Tartrazine (BioDeep_00000014966)

   


代谢物信息卡片


Food Yellow 4:1

化学式: C16H9N4Na3O9S2 (533.9504064)
中文名称: 柠檬黄标准溶液, 食品黄4铝色淀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)[O-])C(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+]
InChI: /q

描述信息

D000074385 - Food Ingredients > D005503 - Food Additives > D005505 - Food Coloring Agents
D004396 - Coloring Agents
Colour additive for desserts, candies, preserves, beverages, prepared meats and canned and frozen vegetables. Putative food allergen

同义名列表

3 个代谢物同义名

Food Yellow 4:1; Tartrazine; Acid Yellow 23



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ghulam Mujtaba, Abdul Hai, Mansoor Ul Hassan Shah, Asad Ullah, Yasir Anwar, Furqan Shah, Muhammad Daud, Afzal Hussain, Faheem Ahmed, Fawzi Banat. Potential of Capparis decidua plant and eggshell composite adsorbent for effective removal of anionic dyes from aqueous medium. Environmental research. 2024 Apr; 247(?):118279. doi: 10.1016/j.envres.2024.118279. [PMID: 38246301]
  • Amina Essawy, Shreen Matar, Nema Mohamed, Wessam Abdel-Wahab, Heba Abdou. Ginkgo biloba extract protects against tartrazine-induced testicular toxicity in rats: involvement of antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. Environmental science and pollution research international. 2024 Feb; 31(10):15065-15077. doi: 10.1007/s11356-024-32047-0. [PMID: 38286926]
  • Atefeh Nasri, Raimo Pohjanvirta. Comparison of in vitro Toxicities of 8-Prenylnaringenin, Tartrazine and 17β-Estradiol, Representatives of Natural and Synthetic Estrogens, in Rat and Human Hepatoma Cell Lines. Endocrine research. 2024 Feb; 49(2):106-116. doi: 10.1080/07435800.2024.2337758. [PMID: 38597376]
  • Demiana H Hanna, Sylvia Nabil Beshay, E El Shafee, Heba Ali Abd El-Rahman. The protective effect of aqueous extract of Stevia rebaudiana against tartrazine toxicity in male Wistar rat. Cell biochemistry and function. 2023 Dec; 41(8):1462-1476. doi: 10.1002/cbf.3886. [PMID: 38010705]
  • G Janet Joshiba, P Senthil Kumar, Gayathri Rangasamy, P Tsopbou Ngueagni, G Pooja, G Bharat Balji, Krishnapandi Alagumalai, Hamed A El-Serehy. Iron doped activated carbon for effective removal of tartrazine and methylene blue dye from the aquatic systems: Kinetics, isotherms, thermodynamics and desorption studies. Environmental research. 2022 12; 215(Pt 3):114317. doi: 10.1016/j.envres.2022.114317. [PMID: 36174758]
  • Ardalan Pasdaran, Negar Azarpira, Reza Heidari, Simin Nourinejad, Maryam Zare, Azadeh Hamedi. Effects of some cosmetic dyes and pigments on the proliferation of human foreskin fibroblasts and cellular oxidative stress; potential cytotoxicity of chlorophyllin and indigo carmine on fibroblasts. Journal of cosmetic dermatology. 2022 Sep; 21(9):3979-3985. doi: 10.1111/jocd.14695. [PMID: 35094478]
  • Limin Wu, Xixi Lv, Yifan Zhang, Qingqing Xin, Yuanchao Zou, Xuejun Li. Tartrazine exposure results in histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in juvenile crucian carp (Carassius carassius). Aquatic toxicology (Amsterdam, Netherlands). 2021 Dec; 241(?):105998. doi: 10.1016/j.aquatox.2021.105998. [PMID: 34706309]
  • Wopara Iheanyichukwu, Adebayo O Adegoke, Olusegun G Adebayo, Modo Emmanuel U, Aziemeola Pius Egelege, Jeremiah T Gona, Fortune M Orluwene. Combine colorants of tartrazine and erythrosine induce kidney injury: involvement of TNF-α gene, caspase-9 and KIM-1 gene expression and kidney functions indices. Toxicology mechanisms and methods. 2021 Jan; 31(1):67-72. doi: 10.1080/15376516.2020.1828523. [PMID: 32981412]
  • Gaber E El-Desoky, Saikh M Wabaidur, Zeid A AlOthman, Mohamed A Habila. Regulatory Role of Nano-Curcumin against Tartrazine-Induced Oxidative Stress, Apoptosis-Related Genes Expression, and Genotoxicity in Rats. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245801. [PMID: 33316931]
  • Gustavo Affonso Pisano Mateus, Tássia Rhuna Tonial Dos Santos, Isabela Sperandino Sanches, Marcela Fernandes Silva, Murilo Barbosa de Andrade, Michele Putti Paludo, Raquel Guttierres Gomes, Rosângela Bergamasco. Evaluation of a magnetic coagulant based on Fe3O4 nanoparticles and Moringa oleifera extract on tartrazine removal: coagulation-adsorption and kinetics studies. Environmental technology. 2020 May; 41(13):1648-1663. doi: 10.1080/09593330.2018.1543358. [PMID: 30382011]
  • Yasmina M Abd-Elhakim, Gihan G Moustafa, Mohamed M Hashem, Haytham A Ali, Khaled Abo-El-Sooud, Abeer E El-Metwally. Influence of the long-term exposure to tartrazine and chlorophyll on the fibrogenic signalling pathway in liver and kidney of rats: the expression patterns of collagen 1-α, TGFβ-1, fibronectin, and caspase-3 genes. Environmental science and pollution research international. 2019 Apr; 26(12):12368-12378. doi: 10.1007/s11356-019-04734-w. [PMID: 30847814]
  • Haddad A El Rabey, Madeha N Al-Seeni, Abdulbasit I Al-Sieni, Amani Mohammed Al-Hamed, Mazin A Zamzami, Fahad M Almutairi. Honey attenuates the toxic effects of the low dose of tartrazine in male rats. Journal of food biochemistry. 2019 04; 43(4):e12780. doi: 10.1111/jfbc.12780. [PMID: 31353602]
  • Mohamed A El-Sakhawy, Dina W Mohamed, Yasmine H Ahmed. Histological and immunohistochemical evaluation of the effect of tartrazine on the cerebellum, submandibular glands, and kidneys of adult male albino rats. Environmental science and pollution research international. 2019 Apr; 26(10):9574-9584. doi: 10.1007/s11356-019-04399-5. [PMID: 30726541]
  • Pan-Yan Liu, Bi-Qing Chen, Shan-Shan Yuan, Bin-Bin Yang, Ting Yang, Ming-Hui Shi, Guang-Hua Lyu. [Determination of common dyes in dyed safflower by near infrared spectroscopy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Apr; 44(8):1537-1544. doi: 10.19540/j.cnki.cjcmm.20190322.102. [PMID: 31090316]
  • Yaser H A Elewa, Amany Abdel-Rahman Mohamed, Azza A A Galal, Nesma I El-Naseery, Osamu Ichii, Yasuhiro Kon. Food Yellow4 reprotoxicity in relation to localization of DMC1 and apoptosis in rat testes: Roles of royal jelly and cod liver oil. Ecotoxicology and environmental safety. 2019 Mar; 169(?):696-706. doi: 10.1016/j.ecoenv.2018.11.082. [PMID: 30500739]
  • Cigdem Velioglu, Mehmet E Erdemli, Mehmet Gul, Zeynep Erdemli, Emrah Zayman, Harika G Bag, Eyup Altinoz. Protective effect of crocin on food azo dye tartrazine-induced hepatic damage by improving biochemical parameters and oxidative stress biomarkers in rats. General physiology and biophysics. 2019 Jan; 38(1):73-82. doi: 10.4149/gpb_2018039. [PMID: 30657462]
  • Nouf Alsalman, Abdulaziz Aljafari, Tanveer A Wani, Seema Zargar. High-Dose Aspirin Reverses Tartrazine-Induced Cell Growth Dysregulation Independent of p53 Signaling and Antioxidant Mechanisms in Rat Brain. BioMed research international. 2019; 2019(?):9096404. doi: 10.1155/2019/9096404. [PMID: 31032366]
  • Alexsandro Jhones Dos Santos, Ignasi Sirés, Carlos A Martínez-Huitle, Enric Brillas. Total mineralization of mixtures of Tartrazine, Ponceau SS and Direct Blue 71 azo dyes by solar photoelectro-Fenton in pre-pilot plant. Chemosphere. 2018 Nov; 210(?):1137-1144. doi: 10.1016/j.chemosphere.2018.07.116. [PMID: 30208539]
  • Diksha Bhatt, Krati Vyas, Shakuntala Singh, P J John, Inderpal Soni. Tartrazine induced neurobiochemical alterations in rat brain sub-regions. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Mar; 113(?):322-327. doi: 10.1016/j.fct.2018.02.011. [PMID: 29427609]
  • Nasser Abdulatif Al-Shabib, Javed Masood Khan, Mohammad A Alsenaidy, Abdulrahman M Alsenaidy, Mohd Shahnawaz Khan, Fohad Mabood Husain, Mohammad Rashid Khan, Mohammad Naseem, Priyankar Sen, Parvez Alam, Rizwan Hasan Khan. Unveiling the stimulatory effects of tartrazine on human and bovine serum albumin fibrillogenesis: Spectroscopic and microscopic study. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Feb; 191(?):116-124. doi: 10.1016/j.saa.2017.09.062. [PMID: 29028503]
  • Mehmet Erman Erdemli, Mehmet Gul, Eyup Altinoz, Emrah Zayman, Zeynep Aksungur, Harika Gozukara Bag. The protective role of crocin in tartrazine induced nephrotoxicity in Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Dec; 96(?):930-935. doi: 10.1016/j.biopha.2017.11.150. [PMID: 29217164]
  • G E El-Desoky, A Abdel-Ghaffar, Z A Al-Othman, M A Habila, Y A Al-Sheikh, H K Ghneim, J P Giesy, M A M Aboul-Soud. Curcumin protects against tartrazine-mediated oxidative stress and hepatotoxicity in male rats. European review for medical and pharmacological sciences. 2017 02; 21(3):635-645. doi: NULL. [PMID: 28239801]
  • Ivana Stachová, Ivona Lhotská, Petr Solich, Dalibor Šatínský. Determination of green, blue and yellow artificial food colorants and their abuse in herb-coloured green Easter beers on tap. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2016 Jul; 33(7):1139-46. doi: 10.1080/19440049.2016.1200198. [PMID: 27295128]
  • Z W Zhong, R G Wu, Z P Wang, H L Tan. An investigation of paper based microfluidic devices for size based separation and extraction applications. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Sep; 1000(?):41-8. doi: 10.1016/j.jchromb.2015.07.010. [PMID: 26209769]
  • Anirban Basu, Gopinatha Suresh Kumar. Thermodynamics of the interaction of the food additive tartrazine with serum albumins: a microcalorimetric investigation. Food chemistry. 2015 May; 175(?):137-42. doi: 10.1016/j.foodchem.2014.11.141. [PMID: 25577062]
  • Priyanka Bolel, Shubhashis Datta, Niharendu Mahapatra, Mintu Halder. Exploration of pH-dependent behavior of the anion receptor pocket of subdomain IIA of HSA: determination of effective pocket charge using the Debye-Hückel limiting law. The journal of physical chemistry. B. 2014 Jan; 118(1):26-36. doi: 10.1021/jp407057f. [PMID: 24364788]
  • Hanan Mohamed Fathy Abd El-Wahab, Gehan Salah El-Deen Moram. Toxic effects of some synthetic food colorants and/or flavor additives on male rats. Toxicology and industrial health. 2013 Mar; 29(2):224-32. doi: 10.1177/0748233711433935. [PMID: 22317828]
  • Priyanka Bolel, Shubhashis Datta, Niharendu Mahapatra, Mintu Halder. Spectroscopic investigation of the effect of salt on binding of tartrazine with two homologous serum albumins: quantification by use of the Debye-Hückel limiting law and observation of enthalpy-entropy compensation. The journal of physical chemistry. B. 2012 Aug; 116(34):10195-204. doi: 10.1021/jp304537m. [PMID: 22834570]
  • Yonglin Gao, Chunmei Li, Jingyu Shen, Huaxian Yin, Xiulin An, Haizhu Jin. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved. Journal of food science. 2011 Aug; 76(6):T125-9. doi: 10.1111/j.1750-3841.2011.02267.x. [PMID: 22417523]
  • Xingren Pan, Pengfei Qin, Rutao Liu, Jing Wang. Characterizing the Interaction between tartrazine and two serum albumins by a hybrid spectroscopic approach. Journal of agricultural and food chemistry. 2011 Jun; 59(12):6650-6. doi: 10.1021/jf200907x. [PMID: 21591756]
  • K A Amin, H Abdel Hameid, A H Abd Elsttar. Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Oct; 48(10):2994-9. doi: 10.1016/j.fct.2010.07.039. [PMID: 20678534]
  • Martine Poul, Gérard Jarry, Mostafa Ould Elhkim, Jean-Michel Poul. Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Feb; 47(2):443-8. doi: 10.1016/j.fct.2008.11.034. [PMID: 19095036]
  • Matti Hannuksela, Tari Haahtela. [Food additive hypersenisivity--near myth]. Duodecim; laaketieteellinen aikakauskirja. 2009; 125(5):527-32. doi: . [PMID: 19385342]
  • Alok Mittal, Jyoti Mittal, Lisha Kurup. Adsorption isotherms, kinetics and column operations for the removal of hazardous dye, Tartrazine from aqueous solutions using waste materials--Bottom Ash and De-Oiled Soya, as adsorbents. Journal of hazardous materials. 2006 Aug; 136(3):567-78. doi: 10.1016/j.jhazmat.2005.12.037. [PMID: 16442722]
  • G Di Lorenzo, M L Pacor, A M Vignola, M Profita, M Esposito-Pellitteri, D Biasi, R Corrocher, C Caruso. Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients. Allergy. 2002 Dec; 57(12):1180-6. doi: 10.1034/j.1398-9995.2002.23767.x. [PMID: 12464047]
  • R Asero. A strange case of 'tuna allergy'. Allergy. 1998 Aug; 53(8):816-7. doi: ". [PMID: 9722237]
  • M L Pachor, G Urbani, P Cortina, C Lunardi, F Nicolis, P Peroli, R Corrocher, P Gotte. Is the Melkersson-Rosenthal syndrome related to the exposure to food additives? A case report. Oral surgery, oral medicine, and oral pathology. 1989 Apr; 67(4):393-5. doi: 10.1016/0030-4220(89)90380-0. [PMID: 2726204]
  • J Stĕrba, P Milácek, J Vítovec. A new method for selective diagnostic staining of hooks of echinococci, cysticerci and tapeworms in histological sections. Folia parasitologica. 1989; 36(4):341-4. doi: NULL. [PMID: 2484916]
  • R D Murdoch, I Pollock, S Naeem. Tartrazine induced histamine release in vivo in normal subjects. Journal of the Royal College of Physicians of London. 1987 Oct; 21(4):257-61. doi: NULL. [PMID: 2445985]
  • R Münzner, J Wever. Mutagenic activity of the feces of rats following oral administration of tartrazine. Archives of toxicology. 1987 Jun; 60(4):328-30. doi: 10.1007/bf01234674. [PMID: 3307706]
  • R D Combes. On the mutagenicity of tartrazine (FD&C Yellow No 5). Archives of toxicology. 1986 May; 59(1):68-70. doi: 10.1007/bf00263962. [PMID: 3741148]
  • D Henschler, D Wild. Mutagenic activity in rat urine after feeding with the azo dye tartrazine. Archives of toxicology. 1985 Aug; 57(3):214-5. doi: 10.1007/bf00290891. [PMID: 4062556]
  • P Milácek, J Vítovec. Differential staining of cryptosporidia by aniline-carbol-methyl violet and tartrazine in smears from feces and scrapings of intestinal mucosa. Folia parasitologica. 1985; 32(1):50. doi: NULL. [PMID: 2580763]
  • S Nicklin, K Miller. Induction of a transient reaginic antibody to tartrazine in an animal model. International archives of allergy and applied immunology. 1985; 76(2):185-7. doi: 10.1159/000233688. [PMID: 2857156]
  • G C Du Mont, R C Beach, I S Menzies. Gastrointestinal permeability in food-allergic eczematous children. Clinical allergy. 1984 Jan; 14(1):55-9. doi: 10.1111/j.1365-2222.1984.tb02190.x. [PMID: 6546534]
  • N Weliky, D C Heiner. Hypersensitivity to chemicals. Correlation of tartrazine hypersensitivity with characteristic serum IgD and IgE immune response patterns. Clinical allergy. 1980 Jul; 10(4):375-95. doi: 10.1111/j.1365-2222.1980.tb02121.x. [PMID: 7449073]
  • D A Moneret-Vautrin, G Demange, C Selve, J P Grilliat, H Savinet. [Induction of reaginic hypersensitivity to tartrazine in the rabbit immunization by ingestion of the covalent conjugate tartrazine-human serum albumin (author's transl)]. Annales d'immunologie. 1979 May; 130C(3):419-30. doi: NULL. [PMID: 89829]
  • R P Brettle, L Curtis, A J Pinching, C J Spry. Tartrazine sensitivity in renal failure. Lancet (London, England). 1979 Jan; 1(8108):167. doi: 10.1016/s0140-6736(79)90570-1. [PMID: 84198]
  • B Wüthrich. Protective effect of ketotifen and disodium cromoglycate against bronchoconstriction induced by aspirin, benzoic acid or tartrazine in intolerant asthmatics. Respiration; international review of thoracic diseases. 1979; 37(4):224-31. doi: 10.1159/000194032. [PMID: 112656]
  • N Weliky, D C Heiner, H Tamura, S Anderson, B Stenius-Aarniala, D F German, C D Hawley, S D Lockey. Correlation of tartrazine hypersensitivity with specific serum IgD levels. Immunological communications. 1979; 8(1):65-71. doi: 10.3109/08820137909044707. [PMID: 422222]
  • J K Weltman, R P Szaro, G A Settipane. An analysis of the role of IgE in intolerance to aspirin and tartrazine. Allergy. 1978 Oct; 33(5):273-81. doi: 10.1111/j.1398-9995.1978.tb01548.x. [PMID: 362975]
  • H Mikkelsen, J C Larsen, F Tarding. Hypersensitivity reactions to food colours with special reference to the natural colour annatto extract (butter colour). Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 1978; ?(1):141-3. doi: 10.1007/978-3-642-66896-8_16. [PMID: 150265]
  • T Honohan, F E Enderlin, B A Ryerson, T M Parkinson. Intestinal absorption of polymeric derivatives of the food dyes sunset yellow and tartrazine in rats. Xenobiotica; the fate of foreign compounds in biological systems. 1977 Dec; 7(12):765-74. doi: 10.3109/00498257709038706. [PMID: 602250]
  • R J Allan, J J Roxon. The effect of dioctyl sodium sulphosuccinate on tartrazine azo reduction by intestinal bacteria. Xenobiotica; the fate of foreign compounds in biological systems. 1977 Mar; 7(3):181-6. doi: 10.3109/00498257709036249. [PMID: 322398]
  • R JONES, A J RYAN, S E WRIGHT. THE METABOLISM AND EXCRETION OF TARTRAZINE IN THE RAT, RABBIT AND MAN. Food and cosmetics toxicology. 1964 Oct; 2(?):447-52. doi: 10.1016/s0015-6264(64)80287-x. [PMID: 14217816]
  • K J DAVIS, O G FITZHUGH, A A NELSON. CHRONIC RAT AND DOG TOXICITY STUDIES ON TARTRAZINE. Toxicology and applied pharmacology. 1964 Sep; 6(?):621-6. doi: 10.1016/0041-008x(64)90095-x. [PMID: 14217004]