Bismuth subsalicylate (BioDeep_00000014670)
代谢物信息卡片
Bismuth subsalicylate
化学式: C7H6BiO4 (363.00699560000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=O)O[Bi]O2.O
InChI: +2
描述信息
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
C26170 - Protective Agent > C2459 - Chemoprotective Agent > C2080 - Cytoprotective Agent
C78276 - Agent Affecting Digestive System or Metabolism > C266 - Antidiarrheal Agent
D005765 - Gastrointestinal Agents > D000930 - Antidiarrheals
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:261649
- KEGG: C07870
- KEGGdrug: D00728
- PubChem: 16682734
- DrugBank: DB01294
- CAS: 87-27-4
- CAS: 14882-18-9
- PubChem: 10072
- NIKKAJI: J792.026A
- RefMet: Bismuth Subsalicylate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marouf Alhalabi, Mohammed Waleed Alassi, Kamal Alaa Eddin, Khaled Cheha. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial.
BMC infectious diseases.
2021 Jul; 21(1):642. doi:
10.1186/s12879-021-06356-5. [PMID: 34218802] - Dong Liang, Jing Ma, Bo Wei. Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness.
Scientific reports.
2021 01; 11(1):2605. doi:
10.1038/s41598-021-82044-3. [PMID: 33510326] - Sheliza Halani, Peter E Wu. Salicylate toxicity from chronic bismuth subsalicylate use.
BMJ case reports.
2020 Nov; 13(11):. doi:
10.1136/bcr-2020-236929. [PMID: 33257373] - Douglas C Wolf, Christine H Wolf, David T Rubin. Temporal Improvement of a COVID-19-Positive Crohn's Disease Patient Treated With Bismuth Subsalicylate.
The American journal of gastroenterology.
2020 08; 115(8):1298. doi:
10.14309/ajg.0000000000000725. [PMID: 32516203] - Bernardo Guevara, Asha Gupta Cogdill. Helicobacter pylori: A Review of Current Diagnostic and Management Strategies.
Digestive diseases and sciences.
2020 07; 65(7):1917-1931. doi:
10.1007/s10620-020-06193-7. [PMID: 32170476] - Alejandra Orona-Ortiz, Luis Medina-Torres, Josué A Velázquez-Moyado, Elizabeth A Pineda-Peña, José Luis Balderas-López, María Josefa Bernad-Bernad, José Carlos Tavares Carvalho, Andrés Navarrete. Mucoadhesive effect of Curcuma longa extract and curcumin decreases the ranitidine effect, but not bismuth subsalicylate on ethanol-induced ulcer model.
Scientific reports.
2019 11; 9(1):16622. doi:
10.1038/s41598-019-53089-2. [PMID: 31719599] - Cláudia Borbinha, Filipa Serrazina, Manuel Salavisa, Miguel Viana-Baptista. Bismuth encephalopathy- a rare complication of long-standing use of bismuth subsalicylate.
BMC neurology.
2019 Aug; 19(1):212. doi:
10.1186/s12883-019-1437-9. [PMID: 31464594] - Alexander K C Leung, Amy A M Leung, Alex H C Wong, Kam L Hon. Travelers' Diarrhea: A Clinical Review.
Recent patents on inflammation & allergy drug discovery.
2019; 13(1):38-48. doi:
10.2174/1872213x13666190514105054. [PMID: 31084597] - Tahir S Kafil, Tran M Nguyen, Petrease H Patton, John K MacDonald, Nilesh Chande, John Wd McDonald. Interventions for treating collagenous colitis.
The Cochrane database of systematic reviews.
2017 11; 11(?):CD003575. doi:
10.1002/14651858.cd003575.pub6. [PMID: 29127772] - Johnathan Sheele, Jessica Cartowski, Angela Dart, Arjun Poddar, Shikha Gupta, Eric Stashko, Bhaskara S Ravi, Crawford Nelson, Ajay Gupta. Saccharomyces boulardii and bismuth subsalicylate as low-cost interventions to reduce the duration and severity of cholera.
Pathogens and global health.
2015 Sep; 109(6):275-82. doi:
10.1179/2047773215y.0000000028. [PMID: 26260354] - A L Johnson, E T Blaine, A D Lewis. Renal pigmentation due to chronic bismuth administration in a rhesus macaque (Macaca mulatta).
Veterinary pathology.
2015 May; 52(3):576-9. doi:
10.1177/0300985814541707. [PMID: 24990482] - Dennis Hinostroza Morales, Javier Díaz Ferrer. [Addition of bismuth subsalicylate to triple eradication therapy for Helicobacter pylori infection: efficiency and adverse events].
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru.
2014 Oct; 34(4):315-20. doi:
NULL. [PMID: 25594755] - Angela L Bingham, Rex O Brown, Roland N Dickerson. Inadvertent exaggerated anticoagulation following use of bismuth subsalicylate in an enterally fed patient receiving warfarin therapy.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.
2013 Dec; 28(6):766-9. doi:
10.1177/0884533613507606. [PMID: 24163322] - Heimo H Wenzl. Diarrhea in chronic inflammatory bowel diseases.
Gastroenterology clinics of North America.
2012 Sep; 41(3):651-75. doi:
10.1016/j.gtc.2012.06.006. [PMID: 22917170] - David J McGee, Alika E George, Elizabeth A Trainor, Katherine E Horton, Ellen Hildebrandt, Traci L Testerman. Cholesterol enhances Helicobacter pylori resistance to antibiotics and LL-37.
Antimicrobial agents and chemotherapy.
2011 Jun; 55(6):2897-904. doi:
10.1128/aac.00016-11. [PMID: 21464244] - Adrienne Atkins, James F X Wellehan, April L Childress, Linda L Archer, William A Fraser, Scott B Citino. Characterization of an outbreak of astroviral diarrhea in a group of cheetahs (Acinonyx jubatus).
Veterinary microbiology.
2009 Apr; 136(1-2):160-5. doi:
10.1016/j.vetmic.2008.10.035. [PMID: 19171442] - Xue-Mei Sun, Zhi-Min Yang. [Plant sulfate assimilation and regulation of the activity of related enzymes under cadmium stress].
Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology.
2006 Feb; 32(1):9-16. doi:
". [PMID: 16477125] - Anthony G Dodge, Lawrence P Wackett. Metabolism of bismuth subsalicylate and intracellular accumulation of bismuth by Fusarium sp. strain BI.
Applied and environmental microbiology.
2005 Feb; 71(2):876-82. doi:
10.1128/aem.71.2.876-882.2005. [PMID: 15691943] - Jason Gilster, Kathy Bacon, Katie Marlink, Brett Sheppard, Clifford Deveney, Michael Rutten. Bismuth subsalicylate increases intracellular Ca2+, MAP-kinase activity, and cell proliferation in normal human gastric mucous epithelial cells.
Digestive diseases and sciences.
2004 Mar; 49(3):370-8. doi:
10.1023/b:ddas.0000020488.55854.99. [PMID: 15139483] - Apolinaria García, Henry Solar, Carlos González, Raúl Zemelman. Effect of EDTA on the resistance of clinical isolates of Acinetobacter baumannii to the bactericidal activity of normal human serum.
Journal of medical microbiology.
2000 Nov; 49(11):1047-1050. doi:
10.1099/0022-1317-49-11-1047. [PMID: 11073160] - J K Furne, F L Suarez, S L Ewing, J Springfield, M D Levitt. Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats.
Digestive diseases and sciences.
2000 Jul; 45(7):1439-43. doi:
10.1023/a:1005580709390. [PMID: 10961726] - F L Suarez, J Furne, J Stiehm, C Garten, M D Levitt. Site of bismuth absorption from bismuth subsalicylate: implications for treatment of colonic conditions.
Digestive diseases and sciences.
2000 Jul; 45(7):1444-6. doi:
10.1023/a:1005532826228. [PMID: 10961727] - L E Bravo, J L Realpe, C Campo, R Mera, P Correa. Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection.
The American journal of gastroenterology.
1999 Sep; 94(9):2380-3. doi:
10.1111/j.1572-0241.1999.01361.x. [PMID: 10483995] - D Bagchi, O R Carryl, M X Tran, M Bagchi, A Garg, M M Milnes, C B Williams, J Balmoori, D J Bagchi, S Mitra, S J Stohs. Acute and chronic stress-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate.
Molecular and cellular biochemistry.
1999 Jun; 196(1-2):109-16. doi:
10.1023/a:1006978431521. [PMID: 10448909] - C K Lee, K Soike, J Hill, K Georgakopoulos, T Tibbitts, J Ingrassia, H Gray, J Boden, H Kleanthous, P Giannasca, T Ermak, R Weltzin, J Blanchard, T P Monath. Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys.
Vaccine.
1999 Mar; 17(11-12):1493-505. doi:
10.1016/s0264-410x(98)00365-x. [PMID: 10195786] - F L Suarez, J K Furne, J Springfield, M D Levitt. Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon.
Gastroenterology.
1998 May; 114(5):923-9. doi:
10.1016/s0016-5085(98)70311-7. [PMID: 9558280] - D Bagchi, O R Carryl, M X Tran, R L Krohn, D J Bagchi, A Garg, M Bagchi, S Mitra, S J Stohs. Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate.
Journal of applied toxicology : JAT.
1998 Jan; 18(1):3-13. doi:
10.1002/(sici)1099-1263(199801/02)18:1<3::aid-jat461>3.0.co;2-k. [PMID: 9526828] - D P Healy, R J Dansereau, A B Dunn, C E Clendening, A W Mounts, G S Deepe. Reduced tetracycline bioavailability caused by magnesium aluminum silicate in liquid formulations of bismuth subsalicylate.
The Annals of pharmacotherapy.
1997 Dec; 31(12):1460-4. doi:
10.1177/106002809703101203. [PMID: 9416381] - W D Chey, L Fisher, G H Elta, J L Barnett, T Nostrant, J DelValle, W L Hasler, J M Scheiman. Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial.
The American journal of gastroenterology.
1997 Sep; 92(9):1483-6. doi:
NULL. [PMID: 9317068] - D Bagchi, O R Carryl, M X Tran, M Bagchi, P J Vuchetich, R L Krohn, S D Ray, S Mitra, S J Stohs. Protection against chemically-induced oxidative gastrointestinal tissue injury in rats by bismuth salts.
Digestive diseases and sciences.
1997 Sep; 42(9):1890-900. doi:
10.1023/a:1018811210175. [PMID: 9331152] - N Rao, P W Brown, P Yerino, J Chang, K K Hwang. Comparative absorption of bismuth in Sprague-Dawley rats following oral administration of preparations containing bismuth sucrose octasulfate, bismuth subsalicylate, and bismuth subcitrate.
Biopharmaceutics & drug disposition.
1997 Jan; 18(1):1-8. doi:
10.1002/(sici)1099-081x(199701)18:1<1::aid-bdd996>3.0.co;2-0. [PMID: 9008264] - N S Horowitz, H F Staats, T J Palker. Effect of bismuth salts on systemic and mucosal immune responses to orally administered cholera toxin.
Immunopharmacology.
1995 Nov; 31(1):31-41. doi:
10.1016/0162-3109(95)00031-2. [PMID: 8655289] - S K Chong, Q Lou, M A Asnicar, S E Zimmerman, J M Croffie, C H Lee, J F Fitzgerald. Helicobacter pylori infection in recurrent abdominal pain in childhood: comparison of diagnostic tests and therapy.
Pediatrics.
1995 Aug; 96(2 Pt 1):211-5. doi:
NULL. [PMID: 7630671] - H H Tsai, A D Dwarakanath, C A Hart, J D Milton, J M Rhodes. Increased faecal mucin sulphatase activity in ulcerative colitis: a potential target for treatment.
Gut.
1995 Apr; 36(4):570-6. doi:
10.1136/gut.36.4.570. [PMID: 7737566] - L Rambout, J Sahai, K Gallicano, L Oliveras, G Garber. Effect of bismuth subsalicylate on ciprofloxacin bioavailability.
Antimicrobial agents and chemotherapy.
1994 Sep; 38(9):2187-90. doi:
10.1128/aac.38.9.2187. [PMID: 7811043] - S Wagner, K Haruma, U Gladziwa, B Soudah, M Gebel, J Bleck, H Schmidt, M Manns. Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.
The American journal of gastroenterology.
1994 Aug; 89(8):1211-8. doi:
. [PMID: 8053437] - B Ruiz, J C Rood, E T Fontham, G T Malcom, F M Hunter, M Sobhan, W D Johnson, P Correa. Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment.
The American journal of gastroenterology.
1994 Apr; 89(4):533-9. doi:
NULL. [PMID: 8147356] - F M Hunter, P Correa, E Fontham, B Ruiz, M Sobhan, I M Samloff. Serum pepsinogens as markers of response to therapy for Helicobacter pylori gastritis.
Digestive diseases and sciences.
1993 Nov; 38(11):2081-6. doi:
10.1007/bf01297088. [PMID: 8223084] - D Figueroa-Quintanilla, E Salazar-Lindo, R B Sack, R León-Barúa, S Sarabia-Arce, M Campos-Sánchez, E Eyzaguirre-Maccan. A controlled trial of bismuth subsalicylate in infants with acute watery diarrheal disease.
The New England journal of medicine.
1993 Jun; 328(23):1653-8. doi:
10.1056/nejm199306103282301. [PMID: 8487823] - C U Nwokolo, E J Prewett, A M Sawyerr, M Hudson, R E Pounder. The effect of histamine H2-receptor blockade on bismuth absorption from three ulcer-healing compounds.
Gastroenterology.
1991 Oct; 101(4):889-94. doi:
10.1016/0016-5085(91)90712-t. [PMID: 1889712] - H Soriano-Brücher, P Avendaño, M O'Ryan, S D Braun, M D Manhart, T K Balm, H A Soriano. Bismuth subsalicylate in the treatment of acute diarrhea in children: a clinical study.
Pediatrics.
1991 Jan; 87(1):18-27. doi:
NULL. [PMID: 1984613] - C U Nwokolo, P Mistry, R E Pounder. The absorption of bismuth and salicylate from oral doses of Pepto-Bismol (bismuth salicylate).
Alimentary pharmacology & therapeutics.
1990 Apr; 4(2):163-9. doi:
10.1111/j.1365-2036.1990.tb00461.x. [PMID: 2104082] - D W Bierer. Bismuth subsalicylate: history, chemistry, and safety.
Reviews of infectious diseases.
1990 Jan; 12 Suppl 1(?):S3-8. doi:
10.1093/clinids/12.supplement_1.s3. [PMID: 2406853] - R León-Barúa, R Tello, M C Morante, M Alvarez, R H Gilman, W M Spira. In vitro and in vivo effects of three bismuth compounds on fermentation by colonic bacteria.
Reviews of infectious diseases.
1990 Jan; 12 Suppl 1(?):S24-9. doi:
10.1093/clinids/12.supplement_1.s24. [PMID: 2305175] - J D Gryboski, S Kocoshis. Effect of bismuth subsalicylate on chronic diarrhea in childhood: a preliminary report.
Reviews of infectious diseases.
1990 Jan; 12 Suppl 1(?):S36-40. doi:
10.1093/clinids/12.supplement_1.s36. [PMID: 2305176] - T W Chang, M Y Dong, S L Gorbach. Effect of bismuth subsalicylate on Clostridium difficile colitis in hamsters.
Reviews of infectious diseases.
1990 Jan; 12 Suppl 1(?):S57-8. doi:
10.1093/clinids/12.supplement_1.s57. [PMID: 2305177] - H E Soriano-Brücher, P Avendaño, M O'Ryan, H A Soriano. Use of bismuth subsalicylate in acute diarrhea in children.
Reviews of infectious diseases.
1990 Jan; 12 Suppl 1(?):S51-6. doi:
10.1093/clinids/12.supplement_1.s51. [PMID: 2406856] - S L Gorbach, N A Cornick, M Silva. Effect of bismuth subsalicylate on fecal microflora.
Reviews of infectious diseases.
1990 Jan; 12 Suppl 1(?):S21-3. doi:
10.1093/clinids/12.supplement_1.s21. [PMID: 2305174] - S Sommer, E B Thorling, A Jakobsen, E Steiness, K Ostergaard. Can bismuth decrease the kidney toxic effect of cis-platinum?.
European journal of cancer & clinical oncology.
1989 Dec; 25(12):1903-4. doi:
10.1016/0277-5379(89)90369-6. [PMID: 2632273] - T E Sox, C A Olson. Binding and killing of bacteria by bismuth subsalicylate.
Antimicrobial agents and chemotherapy.
1989 Dec; 33(12):2075-82. doi:
10.1128/aac.33.12.2075. [PMID: 2694949] - R Steffen, J J Mathewson, C D Ericsson, H L DuPont, A Helminger, T K Balm, K Wolff, F Witassek. Travelers' diarrhea in West Africa and Mexico: fecal transport systems and liquid bismuth subsalicylate for self-therapy.
The Journal of infectious diseases.
1988 May; 157(5):1008-13. doi:
10.1093/infdis/157.5.1008. [PMID: 2896219] - R León-Barúa, R Tello-Casanova. [In vitro effect of 2 pharmaceutical preparations containing bismuth on the fermentative capacity of intestinal bacteria].
Acta gastroenterologica Latinoamericana.
1985; 15(3):157-64. doi:
NULL. [PMID: 3836544] - D Y Graham, M K Estes, L O Gentry. Double-blind comparison of bismuth subsalicylate and placebo in the prevention and treatment of enterotoxigenic Escherichia coli-induced diarrhea in volunteers.
Gastroenterology.
1983 Nov; 85(5):1017-22. doi:
10.1016/s0016-5085(83)80066-3. [PMID: 6352386] - C D Ericsson, S Feldman, L K Pickering, T G Cleary. Influence of subsalicylate bismuth on absorption of doxycycline.
JAMA.
1982 Apr; 247(16):2266-7. doi:
NULL. [PMID: 7040708] - A E Stillman. Black heme-positive stools without gastrointestinal hemorrhage.
The Journal of pediatrics.
1982 Mar; 100(3):414-5. doi:
10.1016/s0022-3476(82)80445-9. [PMID: 6977632] - S Feldman, S L Chen, L K Pickering, T G Cleary, C D Ericsson, M Hulse. Salicylate absorption from a bismuth subsalicylate preparation.
Clinical pharmacology and therapeutics.
1981 Jun; 29(6):788-92. doi:
10.1038/clpt.1981.112. [PMID: 7226711] - M M Goldenberg, R R Brooks, K L Boise. Comparative evaluation of gastrointestinal blood loss in the feces of rats following Pepto-Bismol liquid and aspirin administration.
Life sciences.
1980 Apr; 26(16):1335-42. doi:
10.1016/0024-3205(80)90094-6. [PMID: 6966730] - J A KOLMER. Penicillin in the treatment of experimental syphilis of rabbits. VII. Penicillin 'S-R' and procaine penicillin G in peanut oil with aluminum monostearate, alone and in combination with oxophenarsine hydrochloride (mapharsen) or bismuth subsalicylate.
A.M.A. archives of dermatology and syphilology.
1951 Aug; 64(2):169-76. doi:
10.1001/archderm.1951.01570080053008. [PMID: 14856407] - G M LEWIS. Tissue necrosis from injection of bismuth subsalicylate in vegetable oil.
Archives of dermatology and syphilology.
1946 Dec; 54(6):732. doi:
". [PMID: 20277319]