada, Husam Ghanim, Tufail Syed, Debborah Hofmayer, Priya Mohanty, Devjit Tripathy, Rajesh Garg. Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action.
The Journal of clinical endocrinology and metabolism.
2003 Sep; 88(9):4496-501. doi:
10.1210/jc.2002-021836. [PMID: 12970329] - Mikko Puhakka, Jarkko Magga, Seppo Hietakorpi, Ilkka Penttilä, Paavo Uusimaa, Juha Risteli, Keijo Peuhkurinen. Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation.
Journal of cardiac failure.
2003 Aug; 9(4):325-32. doi:
10.1054/jcaf.2003.38. [PMID: 13680554] - Richard J Gryglewski, Józef Swies, Wojciech Uracz, Stefan Chłopicki, Ewa Marcinkiewicz. Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats.
Thrombosis research.
2003 Jun; 110(5-6):323-9. doi:
10.1016/j.thromres.2003.08.005. [PMID: 14592556] - José L Pérez-Castrillón, Jesús Silva, Isabel Justo, Alberto Sanz, Miguel Martín-Luquero, Rosa Igea, Pilar Escudero, Carol Pueyo, Cristina Díaz, Gonzalo Hernández, Antonio Dueñas. Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms.
American journal of hypertension.
2003 Jun; 16(6):453-9. doi:
10.1016/s0895-7061(03)00845-8. [PMID: 12799093] - Marek Rajzer, Marek Klocek, Kalina Kawecka-Jaszcz. Effect of amlodipine, quinapril, and losartan on pulse wave velocity and plasma collagen markers in patients with mild-to-moderate arterial hypertension.
American journal of hypertension.
2003 Jun; 16(6):439-44. doi:
10.1016/s0895-7061(03)00052-9. [PMID: 12799091] - Shigeki Yamada, Isao Muraoka, Kana Kato, Yoko Hiromi, Rie Takasu, Hachiro Seno, Hirohisa Kawahara, Toshitaka Nabeshima. Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis.
Biological & pharmaceutical bulletin.
2003 Jun; 26(6):872-5. doi:
10.1248/bpb.26.872. [PMID: 12808303] - Barbara Suwelack, Viola Kobelt, Matthias Erfmann, Martin Hausberg, Ulf Gerhardt, Karl-Heinz Rahn, Helge Hohage. Long-term follow-up of ACE-inhibitor versus beta-blocker treatment and their effects on blood pressure and kidney function in renal transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation.
2003 May; 16(5):313-20. doi:
10.1007/s00147-002-0514-x. [PMID: 12759722] - Peter Paul van Geel, Hendrik Buikema, Jean-Lucien Rouleau, Wiek H van Gilst. Genotype-dependent increase in plasma ACE activity after CABG is prevented by ACE inhibition.
The Canadian journal of cardiology.
2003 May; 19(6):701-4. doi:
NULL. [PMID: 12774785] - Maristela Lika Onozato, Akihiro Tojo, Atsuo Goto, Toshiro Fujita. Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy.
Diabetes research and clinical practice.
2003 Feb; 59(2):83-92. doi:
10.1016/s0168-8227(02)00154-7. [PMID: 12560157] - Jeffrey L Blumer, Stephen R Daniels, William J Dreyer, Donald Batisky, Philip D Walson, Doina Roman, Daniele Ouellet. Pharmacokinetics of quinapril in children: assessment during substitution for chronic angiotensin-converting enzyme inhibitor treatment.
Journal of clinical pharmacology.
2003 Feb; 43(2):128-32. doi:
10.1177/0091270002239820. [PMID: 12616664] - Christa Thöne-Reineke, Jan Olivier, Michael Godes, Rüdiger Zart, Ines George, Christian Bauer, Hans-Helmut Neumayer, Berthold Hocher. Effects of angiotensin-converting enzyme inhibition and calcium channel blockade on cardiac apoptosis in rats with 2K1C (two-kidney/one-clip) renovascular hypertension.
Clinical science (London, England : 1979).
2003 Jan; 104(1):79-85. doi:
NULL. [PMID: 12519090] - A Torsello, V Locatelli, S G Cella, A M Sanguini, F Berti. Moexipril and quinapril inhibition of tissue angiotensin-converting enzyme activity in the rat: evidence for direct effects in heart, lung and kidney and stimulation of prostacyclin generation.
Journal of endocrinological investigation.
2003 Jan; 26(1):79-83. doi:
10.1007/bf03345127. [PMID: 12602539] - Tokihiko Sawada, Yasuo Ishii, Tamotsu Tojimbara, Ichiro Nakajima, Shohei Fuchinoue, Satoshi Teraoka. The ACE inhibitor, quinapril, ameliorates peritoneal fibrosis in an encapsulating peritoneal sclerosis model in mice.
Pharmacological research.
2002 Dec; 46(6):505-10. doi:
10.1016/s1043661802002281. [PMID: 12457623] - Marta Ruiz-Ortega, Mónica Ruperez, Oscar Lorenzo, Vanesa Esteban, Julia Blanco, Sergio Mezzano, Jesus Egido. Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney.
Kidney international. Supplement.
2002 Dec; ?(82):S12-22. doi:
10.1046/j.1523-1755.62.s82.4.x. [PMID: 12410849] - Sandra Blanco, Rosa Penin, Irma Casas, Dolores López, Ramón Romero. Effects of antihypertensive drugs in experimental type 2 diabetes-related nephropathy.
Kidney international. Supplement.
2002 Dec; ?(82):S27-31. doi:
10.1046/j.1523-1755.62.s82.6.x. [PMID: 12410851] - Tomoyuki Okuguchi, Tomohiro Osanai, Naoto Fujiwara, Takeshi Kato, Norifumi Metoki, Yoshiyuki Konta, Ken Okumura. Effect of losartan on nocturnal blood pressure in patients with stroke: comparison with angiotensin converting enzyme inhibitor.
American journal of hypertension.
2002 Nov; 15(11):998-1002. doi:
10.1016/s0895-7061(02)02998-9. [PMID: 12441222] - Z Hlubocká, V Umnerová, S Heller, J Peleska, A Jindra, M Jáchymová, J Kvasnicka, M Aschermann, K Horký. [Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy].
Vnitrni lekarstvi.
2002 Aug; 48(8):718-23. doi:
. [PMID: 12425201] - Christiane Barthelemy, Joelle Eurin, Philippe Lechat, Francoise Masson, Micheline Cortines, Nathalie Mougenot, Hayet Soualmia, Alain Carayon. The mechanism of the angiotensin-converting enzyme inhibitor quinapril is not related to bradykinin level in heart tissue.
Peptides.
2002 Jun; 23(6):1161-9. doi:
10.1016/s0196-9781(02)00050-5. [PMID: 12126746] - Takanori Uchida, Kenji Okumura, Takayuki Ito, Hiroki Kamiya, Yasuhiro Nishimoto, Michiharu Yamada, Takahito Tomida, Hideo Matsui, Tetsuo Hayakawa. Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats.
Clinical and experimental pharmacology & physiology.
2002 May; 29(5-6):381-5. doi:
10.1046/j.1440-1681.2002.03668.x. [PMID: 12010179] - Berthold Hocher, Michael Godes, Jan Olivier, Joachim Weil, Thomas Eschenhagen, Torsten Slowinski, Hans-H Neumayer, Christian Bauer, Martin Paul, Yigal M Pinto. Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension.
Journal of hypertension.
2002 Apr; 20(4):745-51. doi:
10.1097/00004872-200204000-00034. [PMID: 11910312] - Kazuyuki Sakata, Roberts Pawlak, Tetumei Urano, Akikazu Takada. Effects of a long-term pharmacological interruption of the renin-angiotensin system on the fibrinolytic system in essential hypertension.
Pathophysiology of haemostasis and thrombosis.
2002 Mar; 32(2):67-75. doi:
10.1159/000065078. [PMID: 12214151] - Ch Abbara, G Aymard, S Hinh, B Diquet. Simultaneous determination of quinapril and its active metabolite quinaprilat in human plasma using high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Jan; 766(2):199-207. doi:
10.1016/s0378-4347(01)00474-1. [PMID: 11824807] - Maristela Lika Onozato, Akihiro Tojo, Atsuo Goto, Toshiro Fujita, Christopher S Wilcox. Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
Kidney international.
2002 Jan; 61(1):186-94. doi:
10.1046/j.1523-1755.2002.00123.x. [PMID: 11786100] - José Angel Prieto, Rosa María Alonso, Rosa María Jiménez. Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction.
Electrophoresis.
2002 Jan; 23(1):102-9. doi:
10.1002/1522-2683(200201)23:1<102::aid-elps102>3.0.co;2-c. [PMID: 11824610] - Christine R Culy, Blair Jarvis. Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders.
Drugs.
2002; 62(2):339-85. doi:
10.2165/00003495-200262020-00009. [PMID: 11817979] - F H Leenen, R White, B Yuan. Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system.
American journal of physiology. Heart and circulatory physiology.
2001 Dec; 281(6):H2410-6. doi:
10.1152/ajpheart.2001.281.6.h2410. [PMID: 11709406]