Ertapenem (BioDeep_00000015005)
Secondary id: BioDeep_00000033218
代谢物信息卡片
(4R,5S,6S)-3-{[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
化学式: C22H25N3O7S (475.141314)
中文名称: 厄他培南
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)NC4=CC=CC(=C4)C(=O)O)C(=O)O)C(C)O
InChI: InChI=1S/C22H25N3O7S/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32)/t9-,10-,13+,14+,15-,16-/m1/s1
描述信息
Meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DH - Carbapenems
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:404903
- KEGG: C90412
- KEGGdrug: D07908
- PubChem: 150610
- Metlin: METLIN85358
- DrugBank: DB00303
- ChEMBL: CHEMBL1359
- MeSH: Ertapenem
- CAS: 153832-46-3
- MetaboLights: MTBLC404903
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Baher I Salman, Roshdy E Saraya. Bio-analytically fluorimetric method for estimation of ertapenem in real human plasma and commercial samples; application to pharmacokinetics study.
Luminescence : the journal of biological and chemical luminescence.
2022 May; 37(5):796-802. doi:
10.1002/bio.4223. [PMID: 35274447] - George G Zhanel, Marianna Pozdirca, Alyssa R Golden, Courtney K Lawrence, Sheryl Zelenitsky, Liam Berry, Frank Schweizer, Denice Bay, Heather Adam, Michael A Zhanel, Philippe Lagacé-Wiens, Andrew Walkty, Neal Irfan, Kurt Naber, Joseph P Lynch, James A Karlowsky. Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria.
Drugs.
2022 Apr; 82(5):533-557. doi:
10.1007/s40265-022-01688-1. [PMID: 35294769] - Ibrahim H Eissa, Mohamed S Alesawy, Abdulrahman M Saleh, Eslam B Elkaeed, Bshra A Alsfouk, Abdul-Aziz M M El-Attar, Ahmed M Metwaly. Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs.
Molecules (Basel, Switzerland).
2022 Mar; 27(7):. doi:
10.3390/molecules27072287. [PMID: 35408684] - Chongmei Tian, Mengyu Xing, Yaping Zhao, Xueyu Fan, Yongfeng Bai, Liping Fu, Siwei Wang. Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla CTX-M-15 and one rmpA2-associated virulence plasmid.
Frontiers in cellular and infection microbiology.
2022; 12(?):984479. doi:
10.3389/fcimb.2022.984479. [PMID: 36250056] - Ahmed S Fayed, Rania M Youssif, Nahla N Salama, Eman S Elzanfaly, Hassan A M Hendawy. Utility of Silver-nanoparticles for Nano Spectrofluorimetric Determination of Meropenem and Ertapenem: Bio-analytical Validation.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 262(?):120077. doi:
10.1016/j.saa.2021.120077. [PMID: 34175763] - Belén Gutiérrez-Gutiérrez, Elena Pérez-Nadales, Salvador Pérez-Galera, Mario Fernández-Ruiz, Jordi Carratalà, Isabel Oriol, Elisa Cordero, José Antonio Lepe, Ban Hock Tan, Laura Corbella, Mical Paul, Alejandra M Natera, Miruna D David, Miguel Montejo, Ranganathan N Iyer, Ligia Camera Pierrotti, Esperanza Merino, Seema Mehta Steinke, Meenakshi M Rana, Patricia Muñoz, Alessandra Mularoni, Christian van Delden, Paolo Antonio Grossi, Elena María Seminari, Filiz Gunseren, Erika D Lease, Emmanuel Roilides, Jesús Fortún, Hande Arslan, Julien Coussement, Zeliha Koçak Tufan, Benoit Pilmis, Marco Rizzi, Belén Loeches, Britt Marie Eriksson, Edson Abdala, Fabio Soldani, Warren Lowman, Wanessa Trindade Clemente, Marta Bodro, María Carmen Fariñas, Esra Kazak, Luis Martínez-Martínez, José María Aguado, Julián Torre-Cisneros, Álvaro Pascual, Jesús Rodríguez-Baño. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients.
Antimicrobial agents and chemotherapy.
2021 10; 65(11):e0110221. doi:
10.1128/aac.01102-21. [PMID: 34370578] - George P Allen, Kristina M Deao, Stephanie A Hill, Sandra M Schipelliti, Thomas Tran. In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae.
International journal of antimicrobial agents.
2021 Oct; 58(4):106417. doi:
10.1016/j.ijantimicag.2021.106417. [PMID: 34391903] - José Antonio Hernández-Ramos, José Manuel Caro-Telle, Miguel Ángel Bruni-Montero, Dolores Canales-Siguero, José Miguel Ferrari-Piquero. Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention.
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria.
2021 09; 45(6):335-339. doi:
NULL. [PMID: 34806574] - Arzu Nazli Zeka, Vildan Avkan-Oguz, Caglar Irmak, Oya Eren Kutsoylu, Sema Alp Cavus, Ziya Kuruüzüm, M Cem Ergon. Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID-19 pandemic.
International journal of clinical practice.
2021 Jul; 75(7):e14230. doi:
10.1111/ijcp.14230. [PMID: 33864405] - Wasim S El Nekidy, Hazem Elrefaei, Terrence J Lee St John, Nizar M Attallah, Farah Kablaoui, Ahmad Nusair, Bartlomiej Piechowski-Jozwiak, Janise Phillips, Islam M Ghazi. Ertapenem Neurotoxicity in Hemodialysis Patients-Safe and Effective Dosing Is Still Needed: A Retrospective Study and Literature Review.
The Annals of pharmacotherapy.
2021 01; 55(1):52-58. doi:
10.1177/1060028020938059. [PMID: 32618479] - Jayesh A Dhanani, Benjamin Ahern, Liad Lupinsky, Karen Jackson, Steven C Wallis, Mohd H Abdul-Aziz, Jeffrey Lipman, Jason A Roberts. Comparative Plasma Pharmacokinetics of Ceftriaxone and Ertapenem in Normoalbuminemia, Hypoalbuminemia, and Albumin Replacement in a Sheep Model.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.02584-19. [PMID: 32366707] - Rebecca Adams, Priya Chopra, Richard Miranda, Aaron Calderon. Ertapenem-induced encephalopathy.
BMJ case reports.
2020 Jun; 13(6):. doi:
10.1136/bcr-2019-231875. [PMID: 32487528] - Deepjyoti Paul, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee. An insight into analysis and elimination of plasmids encoding metallo-β-lactamases in Pseudomonas aeruginosa.
Journal of global antimicrobial resistance.
2020 06; 21(?):3-7. doi:
10.1016/j.jgar.2019.09.002. [PMID: 31518725] - Xi-Wei Ji, Feng Xue, Zi-Sheng Kang, Wei Zhong, Isabelle Hui-San Kuan, Xi-Ping Yang, Xiao Zhu, Yun Li, Yuan Lv. Model-Informed Drug Development, Pharmacokinetic/Pharmacodynamic Cutoff Value Determination, and Antibacterial Efficacy of Benapenem against Enterobacteriaceae.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01751-19. [PMID: 31844001] - G Chen, L M Chen, X M Li. [The 473rd case: renal failure, abdominal pain, and mental abnormality].
Zhonghua nei ke za zhi.
2020 Jan; 59(1):82-85. doi:
10.3760/cma.j.issn.0578-1426.2020.01.016. [PMID: 31887844] - Maria Loose, Isabell Link, Kurt G Naber, Florian M E Wagenlehner. Carbapenem-Containing Combination Antibiotic Therapy against Carbapenem-Resistant Uropathogenic Enterobacteriaceae.
Antimicrobial agents and chemotherapy.
2019 12; 64(1):. doi:
10.1128/aac.01839-19. [PMID: 31636073] - Lama M Hsaiky, Francine D Salinitri, Judy Wong, Sin-Ling T Jennings, Neha H Desai, Alison M Lobkovich, Raymond Cha. Pharmacokinetics and investigation of optimal dose ertapenem in intermittent hemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 10; 34(10):1766-1772. doi:
10.1093/ndt/gfy166. [PMID: 29992286] - Mohamed I Gadallah, Hassan Refat H Ali, Hassan F Askal, Gamal A Saleh. Poly (bromocresol green) flakes-decorated pencil graphite electrode for selective electrochemical sensing applications and pharmacokinetic studies.
Materials science & engineering. C, Materials for biological applications.
2019 Sep; 102(?):634-645. doi:
10.1016/j.msec.2019.03.071. [PMID: 31147035] - Gemma Sanclemente, Marta Bodro, Carlos Cervera, Laura Linares, Frederic Cofán, Francesc Marco, Jordi Bosch, Federico Oppenheimer, Fritz Dieckmann, Asunción Moreno. Perioperative prophylaxis with ertapenem reduced infections caused by extended-spectrum betalactamase-producting Enterobacteriaceae after kidney transplantation.
BMC nephrology.
2019 07; 20(1):274. doi:
10.1186/s12882-019-1461-4. [PMID: 31331289] - J C Bader, E A Lakota, G E Dale, H S Sader, J H Rex, P G Ambrose, S M Bhavnani. Pharmacokinetic-Pharmacodynamic Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.00318-19. [PMID: 30962339] - Jonathan Chambers, Madhu Page-Sharp, Sam Salman, John Dyer, Timothy M E Davis, Kevin T Batty, Laurens Manning. Ertapenem for osteoarticular infections in obese patients: a pharmacokinetic study of plasma and bone concentrations.
European journal of clinical pharmacology.
2019 Apr; 75(4):511-517. doi:
10.1007/s00228-018-2597-z. [PMID: 30511329] - Ying Jiang, Jun Li, Yingrui Zhang, Xinlan Hu, Xiaoguang Zhang, Xiuling Shang, Shurong Gong, Rongguo Yu. Clinical Situations of Bacteriology and Prognosis in Patients with Urosepsis.
BioMed research international.
2019; 2019(?):3080827. doi:
10.1155/2019/3080827. [PMID: 30881985] - Elizabeth A Lakota, Cornelia B Landersdorfer, Li Zhang, Anne N Nafziger, Joseph S Bertino, Sujata M Bhavnani, Alan Forrest. Population Pharmacokinetic Analyses for Ertapenem in Subjects with a Wide Range of Body Sizes.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.00784-18. [PMID: 30061283] - Jen-Jia Yang, Jann-Tay Wang, Aristine Cheng, Yu-Chung Chuang, Wang-Huei Sheng. Impact of broad-spectrum antimicrobial treatment on the ecology of intestinal flora.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2018 Oct; 51(5):681-687. doi:
10.1016/j.jmii.2016.12.009. [PMID: 28693929] - Varsha Rani Gajamer, Amitabha Bhattacharjee, Deepjyoti Paul, Chandrayee Deshamukhya, Ashish Kr Singh, Nilu Pradhan, Hare Krishna Tiwari. Escherichia coli encoding blaNDM-5 associated with community-acquired urinary tract infections with unusual MIC creep-like phenomenon against imipenem.
Journal of global antimicrobial resistance.
2018 09; 14(?):228-232. doi:
10.1016/j.jgar.2018.05.004. [PMID: 29775789] - Triantafyllos Doulias, Stefanie Quickert, Sebastien Weis, Ralf A Claus, Konstantina Kontopoulou, Evangelos J Giamarellos-Bourboulis, Michael Bauer, Ioannis M Koutelidakis. Low-dose hydrocortisone prolongs survival in a lethal sepsis model in adrenalectomized rats.
The Journal of surgical research.
2018 07; 227(?):72-80. doi:
10.1016/j.jss.2018.02.011. [PMID: 29804866] - M A Zuur, S Ghimire, M S Bolhuis, A M A Wessels, R van Altena, W C M de Lange, J G W Kosterink, D J Touw, T S van der Werf, O W Akkerman, J W C Alffenaar. Pharmacokinetics of 2,000 Milligram Ertapenem in Tuberculosis Patients.
Antimicrobial agents and chemotherapy.
2018 05; 62(5):. doi:
10.1128/aac.02250-17. [PMID: 29439978] - Sylvain Goutelle, Florent Valour, Marie-Claude Gagnieu, Frédéric Laurent, Christian Chidiac, Tristan Ferry. Population pharmacokinetics and probability of target attainment of ertapenem administered by subcutaneous or intravenous route in patients with bone and joint infection.
The Journal of antimicrobial chemotherapy.
2018 04; 73(4):987-994. doi:
10.1093/jac/dkx477. [PMID: 29244077] - Karrera Y Djoko, Maud E S Achard, Minh-Duy Phan, Alvin W Lo, Manfredi Miraula, Sasiprapa Prombhul, Steven J Hancock, Kate M Peters, Hanna E Sidjabat, Patrick N Harris, Nataša Mitić, Timothy R Walsh, Gregory J Anderson, William M Shafer, David L Paterson, Gerhard Schenk, Alastair G McEwan, Mark A Schembri. Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants.
Antimicrobial agents and chemotherapy.
2018 02; 62(2):. doi:
10.1128/aac.02280-17. [PMID: 29133551] - Tomas Almorza, Marina Muñoz-Hernández, Antonio Lalueza. Ertapenem-induced neurological toxicity in a patient with stage IV chronic kidney disease.
Enfermedades infecciosas y microbiologia clinica.
2017 11; 35(9):607-608. doi:
10.1016/j.eimc.2016.12.003. [PMID: 28069335] - Michael Seitz, Christian Stief, Raphaela Waidelich, Markus Bader, Derya Tilki. Transrectal ultrasound guided prostate biopsy in the era of increasing fluoroquinolone resistance: prophylaxis with single-dose ertapenem.
World journal of urology.
2017 Nov; 35(11):1681-1688. doi:
10.1007/s00345-017-2043-3. [PMID: 28470334] - Amel Abderrahim, Nassima Djahmi, Charlotte Pujol, Sabina Nedjai, Mohamed Cherif Bentakouk, Djamila Kirane-Gacemi, Mazouz Dekhil, Albert Sotto, Jean-Philippe Lavigne, Alix Pantel. First Case of NDM-1-Producing Klebsiella pneumoniae in Annaba University Hospital, Algeria.
Microbial drug resistance (Larchmont, N.Y.).
2017 Oct; 23(7):895-900. doi:
10.1089/mdr.2016.0213. [PMID: 28437228] - Rossana Rosa, Susan D Rudin, Laura J Rojas, Armando Perez-Cardona, Laura Aragon, David P Nicolau, Federico Perez, Andrea M Hujer, Akin Tekin, Octavio Martinez, Jose F Camargo, Robert A Bonomo, Lilian M Abbo. Application of 'Precision Medicine' Through the Molecular Characterization of Extensively Drug-Resistant Klebsiella pneumoniae in a Multivisceral Transplant Patient.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2017 08; 65(4):701-702. doi:
10.1093/cid/cix387. [PMID: 29017264] - S P van Rijn, M A Zuur, R van Altena, O W Akkerman, J H Proost, W C M de Lange, H A M Kerstjens, D J Touw, T S van der Werf, J G W Kosterink, J W C Alffenaar. Pharmacokinetic Modeling and Limited Sampling Strategies Based on Healthy Volunteers for Monitoring of Ertapenem in Patients with Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2017 04; 61(4):. doi:
10.1128/aac.01783-16. [PMID: 28137814] - Mathias Wittau, Stephan Paschke, Max Kurlbaum, Jan Scheele, Neang S Ly, Evelyn Hemper, Marko Kornmann, Doris Henne-Bruns, Jürgen B Bulitta. Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery.
Antimicrobial agents and chemotherapy.
2017 01; 61(1):. doi:
10.1128/aac.00952-16. [PMID: 27795367] - James A Karlowsky, Daryl J Hoban, Meredith A Hackel, Sibylle H Lob, Daniel F Sahm. Antimicrobial susceptibility of Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Asia-Pacific countries: SMART 2013-2015.
Journal of medical microbiology.
2017 Jan; 66(1):61-69. doi:
10.1099/jmm.0.000421. [PMID: 28051952] - Murat Dizbay, Hasan Selçuk Özger, Ömer Karaşahin, Emine Fusun Karaşahin. Treatment efficacy and superinfection rates in complicated urinarytract infections treated with ertapenem or piperacillin tazobactam.
Turkish journal of medical sciences.
2016 Dec; 46(6):1760-1764. doi:
10.3906/sag-1506-157. [PMID: 28081324] - Mark A Baker, Elena K Schneider, Johnny X Huang, Matthew A Cooper, Jian Li, Tony Velkov. The Plasma Protein Binding Proteome of Ertapenem: A Novel Compound-Centric Proteomic Approach for Elucidating Drug-Plasma Protein Binding Interactions.
ACS chemical biology.
2016 12; 11(12):3353-3364. doi:
10.1021/acschembio.6b00700. [PMID: 27682196] - S A Zelenitsky, C Lawson, D Calic, R E Ariano, J A Roberts, J Lipman, G G Zhanel. Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery.
The Journal of antimicrobial chemotherapy.
2016 10; 71(10):2902-8. doi:
10.1093/jac/dkw247. [PMID: 27402005] - Chien-Chih Wu, Tsung-Yu Pai, Fei-Yuan Hsiao, Li-Jiuan Shen, Fe-Lin Lin Wu. The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations.
Therapeutic drug monitoring.
2016 10; 38(5):587-92. doi:
10.1097/ftd.0000000000000316. [PMID: 27322166] - Charles Dariane, Alexandre Amin, Olivier Lortholary, Alexandre Lalli, Constance Michel, Thomas Le Guilchet, Jean-Marc Treluyer, Thao Nguyen-Khoa, Claudia De Toma, Saïk Urien, Arnaud Méjean, Philippe Bourget, Marc-Olivier Timsit. Plasma and intraprostatic concentrations of ertapenem following preoperative single dose administration: a single-centre prospective experience and clinical implications-the ERTAPRO study.
International journal of antimicrobial agents.
2016 Aug; 48(2):168-74. doi:
10.1016/j.ijantimicag.2016.04.027. [PMID: 27324263] - Hsiu-Chuan Liu, Yuan-Pin Hung, Hsiao-Ju Lin, Hsiao-Chieh Liu, Jen-Chieh Lee, Yi-Hui Wu, Chia-Wen Li, Ming-Chi Li, Wen-Chien Ko. Antimicrobial susceptibility of clinical Enterobacteriaceae isolates at the emergency department in a regional hospital: A threat of extended spectrum beta-lactamase-producers among nursing home residents.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2016 Aug; 49(4):584-90. doi:
10.1016/j.jmii.2015.10.001. [PMID: 26692184] - Maria Lina Mezzatesta, Carla Caio, Floriana Gona, Tiziana Zingali, Iasmine Salerno, Stefania Stefani. Colistin Increases the Cidal Activity of Antibiotic Combinations Against Multidrug-Resistant Klebsiella pneumoniae: An In Vitro Model Comparing Multiple Combination Bactericidal Testing at One Peak Serum Concentration and Time-Kill Method.
Microbial drug resistance (Larchmont, N.Y.).
2016 Jul; 22(5):360-3. doi:
10.1089/mdr.2015.0160. [PMID: 26909754] - Henry F Chambers, Li Basuino, Stephanie M Hamilton, Eun Ju Choo, Pamela Moise. Daptomycin-β-Lactam Combinations in a Rabbit Model of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Endocarditis.
Antimicrobial agents and chemotherapy.
2016 07; 60(7):3976-9. doi:
10.1128/aac.00589-16. [PMID: 27090173] - Michael P Veve, Jamie L Wagner, Rachel M Kenney, Jenny L Grunwald, Susan L Davis. Comparison of fosfomycin to ertapenem for outpatient or step-down therapy of extended-spectrum β-lactamase urinary tract infections.
International journal of antimicrobial agents.
2016 Jul; 48(1):56-60. doi:
10.1016/j.ijantimicag.2016.04.014. [PMID: 27234673] - Sander P van Rijn, Richard van Altena, Onno W Akkerman, Dick van Soolingen, Tridia van der Laan, Wiel C M de Lange, Jos G W Kosterink, Tjip S van der Werf, Jan-Willem C Alffenaar. Pharmacokinetics of ertapenem in patients with multidrug-resistant tuberculosis.
The European respiratory journal.
2016 Apr; 47(4):1229-34. doi:
10.1183/13993003.01654-2015. [PMID: 26743484] - B A Cunha, J Giuga, S Gerson. Predictors of ertapenem therapeutic efficacy in the treatment of urinary tract infections (UTIs) in hospitalized adults: the importance of renal insufficiency and urinary pH.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2016 Apr; 35(4):673-9. doi:
10.1007/s10096-016-2586-z. [PMID: 26873378] - Venkata Madirrala, Paul Rooney, Richard M Heath, Fiona Campbell, Timothy Andrews, Timothy J Neal, Sreedhar Subramanian. Short article: Successful faecal coliform sensitivity-based oral ertapenem therapy for chronic antibiotic-refractory pouchitis: a case series.
European journal of gastroenterology & hepatology.
2016 Mar; 28(3):277-80. doi:
10.1097/meg.0000000000000549. [PMID: 26657456] - Michele L Joyner, Cammey C Manning, Whitney Forbes, Michelle Maiden, Ariel N Nikas. A physiologically-based pharmacokinetic model for the antibiotic ertapenem.
Mathematical biosciences and engineering : MBE.
2016 Feb; 13(1):119-33. doi:
10.3934/mbe.2016.13.119. [PMID: 26776257] - Alessandra Oliva, Alessia Cipolla, Francesca Gizzi, Alessandra D'Abramo, Marco Favaro, Massimiliano De Angelis, Giancarlo Ferretti, Gianluca Russo, Marco Iannetta, Claudio M Mastroianni, Maria T Mascellino, Vincenzo Vullo. Severe Bloodstream Infection due to KPC-Producer E coli in a Renal Transplant Recipient Treated With the Double-Carbapenem Regimen and Analysis of In Vitro Synergy Testing: A Case Report.
Medicine.
2016 Feb; 95(7):e2243. doi:
10.1097/md.0000000000002243. [PMID: 26886594] - Fatih Yılmaz, Himmet Uslu, Fevzi Ersoy. Ertapenem Associated With Seizures in Treatment of Pyelonephritis in a Chronic Peritoneal Dialysis Patient.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2016 Feb; 20(1):89-90. doi:
10.1111/1744-9987.12334. [PMID: 26710680] - Pallavi Thakur, Raman Chawla, Ankita Singh Chakotiya, Ankit Tanwar, Rajeev Goel, Alka Narula, Rajesh Arora, Rakesh Kumar Sharma. Camellia sinensis Ameliorates the Efficacy of Last Line Antibiotics Against Carbapenem Resistant Escherichia coli.
Phytotherapy research : PTR.
2016 Feb; 30(2):314-22. doi:
10.1002/ptr.5535. [PMID: 26620305] - Ekrem Kara, Osman Zikrullah Sahin, Teslime Ayaz, Safak Yildirim, Tuncay Sahutoglu, Ahmet Tufekci. Ertapenem-induced acute reversible peripheral neuropathy in chronic kidney disease: 3 case reports.
Clinical nephrology.
2015 Dec; 84(6):353-7. doi:
10.5414/cn108652. [PMID: 26558370] - Yinfang Zhu, Shunli Ji, Shaohui Li, Cheng Li, Feifang Zhang, Xinmiao Liang. [Analysis of carbapenems by hydrophilic interaction chromatography and its application].
Se pu = Chinese journal of chromatography.
2015 Sep; 33(9):946-50. doi:
10.3724/sp.j.1123.2015.05005. [PMID: 26753282] - K-H Lee, Y-F Ueng, C-W Wu, Y-C Chou, Y-Y Ng, W-C Yang. The recommended dose of ertapenem poses a potential risk for central nervous system toxicity in haemodialysis patients - case reports and literature reviews.
Journal of clinical pharmacy and therapeutics.
2015 Apr; 40(2):240-4. doi:
10.1111/jcpt.12239. [PMID: 25487647] - Wenlong Zhang, Naisheng Zhang, Wei Wang, Fei Wang, Yue Gong, Haichao Jiang, Zecai Zhang, Xiaofei Liu, Xiaojing Song, Tiancheng Wang, Zhuang Ding, Yongguo Cao. Efficacy of cefepime, ertapenem and norfloxacin against leptospirosis and for the clearance of pathogens in a hamster model.
Microbial pathogenesis.
2014 Dec; 77(?):78-83. doi:
10.1016/j.micpath.2014.11.006. [PMID: 25450882] - Uwe Liebchen, Alexander Kratzer, Sebastian G Wicha, Frieder Kees, Charlotte Kloft, Martin G Kees. Unbound fraction of ertapenem in intensive care unit patients.
The Journal of antimicrobial chemotherapy.
2014 Nov; 69(11):3108-11. doi:
10.1093/jac/dku226. [PMID: 24962030] - Matthew K Pickering, Stacy D Brown. Assays for determination of ertapenem for applications in therapeutic drug monitoring, pharmacokinetics and sample stability.
Biomedical chromatography : BMC.
2014 Nov; 28(11):1525-31. doi:
10.1002/bmc.3301. [PMID: 25088456] - Sheo B Singh, Diane Rindgen, Prudence Bradley, Takao Suzuki, Nengxue Wang, Hao Wu, Basheng Zhang, Li Wang, Chongmin Ji, Hongshi Yu, Richard M Soll, David B Olsen, Peter T Meinke, Deborah A Nicoll-Griffith. Design, synthesis, structure-function relationship, bioconversion, and pharmacokinetic evaluation of ertapenem prodrugs.
Journal of medicinal chemistry.
2014 Oct; 57(20):8421-44. doi:
10.1021/jm500879a. [PMID: 25265501] - Jian Zhou, Zuraidah Sulaiman, Ryan M Llorin, Kim-Hor Hee, Lawrence Soon-U Lee, David C Lye, Dale A Fisher, Vincent H Tam. Pharmacokinetics of ertapenem in outpatients with complicated urinary tract infections.
The Journal of antimicrobial chemotherapy.
2014 Sep; 69(9):2517-21. doi:
10.1093/jac/dku143. [PMID: 24797063] - T Borracci, C Adembri, G Accetta, J Berti, I Cappellini, M Lucchese, A Biggeri, A R De Gaudio, A Novelli. Use of the parenteral antibiotic Ertapenem as short term prophylaxis in bariatric surgery: a pharmaco-kinetic-pharmacodynamic study in class III obese female patients.
Minerva anestesiologica.
2014 Sep; 80(9):1005-11. doi:
NULL. [PMID: 24476845] - Alexander Kratzer, Uwe Liebchen, Michael Schleibinger, Martin G Kees, Frieder Kees. Determination of free vancomycin, ceftriaxone, cefazolin and ertapenem in plasma by ultrafiltration: impact of experimental conditions.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jun; 961(?):97-102. doi:
10.1016/j.jchromb.2014.05.021. [PMID: 24878831] - S P van Rijn, A M A Wessels, B Greijdanus, D J Touw, J W C Alffenaar. Quantification and validation of ertapenem using a liquid chromatography-tandem mass spectrometry method.
Antimicrobial agents and chemotherapy.
2014 Jun; 58(6):3481-4. doi:
10.1128/aac.00025-14. [PMID: 24733468] - Nejc Soštaric, Bojana Beovic, Mojca Maticic. Ertapenem-associated seizures in a patient without prior CNS disorder or severe renal dysfunction.
International journal of clinical pharmacology and therapeutics.
2014 Mar; 52(3):255-8. doi:
10.5414/cp202043. [PMID: 24472405] - Giovanni Losco, Rod Studd, Timothy Blackmore. Ertapenem prophylaxis reduces sepsis after transrectal biopsy of the prostate.
BJU international.
2014 Mar; 113 Suppl 2(?):69-72. doi:
10.1111/bju.12590. [PMID: 24894854] - Whocely Victor de Castro, Sandrine Marchand, Isabelle Lamarche, William Couet. Effect of experimentally induced hypovolemia on ertapenem tissue distribution using microdialysis in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Jan; 51(?):45-50. doi:
10.1016/j.ejps.2013.08.017. [PMID: 23999032] - Rachel F Eyler, A Mary Vilay, Ahmed M Nader, Michael Heung, Melissa Pleva, Kevin M Sowinski, Daryl D DePestel, Fritz Sörgel, Martina Kinzig, Bruce A Mueller. Pharmacokinetics of ertapenem in critically ill patients receiving continuous venovenous hemodialysis or hemodiafiltration.
Antimicrobial agents and chemotherapy.
2014; 58(3):1320-6. doi:
10.1128/aac.02090-12. [PMID: 24323468] - Min-Jie Wen, Chih-Chien Sung, Tom Chau, Shih-Hua Lin. Acute prolonged neurotoxicity associated with recommended doses of ertapenem in 2 patients with advanced renal failure.
Clinical nephrology.
2013 Dec; 80(6):474-8. doi:
10.5414/cn107247. [PMID: 22579271] - C-L Chang, L-H Su, C-M Lu, F-T Tai, Y-C Huang, K-K Chang. Outbreak of ertapenem-resistant Enterobacter cloacae urinary tract infections due to a contaminated ureteroscope.
The Journal of hospital infection.
2013 Oct; 85(2):118-24. doi:
10.1016/j.jhin.2013.06.010. [PMID: 23954065] - Sheo B Singh, Diane Rindgen, Prudence Bradley, Lovji Cama, Wanying Sun, Michael J Hafey, Takao Suzuki, Nengxue Wang, Hao Wu, Basheng Zhang, Li Wang, Chongmin Ji, Hongshi Yu, Richard Soll, David B Olsen, Peter T Meinke, Deborah A Nicoll-Griffith. Design, synthesis, and evaluation of prodrugs of ertapenem.
ACS medicinal chemistry letters.
2013 Aug; 4(8):715-9. doi:
10.1021/ml400092n. [PMID: 24900737] - E Dailly, J F Arnould, F Fraissinet, E Naux, M A Letard de la Bouralière, R Bouquié, G Deslandes, P Jolliet, R Le Floch. Pharmacokinetics of ertapenem in burns patients.
International journal of antimicrobial agents.
2013 Jul; 42(1):48-52. doi:
10.1016/j.ijantimicag.2013.02.021. [PMID: 23578794] - Carlo de Werra, Rosa Di Micco, Vincenzo Pilone, Antonio Formato, Emma Montella, Antonietta Lambiase, Domenica Cerbone, Maria Rosaria Catania, Pietro Forestieri. Serum in vivo and in vitro activity of single dose of ertapenem in surgical obese patients for prevention of SSIs.
Obesity surgery.
2013 Jul; 23(7):911-9. doi:
10.1007/s11695-013-0879-1. [PMID: 23504617] - Matthew Pickering, Stacy Brown. Quantification and validation of HPLC-UV and LC-MS assays for therapeutic drug monitoring of ertapenem in human plasma.
Biomedical chromatography : BMC.
2013 May; 27(5):568-74. doi:
10.1002/bmc.2829. [PMID: 23065850] - Robert Sauermann, Bernhard Burian, Angela Burian, Walter Jäger, Martina Höferl, Alexander Stella, Stefanie Theurer, Michaela Riedl, Markus Zeitlinger. Tissue pharmacokinetics of ertapenem at steady-state in diabetic patients with leg infections.
The Journal of antimicrobial chemotherapy.
2013 Apr; 68(4):895-9. doi:
10.1093/jac/dks479. [PMID: 23212112] - Dora E Wiskirchen, Seth T Housman, Richard Quintiliani, David P Nicolau, Joseph L Kuti. Comparative pharmacokinetics, pharmacodynamics, and tolerability of ertapenem 1 gram/day administered as a rapid 5-minute infusion versus the standard 30-minute infusion in healthy adult volunteers.
Pharmacotherapy.
2013 Mar; 33(3):266-74. doi:
10.1002/phar.1197. [PMID: 23400916] - F Bora, I Aliosmanoglu, H Kocak, A Dinckan, H B Uslu, F Gunseren, G Suleymanlar. Drug interaction between tacrolimus and ertapenem in renal transplantation recipients.
Transplantation proceedings.
2012 Dec; 44(10):3029-32. doi:
10.1016/j.transproceed.2012.08.003. [PMID: 23195020] - Benchamas Rimrang, Aroonwadee Chanawong, Aroonlug Lulitanond, Chotechana Wilailuckana, Nicha Charoensri, Pipat Sribenjalux, Waewta Phumsrikaew, Lumyai Wonglakorn, Anusak Kerdsin, Ploenchan Chetchotisakd. Emergence of NDM-1- and IMP-14a-producing Enterobacteriaceae in Thailand.
The Journal of antimicrobial chemotherapy.
2012 Nov; 67(11):2626-30. doi:
10.1093/jac/dks267. [PMID: 22796889] - Scott E Briscoe, Brett C McWhinney, Jeffrey Lipman, Jason A Roberts, Jacobus P J Ungerer. A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 907(?):178-84. doi:
10.1016/j.jchromb.2012.09.016. [PMID: 23026224] - Min Kyu Park, Kyoung Soo Lim, Tae-Eun Kim, Hye-Kyung Han, So-Jeong Yi, Kwang-Hee Shin, Joo-Youn Cho, Sang-Goo Shin, In-Jin Jang, Kyung-Sang Yu. Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases.
Therapeutic drug monitoring.
2012 Oct; 34(5):599-603. doi:
10.1097/ftd.0b013e318260f7b3. [PMID: 22929406] - E Forestier, S Gros, D Peynaud, M Levast, D Boisseau, C Ferry-Blanco, A Labe, C Lecomte, O Rogeaux. [Ertapenem administered intravenously or subcutaneously for urinary tract infections caused by ESBL producing enterobacteriacea].
Medecine et maladies infectieuses.
2012 Sep; 42(9):440-3. doi:
10.1016/j.medmal.2012.07.005. [PMID: 22925551] - Xiao-ling Liu, Dai-zhi Peng, Liang Xue, Wen-ting Shu, Xin Zhou, Jing Liu. [Analysis of resistance phenotype and homology of Klebsiella pneumoniae in burn patients].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2012 Apr; 28(2):96-100. doi:
. [PMID: 22781319] - L H Su, T L Wu, C H Chiu. Development of carbapenem resistance during therapy for non-typhoid Salmonella infection.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2012 Apr; 18(4):E91-4. doi:
10.1111/j.1469-0691.2012.03767.x. [PMID: 22329543] - Shi-Wei Liu, Hong-Jyun Chang, Ju-Hsin Chia, An-Jing Kuo, Tsu-Lan Wu, Ming-Hsun Lee. Outcomes and characteristics of ertapenem-nonsusceptible Klebsiella pneumoniae bacteremia at a university hospital in Northern Taiwan: a matched case-control study.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2012 Apr; 45(2):113-9. doi:
10.1016/j.jmii.2011.09.026. [PMID: 22154994] - Iram Shaifali, Uma Gupta, Syed Esam Mahmood, Jawed Ahmed. Antibiotic susceptibility patterns of urinary pathogens in female outpatients.
North American journal of medical sciences.
2012 Apr; 4(4):163-9. doi:
10.4103/1947-2714.94940. [PMID: 22536558] - Raphaël Lepeule, Etienne Ruppé, Patrick Le, Laurent Massias, Françoise Chau, Amandine Nucci, Agnès Lefort, Bruno Fantin. Cefoxitin as an alternative to carbapenems in a murine model of urinary tract infection due to Escherichia coli harboring CTX-M-15-type extended-spectrum β-lactamase.
Antimicrobial agents and chemotherapy.
2012 Mar; 56(3):1376-81. doi:
10.1128/aac.06233-11. [PMID: 22214774] - Jeffrey J Fong, Lucia Rosé, Elizabeth A Radigan. Clinical outcomes with ertapenem as a first-line treatment option of infections caused by extended-spectrum β-lactamase producing gram-negative bacteria.
The Annals of pharmacotherapy.
2012 Mar; 46(3):347-52. doi:
10.1345/aph.1q473. [PMID: 22395250] - Katie E Cardone, Darren W Grabe, Robert W Kulawy, Rachid Daoui, Joseph Roglieri, Shari Meola, George L Drusano, Thomas P Lodise. Ertapenem pharmacokinetics and pharmacodynamics during continuous ambulatory peritoneal dialysis.
Antimicrobial agents and chemotherapy.
2012 Feb; 56(2):725-30. doi:
10.1128/aac.05515-11. [PMID: 22083473] - J Findlay, A Hamouda, S J Dancer, S G B Amyes. Rapid acquisition of decreased carbapenem susceptibility in a strain of Klebsiella pneumoniae arising during meropenem therapy.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2012 Feb; 18(2):140-6. doi:
10.1111/j.1469-0691.2011.03515.x. [PMID: 21745255] - Daniela Münch, Terry Roemer, Sang Ho Lee, Marianne Engeser, Hans Georg Sahl, Tanja Schneider. Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus.
PLoS pathogens.
2012 Jan; 8(1):e1002509. doi:
10.1371/journal.ppat.1002509. [PMID: 22291598] - A Burian, Z Erdogan, C Jandrisits, M Zeitlinger. Impact of pH on activity of trimethoprim, fosfomycin, amikacin, colistin and ertapenem in human urine.
Pharmacology.
2012; 90(5-6):281-7. doi:
10.1159/000342423. [PMID: 23037005] - Laurent Ferraris, Marie José Butel, Florence Campeotto, Michel Vodovar, Jean Christophe Rozé, Julio Aires. Clostridia in premature neonates' gut: incidence, antibiotic susceptibility, and perinatal determinants influencing colonization.
PloS one.
2012; 7(1):e30594. doi:
10.1371/journal.pone.0030594. [PMID: 22291996] - D Breilh, C Fleureau, J B Gordien, O Joanes-Boyau, J Texier-Maugein, S Rapaport, E Boselli, G Janvier, M C Saux. Pharmacokinetics of free ertapenem in critically ill septic patients: intermittent versus continuous infusion.
Minerva anestesiologica.
2011 Nov; 77(11):1058-62. doi:
NULL. [PMID: 21597443] - V C C Cheng, W C Yam, O T C Lam, J L Y Tsang, E Y F Tse, G K H Siu, J F W Chan, H Tse, K K W To, J W M Tai, P L Ho, K Y Yuen. Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2011 Nov; 30(11):1371-81. doi:
10.1007/s10096-011-1231-0. [PMID: 21468685] - Shudan Chen, Fupin Hu, Yang Liu, Demei Zhu, Honghai Wang, Yingyuan Zhang. Detection and spread of carbapenem-resistant Citrobacter freundii in a teaching hospital in China.
American journal of infection control.
2011 Nov; 39(9):e55-60. doi:
10.1016/j.ajic.2011.02.009. [PMID: 21705111] - Giorgina B Piccoli, Vincenzo Arena, Valentina Consiglio, Maria Chiara Deagostini, Ettore Pelosi, Anastasios Douroukas, Daniele Penna, Giancarlo Cortese. Positron emission tomography in the diagnostic pathway for intracystic infection in adpkd and 'cystic' kidneys. a case series.
BMC nephrology.
2011 Sep; 12(?):48. doi:
10.1186/1471-2369-12-48. [PMID: 21957932] - Marie-Clémence Verdier, Philippe Seguin, Bastien Le Touvet, Anne Cady, Yannick Mallédant, Olivier Tribut. Ertapenem in plasma and peritoneal fluid from patients with severe intra-abdominal infections.
The Journal of antimicrobial chemotherapy.
2011 Aug; 66(8):1934-6. doi:
10.1093/jac/dkr211. [PMID: 21632578] - I Boyadjiev, A Boulamery, N Simon, C Martin, B Bruguerolle, M Leone. Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients.
Antimicrobial agents and chemotherapy.
2011 Jul; 55(7):3573-5. doi:
10.1128/aac.00180-11. [PMID: 21576440] - Wipa Suginta, Kozhinjampara R Mahendran, Watcharin Chumjan, Eric Hajjar, Albert Schulte, Mathias Winterhalter, Helge Weingart. Molecular analysis of antimicrobial agent translocation through the membrane porin BpsOmp38 from an ultraresistant Burkholderia pseudomallei strain.
Biochimica et biophysica acta.
2011 Jun; 1808(6):1552-9. doi:
10.1016/j.bbamem.2010.10.018. [PMID: 21078354] - E Dailly, R Bouquié, G Deslandes, P Jolliet, R Le Floch. A liquid chromatography assay for a quantification of doripenem, ertapenem, imipenem, meropenem concentrations in human plasma: application to a clinical pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 May; 879(15-16):1137-42. doi:
10.1016/j.jchromb.2011.03.038. [PMID: 21474395]