Methacholine chloride (BioDeep_00000015018)
代谢物信息卡片
Methacholine (chloride)
化学式: C8H18ClNO2 (195.1025998)
中文名称: 氯化乙酰甲胆碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C[N+](C)(C)C)OC(=O)C.[Cl-]
InChI: /p-1
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
D019141 - Respiratory System Agents > D016085 - Bronchoconstrictor Agents
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:50142
- KEGG: C75939
- KEGGdrug: D04970
- PubChem: 6114
- ChEMBL: CHEMBL1200764
- MeSH: Methacholine Chloride
- CAS: 62-51-1
- medchemexpress: HY-A0083
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yan-Jiao Chen, Yu Yuan, Lu Peng, Xin-Yi Dong, Yu-Dong Xu, Yu Wang, Yong-Qing Yang. Effects of increasing sensitizing doses of ovalbumin on airway hyperresponsiveness in asthmatic mice.
Immunity, inflammation and disease.
2024 Mar; 12(3):e1225. doi:
10.1002/iid3.1225. [PMID: 38533918] - . [Standard technical specifications for methacholine chloride (Methacholine) bronchial challenge test (2023)].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2024 Feb; 47(2):101-119. doi:
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Life sciences.
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Journal of applied physiology (Bethesda, Md. : 1985).
2015 May; 118(10):1229-33. doi:
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Medicine and science in sports and exercise.
2015 May; 47(5):914-20. doi:
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Phytotherapy research : PTR.
2015 May; 29(5):730-6. doi:
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Pflugers Archiv : European journal of physiology.
2015 Apr; 467(4):817-31. doi:
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Lung.
2015 Feb; 193(1):39-45. doi:
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International archives of allergy and immunology.
2015; 166(2):107-13. doi:
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The Journal of allergy and clinical immunology.
2014 Dec; 134(6):1446-1448.e5. doi:
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American journal of physiology. Lung cellular and molecular physiology.
2014 Dec; 307(11):L859-67. doi:
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Journal of ethnopharmacology.
2014 Oct; 156(?):301-8. doi:
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The Journal of allergy and clinical immunology.
2014 Aug; 134(2):306-13. doi:
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American journal of physiology. Lung cellular and molecular physiology.
2014 Jul; 307(2):L141-8. doi:
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The Journal of allergy and clinical immunology.
2014 Jul; 134(1):63-72. doi:
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Clinics (Sao Paulo, Brazil).
2014 Jul; 69(7):491-6. doi:
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BMC pulmonary medicine.
2014 Jul; 14(?):108. doi:
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Particle and fibre toxicology.
2014 Apr; 11(?):15. doi:
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Human & experimental toxicology.
2014 Mar; 33(3):325-33. doi:
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Pharmacological reports : PR.
2014 Feb; 66(1):56-61. doi:
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American journal of physiology. Endocrinology and metabolism.
2014 Jan; 306(2):E168-76. doi:
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PloS one.
2014; 9(3):e92163. doi:
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Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2013 Nov; 111(5):376-381.e1. doi:
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Transfusion.
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Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2013 Oct; 111(4):286-9. doi:
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Biological trace element research.
2013 Sep; 154(3):363-71. doi:
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Pulmonary pharmacology & therapeutics.
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The clinical respiratory journal.
2013 Jul; 7(3):268-75. doi:
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Journal of ethnopharmacology.
2013 May; 147(2):530-5. doi:
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The Journal of asthma : official journal of the Association for the Care of Asthma.
2013 May; 50(4):342-6. doi:
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The Journal of asthma : official journal of the Association for the Care of Asthma.
2013 May; 50(4):327-33. doi:
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Immunology.
2013 Apr; 138(4):361-9. doi:
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American journal of respiratory cell and molecular biology.
2013 Feb; 48(2):157-63. doi:
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Experimental biology and medicine (Maywood, N.J.).
2013 Feb; 238(2):200-8. doi:
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International immunopharmacology.
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PloS one.
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Cytokine.
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PloS one.
2013; 8(9):e75059. doi:
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Ecotoxicology and environmental safety.
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American journal of physiology. Lung cellular and molecular physiology.
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The Journal of asthma : official journal of the Association for the Care of Asthma.
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
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American journal of respiratory cell and molecular biology.
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