Cromakalim (BioDeep_00000014855)
Main id: BioDeep_00000858731
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dihydro-2H-1-benzopyran-6-carbonitrile
化学式: C16H18N2O3 (286.1317358)
中文名称: 色满卡林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(C(C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
InChI: InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:3921
- KEGG: C11819
- PubChem: 443423
- HMDB: HMDB0250542
- Metlin: METLIN69235
- ChEMBL: CHEMBL49035
- Wikipedia: Cromakalim
- MeSH: Cromakalim
- chemspider: 391644
- CAS: 94470-67-4
- CAS: 94535-51-0
- PubChem: 13983
- NIKKAJI: J259.336J
- KNApSAcK: 3921
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohd Nazam Ansari, Najeeb Ur Rehman, Abdul Samad, Wasim Ahmad. Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies.
Frontiers in bioscience (Landmark edition).
2024 Jan; 29(1):43. doi:
10.31083/j.fbl2901043. [PMID: 38287835] - Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Dawon Kang, Seung Hyun Ahn, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta.
General physiology and biophysics.
2023 May; 42(3):297-306. doi:
10.4149/gpb_2023008. [PMID: 37098743] - Cynthia L Pervan-Steel, Uttio Roy Chowdhury, Hemchand K Sookdeo, Ralph A Casale, Peter I Dosa, Thurein M Htoo, Michael P Fautsch, Barbara M Wirostko. Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (KATP) Channel Opening Prodrug.
Investigative ophthalmology & visual science.
2022 04; 63(4):26. doi:
10.1167/iovs.63.4.26. [PMID: 35486069] - Uttio Roy Chowdhury, Rachel A Kudgus, Bradley H Holman, Tommy A Rinkoski, Cheryl R Hann, Cindy K Bahler, Eric McCloud, Susan E Appt, Joel M Reid, Peter I Dosa, Michael P Fautsch. Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2021 06; 37(5):251-260. doi:
10.1089/jop.2020.0137. [PMID: 33784195] - Brittney R Garner, Amanda J Stolarz, Daniel Stuckey, Mustafa Sarimollaoglu, Yunmeng Liu, Philip T Palade, Nancy J Rusch, Shengyu Mu. KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema.
The Journal of pharmacology and experimental therapeutics.
2021 01; 376(1):40-50. doi:
10.1124/jpet.120.000121. [PMID: 33100270] - Soo Hee Lee, Dawon Kang, Seong-Ho Ok, Ji-Yoon Kim, Sung Il Bae, Yeran Hwang, Kyeong-Eon Park, Jong Won Kim, Ju-Tae Sohn. Lipofundin MCT/LCT Inhibits Levcromakalim-Induced Vasodilation by Inhibiting Endothelial Nitric Oxide Release.
International journal of molecular sciences.
2020 Mar; 21(5):. doi:
10.3390/ijms21051763. [PMID: 32143531] - Uttio Roy Chowdhury, Rachel A Kudgus, Tommy A Rinkoski, Bradley H Holman, Cindy K Bahler, Cheryl R Hann, Joel M Reid, Peter I Dosa, Michael P Fautsch. Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits.
PloS one.
2020; 15(4):e0231841. doi:
10.1371/journal.pone.0231841. [PMID: 32298376] - Soo Hee Lee, Dawon Kang, Seong-Ho Ok, Seong-Chun Kwon, Hyun-Jin Kim, Eun-Jin Kim, Jeong-Min Hong, Ji-Yoon Kim, Sung Il Bae, Seungmin An, Ju-Tae Sohn. Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels.
International journal of molecular sciences.
2018 Jun; 19(7):. doi:
10.3390/ijms19071876. [PMID: 29949899] - Zhijuan Cao, Wenling Dai, Ran Zhang, Lu Chen, Xiangyu Yang, Liang Hu, Li-Yang Chiang, Wentao Liu. Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord.
The Clinical journal of pain.
2016 07; 32(7):617-23. doi:
10.1097/ajp.0000000000000299. [PMID: 26626290] - Jessica R C Priestley, Matthew W Buelow, Scott T McEwen, Brian D Weinberg, Melanie Delaney, Sarah F Balus, Carlyn Hoeppner, Lynn Dondlinger, Julian H Lombard. Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles.
Microvascular research.
2013 Sep; 89(?):134-45. doi:
10.1016/j.mvr.2013.04.004. [PMID: 23628292] - Omonkhelin J Owolabi, Eric K I Omogbai. Evaluation of the potassium channel activator levcromakalim (BRL38227) on the lipid profile, electrolytes and blood glucose levels of streptozotocin-diabetic rats.
Journal of diabetes.
2013 Mar; 5(1):88-94. doi:
10.1111/1753-0407.12001. [PMID: 23374501] - Fumiya Ohmasa, Motoaki Saito, Harunori Oiwa, Panagiota Tsounapi, Kohei Shomori, Kazuyuki Kitatani, Fotios Dimitriadis, Yukako Kinoshita, Keisuke Satoh. Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.
BJU international.
2012 Sep; 110(6 Pt B):E245-52. doi:
10.1111/j.1464-410x.2012.10965.x. [PMID: 22369430] - Shogo Shimizu, Motoaki Saito, Yukako Kinoshita, Fumiya Ohmasa, Fotios Dimitriadis, Kohei Shomori, Atsushi Hayashi, Keisuke Satoh. Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.
British journal of pharmacology.
2011 May; 163(2):272-82. doi:
10.1111/j.1476-5381.2011.01231.x. [PMID: 21250976] - Noriyoshi Teramoto, Hai-Lei Zhu, Atsushi Shibata, Manami Aishima, Emma J Walsh, Masaya Nagao, William C Cole. ATP-sensitive K+ channels in pig urethral smooth muscle cells are heteromultimers of Kir6.1 and Kir6.2.
American journal of physiology. Renal physiology.
2009 Jan; 296(1):F107-17. doi:
10.1152/ajprenal.90440.2008. [PMID: 18945825] - Betty Ng, Youhou Kang, Huanli Xie, Hui Sun, Herbert Y Gaisano. Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.
Cardiovascular research.
2008 Dec; 80(3):365-74. doi:
10.1093/cvr/cvn210. [PMID: 18703534] - B Löhrke, M Derno, H Hammon, C Metges, J Melcher, T Viergutz, W Jentsch, H Zühlke. Nutritional level and energetic source are determinants of elevated circulatory lipohydroperoxide concentration.
The British journal of nutrition.
2008 Jun; 99(6):1255-65. doi:
10.1017/s000711450886240x. [PMID: 18272015] - Joseph D Raffetto, Reagan L Ross, Raouf A Khalil. Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation.
Journal of vascular surgery.
2007 Feb; 45(2):373-80. doi:
10.1016/j.jvs.2006.10.041. [PMID: 17264019] - Francis Fu Yuen Lam, Sai Wang Seto, Yiu Wa Kwan, John Hok Keung Yeung, Paul Chan. Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.
European journal of pharmacology.
2006 Sep; 546(1-3):28-35. doi:
10.1016/j.ejphar.2006.07.038. [PMID: 16928370] - Anwar H Gilani, Arif-ullah Khan, Qaiser Jabeen, Fazal Subhan, Rukhsana Ghafar. Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation.
Journal of ethnopharmacology.
2005 Sep; 100(3):347-52. doi:
10.1016/j.jep.2005.05.010. [PMID: 16002246] - Kenji Sampei, John A Ulatowski, Yoshio Asano, Herman Kwansa, Enrico Bucci, Raymond C Koehler. Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion.
American journal of physiology. Heart and circulatory physiology.
2005 Sep; 289(3):H1191-201. doi:
10.1152/ajpheart.00251.2005. [PMID: 15894576] - Masaki Okajima, Robert Parent, Eric Thorin, Michel Lavallée. Pathophysiological plasma ET-1 levels antagonize beta-adrenergic dilation of coronary resistance vessels in conscious dogs.
American journal of physiology. Heart and circulatory physiology.
2004 Oct; 287(4):H1476-83. doi:
10.1152/ajpheart.00297.2004. [PMID: 15205173] - Xiaochun Jin, Anna P Malykhina, Florea Lupu, Hamid I Akbarali. Altered gene expression and increased bursting activity of colonic smooth muscle ATP-sensitive K+ channels in experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology.
2004 Jul; 287(1):G274-85. doi:
10.1152/ajpgi.00472.2003. [PMID: 14962845] - Majid Rahgozar, Desley A Willgoss, Glenda C Gobé, Zoltán H Endre. ATP-dependent K+ channels in renal ischemia reperfusion injury.
Renal failure.
2003 Nov; 25(6):885-96. doi:
10.1081/jdi-120026024. [PMID: 14669848] - Shampa Chatterjee, Abu-Bakr Al-Mehdi, Irena Levitan, Troy Stevens, Aron B Fisher. Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells.
American journal of physiology. Cell physiology.
2003 Oct; 285(4):C959-67. doi:
10.1152/ajpcell.00511.2002. [PMID: 12826604] - Katsuhiko Muraki. [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2003 Mar; 121(3):143-51. doi:
10.1254/fpj.121.143. [PMID: 12673948] - Thomas A Fey, Murali Gopalakrishnan, James G Strake, Linda L King, Jorge D Brioni, James P Sullivan, Michael J Coghlan, Michael E Brune. Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction.
Neurourology and urodynamics.
2003; 22(2):147-55. doi:
10.1002/nau.10103. [PMID: 12579633] - Jayant S Kulkarni, Anita A Metha, Dev D Santani, Ramesh K Goyal. Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.
Pharmacological research.
2002 Aug; 46(2):101-5. doi:
10.1016/s1043-6618(02)00078-6. [PMID: 12220947] - Claudia Simões, Erik Svensjö, Eliete Bouskela. Effects of cromakalim and glibenclamide on arteriolar and venular diameters and macromolecular leakage in the microcirculation during ischemia/reperfusion.
Journal of cardiovascular pharmacology.
2002 Mar; 39(3):340-6. doi:
10.1097/00005344-200203000-00004. [PMID: 11862112] - Yi Cui, Sandy Tran, Andrew Tinker, Lucie H Clapp. The molecular composition of K(ATP) channels in human pulmonary artery smooth muscle cells and their modulation by growth.
American journal of respiratory cell and molecular biology.
2002 Jan; 26(1):135-43. doi:
10.1165/ajrcmb.26.1.4622. [PMID: 11751213] - Y Luo, W Lai, J Xu. [Role of salbutamol in inducing apoptosis of cultured human airway smooth muscle cells].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2001 Apr; 24(4):219-24. doi:
NULL. [PMID: 11802967] - D Luo, M Nakazawa, Y Yoshida, J Cai, S Imai. Effects of three different Ca(2+) pump ATPase inhibitors on evoked contractions in rabbit aorta and activities of Ca(2+) pump ATPases in porcine aorta.
General pharmacology.
2000 Mar; 34(3):211-20. doi:
10.1016/s0306-3623(00)00064-1. [PMID: 11120383] - A B Al-Mehdi, G Zhao, K Tozawa, A B Fisher. Depolarization-associated iron release with abrupt reduction in pulmonary endothelial shear stress in situ.
Antioxidants & redox signaling.
2000; 2(2):335-45. doi:
10.1089/ars.2000.2.2-335. [PMID: 11229537] - U Russ, U Rauch, U Quast. Pharmacological evidence for a KATP channel in renin-secreting cells from rat kidney.
The Journal of physiology.
1999 Jun; 517 ( Pt 3)(?):781-90. doi:
10.1111/j.1469-7793.1999.0781s.x. [PMID: 10358118] - J Kalliovalkama, P Jolma, J P Tolvanen, M Kähönen, N Hutri-Kähönen, X Wu, P Holm, I Pörsti. Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.
Cardiovascular research.
1999 Jun; 42(3):773-82. doi:
10.1016/s0008-6363(98)00346-0. [PMID: 10533618] - T Kamijo, K Kamei, I Sugo, T Kamiyama, H Sudo, Y Ohba. Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: a comparison with cromakalim and nitroglycerin.
Journal of cardiovascular pharmacology.
1999 Jan; 33(1):93-101. doi:
10.1097/00005344-199901000-00014. [PMID: 9890402] - H M Prior, M S Yates, D J Beech. Role of K+ channels in A2A adenosine receptor-mediated dilation of the pressurized renal arcuate artery.
British journal of pharmacology.
1999 Jan; 126(2):494-500. doi:
10.1038/sj.bjp.0702310. [PMID: 10077243] - S Picard, R Rouet, D Duval, F Chesnay, J L Gérard. KATP channel modulators and myocardial damages induced by ischemia-reperfusion: membrane lipids injury and arrhythmias.
Journal of molecular and cellular cardiology.
1998 Dec; 30(12):2613-21. doi:
10.1006/jmcc.1998.0819. [PMID: 9990533] - A Abe, C Kawazoe, Y Kondo, K Sato. Vascular responsiveness in alloxan-induced diabetes-susceptible (ALS) and resistant (ALR) mice.
The Journal of veterinary medical science.
1998 Oct; 60(10):1119-25. doi:
10.1292/jvms.60.1119. [PMID: 9819766] - Z Rozsa, J Pataricza, J Nemeth, J G Papp. Differential efficacy of vasodilators in hypercholesterolaemic rabbits.
The Journal of pharmacy and pharmacology.
1998 Sep; 50(9):1035-44. doi:
10.1111/j.2042-7158.1998.tb06919.x. [PMID: 9811165] - J I Kourie. Effects of ATP-sensitive potassium channel regulators on chloride channels in the sarcoplasmic reticulum vesicles from rabbit skeletal muscle.
The Journal of membrane biology.
1998 Jul; 164(1):47-58. doi:
10.1007/s002329900392. [PMID: 9636243] - B L Jensen, S Gambaryan, H Scholz, A Kurtz. KATP channels are not essential for pressure-dependent control of renin secretion.
Pflugers Archiv : European journal of physiology.
1998 Apr; 435(5):670-7. doi:
10.1007/s004240050568. [PMID: 9479020] - S P Yu, C H Yeh, S L Sensi, B J Gwag, L M Canzoniero, Z S Farhangrazi, H S Ying, M Tian, L L Dugan, D W Choi. Mediation of neuronal apoptosis by enhancement of outward potassium current.
Science (New York, N.Y.).
1997 Oct; 278(5335):114-7. doi:
10.1126/science.278.5335.114. [PMID: 9311914] - S Nagata, K Takeyama, K Hosoki, T Karasawa. Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-gamma-D-glutamyl)octahydro-1H- indole-2-carboxylic acid.
Arzneimittel-Forschung.
1997 Jun; 47(6):726-30. doi:
. [PMID: 9239450] - J Kawahara, Y Jinno, M Endo, H Izumi, A Takeuchi, T Izawa. KRN4884, a novel K channel opener: antihypertensive effects in conscious renal hypertensive dogs.
Journal of cardiovascular pharmacology.
1997 Jun; 29(6):814-9. doi:
10.1097/00005344-199706000-00016. [PMID: 9234664] - R B Jones, K Dickinson, D M Anthony, A R Marita, C L Kaul, W R Buckett. Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
British journal of pharmacology.
1997 Mar; 120(6):1135-43. doi:
10.1038/sj.bjp.0701019. [PMID: 9134227] - D Fulton, J C McGiff, M S Wolin, P Kaminski, J Quilley. Evidence against a cytochrome P450-derived reactive oxygen species as the mediator of the nitric oxide-independent vasodilator effect of bradykinin in the perfused heart of the rat.
The Journal of pharmacology and experimental therapeutics.
1997 Feb; 280(2):702-9. doi:
NULL. [PMID: 9023282] - G C Rovnyak, S Z Ahmed, C Z Ding, S Dzwonczyk, F N Ferrara, W G Humphreys, G J Grover, D Santafianos, K S Atwal, A J Baird, L G McLaughlin, D E Normandin, P G Sleph, S C Traeger. Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.
Journal of medicinal chemistry.
1997 Jan; 40(1):24-34. doi:
10.1021/jm9605905. [PMID: 9016325] - K M Gillzan, A G Stewart. The role of potassium channels in the inhibitory effects of beta 2-adrenoceptor agonists on DNA synthesis in human cultured airway smooth muscle.
Pulmonary pharmacology & therapeutics.
1997; 10(2):71-9. doi:
10.1006/pupt.1997.0077. [PMID: 9425638] - Y Shimoe, M Yoshizumi, Y Masuda, T Kitagawa, I Katoh. Effect of cromakalim on ischemic and reperfused immature heart: experiments with isolated neonatal New Zealand white rabbit hearts.
The Tokushima journal of experimental medicine.
1996 Dec; 43(3-4):135-41. doi:
NULL. [PMID: 9100462] - N Paulino, V Cechinel-Filho, R A Yunes, J B Calixto. The relaxant effect of extract of Phyllanthus urinaria in the guinea-pig isolated trachea. Evidence for involvement of ATP-sensitive potassium channels.
The Journal of pharmacy and pharmacology.
1996 Nov; 48(11):1158-63. doi:
10.1111/j.2042-7158.1996.tb03913.x. [PMID: 8961165] - R S de Moura, M de Lemos Neto. Effects of potassium channel modulators cromakalim, tetraethylammonium and glibenclamide on the contractility of the isolated human ureter.
The Journal of urology.
1996 Jul; 156(1):276-80. doi:
10.1097/00005392-199607000-00094. [PMID: 8648822] - M Rapacon, P Mieyal, J C McGiff, D Fulton, J Quilley. Contribution of calcium-activated potassium channels to the vasodilator effect of bradykinin in the isolated, perfused kidney of the rat.
British journal of pharmacology.
1996 Jul; 118(6):1504-8. doi:
10.1111/j.1476-5381.1996.tb15566.x. [PMID: 8832078] - K D Garlid, P Paucek, V Yarov-Yarovoy, X Sun, P A Schindler. The mitochondrial KATP channel as a receptor for potassium channel openers.
The Journal of biological chemistry.
1996 Apr; 271(15):8796-9. doi:
10.1074/jbc.271.15.8796. [PMID: 8621517] - J C Kidney, J O Lotvall, Y Lei, K F Chung, P J Barnes. The effect of inhaled K+ channel openers on bronchoconstriction and airway microvascular leakage in anaesthetised guinea pigs.
European journal of pharmacology.
1996 Jan; 296(1):81-7. doi:
10.1016/0014-2999(95)00670-2. [PMID: 8720480] - K W Hong, S E Yoo, S S Yu, J Y Lee, B Y Rhim. Pharmacological coupling and functional role for CGRP receptors in the vasodilation of rat pial arterioles.
The American journal of physiology.
1996 Jan; 270(1 Pt 2):H317-23. doi:
10.1152/ajpheart.1996.270.1.h317. [PMID: 8769767] - S J Hughes, M Hollingsworth. Cellular localization of the inhibitory action of relaxin against uterine spasm.
British journal of pharmacology.
1995 Dec; 116(7):3028-34. doi:
10.1111/j.1476-5381.1995.tb15959.x. [PMID: 8680739] - M Ichinose, M Miura, T Takahashi, H Yamauchi, N Kageyama, M Tomaki, N Endoh, E Sakurai, T Watanabe, K Shirato. Allergic airway response and potassium channels: histamine release and airway inflammation.
Methods and findings in experimental and clinical pharmacology.
1995 Nov; 17 Suppl C(?):36-9. doi:
NULL. [PMID: 8750793] - A Ogasawara, T Hirano, H Hisa, S Satoh. Cromakalim suppresses hypertonic saline-induced renal vasoconstriction in anaesthetized dogs.
Clinical and experimental pharmacology & physiology.
1995 Apr; 22(4):311-3. doi:
10.1111/j.1440-1681.1995.tb02007.x. [PMID: 7671451] - S T Kau, P Zografos, M L Do, T J Halterman, M W McConville, C L Yochim, S Trivedi, B B Howe, J H Li. Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
Pharmacology.
1994 Oct; 49(4):238-48. doi:
10.1159/000139239. [PMID: 7831387] - M Ichinose, M Miura, T Takahashi, H Yamauchi, N Nakajima, A Igarashi, J Ishikawa, H Inoue, K Maeyama, T Watanabe. Antigen-induced airway responses are inhibited by a potassium channel opener.
American journal of respiratory and critical care medicine.
1994 Aug; 150(2):388-93. doi:
10.1164/ajrccm.150.2.7519521. [PMID: 7519521] - L Zhang, A D Bonev, M T Nelson, G M Mawe. Activation of ATP-sensitive potassium currents in guinea-pig gall-bladder smooth muscle by the neuropeptide CGRP.
The Journal of physiology.
1994 Aug; 478 Pt 3(?):483-91. doi:
10.1113/jphysiol.1994.sp020267. [PMID: 7965858] - B Y Rhim, K W Hong. Relaxation by cromakalim and pinacidil of isolated smooth muscle cells from canine coronary artery-multiple sites of action.
Archives internationales de pharmacodynamie et de therapie.
1994 Jul; 328(1):67-81. doi:
. [PMID: 7893192] - S Cyrys, J Daut. The sensitivity of coronary vascular tone to glibenclamide: a study on the isolated perfused guinea pig heart.
Cardiovascular research.
1994 Jun; 28(6):888-93. doi:
10.1093/cvr/28.6.888. [PMID: 7923296] - K Orito, T Yanagisawa, N Taira. A possibility that the ATP-sensitive potassium channel in coronary artery has a high-affinity internal binding site for tetraalkylammonium.
Japanese journal of pharmacology.
1994 Apr; 64(4):297-301. doi:
10.1254/jjp.64.297. [PMID: 8057531] - C A Maggi, S Giuliani, P Santicioli. Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureter.
British journal of pharmacology.
1994 Mar; 111(3):687-94. doi:
10.1111/j.1476-5381.1994.tb14792.x. [PMID: 8019747] - I Nakae, L Quan, K Hashimoto, Y Sugimoto, T Tsutamoto, M Kinoshita. Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs.
Cardiovascular drugs and therapy.
1994 Feb; 8(1):137-45. doi:
10.1007/bf00877102. [PMID: 8086324] - K W Hong, K M Pyo, W S Lee, S S Yu, B Y Rhim. Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation.
The American journal of physiology.
1994 Jan; 266(1 Pt 2):H11-6. doi:
10.1152/ajpheart.1994.266.1.h11. [PMID: 7508205] - U Zwergel, E Klaus, H Englert, T Zwergel. New drugs for renal colic therapy--in-vitro and animal experiments.
Investigative urology (Berlin, Germany).
1994; 5(?):225-9. doi:
NULL. [PMID: 7719311] - H Kontani, M Jinkawa, T Sakai. Effects of levcromakalim on ureteral peristaltic function and cystometrogram in rats.
Japanese journal of pharmacology.
1993 Dec; 63(4):503-11. doi:
10.1254/jjp.63.503. [PMID: 8121083] - Y H Lei, P J Barnes, D F Rogers. Inhibition of neurogenic plasma exudation and bronchoconstriction by a K+ channel activator, BRL 38227, in guinea pig airways in vivo.
European journal of pharmacology.
1993 Aug; 239(1-3):257-9. doi:
10.1016/0014-2999(93)91007-a. [PMID: 8223905] - H Kontani, M Ginkawa, T Sakai. A simple method for measurement of ureteric peristaltic function in vivo and the effects of drugs acting on ion channels applied from the ureter lumen in anesthetized rats.
Japanese journal of pharmacology.
1993 Aug; 62(4):331-8. doi:
10.1254/jjp.62.331. [PMID: 7693993] - J P Bourreau, C Y Kwan, E E Daniel. Distinct pathways to refill ACh-sensitive internal Ca2+ stores in canine airway smooth muscle.
The American journal of physiology.
1993 Jul; 265(1 Pt 1):C28-35. doi:
10.1152/ajpcell.1993.265.1.c28. [PMID: 7687823] - X Villanove, R Marthan, J M Tunon de Lara, P R Johnson, J P Savineau, K O McKay, L A Alouan, C L Armour, J L Black. Sensitization decreases relaxation in human isolated airways.
The American review of respiratory disease.
1993 Jul; 148(1):107-12. doi:
10.1164/ajrccm/148.1.107. [PMID: 8391234] - J Cortijo, C Pedrós, J L Ortiz, E J Morcillo. Effects of cromakalim (BRL 34915) in trachea isolated from actively sensitized guinea-pigs.
The Journal of pharmacy and pharmacology.
1993 May; 45(5):453-7. doi:
10.1111/j.2042-7158.1993.tb05575.x. [PMID: 8099966] - G H Gelband, J R McCullough. Modulation of rabbit aortic Ca(2+)-activated K+ channels by pinacidil, cromakalim, and glibenclamide.
The American journal of physiology.
1993 May; 264(5 Pt 1):C1119-27. doi:
10.1152/ajpcell.1993.264.5.c1119. [PMID: 8498475] - J C Kidney, R W Fuller, Y M Worsdell, E A Lavender, K F Chung, P J Barnes. Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol.
Thorax.
1993 Feb; 48(2):130-3. doi:
10.1136/thx.48.2.130. [PMID: 8493625] - J H Jaggar, E A Harding, B J Ayton, M J Dunne. Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.
Journal of molecular endocrinology.
1993 Feb; 10(1):59-70. doi:
10.1677/jme.0.0100059. [PMID: 8452640] - E J Johns. Effect of BRL 38227 on the adrenergic regulation of the kidney vasculature of the rat.
European journal of pharmacology.
1993 Jan; 230(1):47-51. doi:
10.1016/0014-2999(93)90408-a. [PMID: 8428603] - A B Smith, D L Bertelsen, S T Kau, A L Chun. Effect of cromakalim on micturition function in rats.
Neurourology and urodynamics.
1993; 12(1):99-108. doi:
10.1002/nau.1930120111. [PMID: 8481733] - T Yamagishi, T Yanagisawa, N Taira. K+ channel openers, cromakalim and Ki4032, inhibit agonist-induced Ca2+ release in canine coronary artery.
Naunyn-Schmiedeberg's archives of pharmacology.
1992 Dec; 346(6):691-700. doi:
10.1007/bf00168744. [PMID: 1484567] - J M Pinheiro, A B Malik. K+ATP-channel activation causes marked vasodilation in the hypertensive neonatal pig lung.
The American journal of physiology.
1992 Nov; 263(5 Pt 2):H1532-6. doi:
10.1152/ajpheart.1992.263.5.h1532. [PMID: 1443205] - T Yamagishi, T Yanagisawa, N Taira. Activation of phospholipase C by the agonist U46619 is inhibited by cromakalim-induced hyperpolarization in porcine coronary artery.
Biochemical and biophysical research communications.
1992 Sep; 187(3):1517-22. doi:
10.1016/0006-291x(92)90474-y. [PMID: 1417828] - P W Tomlinson, J V Ramji, C W Filer. Disposition of the enantiomers of cromakalim in rat and cynomolgus monkey.
Xenobiotica; the fate of foreign compounds in biological systems.
1992 Jul; 22(7):799-814. doi:
10.3109/00498259209053142. [PMID: 1455901] - M Miura, M G Belvisi, C D Stretton, M H Yacoub, P J Barnes. Role of potassium channels in bronchodilator responses in human airways.
The American review of respiratory disease.
1992 Jul; 146(1):132-6. doi:
10.1164/ajrccm/146.1.132. [PMID: 1378252] - M Aghi, Z Husain, K K Pillai, J S Qadry, D K Balani, M Imran. Cardioprotective effect of cromakalim (potassium channel opener) in isoproterenol induced myocardial infarction in rats.
Indian journal of experimental biology.
1992 Jul; 30(7):611-4. doi:
NULL. [PMID: 1459635] - T Nakajima, T Shinohara, O Yaoka, A Fukunari, K Shinagawa, K Aoki, A Katoh, T Yamanaka, M Setoguchi, T Tahara. Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
The Journal of pharmacology and experimental therapeutics.
1992 May; 261(2):730-6. doi:
NULL. [PMID: 1578381] - R C Small, J L Berry, R W Foster. Potassium channel opening drugs and the airways.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1992; 25(10):983-98. doi:
NULL. [PMID: 1342832] - M Lebel, J H Grose, Y Lacourcière. Effect of short-term administration of cromakalim on renal hemodynamics and eicosanoid excretion in essential hypertension.
American journal of hypertension.
1991 Sep; 4(9):740-4. doi:
10.1093/ajh/4.9.740. [PMID: 1834087] - R J Kovacs, M T Nelson. ATP-sensitive K+ channels from aortic smooth muscle incorporated into planar lipid bilayers.
The American journal of physiology.
1991 Aug; 261(2 Pt 2):H604-9. doi:
10.1152/ajpheart.1991.261.2.h604. [PMID: 1715132] - J Pratz, S Mondot, F Montier, I Cavero. Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats.
The Journal of pharmacology and experimental therapeutics.
1991 Jul; 258(1):216-22. doi:
. [PMID: 1906538] - J C Clapham, T C Hamilton, S D Longman, R E Buckingham, C A Campbell, G L Ilsley, B Gout. Antihypertensive and haemodynamic properties of the potassium channel activating (-) enantiomer of cromakalim in animal models.
Arzneimittel-Forschung.
1991 Apr; 41(4):385-91. doi:
NULL. [PMID: 1907150] - T Tamaki, K Hasui, T Shoji, K Fukui, H Iwao, Y Abe. Effects of cromakalim on renal hemodynamics and function in dogs: comparison with nicardipine.
Journal of cardiovascular pharmacology.
1991 Feb; 17(2):305-9. doi:
10.1097/00005344-199102000-00017. [PMID: 1709236] - T R Jones, L Charette, M L Garcia, G J Kaczorowski. Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.
The Journal of pharmacology and experimental therapeutics.
1990 Nov; 255(2):697-706. doi:
. [PMID: 1700817] - R Donnelly, H L Elliott, P A Meredith, J L Reid. Clinical studies with the potassium channel activator cromakalim in normotensive and hypertensive subjects.
Journal of cardiovascular pharmacology.
1990 Nov; 16(5):790-5. doi:
10.1097/00005344-199011000-00015. [PMID: 1703602] - S Kudoh, H Nakamura. Direct determination of the antihypertensive agent Cromakalim and its major metabolites in human urine by high-performance liquid chromatography.
Journal of chromatography.
1990 Aug; 515(?):597-602. doi:
10.1016/s0021-9673(01)89359-6. [PMID: 2283381] - C Richer, P Mulder, M P Doussau, P Gautier, J F Giudicelli. Systemic and regional haemodynamic interactions between K+ channel openers and the sympathetic nervous system in the pithed SHR.
British journal of pharmacology.
1990 Jul; 100(3):557-63. doi:
10.1111/j.1476-5381.1990.tb15846.x. [PMID: 2390680] - W Spinelli, C Follmer, R Parsons, T Colatsky. Effects of cromakalim, pinacidil and nicorandil on cardiac refractoriness and arterial pressure in open-chest dogs.
European journal of pharmacology.
1990 Apr; 179(3):243-52. doi:
10.1016/0014-2999(90)90162-y. [PMID: 2142089] - P Thomas, M S Dixon, S J Winterton, D J Sheridan. Acute haemodynamic effects of cromakalim in patients with angina pectoris.
British journal of clinical pharmacology.
1990 Mar; 29(3):325-31. doi:
10.1111/j.1365-2125.1990.tb03643.x. [PMID: 2310656] - K Hayashi, Y Matsumura, Y Yoshida, T Ohyama, K Hisaki, Y Suzuki, S Morimoto. Effects of BRL 34915 (cromakalim) on renal hemodynamics and function in anesthetized dogs.
The Journal of pharmacology and experimental therapeutics.
1990 Mar; 252(3):1240-6. doi:
NULL. [PMID: 2108239]