Valacyclovir hydrochloride (BioDeep_00000014659)
Volatile Flavor Compounds
代谢物信息卡片
Valacyclovir hydrochloride
化学式: C13H21ClN6O4 (360.13127360000004)
中文名称: 盐酸伐昔洛韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=O)OCCOCN1C=NC2=C1N=C(NC2=O)N)N.Cl
InChI: 1H/t8-
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5].
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:9919
- KEGG: C07184
- KEGGdrug: D00398
- PubChem: 135398741
- ChEMBL: CHEMBL1201110
- MeSH: Valacyclovir
- CAS: 136489-37-7
- CAS: 124832-27-5
- PubChem: 9393
- NIKKAJI: J1.402.670C
- medchemexpress: HY-17425A
- KNApSAcK: 9919
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- James Kirkland, Pathmanathan Suganthan. Valacyclovir-associated acute kidney injury.
BMJ case reports.
2022 Jun; 15(6):. doi:
10.1136/bcr-2022-249552. [PMID: 35764333] - Elisabeth J Cohen, Judith S Hochman, Andrea B Troxel, Kathryn A Colby, Bennie H Jeng. Zoster Eye Disease Study: Rationale and Design.
Cornea.
2022 May; 41(5):562-571. doi:
10.1097/ico.0000000000002743. [PMID: 35090154] - Obaidur Rehman, Sudesh Kumar Arya, Ujjwal Prakash Jha, Shifali Nayyar, Itisha Goel. Herpes Zoster Ophthalmicus After COVID-19 Vaccination: Chance Occurrence or More?.
Cornea.
2022 Feb; 41(2):254-256. doi:
10.1097/ico.0000000000002881. [PMID: 34690265] - Narisa Ruenroengbun, Tunlanut Sapankaew, Kamolpat Chaiyakittisopon, Pakpoom Phoompoung, Thundon Ngamprasertchai. Efficacy and Safety of Antiviral Agents in Preventing Allograft Rejection Following CMV Prophylaxis in High-Risk Kidney Transplantation: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
Frontiers in cellular and infection microbiology.
2022; 12(?):865735. doi:
10.3389/fcimb.2022.865735. [PMID: 35433502] - V Faure-Bardon, J Fourgeaud, J Stirnemann, M Leruez-Ville, Y Ville. Secondary prevention of congenital cytomegalovirus infection with valacyclovir following maternal primary infection in early pregnancy.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.
2021 Oct; 58(4):576-581. doi:
10.1002/uog.23685. [PMID: 33998084] - J Schurder, H Lazareth, J Mrad, E Thervet, A Benachi, A J Vivanti. Acute kidney injury after valacyclovir administration for prevention of congenital cytomegalovirus infection.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.
2021 10; 58(4):636-637. doi:
10.1002/uog.23724. [PMID: 34182607] - Olus Uyar, Pier-Luc Plante, Jocelyne Piret, Marie-Christine Venable, Julie Carbonneau, Jacques Corbeil, Guy Boivin. A novel bioluminescent herpes simplex virus 1 for in vivo monitoring of herpes simplex encephalitis.
Scientific reports.
2021 09; 11(1):18688. doi:
10.1038/s41598-021-98047-z. [PMID: 34548521] - David Brandariz-Nuñez, Marcelo Correas-Sanahuja, Sara Maya-Gallego, Isabel Martín Herranz. Neurotoxicity associated with acyclovir and valacyclovir: A systematic review of cases.
Journal of clinical pharmacy and therapeutics.
2021 Aug; 46(4):918-926. doi:
10.1111/jcpt.13464. [PMID: 34146428] - Tsuneaki Kenzaka, Kazuma Sugimoto, Ken Goda, Hozuka Akita. Acute kidney injury and acyclovir-associated encephalopathy after administration of valacyclovir in an elderly person with normal renal function: A case report and literature review.
Medicine.
2021 May; 100(21):e26147. doi:
10.1097/md.0000000000026147. [PMID: 34032768] - Vignesh Kumar, Priyanka Narayanan, Seema Shetty, Afsal P Mohammed. Lower motor neuron facial palsy in a postnatal mother with COVID-19.
BMJ case reports.
2021 Mar; 14(3):. doi:
10.1136/bcr-2020-240267. [PMID: 33649026] - Caroline Opene, Maxwell A Fung, Marc Silverstein. Orf progressiva: giant progressive and destructive infections in the immunocompromised.
Dermatology online journal.
2021 Jan; 27(1):. doi:
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Acta pharmacologica Sinica.
2020 Nov; 41(11):1465-1475. doi:
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The Laryngoscope.
2020 11; 130(11):2688-2689. doi:
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CEN case reports.
2020 08; 9(3):200-203. doi:
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Asian journal of surgery.
2020 Jul; 43(7):783-784. doi:
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Medecine et maladies infectieuses.
2020 May; 50(3):280-287. doi:
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BMC infectious diseases.
2020 Mar; 20(1):234. doi:
10.1186/s12879-020-04960-5. [PMID: 32192456] - D P Devanand, Howard Andrews, William C Kreisl, Qolamreza Razlighi, Anne Gershon, Yaakov Stern, Akiva Mintz, Thomas Wisniewski, Edward Acosta, Julianna Pollina, Mariasofia Katsikoumbas, Karen L Bell, Gregory H Pelton, Deborah Deliyannides, K M Prasad, Edward D Huey. Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial.
BMJ open.
2020 02; 10(2):e032112. doi:
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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2019 09; 19(9):2457-2467. doi:
10.1111/ajt.15507. [PMID: 31220412] - Eun Jeong Ko, Ji Hyun Yu, Chul Woo Yang, Byung Ha Chung. Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy.
The Korean journal of internal medicine.
2019 Mar; 34(2):375-382. doi:
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The Journal of infectious diseases.
2019 01; 219(2):234-244. doi:
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Clinical and experimental dermatology.
2019 01; 44(1):92-94. doi:
10.1111/ced.13748. [PMID: 30259552] - Archana Chacko, Amaldoss M J Newton. Synthesis and Characterization of Valacyclovir HCl Hybrid Solid Lipid Nanoparticles by Using Natural Oils.
Recent patents on drug delivery & formulation.
2019; 13(1):46-61. doi:
10.2174/1872211313666190304142129. [PMID: 30836929] - Yoshiaki Ohtsu, Yoko Susaki, Kiyoshi Noguchi. Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents.
European journal of drug metabolism and pharmacokinetics.
2018 Dec; 43(6):693-706. doi:
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BMC infectious diseases.
2018 Nov; 18(1):573. doi:
10.1186/s12879-018-3493-y. [PMID: 30442095] - Takashi Yoshimura, Tatsuya Kawasaki, Ayumi Shirota, Masashi Saeki, Yuki Okada, Hiroshi Okada. Valacyclovir-induced Neurotoxicity in a Patient with a Preserved Renal Function.
Internal medicine (Tokyo, Japan).
2018 Nov; 57(21):3213-3216. doi:
10.2169/internalmedicine.0403-17. [PMID: 29877263] - Le Sun, Chao Wang, Youxi Zhang. A physiologically based pharmacokinetic model for valacyclovir established based on absolute expression quantity of hPEPT1 and its application.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Oct; 123(?):560-568. doi:
10.1016/j.ejps.2018.07.057. [PMID: 30081070] - Jian Shi, Yongjun Hu, David E Smith, Hao-Jie Zhu. A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of valacyclovir and its metabolite acyclovir in mouse and human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Aug; 1092(?):447-452. doi:
10.1016/j.jchromb.2018.06.040. [PMID: 29945109] - Marta Ferreira, Cristina Vega, Begoña Rivas, Rafael Selgas. Acute renal failure and severe neurotoxicity after unintentional overdose of valacyclovir in a geriatric population: A case report.
Nefrologia.
2018 May; 38(3):323-325. doi:
10.1016/j.nefro.2017.05.007. [PMID: 29523376] - Jian Huang, Jinhua Huang, Yaping Xiang, Lihua Gao, Yizhi Pan, Jianyun Lu. [Topical ozone therapy: An innovative solution to patients with herpes zoster].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2018 Feb; 43(2):168-172. doi:
10.11817/j.issn.1672-7347.2018.02.011. [PMID: 29559601] - Zhihua Yue, Jinhai Shi, Haona Li, Huiyi Li. Association between Concomitant Use of Acyclovir or Valacyclovir with NSAIDs and an Increased Risk of Acute Kidney Injury: Data Mining of FDA Adverse Event Reporting System.
Biological & pharmaceutical bulletin.
2018 Feb; 41(2):158-162. doi:
10.1248/bpb.b17-00547. [PMID: 29187701] - Yanfang Han, Qing Guo, Shaozhen Mai, Liangchun Wang, Min Xu, Guozhen Tan. Acute renal injury induced by oral valacyclovir.
European journal of dermatology : EJD.
2018 02; 28(1):122-123. doi:
10.1684/ejd.2017.3189. [PMID: 29336319] - Bei Yang, David E Smith. In Silico Absorption Analysis of Valacyclovir in Wildtype and Pept1 Knockout Mice Following Oral Dose Escalation.
Pharmaceutical research.
2017 Nov; 34(11):2349-2361. doi:
10.1007/s11095-017-2242-z. [PMID: 28770489] - Antoine Rousseau, David Boutolleau, Karine Titier, Tristan Bourcier, Christophe Chiquet, Michel Weber, Joseph Colin, Julie Gueudry, Mohamed M'Garrech, Bahram Bodaghi, Sonia Burrel, Henri Agut, Claire Deback, Marc Labetoulle. Recurrent herpetic keratitis despite antiviral prophylaxis: A virological and pharmacological study.
Antiviral research.
2017 Oct; 146(?):205-212. doi:
10.1016/j.antiviral.2017.09.013. [PMID: 28939476] - Lara K Maxwell, Bradford G Bentz, Lyndi L Gilliam, Jerry W Ritchey, Nicola Pusterla, R Eberle, Todd C Holbrook, Dianne McFarlane, Grant B Rezabek, James Meinkoth, Chase Whitfield, Carla L Goad, George P Allen. Efficacy of the early administration of valacyclovir hydrochloride for the treatment of neuropathogenic equine herpesvirus type-1 infection in horses.
American journal of veterinary research.
2017 Oct; 78(10):1126-1139. doi:
10.2460/ajvr.78.10.1126. [PMID: 28945127] - Bhanu Prasad, Mark McIsaac, Julie Toppings. Valacyclovir-associated neurotoxicity treated with intensification of peritoneal dialysis.
BMJ case reports.
2017 07; 2017(?):. doi:
10.1136/bcr-2017-220678. [PMID: 28765478] - Rakesh Kumar, V R Sinha. Lipid Nanocarrier: an Efficient Approach Towards Ocular Delivery of Hydrophilic Drug (Valacyclovir).
AAPS PharmSciTech.
2017 Apr; 18(3):884-894. doi:
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Ophthalmology.
2017 03; 124(3):382-392. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2017 02; 45(2):137-144. doi:
10.1124/dmd.116.071118. [PMID: 27895114] - Erica Andersen-Nissen, Joanne T Chang, Katherine K Thomas, Devin Adams, Connie Celum, Jorge Sanchez, Robert W Coombs, M Juliana McElrath, Jared M Baeten. Herpes Simplex Virus Suppressive Therapy in Herpes Simplex Virus-2/Human Immunodeficiency Virus-1 Coinfected Women Is Associated With Reduced Systemic CXCL10 But Not Genital Cytokines.
Sexually transmitted diseases.
2016 12; 43(12):761-764. doi:
10.1097/olq.0000000000000523. [PMID: 27832025] - Alexander K Schuster, Björn C Harder, Frank C Schlichtenbrede, Marc N Jarczok, Jonas Tesarz. Valacyclovir versus acyclovir for the treatment of herpes zoster ophthalmicus in immunocompetent patients.
The Cochrane database of systematic reviews.
2016 11; 11(?):CD011503. doi:
10.1002/14651858.cd011503.pub2. [PMID: 27841441] - Mitsuyoshi Nakatani, Mitsuhiro Tsukino, Ryosuke Takahashi, Akio Ikeda. Periodic synchronous discharge occurred in an elderly with acute valacyclovir-associated encephalopathy.
Rinsho shinkeigaku = Clinical neurology.
2016 07; 56(7):504-7. doi:
10.5692/clinicalneurol.cn-000892. [PMID: 27356736] - Dimitrios Chanouzas, Lovesh Dyall, Peter Nightingale, Charles Ferro, Paul Moss, Matthew David Morgan, Lorraine Harper. Valaciclovir to prevent Cytomegalovirus mediated adverse modulation of the immune system in ANCA-associated vasculitis (CANVAS): study protocol for a randomised controlled trial.
Trials.
2016 07; 17(1):338. doi:
10.1186/s13063-016-1482-2. [PMID: 27450392] - Hanan Polansky, Adrian Javaherian, Edan Itzkovitz. Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir.
Drug design, development and therapy.
2016; 10(?):2713-22. doi:
10.2147/dddt.s112852. [PMID: 27621592] - Marilyn Chavannes, Rohit S Doad, Gurinder J S Doad. Valacyclovir and acute renal failure.
Journal of the Medical Association of Georgia.
2016; 105(3):14. doi:
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Transplant infectious disease : an official journal of the Transplantation Society.
2015 Jun; 17(3):334-41. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2015 Jun; 60(11):1708-14. doi:
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Clinical journal of the American Society of Nephrology : CJASN.
2015 Feb; 10(2):294-304. doi:
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BMJ case reports.
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The American journal of the medical sciences.
2014 Dec; 348(6):455-9. doi:
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American journal of therapeutics.
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Pharmacoepidemiology and drug safety.
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PloS one.
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Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
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Pediatric transplantation.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Mar; 28(3):758-65. doi:
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Journal of virology.
2013 Mar; 87(5):2791-802. doi:
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The Cochrane database of systematic reviews.
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Acta virologica.
2013; 57(3):375-7. doi:
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Faraday discussions.
2013; 164(?):135-46. doi:
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Renal failure.
2013; 35(2):289-90. doi:
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Clinical medicine & research.
2012 Nov; 10(4):240-1. doi:
10.3121/cmr.2012.1091. [PMID: 22997354] - Tomas Reischig, Petra Hribova, Pavel Jindra, Ondrej Hes, Mirko Bouda, Vladislav Treska, Ondrej Viklicky. Long-term outcomes of pre-emptive valganciclovir compared with valacyclovir prophylaxis for prevention of cytomegalovirus in renal transplantation.
Journal of the American Society of Nephrology : JASN.
2012 Sep; 23(9):1588-97. doi:
10.1681/asn.2012010100. [PMID: 22917575] - Rowena Delos Santos, Daniel C Brennan. Randomized trial of pre-emptive or prophylactic valganciclovir therapy for prevention of cytomegalovirus infection in renal transplantation.
Journal of the American Society of Nephrology : JASN.
2012 Sep; 23(9):1446-8. doi:
10.1681/asn.2012070729. [PMID: 22878958] - Alan S Boyd, Jeffrey P Zwerner, Jami L Miller. Herpes simplex virus-induced plasmacytic atypia.
Journal of cutaneous pathology.
2012 Feb; 39(2):270-3. doi:
10.1111/j.1600-0560.2011.01817.x. [PMID: 22077666] - Alison L Drake, Alison C Roxby, Francisca Ongecha-Owuor, James Kiarie, Grace John-Stewart, Anna Wald, Barbra A Richardson, Jane Hitti, Julie Overbaugh, Sandra Emery, Carey Farquhar. Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial.
The Journal of infectious diseases.
2012 Feb; 205(3):366-75. doi:
10.1093/infdis/jir766. [PMID: 22147786] - Alison C Roxby, Alison L Drake, Francisca Ongecha-Owuor, James N Kiarie, Barbra Richardson, Daniel N Matemo, Julie Overbaugh, Sandra Emery, Grace C John-Stewart, Anna Wald, Carey Farquhar. Effects of valacyclovir on markers of disease progression in postpartum women co-infected with HIV-1 and herpes simplex virus-2.
PloS one.
2012; 7(6):e38622. doi:
10.1371/journal.pone.0038622. [PMID: 22701683] - Lukas Kielberger, Mirko Bouda, Pavel Jindra, Tomas Reischig. Pharmacoeconomic impact of different regimens to prevent cytomegalovirus infection in renal transplant recipients.
Kidney & blood pressure research.
2012; 35(6):407-16. doi:
10.1159/000335962. [PMID: 22584353] - Kenneth Mugwanya, Jared M Baeten, Nelly R Mugo, Elizabeth Irungu, Kenneth Ngure, Connie Celum. High-dose valacyclovir HSV-2 suppression results in greater reduction in plasma HIV-1 levels compared with standard dose acyclovir among HIV-1/HSV-2 coinfected persons: a randomized, crossover trial.
The Journal of infectious diseases.
2011 Dec; 204(12):1912-7. doi:
10.1093/infdis/jir649. [PMID: 21998479] - Dipanjan Goswami, Arshad Khuroo, Sanjay Gurule, Yogesh Modhave, Tausif Monif. Controlled ex-vivo plasma hydrolysis of valaciclovir to acyclovir demonstration using tandem mass spectrometry.
Biomedical chromatography : BMC.
2011 Nov; 25(11):1189-200. doi:
10.1002/bmc.1590. [PMID: 21400550] - Onkar Singh, Saurabh Saxena, Sanjeev Mishra, Arshad Khuroo, Tausif Monif. Determination of valganciclovir and ganciclovir in human plasma by liquid chromatography tandem mass spectrometric detection.
Clinical biochemistry.
2011 Jul; 44(10-11):907-15. doi:
10.1016/j.clinbiochem.2011.04.003. [PMID: 21515246] - John P Sabo, Xiuyu Julie Cong, Michael-Friedrich Kraft, Lacey Wallace, Mark A Castles, Stefan Mauss, Thomas R MacGregor. Lack of a pharmacokinetic interaction between steady-state tipranavir/ritonavir and single-dose valacyclovir in healthy volunteers.
European journal of clinical pharmacology.
2011 Mar; 67(3):277-81. doi:
10.1007/s00228-010-0907-1. [PMID: 20963404] - Darren M Roberts, Myles W H Smith, Brendan J McMullan, Jacob Sevastos, Ric O Day. Acute kidney injury due to crystalluria following acute valacyclovir overdose.
Kidney international.
2011 Mar; 79(5):574. doi:
10.1038/ki.2010.496. [PMID: 21321560] - G Kambhampati, U Pakkivenkata, A Kazory. Valacyclovir neurotoxicity can be effectively managed by hemodialysis.
European journal of neurology.
2011 Mar; 18(3):e33. doi:
10.1111/j.1468-1331.2010.03250.x. [PMID: 21087359] - Nigel D Toussaint, Marcus B P Tan, Kathy Nicholls, Rowan G Walker, Solomon J Cohney. Low-dose valaciclovir and cytomegalovirus immunoglobulin to prevent cytomegalovirus disease in high-risk renal transplant recipients.
Nephrology (Carlton, Vic.).
2011 Jan; 16(1):113-7. doi:
10.1111/j.1440-1797.2010.01379.x. [PMID: 21175987] - Jared M Baeten, Jairam Lingappa, Ingrid Beck, Lisa M Frenkel, Gregory Pepper, Connie Celum, Anna Wald, Kenneth H Fife, Edwin Were, Nelly Mugo, Jorge Sanchez, Myron Essex, Joseph Makhema, James Kiarie, Carey Farquhar, Lawrence Corey. Herpes simplex virus type 2 suppressive therapy with acyclovir or valacyclovir does not select for specific HIV-1 resistance in HIV-1/HSV-2 dually infected persons.
The Journal of infectious diseases.
2011 Jan; 203(1):117-21. doi:
10.1093/infdis/jiq013. [PMID: 21148504] - Tomá Reischig, Miroslav Prucha, Lenka Sedlackova, Daniel Lysak, Pavel Jindra, Mirko Bouda, Martin Matejovic. Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant recipients.
Antiviral therapy.
2011; 16(8):1227-35. doi:
10.3851/imp1879. [PMID: 22155904] - Akio Takayanagi, Takeshi Maehana, Yuuki Kyoda, Masahiro Yanase. [Neurotoxicity of valacyclovir in a peritoneal dialysis patient].
Hinyokika kiyo. Acta urologica Japonica.
2010 Nov; 56(11):617-9. doi:
NULL. [PMID: 21187705] - Francesca Leone, Ahmed Akl, Magali Giral, Jacques Dantal, Gilles Blancho, Jean-Paul Soulillou, Diego Cantarovich. Six months anti-viral prophylaxis significantly decreased cytomegalovirus disease compared with no anti-viral prophylaxis following renal transplantation.
Transplant international : official journal of the European Society for Organ Transplantation.
2010 Sep; 23(9):897-906. doi:
10.1111/j.1432-2277.2010.01073.x. [PMID: 20230540] - Björn Pasternak, Anders Hviid. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects.
JAMA.
2010 Aug; 304(8):859-66. doi:
10.1001/jama.2010.1206. [PMID: 20736469] - Heather E Vezina, Henry H Balfour, Dennis R Weller, Bruce J Anderson, Richard C Brundage. Valacyclovir pharmacokinetics and exploratory pharmacodynamics in young adults with Epstein-Barr virus infectious mononucleosis.
Journal of clinical pharmacology.
2010 Jul; 50(7):734-42. doi:
10.1177/0091270009351884. [PMID: 19897764] - Mustafa Keles, Rahsan Yildirim, Abdullah Uyanik, Meral Turkmen, Yusuf Bilen, Bulent Aydinli, Ramazan Cetinkaya, Kamil Yalcin Polat. Neutropenia related to valacyclovir and valganciclovir in 2 renal transplant patients and treatment with granulocyte colony stimulating factor: a case report.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2010 Jun; 8(2):181-3. doi:
NULL. [PMID: 20565377] - James P Smith, Stephen Weller, Benjamin Johnson, Janet Nicotera, James M Luther, David W Haas. Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function.
Antimicrobial agents and chemotherapy.
2010 Mar; 54(3):1146-51. doi:
10.1128/aac.00729-09. [PMID: 20038622] - Hui Lin, Yuan Tian, Ji-Xin Tian, Zun-Jian Zhang, Guo-Guang Mao. Pharmacokinetics and bioequivalence study of valacyclovir hydrochloride capsules after single dose administration in healthy Chinese male volunteers.
Arzneimittel-Forschung.
2010; 60(3):162-7. doi:
10.1055/s-0031-1296266. [PMID: 20422949] - Rita Neves, Susana Almeida, Augusto Filipe, Ana Cristina Franco Spinola, Zohreh Abolfathi, Ann Lévesque, Jordi Ortuño, Alex Torns. Bioequivalence studies of two different film-coated tablet formulations of valacyclovir of two different strengths in healthy volunteers.
Arzneimittel-Forschung.
2010; 60(5):273-81. doi:
10.1055/s-0031-1296285. [PMID: 20533765] - Tomás Reischig, Jana Nemcová, Tomás Vanecek, Pavel Jindra, Ondrej Hes, Mirko Bouda, Vladislav Treska. Intragraft cytomegalovirus infection: a randomized trial of valacyclovir prophylaxis versus pre-emptive therapy in renal transplant recipients.
Antiviral therapy.
2010; 15(1):23-30. doi:
10.3851/imp1485. [PMID: 20167988] - Ming Lim, Esse Menson, C Y William Tong, Jean-Pierre Lin. Use of therapeutic drug monitoring in the long-term valaciclovir therapy of relapsing herpes simplex virus encephalitis in children.
The Journal of antimicrobial chemotherapy.
2009 Dec; 64(6):1340-1. doi:
10.1093/jac/dkp373. [PMID: 19828489] - G F Ferreira, R A Oliveira, M Lucon, F J de Paula, A M Lucon, L E Ianhez, M Srougi, E Sabbaga. Hemorrhagic cystitis secondary to adenovirus or herpes simplex virus infection following renal transplantation: four case reports.
Transplantation proceedings.
2009 Dec; 41(10):4416-9. doi:
10.1016/j.transproceed.2009.09.059. [PMID: 20005412] - Allan C Gelber. Distinctly different purpura on different arms.
Lancet (London, England).
2009 Sep; 374(9694):1010. doi:
10.1016/s0140-6736(09)60290-7. [PMID: 19766882] - Roy R Jurhill, Haitze van der Veen, Geert J L H van Leenders, Paul C M S Verhagen. Reduction of serum prostate-specific antigen levels following varicella-zoster infection and valaciclovir treatment in prostate cancer.
European urology.
2009 Aug; 56(2):392-4. doi:
10.1016/j.eururo.2009.02.025. [PMID: 19278776] - L Zeng, C E Nath, E Y L Blair, P J Shaw, K Stephen, J W Earl, J C Coakley, A J McLachlan. Population pharmacokinetics of acyclovir in children and young people with malignancy after administration of intravenous acyclovir or oral valacyclovir.
Antimicrobial agents and chemotherapy.
2009 Jul; 53(7):2918-27. doi:
10.1128/aac.01138-08. [PMID: 19414579] - Anita K Satyaprakash, Anne Marie Tremaine, Arwen A Stelter, Rosella Creed, Parisa Ravanfar, Natalia Mendoza, Satish K Mehta, Peter L Rady, Duane L Pierson, Stephen K Tyring. Viremia in acute herpes zoster.
The Journal of infectious diseases.
2009 Jul; 200(1):26-32. doi:
10.1086/599381. [PMID: 19469706] - B Garré, K Baert, H Nauwynck, P Deprez, P De Backer, S Croubels. Multiple oral dosing of valacyclovir in horses and ponies.
Journal of veterinary pharmacology and therapeutics.
2009 Jun; 32(3):207-12. doi:
10.1111/j.1365-2885.2008.01025.x. [PMID: 19646083] - Inge R F van Berlo-van de Laar, Esther R Goet, Anders Helldén, Henk E Sluiter. [Adverse effect of valaciclovir in disturbed kidney function].
Nederlands tijdschrift voor geneeskunde.
2009 Apr; 153(15):706-9. doi:
NULL. [PMID: 19452773] - T Asahi, M Tsutsui, M Wakasugi, D Tange, C Takahashi, K Tokui, S Okazawa, H Okudera. Valacyclovir neurotoxicity: clinical experience and review of the literature.
European journal of neurology.
2009 Apr; 16(4):457-60. doi:
10.1111/j.1468-1331.2008.02527.x. [PMID: 19187258]