Cromakalim (BioDeep_00000014855)
Main id: BioDeep_00000858731
human metabolite blood metabolite
代谢物信息卡片
化学式: C16H18N2O3 (286.1317358)
中文名称: 色满卡林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(C(C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C
InChI: InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:3921
- KEGG: C11819
- PubChem: 443423
- HMDB: HMDB0250542
- Metlin: METLIN69235
- ChEMBL: CHEMBL49035
- Wikipedia: Cromakalim
- MeSH: Cromakalim
- chemspider: 391644
- CAS: 94470-67-4
- CAS: 94535-51-0
- PubChem: 13983
- NIKKAJI: J259.336J
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mohd Nazam Ansari, Najeeb Ur Rehman, Abdul Samad, Wasim Ahmad. Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies.
Frontiers in bioscience (Landmark edition).
2024 Jan; 29(1):43. doi:
10.31083/j.fbl2901043
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General physiology and biophysics.
2023 May; 42(3):297-306. doi:
10.4149/gpb_2023008
. [PMID: 37098743] - Cynthia L Pervan-Steel, Uttio Roy Chowdhury, Hemchand K Sookdeo, Ralph A Casale, Peter I Dosa, Thurein M Htoo, Michael P Fautsch, Barbara M Wirostko. Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (KATP) Channel Opening Prodrug.
Investigative ophthalmology & visual science.
2022 04; 63(4):26. doi:
10.1167/iovs.63.4.26
. [PMID: 35486069] - Uttio Roy Chowdhury, Rachel A Kudgus, Bradley H Holman, Tommy A Rinkoski, Cheryl R Hann, Cindy K Bahler, Eric McCloud, Susan E Appt, Joel M Reid, Peter I Dosa, Michael P Fautsch. Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2021 06; 37(5):251-260. doi:
10.1089/jop.2020.0137
. [PMID: 33784195] - Brittney R Garner, Amanda J Stolarz, Daniel Stuckey, Mustafa Sarimollaoglu, Yunmeng Liu, Philip T Palade, Nancy J Rusch, Shengyu Mu. KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema.
The Journal of pharmacology and experimental therapeutics.
2021 01; 376(1):40-50. doi:
10.1124/jpet.120.000121
. [PMID: 33100270] - Soo Hee Lee, Dawon Kang, Seong-Ho Ok, Ji-Yoon Kim, Sung Il Bae, Yeran Hwang, Kyeong-Eon Park, Jong Won Kim, Ju-Tae Sohn. Lipofundin MCT/LCT Inhibits Levcromakalim-Induced Vasodilation by Inhibiting Endothelial Nitric Oxide Release.
International journal of molecular sciences.
2020 Mar; 21(5):. doi:
10.3390/ijms21051763
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PloS one.
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International journal of molecular sciences.
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The Clinical journal of pain.
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Journal of diabetes.
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British journal of pharmacology.
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American journal of physiology. Renal physiology.
2009 Jan; 296(1):F107-17. doi:
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. [PMID: 18945825] - Betty Ng, Youhou Kang, Huanli Xie, Hui Sun, Herbert Y Gaisano. Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.
Cardiovascular research.
2008 Dec; 80(3):365-74. doi:
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The British journal of nutrition.
2008 Jun; 99(6):1255-65. doi:
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Journal of vascular surgery.
2007 Feb; 45(2):373-80. doi:
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European journal of pharmacology.
2006 Sep; 546(1-3):28-35. doi:
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Journal of ethnopharmacology.
2005 Sep; 100(3):347-52. doi:
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American journal of physiology. Heart and circulatory physiology.
2005 Sep; 289(3):H1191-201. doi:
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American journal of physiology. Heart and circulatory physiology.
2004 Oct; 287(4):H1476-83. doi:
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. [PMID: 15205173] - Xiaochun Jin, Anna P Malykhina, Florea Lupu, Hamid I Akbarali. Altered gene expression and increased bursting activity of colonic smooth muscle ATP-sensitive K+ channels in experimental colitis.
American journal of physiology. Gastrointestinal and liver physiology.
2004 Jul; 287(1):G274-85. doi:
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Renal failure.
2003 Nov; 25(6):885-96. doi:
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. [PMID: 14669848] - Shampa Chatterjee, Abu-Bakr Al-Mehdi, Irena Levitan, Troy Stevens, Aron B Fisher. Shear stress increases expression of a KATP channel in rat and bovine pulmonary vascular endothelial cells.
American journal of physiology. Cell physiology.
2003 Oct; 285(4):C959-67. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2003 Mar; 121(3):143-51. doi:
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. [PMID: 12673948] - Thomas A Fey, Murali Gopalakrishnan, James G Strake, Linda L King, Jorge D Brioni, James P Sullivan, Michael J Coghlan, Michael E Brune. Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction.
Neurourology and urodynamics.
2003; 22(2):147-55. doi:
10.1002/nau.10103
. [PMID: 12579633] - Jayant S Kulkarni, Anita A Metha, Dev D Santani, Ramesh K Goyal. Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic rats.
Pharmacological research.
2002 Aug; 46(2):101-5. doi:
10.1016/s1043-6618(02)00078-6
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Journal of cardiovascular pharmacology.
2002 Mar; 39(3):340-6. doi:
10.1097/00005344-200203000-00004
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American journal of respiratory cell and molecular biology.
2002 Jan; 26(1):135-43. doi:
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Antioxidants & redox signaling.
2000; 2(2):335-45. doi:
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The Journal of physiology.
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Cardiovascular research.
1999 Jun; 42(3):773-82. doi:
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Journal of cardiovascular pharmacology.
1999 Jan; 33(1):93-101. doi:
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British journal of pharmacology.
1999 Jan; 126(2):494-500. doi:
10.1038/sj.bjp.0702310
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Journal of molecular and cellular cardiology.
1998 Dec; 30(12):2613-21. doi:
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The Journal of veterinary medical science.
1998 Oct; 60(10):1119-25. doi:
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1998 Sep; 50(9):1035-44. doi:
10.1111/j.2042-7158.1998.tb06919.x
. [PMID: 9811165] - J I Kourie. Effects of ATP-sensitive potassium channel regulators on chloride channels in the sarcoplasmic reticulum vesicles from rabbit skeletal muscle.
The Journal of membrane biology.
1998 Jul; 164(1):47-58. doi:
10.1007/s002329900392
. [PMID: 9636243] - B L Jensen, S Gambaryan, H Scholz, A Kurtz. KATP channels are not essential for pressure-dependent control of renin secretion.
Pflugers Archiv : European journal of physiology.
1998 Apr; 435(5):670-7. doi:
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Science (New York, N.Y.).
1997 Oct; 278(5335):114-7. doi:
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Arzneimittel-Forschung.
1997 Jun; 47(6):726-30. doi:
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1997 Jun; 29(6):814-9. doi:
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British journal of pharmacology.
1997 Mar; 120(6):1135-43. doi:
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1997 Jan; 40(1):24-34. doi:
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Pulmonary pharmacology & therapeutics.
1997; 10(2):71-9. doi:
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. [PMID: 9425638] - Y Shimoe, M Yoshizumi, Y Masuda, T Kitagawa, I Katoh. Effect of cromakalim on ischemic and reperfused immature heart: experiments with isolated neonatal New Zealand white rabbit hearts.
The Tokushima journal of experimental medicine.
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American journal of respiratory and critical care medicine.
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The Journal of physiology.
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Japanese journal of pharmacology.
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British journal of pharmacology.
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