BENZNIDAZOLE (BioDeep_00000014965)
Secondary id: BioDeep_00000176539
代谢物信息卡片
BENZNIDAZOLE
化学式: C12H12N4O3 (260.0909362)
中文名称: 苄硝唑
谱图信息:
最多检出来源 Homo sapiens(blood) 97.73%
分子结构信息
SMILES: C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]
InChI: InChI=1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01C - Agents against leishmaniasis and trypanosomiasis > P01CA - Nitroimidazole derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D009676 - Noxae > D009153 - Mutagens
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:133833
- KEGG: C74184
- KEGGdrug: D02489
- PubChem: 31593
- DrugBank: DB11989
- ChEMBL: CHEMBL110
- CAS: 22994-85-0
- PMhub: MS000013304
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Danya A Dean, Jarrod Roach, Rebecca Ulrich vonBargen, Yi Xiong, Shelley S Kane, London Klechka, Kate Wheeler, Michael Jimenez Sandoval, Mahbobeh Lesani, Ekram Hossain, Mitchelle Katemauswa, Miranda Schaefer, Morgan Harris, Sayre Barron, Zongyuan Liu, Chongle Pan, Laura-Isobel McCall. Persistent Biofluid Small-Molecule Alterations Induced by Trypanosoma cruzi Infection Are Not Restored by Parasite Elimination.
ACS infectious diseases.
2023 11; 9(11):2173-2189. doi:
10.1021/acsinfecdis.3c00261. [PMID: 37883691] - Zongyuan Liu, Rebecca Ulrich vonBargen, April L Kendricks, Kate Wheeler, Ana Carolina Leão, Krithivasan Sankaranarayanan, Danya A Dean, Shelley S Kane, Ekram Hossain, Jeroen Pollet, Maria Elena Bottazzi, Peter J Hotez, Kathryn M Jones, Laura-Isobel McCall. Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease.
Nature communications.
2023 10; 14(1):6769. doi:
10.1038/s41467-023-42247-w. [PMID: 37880260] - Eva C Arrua, Olga Hartwig, Brigitta Loretz, Xabier Murgia, Duy-Khiet Ho, Guillaume Bastiat, Claus-Michael Lehr, Claudio J Salomon. Formulation of benznidazole-lipid nanocapsules: Drug release, permeability, biocompatibility, and stability studies.
International journal of pharmaceutics.
2023 Jul; 642(?):123120. doi:
10.1016/j.ijpharm.2023.123120. [PMID: 37307960] - Davi Alvarenga Lima, Leilane Oliveira Gonçalves, João Luís Reis-Cunha, Paul Anderson Souza Guimarães, Jeronimo Conceição Ruiz, Daniel Barbosa Liarte, Silvane Maria Fonseca Murta. Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations.
Parasites & vectors.
2023 May; 16(1):167. doi:
10.1186/s13071-023-05775-4. [PMID: 37217925] - Jun Li, Nasir Tajuddeen, Doris Feineis, Virima Mudogo, Marcel Kaiser, Ean-Jeong Seo, Thomas Efferth, Gerhard Bringmann. Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities.
Bioorganic & medicinal chemistry letters.
2023 Apr; 86(?):129258. doi:
10.1016/j.bmcl.2023.129258. [PMID: 36972793] - Luiz P M O Leão, Nátalie de B Vieira, Paula P S Oliveira, Daniela A Chagas-Paula, Marisi G Soares, Thiago B Souza, João L Baldim, Thais A Costa-Silva, Andre G Tempone, Danielle F Dias, João Henrique G Lago. Structure-activity relationship study of antitrypanosomal analogues of gibbilimbol B using multivariate analysis and computation-aided drug design.
Bioorganic & medicinal chemistry letters.
2023 03; 83(?):129190. doi:
10.1016/j.bmcl.2023.129190. [PMID: 36805048] - Ana Maria Murta Santi, Juliana Martins Ribeiro, João Luís Reis-Cunha, Gabriela de Assis Burle-Caldas, Isabella Fernandes Martins Santos, Paula Alves Silva, Daniela de Melo Resende, Daniella Castanheira Bartholomeu, Santuza Maria Ribeiro Teixeira, Silvane Maria Fonseca Murta. Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi.
PLoS neglected tropical diseases.
2022 10; 16(10):e0010845. doi:
10.1371/journal.pntd.0010845. [PMID: 36260546] - Steven Van Den Broucke, Maxim Van Herreweghe, Annelies Breynaert, Marjan Van Esbroeck, Carine Truyens, Tess De Bruyne, Nina Hermans, Ralph Huits. Mitigation of benznidazole toxicity and oxidative stress following ascorbic acid supplementation in an adult traveller with chronic indeterminate Chagas' disease.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1748-1752. doi:
10.1093/jac/dkac093. [PMID: 35325159] - Juliana Almeida-Silva, Diego Silva Menezes, Juan Mateus Pereira Fernandes, Márcio Cerqueira Almeida, Deyvison Rhuan Vasco-Dos-Santos, Roberto Magalhães Saraiva, Alessandra Lifsitch Viçosa, Sandra Aurora Chavez Perez, Sônia Gumes Andrade, Ana Márcia Suarez-Fontes, Marcos André Vannier-Santos. The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance.
Frontiers in cellular and infection microbiology.
2022; 12(?):926699. doi:
10.3389/fcimb.2022.926699. [PMID: 35967878] - Niamh Murphy, M Victoria Cardinal, Tapan Bhattacharyya, Gustavo F Enriquez, Natalia P Macchiaverna, Alejandra Alvedro, Héctor Freilij, Pablo Martinez de Salazar, Israel Molina, Pascal Mertens, Quentin Gilleman, Ricardo E Gürtler, Michael A Miles. Assessing antibody decline after chemotherapy of early chronic Chagas disease patients.
Parasites & vectors.
2021 Oct; 14(1):543. doi:
10.1186/s13071-021-05040-6. [PMID: 34670602] - Paola García-Huertas, Nora Cardona-Castro. Advances in the treatment of Chagas disease: Promising new drugs, plants and targets.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Oct; 142(?):112020. doi:
10.1016/j.biopha.2021.112020. [PMID: 34392087] - Wendy Lorena Quintero, Erika Marcela Moreno, Sandra Milena Leal Pinto, Sandra Milena Sanabria, Elena Stashenko, Liliana Torcoroma García. Immunomodulatory, trypanocide, and antioxidant properties of essential oil fractions of Lippia alba (Verbenaceae).
BMC complementary medicine and therapies.
2021 Jul; 21(1):187. doi:
10.1186/s12906-021-03347-6. [PMID: 34215249] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Marcel Kaiser, Gerhard Bringmann. Spirombandakamine A3 and Cyclombandakamines A8 and A9, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Ancistrocladus Plant.
Journal of natural products.
2021 04; 84(4):1335-1344. doi:
10.1021/acs.jnatprod.1c00063. [PMID: 33843232] - Marcella Paula Mansano Sarto, Hevillyn Fernanda Lucas da Silva, Nilma de Souza Fernandes, Ana Paula de Abreu, Gerson Zanusso Junior, Max Jean de Ornelas Toledo. Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II.
BMC complementary medicine and therapies.
2021 Feb; 21(1):77. doi:
10.1186/s12906-021-03248-8. [PMID: 33632196] - Marisa L Fernández, María E Marson, Guido E Mastrantonio, Marcelo A Corti, Ulises Fleitas, Susana C Lloveras, Nicolas Lista, Maria M Priarone, Cecilia Domínguez, Facundo Garcia-Bournissen. Benznidazole in Cerebrospinal Fluid: a Case Series of Chagas Disease Meningoencephalitis in HIV-Positive Patients.
Antimicrobial agents and chemotherapy.
2021 02; 65(3):. doi:
10.1128/aac.01922-20. [PMID: 33361290] - Antônia Carla de Jesus Oliveira, Luíse Lopes Chaves, Fábio de Oliveira Silva Ribeiro, Laís Ramos Monteiro de Lima, Thaisa Cardoso Oliveira, Fátima García-Villén, César Viseras, Regina C M de Paula, Pedro José Rolim-Neto, Fernando Hallwass, Edson C Silva-Filho, Durcilene Alves da Silva, José Lamartine Soares-Sobrinho, Mônica Felts de La Roca Soares. Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems.
Carbohydrate polymers.
2021 Feb; 254(?):117226. doi:
10.1016/j.carbpol.2020.117226. [PMID: 33357841] - Suzana Marques de Jesus, Leonardo Pinto, Fernanda de Lima Moreira, Glauco Henrique Balthazar Nardotto, Rodrigo Cristofoletti, Luísa Perin, Kátia da Silva Fonseca, Pauliana Barbêdo, Lorena Cera Bandeira, Paula Melo de Abreu Vieira, Claudia Martins Carneiro. Pharmacokinetics of Benznidazole in Experimental Chronic Chagas Disease Using the Swiss Mouse-Berenice-78 Trypanosoma cruzi Strain Model.
Antimicrobial agents and chemotherapy.
2021 01; 65(2):. doi:
10.1128/aac.01383-20. [PMID: 33168611] - Glaucia Vilar-Pereira, Leda Castaño Barrios, Andrea Alice da Silva, Angelica Martins Batista, Isabela Resende Pereira, Otacílio Cruz Moreira, Constança Britto, Hílton Antônio Mata Dos Santos, Joseli Lannes-Vieira. Memory impairment in chronic experimental Chagas disease: Benznidazole therapy reversed cognitive deficit in association with reduction of parasite load and oxidative stress in the nervous tissue.
PloS one.
2021; 16(1):e0244710. doi:
10.1371/journal.pone.0244710. [PMID: 33400707] - Alexandra Neuenschwander, Vinicius P C Rocha, Tanira M Bastos, Laurence Marcourt, Hugo Morin, Cláudia Q da Rocha, Gabriela B Grimaldi, Karoline A F de Sousa, Jadson N Borges, Elisabeth Rivara-Minten, Jean-Luc Wolfender, Milena B P Soares, Emerson F Queiroz. Production of Highly Active Antiparasitic Compounds from the Controlled Halogenation of the Arrabidaea brachypoda Crude Plant Extract.
Journal of natural products.
2020 09; 83(9):2631-2640. doi:
10.1021/acs.jnatprod.0c00433. [PMID: 32902988] - Cyril Fersing, Clotilde Boudot, Caroline Castera-Ducros, Emilie Pinault, Sébastien Hutter, Romain Paoli-Lombardo, Nicolas Primas, Julien Pedron, Line Seguy, Sandra Bourgeade-Delmas, Alix Sournia-Saquet, Jean-Luc Stigliani, Jean-Yves Brossas, Luc Paris, Alexis Valentin, Susan Wyllie, Alan H Fairlamb, Élisa Boutet-Robinet, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Alexandre Destere, Dominique Mazier, Pascal Rathelot, Bertrand Courtioux, Nadine Azas, Pierre Verhaeghe, Patrice Vanelle. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
European journal of medicinal chemistry.
2020 Sep; 202(?):112558. doi:
10.1016/j.ejmech.2020.112558. [PMID: 32652409] - María Gabriela Álvarez, Juan Carlos Ramírez, Graciela Bertocchi, Marisa Fernández, Yolanda Hernández, Bruno Lococo, Constanza Lopez-Albizu, Alejandro Schijman, Carolina Cura, Marcelo Abril, Susana Laucella, Rick L Tarleton, María Ailen Natale, Melisa Castro Eiro, Sergio Sosa-Estani, Rodolfo Viotti. New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.
Antimicrobial agents and chemotherapy.
2020 08; 64(9):. doi:
10.1128/aac.00439-20. [PMID: 32571827] - Luísa Perin, Leonardo Pinto, Glauco Henrique Balthazar Nardotto, Kátia da Silva Fonseca, Beatriz Oliveira Paiva, Thaís Fernanda Rodrigues Bastos Mendes, Israel Molina, Rodrigo Correa-Oliveira, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro. Population pharmacokinetics and biodistribution of benznidazole in mice.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2213-2221. doi:
10.1093/jac/dkaa130. [PMID: 32356873] - Andréa A S Mendonça, Elda Gonçalves-Santos, Thaiany G Souza-Silva, Kelly J González-Lozano, Ivo S Caldas, Reggiani V Gonçalves, Lívia F Diniz, Rômulo D Novaes. Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
International immunopharmacology.
2020 Aug; 85(?):106611. doi:
10.1016/j.intimp.2020.106611. [PMID: 32447223] - Rito Santo Pereira, Aparecida Donizette Malvezi, Maria Isabel Lovo-Martins, Bruno Fernando Cruz Lucchetti, Jussevania Pereira Santos, Eliandro Reis Tavares, Waldiceu Aparecido Verri, Eduardo José de Almeida Araújo, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho. Combination Therapy Using Benznidazole and Aspirin during the Acute Phase of Experimental Chagas Disease Prevents Cardiovascular Dysfunction and Decreases Typical Cardiac Lesions in the Chronic Phase.
Antimicrobial agents and chemotherapy.
2020 06; 64(7):. doi:
10.1128/aac.00069-20. [PMID: 32366719] - Victoria Perez-Zetune, Stephanie R Bialek, Susan P Montgomery, Eileen Stillwaggon. Congenital Chagas Disease in the United States: The Effect of Commercially Priced Benznidazole on Costs and Benefits of Maternal Screening.
The American journal of tropical medicine and hygiene.
2020 05; 102(5):1086-1089. doi:
10.4269/ajtmh.20-0005. [PMID: 32100696] - Ana Cláudia Alvarenga Carneiro, G P Costa, Cyntia Silva Ferreira, Isalira Peroba Rezende Ramos, Mariáurea Matias Sarandy, Ana Luísa Junqueira Leite, A P J Menezes, B M Silva, K O P C Nogueira, A C C Carvalho, Reggiani Vilela Gonçalves, André Talvani. Combination therapy with benznidazole and doxycycline shows no additive effect to monotherapy with benznidazole in mice infected with the VL-10 strain of the Trypanosoma cruzi.
International journal of cardiology.
2020 01; 299(?):243-248. doi:
10.1016/j.ijcard.2019.07.047. [PMID: 31353153] - Dieudonné Tshitenge Tshitenge, Torsten Bruhn, Doris Feineis, David Schmidt, Virima Mudogo, Marcel Kaiser, Reto Brun, Frank Würthner, Suresh Awale, Gerhard Bringmann. Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells.
Journal of natural products.
2019 11; 82(11):3150-3164. doi:
10.1021/acs.jnatprod.9b00755. [PMID: 31630523] - Shaimaa Fayez, Jun Li, Doris Feineis, Laurent Aké Assi, Marcel Kaiser, Reto Brun, Mohamed A Anany, Harald Wajant, Gerhard Bringmann. A Near-Complete Series of Four Atropisomeric Jozimine A2-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from Ancistrocladus abbreviatus.
Journal of natural products.
2019 11; 82(11):3033-3046. doi:
10.1021/acs.jnatprod.9b00589. [PMID: 31642313] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Maria Elena Ferreira, Antonieta Rojas de Arias, Gloria Yaluff, Ninfa Vera de Bilbao, Hector Nakayama, Susana Torres, Alicia Schinini, Susana Torres, Elva Serna, Ana Claudia Torrecilhas, Alain Fournet, Gerardo Cebrián-Torrejón. Helietta apiculata: a tropical weapon against Chagas disease.
Natural product research.
2019 Nov; 33(22):3308-3311. doi:
10.1080/14786419.2018.1472594. [PMID: 29745731] - Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae.
Bioorganic & medicinal chemistry letters.
2019 10; 29(20):126642. doi:
10.1016/j.bmcl.2019.126642. [PMID: 31515186] - Eufrânio N da Silva Júnior, Guilherme A M Jardim, Claus Jacob, Uttam Dhawa, Lutz Ackermann, Solange L de Castro. Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.
European journal of medicinal chemistry.
2019 Oct; 179(?):863-915. doi:
10.1016/j.ejmech.2019.06.056. [PMID: 31306817] - Clara Vásquez Velásquez, Graciela Russomando, Emilio E Espínola, Zunilda Sanchez, Kota Mochizuki, Yelin Roca, Jimmy Revollo, Angelica Guzman, Benjamín Quiroga, Susana Rios Morgan, Roberto Vargas Ortiz, Alberto Zambrana Ortega, Eida Espinoza, Juan Eiki Nishizawa, Mohamed Gomaa Kamel, Mihoko Kikuchi, Shusaku Mizukami, Kesara Na-Bangchang, Nguyen Tien Huy, Kenji Hirayama. IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia.
PLoS neglected tropical diseases.
2019 09; 13(9):e0007715. doi:
10.1371/journal.pntd.0007715. [PMID: 31553732] - Daiane D Ferreira, Fernanda S Sousa, Thais A Costa-Silva, Juliana Q Reimão, Ana C Torrecilhas, Deidre M Johns, Claire E Sear, Kathia M Honorio, João Henrique G Lago, Edward A Anderson, Andre G Tempone. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi.
European journal of medicinal chemistry.
2019 Aug; 176(?):162-174. doi:
10.1016/j.ejmech.2019.05.001. [PMID: 31103897] - Itzel Santiago-Figueroa, Alejandro Lara-Bueno, Roberto González-Garduño, Ma Eugenia López-Arellano, Jorge Luis de la Rosa-Arana, Ema de Jesús Maldonado-Simán. Anthelmintic resistance in hair sheep farms in a sub-humid tropical climate, in the Huasteca Potosina, Mexico.
Veterinary parasitology, regional studies and reports.
2019 08; 17(?):100292. doi:
10.1016/j.vprsr.2019.100292. [PMID: 31303239] - Marianne Rocha Simões-Silva, Raiza Brandão Peres, Constança Britto, Cynthia Machado Cascabulho, Gabriel de Melo Oliveira, Aline Nefertiti da Gama, Cristiane França da Silva, Karine Lima da Costa, Paula Finamore Araújo, Jerônimo Diego de Souza Campos, Marcos Meuser Batista, Kelly Cristina Demarque, Otacílio da Cruz Moreira, Maria de Nazaré Correia Soeiro. Impact of levamisole in co-administration with benznidazole on experimental Chagas disease.
Parasitology.
2019 07; 146(8):1055-1062. doi:
10.1017/s0031182019000374. [PMID: 31046850] - Jeremiah D Momper, Nathan J Hanan, Steven S Rossi, Mark H Mirochnick, Maria Luisa Cafferata, Antonia Lavenia, Isolina Flores, Luz Gibbons, Alvaro Ciganda, Sergio Sosa Estani, Edmund V Capparelli, Pierre Buekens. Determination of Benznidazole in Human Dried Blood Spots by Liquid Chromatography-Mass Spectrometry to Monitor Adherence to Trypanosoma cruzi Infection Treatment in Infants and Children.
The American journal of tropical medicine and hygiene.
2019 07; 101(1):116-122. doi:
10.4269/ajtmh.18-0852. [PMID: 31115303] - Emerson A Oliveira, Ivanildo A Brito, Marta L Lima, Maiara Romanelli, José T Moreira-Filho, Bruno J Neves, Carolina H Andrade, Patricia Sartorelli, Andre G Tempone, Thais A Costa-Silva, João Henrique G Lago. Antitrypanosomal Activity of Acetogenins Isolated from the Seeds of Porcelia macrocarpa Is Associated with Alterations in Both Plasma Membrane Electric Potential and Mitochondrial Membrane Potential.
Journal of natural products.
2019 05; 82(5):1177-1182. doi:
10.1021/acs.jnatprod.8b00890. [PMID: 31046273] - Cleber C Melo-Filho, Rodolpho C Braga, Eugene N Muratov, Caio Haddad Franco, Carolina B Moraes, Lucio H Freitas-Junior, Carolina Horta Andrade. Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening.
European journal of medicinal chemistry.
2019 Feb; 163(?):649-659. doi:
10.1016/j.ejmech.2018.11.062. [PMID: 30562700] - Edmundo J N Camara, Vitor R R Mendonca, Ligia C L Souza, Juliana S Carvalho, Ruda A Lessa, Ramon Gatto, Luan O Barreto, Giulianna Chiacchio, Eduardo Amarante, Monaliza Cunha, Luis S Alves-Silva, Benelson A C Guimarães, Manoel Barral-Netto. Elevated IL-17 levels and echocardiographic signs of preserved myocardial function in benznidazole-treated individuals with chronic Chagas' disease.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2019 Feb; 79(?):123-130. doi:
10.1016/j.ijid.2018.11.369. [PMID: 30528394] - Julio Alonso-Padilla, Dolors Tassies, Nuria Cortes-Serra, Joaquim Gascon, Joan-Carles Reverter, María-Jesús Pinazo. Host-Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma.
Methods in molecular biology (Clifton, N.J.).
2019; 1955(?):275-286. doi:
10.1007/978-1-4939-9148-8_21. [PMID: 30868535] - Carlos Robello, Doris Patricia Maldonado, Anna Hevia, Marina Hoashi, Paola Frattaroli, Valentina Montacutti, Adriana Heguy, Igor Dolgalev, Maricruz Mojica, Gregorio Iraola, Maria G Dominguez-Bello. The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.
PloS one.
2019; 14(2):e0212593. doi:
10.1371/journal.pone.0212593. [PMID: 30807605] - M Montero, M Mir, E Sulleiro, J L Avalos Esquivel, E García López, D Molina-Morant, I López Montesinos, L Sorlí, G Veliz Espinosa, E Mounteis Oliva, M Crespo, I Monge, J P Horcajada, S Grau, J Pascual. High-dose benznidazole in a 62-year-old Bolivian kidney transplant recipient with Chagas central nervous system involvement.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2019 Jan; 78(?):103-106. doi:
10.1016/j.ijid.2018.10.014. [PMID: 30391324] - Danilo César Galindo Bedor, Noely Camila Tavares Cavalcanti Bedor, José Wellithom Viturino da Silva, Giovana Damasceno Sousa, Davi Pereira de Santana, Facundo Garcia-Bournissen, Jaime Altcheh, Bethania Blum, Fabiana Alves, Isabela Ribeiro. Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment.
Antimicrobial agents and chemotherapy.
2018 12; 62(12):. doi:
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