bufexamac (BioDeep_00000014992)
natural product Volatile Flavor Compounds
代谢物信息卡片
化学式: C12H17NO3 (223.1208372)
中文名称: 丁苯羟酸, 布非沙美
谱图信息:
最多检出来源 Escherichia coli(natural_products) 11.76%
分子结构信息
SMILES: C1(C=CC(=CC=1)OCCCC)CC(=O)NO
InChI: InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
描述信息
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3322
同义名列表
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:31317
- KEGG: C74254
- KEGGdrug: D01271
- PubChem: 2466
- Metlin: METLIN44293
- DrugBank: DB13346
- ChEMBL: CHEMBL94394
- MeSH: Bufexamac
- CAS: 2438-72-4
- CAS: 2438-72-4, 1353882-38-8 (sodium salt)
- MoNA: CCMSLIB00000078541
- MoNA: EQ332256
- MoNA: EQ332255
- MoNA: EQ332254
- MoNA: EQ332253
- MoNA: EQ332252
- MoNA: EQ332251
- MoNA: EQ332206
- MoNA: EQ332205
- MoNA: EQ332204
- MoNA: EQ332203
- MoNA: EQ332202
- MoNA: EQ332201
- PMhub: MS000001435
- RefMet: Bufexamac
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ritu Gupta, Kurosh Parsi. Chronic urticaria due to Blastocystis hominis.
The Australasian journal of dermatology.
2006 May; 47(2):117-9. doi:
10.1111/j.1440-0960.2006.00244.x. [PMID: 16637808] - Hagen Trommer, Reinhard H H Neubert. Screening for new antioxidative compounds for topical administration using skin lipid model systems.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2005 Sep; 8(3):494-506. doi:
". [PMID: 16401395] - Hagen Trommer, Manuela Plätzer, Klaus Raith, Wolfgang Wohlrab, Hans-Peter Podhaisky, Reinhard H H Neubert. Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action.
The Journal of pharmacy and pharmacology.
2003 Oct; 55(10):1379-88. doi:
10.1211/002235703322461569. [PMID: 14607020] - Stephanie Maxine Ross. An integrative approach to eczema (atopic dermatitis).
Holistic nursing practice.
2003 Jan; 17(1):56-62. doi:
10.1097/00004650-200301000-00011. [PMID: 12597676] - M M Suominen, R M Tulamo, M O Anttila, S M Sankari, K Király, T Lapveteläinen, H J Helminen. Effects of intra-articular injections of bufexamac suspension in healthy horses.
American journal of veterinary research.
2001 Oct; 62(10):1629-35. doi:
10.2460/ajvr.2001.62.1629. [PMID: 11592331] - K Müller, H Prinz. Antipsoriatic anthrones with modulated redox properties. 4. Synthesis and biological activity of novel 9,10-dihydro-1,8-dihydroxy-9-oxo-2-anthracenecarboxylic and -hydroxamic acids.
Journal of medicinal chemistry.
1997 Aug; 40(17):2780-7. doi:
10.1021/jm9701785. [PMID: 9276024] - G Lubec. [Treatment of diaper rash with Parfenac lipid ointment (bufexamac). A study by Austrian pediatricians].
Padiatrie und Padologie.
1989; 24(3):227-36. doi:
". [PMID: 2682472] - H J Glowania, B Hampl. [Results of a study of the resorption of bufexamac following rectal administration].
Zeitschrift fur Hautkrankheiten.
1988 Mar; 63(3):211. doi:
. [PMID: 3388925] - P Aertgeerts, M Albring, F Klaschka, T Nasemann, R Patzelt-Wenczler, K Rauhut, B Weigl. [Comparative testing of Kamillosan cream and steroidal (0.25\% hydrocortisone, 0.75\% fluocortin butyl ester) and non-steroidal (5\% bufexamac) dermatologic agents in maintenance therapy of eczematous diseases].
Zeitschrift fur Hautkrankheiten.
1985 Feb; 60(3):270-7. doi:
". [PMID: 3158124] - J E Birnbaum, T M Sapp, E L Tolman. Cyclic AMP-phosphodiesterase and epidermal mitosis.
The Journal of investigative dermatology.
1976 Aug; 67(2):235-9. doi:
10.1111/1523-1747.ep12513381. [PMID: 181495]