Doxazosin mesylate (BioDeep_00000014999)
natural product
代谢物信息卡片
Doxazosin mesylate
化学式: C24H29N5O8S (547.1736754000001)
中文名称: 甲磺酸多沙唑嗪
谱图信息:
最多检出来源 Escherichia coli(natural_products) 66.67%
分子结构信息
SMILES: C12(=CC(=C(C=C1C(=NC(=N2)N3CCN(CC3)C(C4COC5=C(O4)C=CC=C5)=O)N)OC)OC).S(=O)(O)(=O)C
InChI: 1H3,(H,2,3,4)
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:4709
- KEGG: C76492
- KEGGdrug: D00608
- PubChem: 62978
- ChEMBL: CHEMBL1200561
- MeSH: Doxazosin
- CAS: 77883-43-3
- CAS: 77883-43-3, 74191-85-8 (free base)
- MoNA: CCMSLIB00000078096
- medchemexpress: HY-B0098A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yi Zheng, Fuding Bai, Nan Zhang, Huifeng Wu. Analysis of Voiding Impairment after Prostate Biopsy and the Effect of Doxazosin Treatment: Outcomes from a Regional Cancer Center.
Urologia internationalis.
2022; 106(1):97-102. doi:
10.1159/000517534. [PMID: 34404051] - Marta Araujo-Castro, Rogelio Garcia Centeno, María-Carmen López-García, Cristina Lamas, Cristina Álvarez-Escolá, María Calatayud Gutiérrez, Concepción Blanco-Carrera, Paz de Miguel Novoa, Nuria Valdés, Paola Gracia Gimeno, Mariana Tomé Fernández-Ladreda, César Mínguez Ojeda, Juan Carlos Percovich Hualpa, Mireia Mora, Óscar Vidal, Ana Serrano Romero, Felicia Alexandra Hanzu, Victoria Gómez Dos Santos. Risk factors for intraoperative complications in pheochromocytomas.
Endocrine-related cancer.
2021 09; 28(11):695-703. doi:
10.1530/erc-21-0230. [PMID: 34379605] - Jianming Guo, Rong Tang. Efficacy and tolerability of doxazosin gastro-intestinal therapeutic system versus tamsulosin in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: A systematic review and meta-analysis.
Medicine.
2021 Aug; 100(33):e26955. doi:
10.1097/md.0000000000026955. [PMID: 34414962] - Hikaru Hori. Doxazosin improved COVID-19 associated nightmare in a patient with major depressive disorder: a case report with a positive rechallenge.
International clinical psychopharmacology.
2021 07; 36(4):221-223. doi:
10.1097/yic.0000000000000364. [PMID: 34030164] - Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey. Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection.
eLife.
2021 06; 10(?):. doi:
10.7554/elife.61700. [PMID: 34114951] - Gregory L Hundemer, Greg A Knoll, William Petrcich, Swapnil Hiremath, Marcel Ruzicka, Kevin D Burns, Cedric Edwards, Ann Bugeja, Emily Rhodes, Manish M Sood. Kidney, Cardiac, and Safety Outcomes Associated With α-Blockers in Patients With CKD: A Population-Based Cohort Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 02; 77(2):178-189.e1. doi:
10.1053/j.ajkd.2020.07.018. [PMID: 32920153] - P Iglesias, E Santacruz, P García-Sancho, A P Marengo, F Guerrero-Pérez, H Pian, C Fajardo, C Villabona, J J Díez. Pheochromocytoma: A three-decade clinical experience in a multicenter study.
Revista clinica espanola.
2021 Jan; 221(1):18-25. doi:
10.1016/j.rceng.2019.12.011. [PMID: 33998473] - Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults.
The Cochrane database of systematic reviews.
2020 11; 11(?):CD013393. doi:
10.1002/14651858.cd013393.pub2. [PMID: 33179245] - Mahmoud A Omar, Abobakr A Mohamed, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad. Mending the fluorescence of two α-blockers through a semiquinoid formation: Hyphenated with experimental design optimization.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Oct; 240(?):118624. doi:
10.1016/j.saa.2020.118624. [PMID: 32604051] - Samar Rezq, Ahmed M Nasr, Aya Shaheen, Shimaa M Elshazly. Doxazosin down-regulates sodium-glucose cotransporter-2 and exerts a renoprotective effect in rat models of acute renal injury.
Basic & clinical pharmacology & toxicology.
2020 May; 126(5):413-423. doi:
10.1111/bcpt.13371. [PMID: 31788938] - N O Mansour. Validated RP-HPLC method for quantification of doxazosin in human plasma: Application in a bioequivalence study.
Annales pharmaceutiques francaises.
2020 Jan; 78(1):42-48. doi:
10.1016/j.pharma.2019.10.003. [PMID: 31796268] - Daryl I Shorter, Xuefeng Zhang, Coreen B Domingo, Ellen M Nielsen, Thomas R Kosten, David A Nielsen. Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant.
The American journal of drug and alcohol abuse.
2020; 46(2):184-193. doi:
10.1080/00952990.2019.1674864. [PMID: 31914324] - Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension.
F1000Research.
2020; 9(?):. doi:
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Addiction biology.
2019 05; 24(3):531-538. doi:
10.1111/adb.12611. [PMID: 29498170] - Kyle Johnson, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko. Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study.
Journal of the American Heart Association.
2019 04; 8(8):e011961. doi:
10.1161/jaha.119.011961. [PMID: 30943832] - Mahmoud A Omar, Mohamed A Hammad, Baher I Salman. Micellar enhanced spectrofluorimetric approach for nanogram detection of certain α1 -blocker drugs: Application in pharmaceutical preparations and human plasma.
Luminescence : the journal of biological and chemical luminescence.
2018 Nov; 33(7):1226-1234. doi:
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The lancet. Diabetes & endocrinology.
2018 06; 6(6):464-475. doi:
10.1016/s2213-8587(18)30071-8. [PMID: 29655877] - Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. An efficient spectrofluorimetric method adopts doxazosin, terazosin and alfuzosin coupling with orthophthalaldehyde: Application in human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Apr; 195(?):215-222. doi:
10.1016/j.saa.2018.01.077. [PMID: 29414581] - Daniel Cervantes-Garcia, Adriana Guadalupe Cuellar-Juarez, Gissela Borrego-Soto, Augusto Rojas-Martinez, Liseth Rubi Aldaba-Muruato, Eva Salinas, Javier Ventura-Juarez, Martin Humberto Muñoz-Ortega. Adenoviral‑bone morphogenetic protein‑7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model.
Molecular medicine reports.
2017 Dec; 16(6):9431-9440. doi:
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Journal of the American Heart Association.
2017 Nov; 6(11):. doi:
10.1161/jaha.117.006986. [PMID: 29151036] - Sanket S Dhruva, Chenxi Huang, Erica S Spatz, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Xiao Xu, Curt D Furberg, Barry R Davis, Sara L Pressel, Ronald R Coifman, Harlan M Krumholz. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
Hypertension (Dallas, Tex. : 1979).
2017 07; 70(1):94-102. doi:
10.1161/hypertensionaha.117.09221. [PMID: 28559399] - Kodai Suzuki, Takahito Miyake, Hideshi Okada, Fuminori Yamaji, Yuichiro Kitagawa, Tetsuya Fukuta, Ryu Yasuda, Yoshihito Tanaka, Haruka Okamoto, Sho Nachi, Tomoaki Doi, Takahiro Yoshida, Keisuke Kumada, Shozo Yoshida, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura. Thyrotoxic and pheochromocytoma multisystem crisis: a case report.
Journal of medical case reports.
2017 Jun; 11(1):173. doi:
10.1186/s13256-017-1299-y. [PMID: 28641581] - Chun-Sheng Song, Jia-You Zhao, Jun Guo, De-Gui Chang, Lei Chen, Rui Zhang, Fu Wang. [Treatment of Benign Prostatic Hyperplasia by Longbishu Capsule Combined Doxazosin Mesylate Tablet].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2016 Dec; 36(12):1465-1469. doi:
". [PMID: 30650291] - V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov. Effect of Doxazosin on Autonomic Nervous Control and Urodynamics of Rat Urinary Bladder during Modeled Infravesical Obstruction.
Bulletin of experimental biology and medicine.
2016 Sep; 161(5):657-661. doi:
10.1007/s10517-016-3479-y. [PMID: 27709382] - Yung-Chin Lee, Yung-Shun Juan, Chia-Chu Liu, Bo-Ying Bao, Chii-Jye Wang, Wen-Jeng Wu, Chun-Nung Huang, Shu-Pin Huang. The association of endothelial nitric oxide synthase (eNOS) G894T gene polymorphism with responsiveness to a selective α1 -blocker in men with benign prostatic hyperplasia related lower urinary tract symptoms.
BJU international.
2016 08; 118(2):313-9. doi:
10.1111/bju.13468. [PMID: 26940040] - Qian Du, De-zhi Kong, Pan-pan Zhang, Lei-ming Ren. [Quantification of (-)doxazosin at very low concentration in rat plasma samples by SPE-LC-MS/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 07; 51(7):1125-9. doi:
NULL. [PMID: 29897217] - Steven A Kaplan, Jeannette Y Lee, Alan G Meehan, John W Kusek. Time Course of Incident Adverse Experiences Associated with Doxazosin, Finasteride and Combination Therapy in Men with Benign Prostatic Hyperplasia: The MTOPS Trial.
The Journal of urology.
2016 06; 195(6):1825-9. doi:
10.1016/j.juro.2015.11.065. [PMID: 26678956] - Paweł Kroll, Ewa Gajewska, Jacek Zachwieja, Magdalena Sobieska, Przemysław Mańkowski. An Evaluation of the Efficacy of Selective Alpha-Blockers in the Treatment of Children with Neurogenic Bladder Dysfunction--Preliminary Findings.
International journal of environmental research and public health.
2016 Mar; 13(3):. doi:
10.3390/ijerph13030321. [PMID: 26999168] - Mahmoud A Omar, Mohamed A Hammad, Baher I Salman, Sayed M Derayea. Highly sensitive spectrofluorimetric method for determination of doxazosin through derivatization with fluorescamine; Application to content uniformity testing.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2016 Mar; 157(?):55-60. doi:
10.1016/j.saa.2015.12.012. [PMID: 26716887] - José A T Poloni, Lauro da F Beltrão, Elizete Keitel, Tiana Tasca, Liane N Rotta. Trichomonas vaginalis erythrophagocytosis in the urine sediment.
International journal of STD & AIDS.
2016 Feb; 27(2):157-8. doi:
10.1177/0956462415610680. [PMID: 26468272] - Mariola Chudzik, Joanna Równicka-Zubik, Jadwiga Pożycka, Bartosz Pawelczak, Anna Sulkowska. Analysis of Aged Human Serum Albumin Affinity for Doxazosin.
Current protein & peptide science.
2016; 17(2):198-208. doi:
10.2174/1389203716666151102103923. [PMID: 26521959] - Bryan Williams, Thomas M MacDonald, Steve Morant, David J Webb, Peter Sever, Gordon McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Jackie Salsbury, Isla Mackenzie, Sandosh Padmanabhan, Morris J Brown. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.
Lancet (London, England).
2015 Nov; 386(10008):2059-2068. doi:
10.1016/s0140-6736(15)00257-3. [PMID: 26414968] - Qing Li, Dezhi Kong, Qian Du, Jing Zhao, Yaqin Zhen, Tonghui Li, Leiming Ren. Enantioselective pharmacokinetics of doxazosin and pharmacokinetic interaction between the isomers in rats.
Chirality.
2015 Oct; 27(10):738-44. doi:
10.1002/chir.22483. [PMID: 26205661] - Dezhi Kong, Qing Li, Panpan Zhang, Wei Zhang, Yaqin Zhen, Leiming Ren. The truth about the lower plasma concentration of the (-)-isomer after racemic doxazosin administration in rats: Stereoselective inhibition of the (-)-isomer by the (+)-isomer at CYP3A.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Sep; 77(?):238-45. doi:
10.1016/j.ejps.2015.06.022. [PMID: 26116989] - Onur Telli, Mehmet Ilker Gokce, Erdem Ozturk, Evren Suer, Murat Mermerkaya, Faraj Afandiyev, Cihat Ozcan, Adil Gucal Guclu, Tarkan Soygur, Berk Burgu. What is the best option for 10-20mm renal pelvic stones undergoing ESWL in the pediatric population: stenting, alpha blockers or conservative follow-up?.
Journal of pediatric surgery.
2015 Sep; 50(9):1532-4. doi:
10.1016/j.jpedsurg.2014.11.045. [PMID: 25783320] - Victor C Lin, Chun-Hou Liao, Chung-Cheng Wang, Hann-Chorng Kuo. 5α-Reductase inhibitor is less effective in men with small prostate volume and low serum prostatic specific antigen level.
Journal of the Formosan Medical Association = Taiwan yi zhi.
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Aug; 147(?):178-84. doi:
10.1016/j.saa.2015.02.062. [PMID: 25840026] - De-gui Chang, Guang-sen Li, Cheng-hua Peng, Xu-jun Yu, Pei-hai Zhang, Ming-shuai Bi, Di-ang Chen, Yao-dong You, Xing-zhi Yang. [Longbishu Capsule combined with mesylate doxazosin: an efficacious therapy for benign prostatic hyperplasia].
Zhonghua nan ke xue = National journal of andrology.
2015 Feb; 21(2):165-9. doi:
NULL. [PMID: 25796693] - Nannan Gao, Hao Wu, Yafen Chang, Xiaozhen Guo, Lizhen Zhang, Liming Du, Yunlong Fu. Mixed micelle cloud point-magnetic dispersive μ-solid phase extraction of doxazosin and alfuzosin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Jan; 134(?):10-6. doi:
10.1016/j.saa.2014.06.095. [PMID: 24995413] - Massimiliano Tognolini, Alessio Lodola. Targeting the Eph-ephrin System with Protein-Protein Interaction (PPI) Inhibitors.
Current drug targets.
2015; 16(10):1048-56. doi:
10.2174/1389450116666150825144457. [PMID: 26302794] - Gen Yasuda, Sanae Saka, Daisaku Ando, Nobuhito Hirawa. Effects of doxazosin as the third agent on morning hypertension and position-related blood pressure changes in diabetic patients with chronic kidney disease.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2015; 37(1):75-81. doi:
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Chinese journal of integrative medicine.
2014 Nov; 20(11):818-22. doi:
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The Journal of urology.
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Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
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Endocrine journal.
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Urology journal.
2013 09; 10(3):993-8. doi:
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Drug and alcohol dependence.
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Yao xue xue bao = Acta pharmaceutica Sinica.
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Journal of human lactation : official journal of International Lactation Consultant Association.
2013 May; 29(2):150-3. doi:
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International journal of clinical practice.
2013 Apr; 67(4):356-62. doi:
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Journal of applied toxicology : JAT.
2013 Mar; 33(3):209-13. doi:
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Alcoholism, clinical and experimental research.
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2012 Sep; 25(5):750-4. doi:
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Pharmacogenetics and genomics.
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Zhonghua wai ke za zhi [Chinese journal of surgery].
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Journal of hypertension.
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International journal of andrology.
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The Journal of clinical endocrinology and metabolism.
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Journal of the American College of Cardiology.
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The Journal of international medical research.
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Journal of clinical hypertension (Greenwich, Conn.).
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Hinyokika kiyo. Acta urologica Japonica.
2009 Jun; 55(6):377-80. doi:
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Oncology research.
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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