chlormezanone (BioDeep_00000014957)

 

Secondary id: BioDeep_00000017961

natural product


代谢物信息卡片


Chlormezanone (Trancopal)

化学式: C11H12ClNO3S (273.0226392)
中文名称: 氯美扎酮
谱图信息: 最多检出来源 Homo sapiens(blood) 12%

分子结构信息

SMILES: C1=C(C=CC(=C1)C2S(CCC(N2C)=O)(=O)=O)Cl
InChI: InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3

描述信息

M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents > M03BB - Oxazol, thiazine, and triazine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
CONFIDENCE standard compound; INTERNAL_ID 1251; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3476; ORIGINAL_PRECURSOR_SCAN_NO 3474
CONFIDENCE standard compound; INTERNAL_ID 1251; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3477; ORIGINAL_PRECURSOR_SCAN_NO 3475
CONFIDENCE standard compound; INTERNAL_ID 1251; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3491; ORIGINAL_PRECURSOR_SCAN_NO 3489
CONFIDENCE standard compound; INTERNAL_ID 1251; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3493; ORIGINAL_PRECURSOR_SCAN_NO 3491
Chlormezanone resembles benzodiazepine. The action of Chlormezanone is similar to benzodiazepine-type agents. Chlormezanone is used as an anxiolytic and a muscle relaxant.

同义名列表

2 个代谢物同义名

chlormezanone; Chlormezanone (Trancopal)



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • A Seeling, H Oelschläger, D Rothley. [Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone]. Die Pharmazie. 2000 Apr; 55(4):293-6. doi: NULL. [PMID: 10798243]
  • W Klinger, H Oelschläger, D Rothley, E Karge, A Seeling. Interaction of chlormezanone enantiomers with rat liver microsomes. European journal of drug metabolism and pharmacokinetics. 1999 Jan; 24(1):63-8. doi: 10.1007/bf03190012. [PMID: 10412893]
  • H Oelschläger, W Klinger, D Rothley, A Seeling, H Bockhard, B Hofmann, H Machts, H Riederer, H Rackur. [Cleavage and biotransformation of the central muscle relaxant chlormezanone]. Die Pharmazie. 1998 Sep; 53(9):620-4. doi: . [PMID: 9770210]
  • W Klinger, H Oelschläger, E Karge, D Rothley. Interaction of chlormezanone with rat liver microsomes and its degradation. European journal of drug metabolism and pharmacokinetics. 1997 Apr; 22(2):165-71. doi: 10.1007/bf03189801. [PMID: 9248786]
  • H Schütz, A Eichinger, V Nitsche, R Hofmann. Relative bioavailability of 3 different chlormezanone 200 mg preparations after single dose oral administration. International journal of clinical pharmacology and therapeutics. 1997 Mar; 35(3):112-6. doi: NULL. [PMID: 9089000]
  • C Köppel, J Kristinsson, A Wagemann, J Tenczer, F Martens. Chlormezanone plasma and blood levels in patients after single and repeated oral doses and after suicidal drug overdose. European journal of drug metabolism and pharmacokinetics. 1991 Jan; 16(1):43-7. doi: 10.1007/bf03189873. [PMID: 1936060]
  • N Bernard, J P Fauvel, N Pozet, N Ferry, G Cuisinaud, P Haond, P Chapuy, J Sassard. Pharmacokinetics of chlormezanone in elderly patients. European journal of clinical pharmacology. 1991; 41(6):603-7. doi: 10.1007/bf00314993. [PMID: 1815974]
  • V Gautier, G Vinçon, F Demotes-Mainard, H Albin. [Pharmacokinetics of chlormezanone in healthy volunteers]. Therapie. 1990 Jul; 45(4):315-9. doi: NULL. [PMID: 2399514]
  • S L Ali, H Blume. Determination of chlormezanone in human plasma after administration of chlormezanone formulations. Arzneimittel-Forschung. 1987 Dec; 37(12):1396-9. doi: NULL. [PMID: 3449070]
  • C Köppel, J Tenczer, A Wagemann. Metabolism of chlormezanone in man. Arzneimittel-Forschung. 1986 Jul; 36(7):1116-8. doi: . [PMID: 3768082]
  • K Ohya, S Shintani, W Suzuki, M Sano. Sensitive and selective method for the determination of chlormezanone in plasma by electron-capture gas chromatography. Journal of chromatography. 1980 Nov; 221(1):67-74. doi: 10.1016/s0378-4347(00)81008-7. [PMID: 7451625]
  • H Hakusui, H Tachizawa, M Sano. Biotransformation of chlormezanone, 2-(4-chlorophenyl)-3-methyl-4-metathiazanone-1,1-dioxide, a muscle-relaxing and tranquillizing agent: the effect of combination with aspirin on its metabolic fate in rats and mice. Xenobiotica; the fate of foreign compounds in biological systems. 1978 Apr; 8(4):229-38. doi: 10.3109/00498257809056144. [PMID: 645106]
  • E Cayanis, E D Gomperts, D Balinsky, P Disler, A Myers. G6PD hillbrow: a new variant of glucose-6-phosphate dehydrogenase associated with drug-induced haemolytic anaemia. British journal of haematology. 1975 Jul; 30(3):343-50. doi: 10.1111/j.1365-2141.1975.tb00550.x. [PMID: 1201217]
  • A Furlani, A P Tomasi. [Tissue levels of radioactivity after 2 methods of administration of tritiated chlormethazanone]. Bollettino della Societa italiana di biologia sperimentale. 1969 Mar; 45(6):345-9. doi: NULL. [PMID: 5400452]
  • E W McChesney, W F Banks, G A Portmann, A V Crain. Metabolism of chlormezanone in man and laboratory animals. Biochemical pharmacology. 1967 May; 16(5):813-26. doi: 10.1016/0006-2952(67)90054-8. [PMID: 6036732]