Benzhydramine HCl (BioDeep_00000015020)
Volatile Flavor Compounds
代谢物信息卡片
Diphenhydramine Hydrochloride
化学式: C17H21NO.HCl (291.13898320000004)
中文名称: 盐酸苯海拉明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D018926 - Anti-Allergic Agents
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:4637
- KEGG: C07784
- KEGGdrug: D00669
- PubChem: 8980
- ChEMBL: CHEMBL1620
- MeSH: Diphenhydramine
- CAS: 1219795-16-0
- CAS: 8052-21-9
- CAS: 147-24-0
- PubChem: 9986
- medchemexpress: HY-B0303A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dongqi Zhou, Ting Zhou, Shiyun Tang, Qing Li, Wen Li, Gaofeng Gan, Mingqiao Li, Qiu Chen. Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy.
Frontiers in endocrinology.
2024; 15(?):1354950. doi:
10.3389/fendo.2024.1354950. [PMID: 38332893] - Angela Barreto, Joana Santos, Lara Almeida, Vítor Tavares, Edgar Pinto, Maria Celeiro, Carmen Garcia-Jares, Vera L Maria. First approach to assess the effects of nanoplastics on the soil species Folsomia candida: A mixture design with bisphenol A and diphenhydramine.
NanoImpact.
2023 01; 29(?):100450. doi:
10.1016/j.impact.2023.100450. [PMID: 36610661] - Tuyen Van Nguyen, Adam Bořík, Josef Velíšek, Antonín Kouba, Vladimír Žlábek, Anna Koubová. Integrated biomarker response in signal crayfish Pacifastacus leniusculus exposed to diphenhydramine.
Chemosphere.
2022 Dec; 308(Pt 2):136382. doi:
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Clinical toxicology (Philadelphia, Pa.).
2022 08; 60(8):993-994. doi:
10.1080/15563650.2022.2066543. [PMID: 35475765] - Ju-Tae Sohn. Comment on 'Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports'.
Clinical toxicology (Philadelphia, Pa.).
2022 08; 60(8):992-993. doi:
10.1080/15563650.2022.2057324. [PMID: 35343867] - Sigal Klainbart, Meital Grabarnik, Efrat Kelmer, Orit Chai, Olga Cuneah, Gilad Segev, Itamar Aroch. Clinical manifestations, laboratory findings, treatment and outcome of acute organophosphate or carbamate intoxication in 39 cats.
The Veterinary record.
2022 07; 191(1):e1633. doi:
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Journal of chromatographic science.
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Environment international.
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2022 May; 60(5):550-558. doi:
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Journal of veterinary pharmacology and therapeutics.
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PloS one.
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Brain research.
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Luminescence : the journal of biological and chemical luminescence.
2021 May; 36(3):733-741. doi:
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American journal of therapeutics.
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The Journal of biological chemistry.
2021 Jan; 296(?):100216. doi:
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International journal of biological macromolecules.
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Veterinary dermatology.
2020 Aug; 31(4):256-e58. doi:
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Complementary therapies in medicine.
2020 May; 50(?):102401. doi:
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Molecular pharmacology.
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Analytical chemistry.
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International journal of pharmaceutics.
2019 May; 563(?):406-412. doi:
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The American journal of case reports.
2019 May; 20(?):758-763. doi:
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Veterinary dermatology.
2019 Apr; 30(2):91-e24. doi:
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Life sciences.
2019 Feb; 219(?):190-198. doi:
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PloS one.
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Molecular pharmaceutics.
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Journal of pharmaceutical and biomedical analysis.
2018 Jul; 156(?):263-271. doi:
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Chemosphere.
2018 Jul; 202(?):460-466. doi:
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Analytical chemistry.
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Clinical pharmacology in drug development.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):652-655. doi:
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Journal of the Formosan Medical Association = Taiwan yi zhi.
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Chemical & pharmaceutical bulletin.
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The AAPS journal.
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Xenobiotica; the fate of foreign compounds in biological systems.
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2014 May; 103(5):1557-62. doi:
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Pediatric emergency care.
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2013 Jul; 51(6):493-6. doi:
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Journal of pharmaceutical and biomedical analysis.
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The Journal of investigative dermatology.
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Environmental toxicology and chemistry.
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Clinical toxicology (Philadelphia, Pa.).
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Pharmaceutical biology.
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Methods and findings in experimental and clinical pharmacology.
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Molecular and cellular biochemistry.
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