CCCP (BioDeep_00000015021)
Main id: BioDeep_00000008524
Volatile Flavor Compounds
代谢物信息卡片
Carbonyl cyanide m-chlorophenyl hydrazone
化学式: C9H5ClN4 (204.020272)
中文名称: 羰基氰酯-3-氯苯基腙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)Cl)NN=C(C#N)C#N
InChI: InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H
描述信息
D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents
D007476 - Ionophores > D061209 - Proton Ionophores
D049990 - Membrane Transport Modulators
CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:3259
- KEGG: C11164
- KEGG: C75608
- PubChem: 2603
- ChEMBL: CHEMBL224214
- MeSH: Carbonyl Cyanide m-Chlorophenyl Hydrazone
- CAS: 555-60-2
- PubChem: 13346
- NIKKAJI: J13.752I
- RefMet: CCCP
- medchemexpress: HY-100941
- KNApSAcK: 3259
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Leidy Patricia Bedoya-Pérez, Alejandro Aguilar-Vera, Mishael Sánchez-Pérez, José Utrilla, Christian Sohlenkamp. Enhancing Escherichia coli abiotic stress resistance through ornithine lipid formation.
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Journal of natural products.
2022 06; 85(6):1459-1473. doi:
10.1021/acs.jnatprod.1c01107. [PMID: 35621995] - Ganjoo Mahalaxmi, Sivasailam Ashok, Gangadharan Arun, Gopala Srinivas. Albumin binds to uncoupler CCCP to diminish depolarization of mitochondria.
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2022 Apr; 80(?):105325. doi:
10.1016/j.tiv.2022.105325. [PMID: 35121064] - Michael J Munson, Benan J Mathai, Matthew Yoke Wui Ng, Laura Trachsel-Moncho, Laura R de la Ballina, Anne Simonsen. GAK and PRKCD kinases regulate basal mitophagy.
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2015 Jun; 362(12):fnv082. doi:
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Plant signaling & behavior.
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Journal of experimental botany.
2014 Jun; 65(9):2287-94. doi:
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Journal of natural products.
2011 Jul; 74(7):1621-9. doi:
10.1021/np200336g. [PMID: 21661731] - João P Monteiro, André F Martins, Marlene Lúcio, Salette Reis, Carlos F G C Geraldes, Paulo J Oliveira, Amália S Jurado. Interaction of carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) with lipid membrane systems: a biophysical approach with relevance to mitochondrial uncoupling.
Journal of bioenergetics and biomembranes.
2011 Jun; 43(3):287-98. doi:
10.1007/s10863-011-9359-2. [PMID: 21607731] - G V Danylovich, Iu V Danylovich, V F Gorchev. [Comparative investigation by spectrofluorimetry and flow cytometry of plasma and inner mitochondrial membranes polarisation in smooth muscle cell using potential-sensitive probe DiOC6(3)].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2011 May; 83(3):99-105. doi:
NULL. [PMID: 21888060] - Lesław B Lahuta, Tomasz Dzik. D-chiro-inositol affects accumulation of raffinose family oligosaccharides in developing embryos of Pisum sativum.
Journal of plant physiology.
2011 Mar; 168(4):352-8. doi:
10.1016/j.jplph.2010.07.027. [PMID: 20947202] - Emily Peterson, Ted Ryser, Spencer Funk, Daniel Inouye, Mukesh Sharma, Huajun Qin, Timothy A Cross, David D Busath. Functional reconstitution of influenza A M2(22-62).
Biochimica et biophysica acta.
2011 Feb; 1808(2):516-21. doi:
10.1016/j.bbamem.2010.10.010. [PMID: 20969830] - Jing Jin, Jiyu Zhang, Na Guo, Haihua Feng, Lei Li, Junchao Liang, Kai Sun, Xiuping Wu, Xuelin Wang, Mingyuan Liu, Xuming Deng, Lu Yu. The plant alkaloid piperine as a potential inhibitor of ethidium bromide efflux in Mycobacterium smegmatis.
Journal of medical microbiology.
2011 Feb; 60(Pt 2):223-229. doi:
10.1099/jmm.0.025734-0. [PMID: 21051548] - Yoko Komori, Megumi Tanaka, Motoko Kuba, Masahiro Ishii, Maiko Abe, Naoki Kitamura, Alexei Verkhratsky, Izumi Shibuya, Govindan Dayanithi. Ca(2+) homeostasis, Ca(2+) signalling and somatodendritic vasopressin release in adult rat supraoptic nucleus neurones.
Cell calcium.
2010 Dec; 48(6):324-32. doi:
10.1016/j.ceca.2010.10.002. [PMID: 21047683] - Antonio Peña, Norma Silvia Sánchez, Martha Calahorra. Estimation of the electric plasma membrane potential difference in yeast with fluorescent dyes: comparative study of methods.
Journal of bioenergetics and biomembranes.
2010 Oct; 42(5):419-32. doi:
10.1007/s10863-010-9311-x. [PMID: 21063758] - Kairo Wakamatsu, Masaru Fujimoto, Mikio Nakazono, Shin-ichi Arimura, Nobuhiro Tsutsumi. Fusion of mitochondria in tobacco suspension cultured cells is dependent on the cellular ATP level but not on actin polymerization.
Plant cell reports.
2010 Oct; 29(10):1139-45. doi:
10.1007/s00299-010-0897-6. [PMID: 20632008] - Craig C Beeson, Gyda C Beeson, Rick G Schnellmann. A high-throughput respirometric assay for mitochondrial biogenesis and toxicity.
Analytical biochemistry.
2010 Sep; 404(1):75-81. doi:
10.1016/j.ab.2010.04.040. [PMID: 20465991] - O O Polygalova, A A Ponomareva. [Protonophores as inducers of energy dependent changes in the ultrastructure of wheat root cells mitochondria].
Tsitologiia.
2010; 52(3):211-8. doi:
NULL. [PMID: 20429298] - Cho S Aung, Weilan Ye, Greg Plowman, Amelia A Peters, Gregory R Monteith, Sarah J Roberts-Thomson. Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells.
Carcinogenesis.
2009 Nov; 30(11):1962-9. doi:
10.1093/carcin/bgp223. [PMID: 19755660] - Ching-Hsein Chen, Shu-Jem Su, Kee-Lung Chang, Mei-Wen Huang, Soong-Yu Kuo. The garlic ingredient diallyl sulfide induces Ca(2+) mobilization in Madin-Darby canine kidney cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Sep; 47(9):2344-50. doi:
10.1016/j.fct.2009.06.028. [PMID: 19555733] - I C Karapanos, K A Akoumianakis, C M Olympios, H C Passam. The effect of substrate, ADP and uncoupler on the respiration of tomato pollen during incubation in vitro at moderately high temperature.
Sexual plant reproduction.
2009 Sep; 22(3):133-40. doi:
10.1007/s00497-009-0098-z. [PMID: 20033434] - Vandana Kalia, Rajni Miglani, Kedar P Purnapatre, Tarun Mathur, Smita Singhal, Seema Khan, Sreedhara R Voleti, Dilip J Upadhyay, Kulvinder Singh Saini, Ashok Rattan, V Samuel Raj. Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
Antimicrobial agents and chemotherapy.
2009 Apr; 53(4):1427-33. doi:
10.1128/aac.00887-08. [PMID: 19075051] - Tomás Hendrych, Marie Kodedová, Karel Sigler, Dana Gásková. Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p.
Biochimica et biophysica acta.
2009 Mar; 1788(3):717-23. doi:
10.1016/j.bbamem.2008.12.001. [PMID: 19111673] - Uwe Winkler, Gerhard Zotz. Highly efficient uptake of phosphorus in epiphytic bromeliads.
Annals of botany.
2009 Feb; 103(3):477-84. doi:
10.1093/aob/mcn231. [PMID: 19033287] - Bimal Jana, Subrata Panja, Swati Saha, Tarakdas Basu. Mechanism of protonophores-mediated induction of heat-shock response in Escherichia coli.
BMC microbiology.
2009 Jan; 9(?):20. doi:
10.1186/1471-2180-9-20. [PMID: 19178705] - F Ardón, E Rodríguez-Miranda, C Beltrán, A Hernández-Cruz, A Darszon. Mitochondrial inhibitors activate influx of external Ca(2+) in sea urchin sperm.
Biochimica et biophysica acta.
2009 Jan; 1787(1):15-24. doi:
10.1016/j.bbabio.2008.10.003. [PMID: 19000650] - Jian Liu, Mahamud Subir, Kim Nguyen, Kenneth B Eisenthal. Second harmonic studies of ions crossing liposome membranes in real time.
The journal of physical chemistry. B.
2008 Dec; 112(48):15263-6. doi:
10.1021/jp806690z. [PMID: 18989915] - Alexander G Volkov, Tejumade Adesina, Emil Jovanov. Charge induced closing of Dionaea muscipula Ellis trap.
Bioelectrochemistry (Amsterdam, Netherlands).
2008 Nov; 74(1):16-21. doi:
10.1016/j.bioelechem.2008.02.004. [PMID: 18400564] - Erin M Baggaley, Austin C Elliott, Jason I E Bruce. Oxidant-induced inhibition of the plasma membrane Ca2+-ATPase in pancreatic acinar cells: role of the mitochondria.
American journal of physiology. Cell physiology.
2008 Nov; 295(5):C1247-60. doi:
10.1152/ajpcell.00083.2008. [PMID: 18787078] - Gerard P Sergeant, Eamonn Bradley, Keith D Thornbury, Noel G McHale, Mark A Hollywood. Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra.
The Journal of physiology.
2008 Oct; 586(19):4631-42. doi:
10.1113/jphysiol.2008.159194. [PMID: 18703577] - M L Torres, F Ortega, I Cuaranta, J González, S Sanchez-Armass. Anionic selectivity sequence of the Cl(-)-H+ symporter in the synaptosomal preparation from rat brain cortex.
Neurochemical research.
2008 Aug; 33(8):1574-81. doi:
10.1007/s11064-008-9685-x. [PMID: 18404376] - Renata A Zvyagilskaya, Fredrik Lundh, Dieter Samyn, Johanna Pattison-Granberg, Jean-Marie Mouillon, Yulia Popova, Johan M Thevelein, Bengt L Persson. Characterization of the Pho89 phosphate transporter by functional hyperexpression in Saccharomyces cerevisiae.
FEMS yeast research.
2008 Aug; 8(5):685-96. doi:
10.1111/j.1567-1364.2008.00408.x. [PMID: 18625026] - Adam J Koppers, Geoffry N De Iuliis, Jane M Finnie, Eileen A McLaughlin, R John Aitken. Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa.
The Journal of clinical endocrinology and metabolism.
2008 Aug; 93(8):3199-207. doi:
10.1210/jc.2007-2616. [PMID: 18492763] - Li Huang, Marta C Yappert, Marcia M Jumblatt, Douglas Borchman. Hyperoxia and thyroxine treatment and the relationships between reactive oxygen species generation, mitochondrial membrane potential, and cardiolipin in human lens epithelial cell cultures.
Current eye research.
2008 Jul; 33(7):575-86. doi:
10.1080/02713680802167554. [PMID: 18600490] - Nelson B Cole, Diane Dieuliis, Paul Leo, Drake C Mitchell, Robert L Nussbaum. Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Experimental cell research.
2008 Jun; 314(10):2076-89. doi:
10.1016/j.yexcr.2008.03.012. [PMID: 18440504] - José V Montoya G, Jhon-Jairo Sutachan, Alexandra Corrales, Fang Xu, Thomas J J Blanck, Esperanza Recio-Pinto. Pulses of extracellular K+ produce two cytosolic Ca2+ transients that display different temperature dependence and carbonyl cyanide m-chlorophenyl sensitivity in SH-SY5Y cells.
Brain research.
2008 Jun; 1213(?):12-26. doi:
10.1016/j.brainres.2008.03.022. [PMID: 18448083] - Michele B P Pereira, Renata Tisi, Luciano G Fietto, Anamaria S Cardoso, Mônica M França, Fernanda M Carvalho, Maria José M Trópia, Enzo Martegani, Ieso M Castro, Rogelio L Brandão. Carbonyl cyanide m-chlorophenylhydrazone induced calcium signaling and activation of plasma membrane H(+)-ATPase in the yeast Saccharomyces cerevisiae.
FEMS yeast research.
2008 Jun; 8(4):622-30. doi:
10.1111/j.1567-1364.2008.00380.x. [PMID: 18399987] - Daisei Ueno, Takashi Iwashita, Fang-Jie Zhao, Jian Feng Ma. Characterization of Cd translocation and identification of the Cd form in xylem sap of the Cd-hyperaccumulator Arabidopsis halleri.
Plant & cell physiology.
2008 Apr; 49(4):540-8. doi:
10.1093/pcp/pcn026. [PMID: 18281325] - Eugene G Rikhvanov, Kim Z Gamburg, Nina N Varakina, Tatyana M Rusaleva, Irina V Fedoseeva, Elena L Tauson, Irina V Stupnikova, Alexey V Stepanov, Genadii B Borovskii, Victor K Voinikov. Nuclear-mitochondrial cross-talk during heat shock in Arabidopsis cell culture.
The Plant journal : for cell and molecular biology.
2007 Nov; 52(4):763-78. doi:
10.1111/j.1365-313x.2007.03275.x. [PMID: 17883376] - S D Cox, J L Markham. Susceptibility and intrinsic tolerance of Pseudomonas aeruginosa to selected plant volatile compounds.
Journal of applied microbiology.
2007 Oct; 103(4):930-6. doi:
10.1111/j.1365-2672.2007.03353.x. [PMID: 17897196] - Michael R Thorpe, Abigail P Ferrieri, Matthias M Herth, Richard A Ferrieri. 11C-imaging: methyl jasmonate moves in both phloem and xylem, promotes transport of jasmonate, and of photoassimilate even after proton transport is decoupled.
Planta.
2007 Jul; 226(2):541-51. doi:
10.1007/s00425-007-0503-5. [PMID: 17356850] - Haley C Stevens, J Wylie Nichols. The proton electrochemical gradient across the plasma membrane of yeast is necessary for phospholipid flip.
The Journal of biological chemistry.
2007 Jun; 282(24):17563-7. doi:
10.1074/jbc.m700454200. [PMID: 17452326] - Kanjana Wiangnon, Wuttinun Raksajit, Aran Incharoensakdi. Presence of a Na+-stimulated P-type ATPase in the plasma membrane of the alkaliphilic halotolerant cyanobacterium Aphanothece halophytica.
FEMS microbiology letters.
2007 May; 270(1):139-45. doi:
10.1111/j.1574-6968.2007.00667.x. [PMID: 17302934] - Catherine A Brissette, Sheila A Lukehart. Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola.
Infection and immunity.
2007 May; 75(5):2307-15. doi:
10.1128/iai.01718-06. [PMID: 17325047] - Tony D Gover, Thaís H V Moreira, Joseph P Y Kao, Daniel Weinreich. Calcium regulation in individual peripheral sensory nerve terminals of the rat.
The Journal of physiology.
2007 Jan; 578(Pt 2):481-90. doi:
10.1113/jphysiol.2006.119008. [PMID: 17095566] - Subrata Panja, Swati Saha, Bimal Jana, Tarakdas Basu. Role of membrane potential on artificial transformation of E. coli with plasmid DNA.
Journal of biotechnology.
2006 Dec; 127(1):14-20. doi:
10.1016/j.jbiotec.2006.06.008. [PMID: 16876281]