Medphalan (BioDeep_00000014843)
Secondary id: BioDeep_00001868622
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid
化学式: C13H18Cl2N2O2 (304.0745268)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.5%
分子结构信息
SMILES: C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
InChI: InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)
描述信息
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents > D019653 - Myeloablative Agonists
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
15 个代谢物同义名
2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid; 2-Amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoate; 2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate; 4-(Bis(2-chloroethyl)amino)phenylalanine; Mustard, phenylalanine; Phenylalanine mustard; Sarcolysine; Sarcolysin; Sarkolysin; Merphalan; Medphalan; melphalan; Alkeran; L-PAM; Merphalan
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:82339
- KEGG: C19256
- PubChem: 4053
- HMDB: HMDB0244533
- Metlin: METLIN72976
- ChEMBL: CHEMBL429405
- MeSH: Melphalan
- chemspider: 3913
- CAS: 531-76-0
- PubChem: 124489928
- KNApSAcK: 82339
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mani Sharma, S S S S Sudha Ambadipudi, Neeraj Kumar Chouhan, V Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla. Design, synthesis and biological evaluation of novel cationic liposomes loaded with melphalan for the treatment of cancer.
Bioorganic & medicinal chemistry letters.
2023 Nov; ?(?):129549. doi:
10.1016/j.bmcl.2023.129549. [PMID: 37952597] - Anaïs Brion, Juliane Chaud, Maxime Klimezak, Frédéric Bolze, Laura Ohlmann, Jérémie Léonard, Stefan Chassaing, Benoît Frisch, Antoine Kichler, Béatrice Heurtault, Alexandre Specht. Photoactivatable Liposomes for Blue to Deep Red Light-Activated Surface Drug Release: Application to Controlled Delivery of the Antitumoral Drug Melphalan.
Bioconjugate chemistry.
2023 07; 34(7):1304-1315. doi:
10.1021/acs.bioconjchem.3c00197. [PMID: 37392184] - Jade L Kutzke, Julianna A Merten, Amanda G Pawlenty, Erin F Barreto, Gabe T Bartoo, Kristin C Mara, Mark R Litzow, William J Hogan, Mithun V Shah, Abhishek A Mangaonkar, Nelson Leung, Hassan B Alkhateeb. Relationship of iothalamate clearance and NRM in patients receiving fludarabine and melphalan reduced-intensity conditioning.
Blood advances.
2022 07; 6(13):3844-3849. doi:
10.1182/bloodadvances.2021006395. [PMID: 35522968] - Shuhui Li, Christopher C Dvorak, Ying Lu, Danna Chan, Jogarao V S Gobburu, Janel Long-Boyle, Beth Apsel Winger. Population Pharmacokinetics of Melphalan for Pediatric Patients Undergoing Hematopoietic Cell Transplantation.
Journal of clinical pharmacology.
2022 Jul; 62(7):873-882. doi:
10.1002/jcph.2030. [PMID: 35048362] - Pin Yu, Wei Deng, Linlin Bao, Yajin Qu, Yanfeng Xu, Wenjie Zhao, Yunlin Han, Chuan Qin. Comparative pathology of the nasal epithelium in K18-hACE2 Tg mice, hACE2 Tg mice, and hamsters infected with SARS-CoV-2.
Veterinary pathology.
2022 07; 59(4):602-612. doi:
10.1177/03009858211071016. [PMID: 35094625] - Xiang Liu, Helen Mostafavi, Wern Hann Ng, Joseph R Freitas, Nicholas J C King, Ali Zaid, Adam Taylor, Suresh Mahalingam. The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from Wuhan.
mBio.
2022 06; 13(3):e0068322. doi:
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Molecules (Basel, Switzerland).
2022 Jun; 27(13):. doi:
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JCI insight.
2022 06; 7(11):. doi:
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Virology journal.
2022 05; 19(1):86. doi:
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BMC cancer.
2022 Apr; 22(1):442. doi:
10.1186/s12885-022-09539-8. [PMID: 35459129] - Maya Abdallah, Vaishali Sanchorawala. Update on the Contemporary Treatment of Light Chain Amyloidosis Including Stem Cell Transplantation.
The American journal of medicine.
2022 04; 135 Suppl 1(?):S30-S37. doi:
10.1016/j.amjmed.2022.01.011. [PMID: 35081382] - Ting Y Wong, Alexander M Horspool, Brynnan P Russ, Chengjin Ye, Katherine S Lee, Michael T Winters, Justin R Bevere, Olivia A Miller, Nathaniel A Rader, Melissa Cooper, Theodore Kieffer, Julien Sourimant, Alexander L Greninger, Richard K Plemper, James Denvir, Holly A Cyphert, Mariette Barbier, Jordi B Torrelles, Ivan Martinez, Luis Martinez-Sobrido, F Heath Damron. Evaluating Antibody Mediated Protection against Alpha, Beta, and Delta SARS-CoV-2 Variants of Concern in K18-hACE2 Transgenic Mice.
Journal of virology.
2022 03; 96(6):e0218421. doi:
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Viruses.
2022 03; 14(3):. doi:
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Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
2022 Mar; 29(1):1-7. doi:
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The Lancet. Haematology.
2022 Feb; 9(2):e98-e110. doi:
10.1016/s2352-3026(21)00381-1. [PMID: 35032434] - Junan Li, Avinash K Persaud, Jasmine A Johnson, Dougkas W Sborov, Mitch A Phelps, Craig C Hofmeister, Ming J Poi. A Single Nucleotide Polymorphism (SNP) in the SLC22A3 Transporter Gene Is Associated With the Severity of Oral Mucositis in Multiple Myeloma Patients Receiving Autologous Stem Cell Transplant Followed by Melphalan Therapy.
Anticancer research.
2022 Jan; 42(1):385-395. doi:
10.21873/anticanres.15497. [PMID: 34969749] - Roberto Mina, Francesca Gay. The role of autologous stem-cell transplantation in multiple myeloma in 2021.
Current opinion in oncology.
2021 11; 33(6):642-647. doi:
10.1097/cco.0000000000000783. [PMID: 34419954] - Yu A Tereshkina, T I Torkhovskaya, M A Sanzhakov, L V Kostryukova, Yu Yu Khudoklinova, E G Tikhonova. [The effect of lipid derivative of anti-tumor drug sarcolysin embedded in phospholipid nanoparticles in the experiments in vivo].
Biomeditsinskaia khimiia.
2021 Nov; 67(6):491-499. doi:
10.18097/pbmc20216706491. [PMID: 34964443] - Sandra Lockmer, Katarina Uttervall, Muhammad Kashif, Carina Svärd, Katarina Malmsten, Evellyn Fletcher-Torres, Evren Alici, Johan Lund, Hareth Nahi. Antibody response to COVID-19 mRNA vaccine (Comirnaty) in myeloma patients treated with high-dose melphalan and/or immunotherapy.
American journal of hematology.
2021 11; 96(11):E443-E446. doi:
10.1002/ajh.26348. [PMID: 34524709] - Michael Heider, Sandra Grass, Veronika Dill, Stephanie Rämisch, Christof Winter, Mareike Verbeek, Katharina S Götze, Florian Bassermann, Stefanie Jilg. Cyclophosphamide plus etoposide is a safe and effective mobilization regimen in patients with multiple myeloma.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2021 Oct; 60(5):103197. doi:
10.1016/j.transci.2021.103197. [PMID: 34175195] - Brittany Seibert, C Joaquín Cáceres, Stivalis Cardenas-Garcia, Silvia Carnaccini, Ginger Geiger, Daniela S Rajao, Elizabeth Ottesen, Daniel R Perez. Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model.
Microbiology spectrum.
2021 09; 9(1):e0053621. doi:
10.1128/spectrum.00536-21. [PMID: 34378965] - H R Wardill, C E M de Mooij, A R da Silva Ferreira, I P van de Peppel, R Havinga, H J M Harmsen, W J E Tissing, N M A Blijlevens. Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever.
Cancer chemotherapy and pharmacology.
2021 08; 88(2):173-188. doi:
10.1007/s00280-021-04273-7. [PMID: 33877390] - María José Cejalvo, Gabriela Bustamante, Esther González, Judith Vázquez-Álvarez, Ricarda García, Ángel Ramírez-Payer, Ernesto Pérez-Persona, Eugenia Abella, Sebastián Garzón, Antoni García, Isidro Jarque, Marta Sonia González, Antonia Sampol, Cristina Motlló, Josep María Martí, Magdalena Alcalá, Rafael Duro, Yolanda González, José Luis Sastre, Josep Sarrà, Giselle Lostaunau, Rocío López, Javier de la Rubia. Treatment patterns and outcomes in real-world transplant-ineligible patients newly diagnosed with multiple myeloma.
Annals of hematology.
2021 Jul; 100(7):1769-1778. doi:
10.1007/s00277-021-04529-5. [PMID: 33885924] - Christian A Gordillo, Sapna Parmar, Miranda Blanco, Elsa M Delille, Amer Assal, Markus Mapara, Ran Reshef. Gastrointestinal toxicity of high-dose melphalan in autologous hematopoietic stem cell transplantation: identification of risk factors and a benchmark for experimental therapies.
Annals of hematology.
2021 Jul; 100(7):1863-1870. doi:
10.1007/s00277-020-04378-8. [PMID: 33388856] - Ji-Young Lim, Tae-Woo Kim, Da-Bin Ryu, Sung-Soo Park, Sung-Eun Lee, Byung-Soo Kim, Chang-Ki Min. Myeloma-Secreted Galectin-1 Potently Interacts with CD304 on Monocytic Myeloid-Derived Suppressor Cells.
Cancer immunology research.
2021 05; 9(5):503-513. doi:
10.1158/2326-6066.cir-20-0663. [PMID: 33771821] - Ljupco Veskovski, Per-Ola Andersson, Ingemar Turesson, Daniel Malmodin, Anders Pedersen, Ulf-Henrik Mellqvist. Serum metabolomic profiling correlated with ISS and clinical outcome for multiple myeloma patients treated with high-dose melphalan and autologous stem cell transplantation.
Experimental hematology.
2021 05; 97(?):79-88.e8. doi:
10.1016/j.exphem.2021.02.007. [PMID: 33609593] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Raphael Szalat, Shayna Sarosiek, Andrea Havasi, Dina Brauneis, J Mark Sloan, Vaishali Sanchorawala. Organ responses after highdose melphalan and stemcell transplantation in AL amyloidosis.
Leukemia.
2021 03; 35(3):916-919. doi:
10.1038/s41375-020-1006-7. [PMID: 32737434] - Q Wang, Z B Long, M Qian, J Feng, X X Guo, A M Yang, Y You, G J Fei. [The 486th case: chronic diarrhea and orthostatic hypotension].
Zhonghua nei ke za zhi.
2021 Mar; 60(3):284-288. doi:
10.3760/cma.j.cn112138-20200318-00260. [PMID: 33663184] - Shin-Ichi Fuchida. [Treatment strategy for immunoglobulin light chain amyloidosis].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2021; 62(8):1160-1166. doi:
10.11406/rinketsu.62.1160. [PMID: 34497203] - Sergio Giralt. Primary refractory multiple myeloma - what role for high dose melphalan?.
Leukemia & lymphoma.
2020 12; 61(12):2785. doi:
10.1080/10428194.2020.1811276. [PMID: 33222564] - Vania Hungria, Deborah M Martínez-Baños, María-Victoria Mateos, Meletios A Dimopoulos, Michele Cavo, Bart Heeg, Andrea Garcia, Annette Lam, Gerardo Machnicki, Jianming He, Mariana Fernandez. Daratumumab Plus Bortezomib, Melphalan, and Prednisone Versus Standard of Care in Latin America for Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Propensity Score Matching Analysis.
Advances in therapy.
2020 12; 37(12):4996-5009. doi:
10.1007/s12325-020-01521-9. [PMID: 33067698] - Victor Passos Gibson, Rabeb Mouna Derbali, Huu Trong Phan, Houda Tahiri, Christine Allen, Pierre Hardy, Jeanne Leblond Chain. Survivin silencing improved the cytotoxicity of carboplatin and melphalan in Y79 and primary retinoblastoma cells.
International journal of pharmaceutics.
2020 Nov; 589(?):119824. doi:
10.1016/j.ijpharm.2020.119824. [PMID: 32861768] - Shebli Atrash, Manisha Bhutani, Barry Paul, Peter M Voorhees, Saad Z Usmani. Management of newly diagnosed transplant ineligible multiple myeloma.
Leukemia & lymphoma.
2020 11; 61(11):2549-2560. doi:
10.1080/10428194.2020.1786558. [PMID: 32623918] - Karen Sweiss, Bhaskar Vemu, Craig C Hofmeister, Eric Wenzler, Gregory Sampang Calip, John P Galvin, Nadim Mahmud, Damiano Rondelli, Jeremy James Johnson, Pritesh Patel. Development of a method for clinical pharmacokinetic testing to allow for targeted Melphalan dosing in multiple myeloma patients undergoing autologous transplant.
British journal of clinical pharmacology.
2020 11; 86(11):2165-2173. doi:
10.1111/bcp.14308. [PMID: 32285957] - Rishav Bansal, Sumitabh Singh, Sunny Singhal, Gevesh Dewangan, Chandan Jyoti Das, Aparajit Ballav Dey. Drooping shoulders: A rare manifestation of an uncommon disease.
The National medical journal of India.
2020 Sep; 33(5):276-277. doi:
10.4103/0970-258x.317479. [PMID: 34213453] - Morie A Gertz, Angela Dispenzieri. Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review.
JAMA.
2020 07; 324(1):79-89. doi:
10.1001/jama.2020.5493. [PMID: 32633805] - Florent Malard, Mohamad Mohty. Management of patients with multiple myeloma during the COVID-19 pandemic.
The Lancet. Haematology.
2020 06; 7(6):e435-e437. doi:
10.1016/s2352-3026(20)30124-1. [PMID: 32353254] - Michele Cavo, Francesca Gay, Meral Beksac, Lucia Pantani, Maria Teresa Petrucci, Meletios A Dimopoulos, Luca Dozza, Bronno van der Holt, Sonja Zweegman, Stefania Oliva, Vincent H J van der Velden, Elena Zamagni, Giuseppe A Palumbo, Francesca Patriarca, Vittorio Montefusco, Monica Galli, Vladimir Maisnar, Barbara Gamberi, Markus Hansson, Angelo Belotti, Ludek Pour, Paula Ypma, Mariella Grasso, Alexsandra Croockewit, Stelvio Ballanti, Massimo Offidani, Iolanda D Vincelli, Renato Zambello, Anna Marina Liberati, Niels Frost Andersen, Annemiek Broijl, Rossella Troia, Anna Pascarella, Giulia Benevolo, Mark-David Levin, Gerard Bos, Heinz Ludwig, Sara Aquino, Anna Maria Morelli, Ka Lung Wu, Rinske Boersma, Roman Hajek, Marc Durian, Peter A von dem Borne, Tommaso Caravita di Toritto, Thilo Zander, Christoph Driessen, Giorgina Specchia, Anders Waage, Peter Gimsing, Ulf-Henrik Mellqvist, Marinus van Marwijk Kooy, Monique Minnema, Caroline Mandigers, Anna Maria Cafro, Angelo Palmas, Susanna Carvalho, Andrew Spencer, Mario Boccadoro, Pieter Sonneveld. Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.
The Lancet. Haematology.
2020 Jun; 7(6):e456-e468. doi:
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Annals of hematology.
2020 Apr; 99(4):855-866. doi:
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Best practice & research. Clinical haematology.
2020 03; 33(1):101151. doi:
10.1016/j.beha.2020.101151. [PMID: 32139016] - Tal Schechter, Evelio Perez-Albuerne, Tiffany F Lin, Meredith S Irwin, Mohammed Essa, Ami V Desai, Haydar Frangoul, Gregory Yanik, L Lee Dupuis, David Jacobsohn, Morris Kletzel, Mark Ranalli, Sandeep Soni, Alix E Seif, Stephan Grupp, Christopher C Dvorak. Veno-occlusive disease after high-dose busulfan-melphalan in neuroblastoma.
Bone marrow transplantation.
2020 03; 55(3):531-537. doi:
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Bone marrow transplantation.
2020 02; 55(2):376-383. doi:
10.1038/s41409-019-0661-7. [PMID: 31534191] - Naoya Toriu, Naoki Sawa, Rikako Hiramatsu, Hiroki Mizuno, Daisuke Ikuma, Akinari Sekine, Noriko Hayami, Keiichi Sumida, Masayuki Yamanouchi, Eiko Hasegawa, Junichi Hoshino, Kenmei Takaichi, Atsushi Wake, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara. Regression of renal amyloid deposits by VAD therapy plus autologous stem cell transplantation in a patient with primary AL amyloidosis.
CEN case reports.
2020 02; 9(1):6-10. doi:
10.1007/s13730-019-00416-1. [PMID: 31522370] - Aswin Anand Pai, Anup J Devasia, John Carl Panetta, Sathya Mani, Raveen Stephen Stallon Illangeswaran, Ezhilpavai Mohanan, Balaji Balakrishnan, Kavitha M Lakshmi, Uday Kulkarni, Fouzia N Aboobacker, Anu Korula, Aby Abraham, Alok Srivastava, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian. Pharmacokinetics and Efficacy of Generic Melphalan Is Comparable to Innovator Formulation in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.
Clinical lymphoma, myeloma & leukemia.
2020 02; 20(2):130-135.e1. doi:
10.1016/j.clml.2019.08.013. [PMID: 31791694] - Manisha Bhutani, Saad Z Usmani. Quadruplets come of age for newly diagnosed multiple myeloma.
Lancet (London, England).
2020 01; 395(10218):94-96. doi:
10.1016/s0140-6736(19)33063-6. [PMID: 31836198] - Vaishali Sanchorawala. High-Dose Melphalan and Autologous Peripheral Blood Stem Cell Transplantation in AL Amyloidosis.
Acta haematologica.
2020; 143(4):381-387. doi:
10.1159/000506498. [PMID: 32248194] - Oksana Shevchuk, Elisaveta Snezhkova, Veronika Sarnatskaya, Victor Mikhailenko, Alexei Glavin, Lyudmyla Makovetska, Kvitoslava Bardakhivska, Inna Birchenko, Oleksandr Kozynchenko, Volodymyr Nikolaev. Effect of Primary and Secondary Beads of Carbon Enterosorbent on Haematological Parameters and Oxidative Stress Development Caused by Melphalan in Rats.
Medicina (Kaunas, Lithuania).
2019 Sep; 55(9):. doi:
10.3390/medicina55090557. [PMID: 31480729] - Ryan C Schofield, Heather J Landau, Sergio A Giralt, Gunjan L Shah, Michael Scordo, Andrew Lin, Elaine Zanutto, Lakshmi V Ramanathan, Melissa S Pessin, Dean C Carlow. Measurement of the DNA alkylating agents busulfan and melphalan in human plasma by mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1125(?):121711. doi:
10.1016/j.jchromb.2019.121711. [PMID: 31376591] - Yaohua Cao, Ning Wan, Zhuoru Liang, Jingmei Xie, Sen Wang, Tengfei Lin, Tiantian Zhang, Jie Jiang. Treatment Outcomes in Patients With Newly Diagnosed Multiple Myeloma Who Are Ineligible for Stem-Cell Transplantation: Systematic Review and Network Meta-analysis.
Clinical lymphoma, myeloma & leukemia.
2019 08; 19(8):e478-e488. doi:
10.1016/j.clml.2019.04.009. [PMID: 31130487] - Najla El Jurdi, Ali Filali-Mouhim, Iman Salem, Mauricio Retuerto, Nina Margaret Dambrosio, Linda Baer, Hillard M Lazarus, Paolo Caimi, Brenda Cooper, Benjamin Tomlinson, Leland Metheny, Ehsan Malek, Folashade Otegbeye, Rafick-Pierre Sekaly, Mahmoud Ghannoum, Marcos de Lima. Gastrointestinal Microbiome and Mycobiome Changes during Autologous Transplantation for Multiple Myeloma: Results of a Prospective Pilot Study.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2019 08; 25(8):1511-1519. doi:
10.1016/j.bbmt.2019.04.007. [PMID: 30959164] - Zohra El Ati, Rais Lamia, Jouda Cherif, Hela Jbali, Lilia Ben Fatma, Ikram Mami, Rania Khedher, Wided Smaoui, Madiha Krid, Fethi Ben Hamida, Soumaya Beji, Mohamed Karim Zouaghi. Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2019 Jul; 30(4):974-977. doi:
10.4103/1319-2442.265477. [PMID: 31464258] - Baojian Liu, Yan Wang, Ming Bai, Di Wang, Jin Zhao, Ming Zhang, Shiren Sun. Cyclophosphamide + Thalidomide + Dexamethasone Versus Melphalan + Dexamethasone for the Treatment of Amyloid Light-chain Amyloidosis With Kidney Involvement: A Retrospective Study in Chinese Patients.
Clinical therapeutics.
2019 06; 41(6):1186-1198. doi:
10.1016/j.clinthera.2018.12.003. [PMID: 30718006] - Lalit Kumar, Dev Ramavath, Babita Kataria, Akash Tiwari, Abhishek Raj, Santosh Kumar Chellapuram, Anjali Mookerjee, Ranjit Kumar Sahoo, Prabhat S Malik, Atul Sharma, Ritu Gupta, Om Dutt Sharma, Ahitagni Biswas, Rakesh Kumar, Sanjay Thulkar. High-dose chemotherapy followed by autologous stem cell transplant for multiple myeloma: Predictors of long-term outcome.
The Indian journal of medical research.
2019 06; 149(6):730-739. doi:
10.4103/ijmr.ijmr_1593_18. [PMID: 31496525] - Liusheng Huang, Vincent Cheah, Danna Chan, Florence Marzan, Christopher C Dvorak, Francesca T Aweeka, Janel Long-Boyle. Determination of melphalan in human plasma by UPLC-UV method.
Cancer chemotherapy and pharmacology.
2019 05; 83(5):905-910. doi:
10.1007/s00280-019-03786-6. [PMID: 30847504] - Sanjay Kumar Bhadada, Ruban Dhaliwal, Vandana Dhiman, Sudhaker D Rao. Fibrogenesis Imperfecta Ossium.
Calcified tissue international.
2019 05; 104(5):561-569. doi:
10.1007/s00223-019-00547-8. [PMID: 31069441] - Hao Zhao, Xu-Fei Huang, Xue-Min Gao, Hao Cai, Lu Zhang, Jun Feng, Xin-Xin Cao, Dao-Bin Zhou, Jian Li. What is the best first-line treatment for POEMS syndrome: autologous transplantation, melphalan and dexamethasone, or lenalidomide and dexamethasone?.
Leukemia.
2019 04; 33(4):1023-1029. doi:
10.1038/s41375-019-0391-2. [PMID: 30700844] - Cindy Varga, Raymond L Comenzo. High-dose melphalan and stem cell transplantation in systemic AL amyloidosis in the era of novel anti-plasma cell therapy: a comprehensive review.
Bone marrow transplantation.
2019 04; 54(4):508-518. doi:
10.1038/s41409-018-0284-4. [PMID: 30089901] - Seyed Nasrollah Tabatabaei, Rabeb Mouna Derbali, Chun Yang, Rosanne Superstein, Patrick Hamel, Jeanne Leblond Chain, Pierre Hardy. Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.
Journal of controlled release : official journal of the Controlled Release Society.
2019 03; 298(?):177-185. doi:
10.1016/j.jconrel.2019.02.014. [PMID: 30776396] - L S Liao, Z H Zheng, S Qu, T N Wei, Y Xie, Y Lin, B Y Chen, W M Chen. [Autologous peripheral blood stem cell transplantation for POEMS syndrome].
Zhonghua nei ke za zhi.
2019 Mar; 58(3):209-212. doi:
10.3760/cma.j.issn.0578-1426.2019.03.011. [PMID: 30803180] - Alfred Chung, Michaela Liedtke. Therapy-related myeloid neoplasms after treatment for plasma-cell disorders.
Best practice & research. Clinical haematology.
2019 03; 32(1):54-64. doi:
10.1016/j.beha.2019.02.003. [PMID: 30927976] - J K Duong, G J Veal, C E Nath, P J Shaw, J Errington, R Ladenstein, A V Boddy. Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function.
British journal of clinical pharmacology.
2019 01; 85(1):136-146. doi:
10.1111/bcp.13774. [PMID: 30261554] - Wencui Chen, Guisheng Ren, Ke Zuo, Xianghua Huang. Complete remission of both immunoglobulin light chain amyloidosis and psoriasis after autologous hematopoietic stem cell transplantation: A case report.
Medicine.
2018 Dec; 97(50):e13589. doi:
10.1097/md.0000000000013589. [PMID: 30558027] - Mukul Aggarwal, Narendra Agrawal, Neha Yadav, Priyanka Verma, Rayaz Ahmed, Pallavi Mehta, Jyotsna Kapoor, Dinesh Bhurani. Autologous stem cell transplantation in first remission is associated with better progression-free survival in multiple myeloma.
Annals of hematology.
2018 Oct; 97(10):1869-1877. doi:
10.1007/s00277-018-3370-1. [PMID: 29781040] - Deep K Hathi, Elizabeth N DeLassus, Samuel Achilefu, Jonathan McConathy, Monica Shokeen. Imaging Melphalan Therapy Response in Preclinical Extramedullary Multiple Myeloma with 18F-FDOPA and 18F-FDG PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2018 10; 59(10):1551-1557. doi:
10.2967/jnumed.118.208744. [PMID: 29700126] - Binod Dhakal, Anita D'Souza, Arjun Lakshman, Mehdi Hamadani, Saurabh Chhabra, Robert Thompson, Nirav Shah, Marcelo Pasquini, Paramweswaran Hari. Pharmacokinetics of High-Dose Propylene Glycol-Free Melphalan in Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2018 08; 24(8):1610-1614. doi:
10.1016/j.bbmt.2018.04.028. [PMID: 29751116] - Haruko Shima, Yuji Yamada, Hiroshi Asanuma, Hiroyuki Shimada. High-dose chemotherapy without whole lung radiation for refractory pulmonary metastases in an infant with stage IV favorable histology Wilms tumor.
Pediatric blood & cancer.
2018 08; 65(8):e27078. doi:
10.1002/pbc.27078. [PMID: 29676506] - Daria Tretiakova, Natalia Onishchenko, Ivan Boldyrev, Ilya Mikhalyov, Alexander Tuzikov, Nicolai Bovin, Evgeniy Evtushenko, Elena Vodovozova. Influence of stabilizing components on the integrity of antitumor liposomes loaded with lipophilic prodrug in the bilayer.
Colloids and surfaces. B, Biointerfaces.
2018 Jun; 166(?):45-53. doi:
10.1016/j.colsurfb.2018.02.061. [PMID: 29533843] - Andrea Havasi, Gheorghe Doros, Vaishali Sanchorawala. Predictive value of the new renal response criteria in AL amyloidosis treated with high dose melphalan and stem cell transplantation.
American journal of hematology.
2018 05; 93(5):E129-E132. doi:
10.1002/ajh.25066. [PMID: 29430701] - Yutaro Suzuki, Junji Koya, Kazutoshi Ebisawa, Hiroyuki Abe, Aya Shinozaki-Ushiku, Fumihiko Nakamura, Mineo Kurokawa. Sequential development of monoclonal B cell lymphocytosis-derived small lymphocytic lymphoma and plasma cell leukemia.
Annals of hematology.
2018 May; 97(5):917-919. doi:
10.1007/s00277-018-3248-2. [PMID: 29417202] - Alfred L Garfall, Edward A Stadtmauer, Wei-Ting Hwang, Simon F Lacey, Jan Joseph Melenhorst, Maria Krevvata, Martin P Carroll, William H Matsui, Qiuju Wang, Madhav V Dhodapkar, Kavita Dhodapkar, Rituparna Das, Dan T Vogl, Brendan M Weiss, Adam D Cohen, Patricia A Mangan, Emily C Ayers, Selene Nunez-Cruz, Irina Kulikovskaya, Megan M Davis, Anne Lamontagne, Karen Dengel, Naseem Ds Kerr, Regina M Young, Donald L Siegel, Bruce L Levine, Michael C Milone, Marcela V Maus, Carl H June. Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.
JCI insight.
2018 04; 3(8):. doi:
10.1172/jci.insight.120505. [PMID: 29669947] - Nicola Lepori, Wisit Cheungpasitporn, Sanjeev Sethi, David Murray, Shaji Kumar, Nelson Leung, Karthik V Giridhar, Fernando C Fervenza. High-dose melphalan and autologous hematopoietic stem cell transplant in patient with C3 glomerulonephritis associated with monoclonal gammopathy
.
Clinical nephrology.
2018 Apr; 89(4):291-299. doi:
10.5414/cn109300. [PMID: 29249234] - P Decker, J Galland, J Risse, M Claudin, S Mohamed, A Perrot, D Wahl. [A POEMS syndrome revealed by a blue toe syndrome].
La Revue de medecine interne.
2018 Feb; 39(2):127-129. doi:
10.1016/j.revmed.2017.09.005. [PMID: 29288001] - Felipe Batalini, Laura Econimo, Karen Quillen, J Mark Sloan, Shayna Sarosiek, Dina Brauneis, Andrea Havasi, Lauren Stern, Laura M Dember, Vaishali Sanchorawala. High-Dose Melphalan and Stem Cell Transplantation in Patients on Dialysis Due to Immunoglobulin Light-Chain Amyloidosis and Monoclonal Immunoglobulin Deposition Disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2018 01; 24(1):127-132. doi:
10.1016/j.bbmt.2017.08.031. [PMID: 28865972] - Nicolas Simon, Valérie Coiteux, Bénédicte Bruno, Sophie Taque, Amandine Charbonnier, Laetitia Souchet, Laure Vincent, Ibrahim Yakoub-Agha, Yves Chalandon. [Dose adaptation of the drugs used for hematopoietic stem-cell transplantation in patients with comorbidity: Obesity, chronic renal disease or hepatopathy: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Bulletin du cancer.
2017 Dec; 104(12S):S99-S105. doi:
10.1016/j.bulcan.2017.07.010. [PMID: 29173979] - W W T Nyunt, R Remli, F A Abdul Muttlib, C F Leong, N Masir, N R Tumian, S F S Abdul Wahid. POEMS syndrome.
The Malaysian journal of pathology.
2017 Dec; 39(3):297-303. doi:
NULL. [PMID: 29279594] - Barbara Spitzer, Ann A Jakubowski, Esperanza B Papadopoulos, Kirsten Fuller, Patrick D Hilden, James W Young, Juliet N Barker, Guenther Koehne, Miguel-Angel Perales, Katharine C Hsu, Marcel R van den Brink, Nancy A Kernan, Susan E Prockop, Andromachi Scaradavou, Hugo Castro-Malaspina, Richard J O'Reilly, Farid Boulad. A Chemotherapy-Only Regimen of Busulfan, Melphalan, and Fludarabine, and Rabbit Antithymocyte Globulin Followed by Allogeneic T-Cell Depleted Hematopoietic Stem Cell Transplantations for the Treatment of Myeloid Malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2017 Dec; 23(12):2088-2095. doi:
10.1016/j.bbmt.2017.07.004. [PMID: 28711727] - Vallari Shah, Kevin D Boyd, Richard S Houlston, Martin F Kaiser. Constitutional mutation in CDKN2A is associated with long term survivorship in multiple myeloma: a case report.
BMC cancer.
2017 Nov; 17(1):718. doi:
10.1186/s12885-017-3715-5. [PMID: 29110637] - E Viziteu, B Klein, J Basbous, Y-L Lin, C Hirtz, C Gourzones, L Tiers, A Bruyer, L Vincent, C Grandmougin, A Seckinger, H Goldschmidt, A Constantinou, P Pasero, D Hose, J Moreaux. RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Leukemia.
2017 10; 31(10):2104-2113. doi:
10.1038/leu.2017.54. [PMID: 28186131] - Saba Zaidi, Sidra Sattar, Khealani Bhojo Asumal. An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2017 Oct; 27(10):651-653. doi:
2728. [PMID: 29056130] - Waleed Mohammed-Saeid, Deborah Michel, Ildiko Badea, Anas El-Aneed. Rapid and simple flow injection analysis tandem mass spectrometric method for the quantification of melphalan in a lipid-based drug delivery system.
Rapid communications in mass spectrometry : RCM.
2017 Sep; 31(18):1481-1490. doi:
10.1002/rcm.7926. [PMID: 28667829] - Jan Moritz Middeke, Regina Herbst, Stefani Parmentier, Gesine Bug, Mathias Hänel, Gernot Stuhler, Kerstin Schäfer-Eckart, Wolf Rösler, Stefan Klein, Wolfgang Bethge, Ulrich Bitz, Bozena Büttner, Holger Knoth, Nael Alakel, Markus Schaich, Anke Morgner, Michael Kramer, Katja Sockel, Malte von Bonin, Friedrich Stölzel, Uwe Platzbecker, Christoph Röllig, Christian Thiede, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig. Long-Term Follow-Up and Impact of Comorbidity before Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia-Lessons Learned from the Prospective BRIDGE Trial.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2017 Sep; 23(9):1491-1497. doi:
10.1016/j.bbmt.2017.05.014. [PMID: 28527985] - Andreas Nyström Wendt, Jan Mattsson, Roger Olofsson Bagge. Myoglobin does not predict local toxicity in isolated limb perfusion.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.
2017 09; 33(6):679-683. doi:
10.1080/02656736.2017.1309082. [PMID: 28540796] - Fernando Caravaca-Fontán, Eduardo Gutiérrez, Ramón Delgado Lillo, Manuel Praga. Monoclonal gammopathies of renal significance.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2017 Sep; 37(5):465-477. doi:
10.1016/j.nefro.2017.03.012. [PMID: 28946960] - Stefano Guadagni, Giancarlo Palumbo, Giammaria Fiorentini, Marco Clementi, Luca Marsili, Aldo Victor Giordano, Francesco Masedu, Marco Valenti. Surgical versus percutaneous isolated pelvic perfusion (IPP) for advanced melanoma: comparison in terms of melphalan pharmacokinetic pelvic bio-availability.
BMC research notes.
2017 Aug; 10(1):411. doi:
10.1186/s13104-017-2738-y. [PMID: 28810925] - Fabrizio Esma, Marco Salvini, Rossella Troia, Mario Boccadoro, Alessandra Larocca, Chiara Pautasso. Melphalan hydrochloride for the treatment of multiple myeloma.
Expert opinion on pharmacotherapy.
2017 Aug; 18(11):1127-1136. doi:
10.1080/14656566.2017.1349102. [PMID: 28658983] - Takayuki Katsuno, Shige Mizuno, Masatsuna Mabuchi, Naotake Tsuboi, Atsushi Komatsuda, Shoichi Maruyama. Long-term renal survival of γ3-heavy chain deposition disease: a case report.
BMC nephrology.
2017 Jul; 18(1):239. doi:
10.1186/s12882-017-0645-z. [PMID: 28716013] - Sung-Eun Lee, Kyungmee Choi, Seunghoon Han, Jongtae Lee, Taegon Hong, Gab-Jin Park, Dong-Seok Yim, Chang-Ki Min. Bortezomib pharmacokinetics in tumor response and peripheral neuropathy in multiple myeloma patients receiving bortezomib-containing therapy.
Anti-cancer drugs.
2017 07; 28(6):660-668. doi:
10.1097/cad.0000000000000506. [PMID: 28430745] - Gustavo Henrique Rodrigues, Graziella Chagas Jaguar, Fabio Abreu Alves, Andre Guollo, Vanessa Oliveira Camandoni, Aline Santos Damascena, Vladmir Claudio Cordeiro Lima. Variability of high-dose melphalan exposure on oral mucositis in patients undergoing prophylactic low-level laser therapy.
Lasers in medical science.
2017 Jul; 32(5):1089-1095. doi:
10.1007/s10103-017-2211-0. [PMID: 28512727] - Ming J Poi, Junan Li, Douglas W Sborov, Zachary VanGundy, Yu Kyoung Cho, Misty Lamprecht, Flavia Pichiorri, Mitch A Phelps, Craig C Hofmeister. Polymorphism in ANRIL is associated with relapse in patients with multiple myeloma after autologous stem cell transplant.
Molecular carcinogenesis.
2017 07; 56(7):1722-1732. doi:
10.1002/mc.22626. [PMID: 28150872] - B O Boostrom, A S Moore, C J DeRegis, C Robat, K Freeman, D H Thamm. Canine Cutaneous Plasmacytosis: 21 Cases (2005-2015).
Journal of veterinary internal medicine.
2017 Jul; 31(4):1074-1080. doi:
10.1111/jvim.14729. [PMID: 28514049] - Daniela Svetlovska, Viera Miskovska, Dana Cholujova, Paulina Gronesova, Silvia Cingelova, Michal Chovanec, Zuzana Sycova-Mila, Jana Obertova, Patrik Palacka, Jan Rajec, Katarina Kalavska, Vanda Usakova, Jan Luha, Dalibor Ondrus, Stanislav Spanik, Jozef Mardiak, Michal Mego. Plasma Cytokines Correlated With Disease Characteristics, Progression-Free Survival, and Overall Survival in Testicular Germ-Cell Tumor Patients.
Clinical genitourinary cancer.
2017 06; 15(3):411-416.e2. doi:
10.1016/j.clgc.2017.01.027. [PMID: 28237180] - P A von dem Borne, M F Jonkman, R van Doorn. Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy: association with disappearance of M-protein.
The British journal of dermatology.
2017 May; 176(5):1341-1344. doi:
10.1111/bjd.14954. [PMID: 27516004] - Salomon Manier, Chia-Jen Liu, Hervé Avet-Loiseau, Jihye Park, Jiantao Shi, Federico Campigotto, Karma Z Salem, Daisy Huynh, Siobhan V Glavey, Bradley Rivotto, Antonio Sacco, Aldo M Roccaro, Juliette Bouyssou, Stéphane Minvielle, Philippe Moreau, Thierry Facon, Xavier Leleu, Edie Weller, Lorenzo Trippa, Irene M Ghobrial. Prognostic role of circulating exosomal miRNAs in multiple myeloma.
Blood.
2017 04; 129(17):2429-2436. doi:
10.1182/blood-2016-09-742296. [PMID: 28213378] - Vivek Bhat, Hemant Vira, Navin Khattry, Manoj Toshniwal. Cryptococcus laurentii diarrhea post hematopoietic stem cell transplant.
Transplant infectious disease : an official journal of the Transplantation Society.
2017 Apr; 19(2):. doi:
10.1111/tid.12663. [PMID: 28083955] - Ruth Ladenstein, Ulrike Pötschger, Andrew D J Pearson, Penelope Brock, Roberto Luksch, Victoria Castel, Isaac Yaniv, Vassilios Papadakis, Geneviève Laureys, Josef Malis, Walentyna Balwierz, Ellen Ruud, Per Kogner, Henrik Schroeder, Ana Forjaz de Lacerda, Maja Beck-Popovic, Pavel Bician, Miklós Garami, Toby Trahair, Adela Canete, Peter F Ambros, Keith Holmes, Mark Gaze, Günter Schreier, Alberto Garaventa, Gilles Vassal, Jean Michon, Dominique Valteau-Couanet. Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.
The Lancet. Oncology.
2017 04; 18(4):500-514. doi:
10.1016/s1470-2045(17)30070-0. [PMID: 28259608] - Michael W Epperly, Byung-Han Rhieu, Darcy Franicola, Tracy Dixon, Shaonan Cao, Xichen Zhang, Donna Shields, Hong Wang, Peter Wipf, Joel S Greenberger. Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.
In vivo (Athens, Greece).
2017 Mar; 31(2):159-168. doi:
10.21873/invivo.11040. [PMID: 28358695] - L Raida, A Kuba, Z Rusinakova, R Szotkowska, I Skoumalova, E Faber, T Szotkowski, P Rohon, J Hubacek, K Indrak, Z Pikalova, M Jarosova, M Divoka, K Langova, T Papajik. Allogeneic stem cell transplantation after fludarabine, melphalan and thymoglobulin followed by early withdrawal of prophylactic immunosuppression in patients with acute lymphoblastic leukemia - update of single center study.
Neoplasma.
2017 ; 64(5):762-769. doi:
10.4149/neo_2017_515. [PMID: 28592129]